Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.0231 | 0.0231 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0106 | 0.2719 | 0.2719 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0101 | 0.2523 | 0.2704 |
Echinococcus granulosus | expressed conserved protein | 0.0098 | 0.2405 | 0.2578 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0105 | 0.2655 | 0.2846 |
Echinococcus granulosus | jumonji domain containing protein | 0.0043 | 0.0221 | 0.0237 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0045 | 0.0295 | 0.0295 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.0231 | 0.0231 |
Brugia malayi | MH2 domain containing protein | 0.0127 | 0.3524 | 0.3524 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0105 | 0.2655 | 0.2846 |
Schistosoma mansoni | patched 1 | 0.0045 | 0.0295 | 0.0295 |
Brugia malayi | CHE-14 protein | 0.0045 | 0.0295 | 0.0295 |
Loa Loa (eye worm) | hypothetical protein | 0.0274 | 0.9329 | 0.9329 |
Onchocerca volvulus | 0.0056 | 0.0726 | 0.5 | |
Echinococcus multilocularis | protein patched | 0.0045 | 0.0295 | 0.0317 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.015 | 0.4429 | 0.4748 |
Brugia malayi | jmjC domain containing protein | 0.0101 | 0.2523 | 0.2523 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0274 | 0.9329 | 1 |
Brugia malayi | hypothetical protein | 0.0274 | 0.9329 | 0.9329 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0127 | 0.3524 | 0.3524 |
Schistosoma mansoni | jumonji domain containing protein | 0.0081 | 0.17 | 0.17 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.2655 | 0.2655 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0056 | 0.0726 | 0.0726 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0045 | 0.0295 | 0.0317 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0695 | 0.0695 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0274 | 0.9329 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0295 | 0.0295 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0127 | 0.3524 | 0.3524 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0043 | 0.0221 | 0.0237 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0045 | 0.0295 | 0.0317 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0064 | 0.1044 | 0.1044 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0105 | 0.2655 | 0.2655 |
Schistosoma mansoni | survival motor neuron protein | 0.0056 | 0.0726 | 0.0726 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.0231 | 0.0231 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0105 | 0.2655 | 0.5 |
Echinococcus multilocularis | protein dispatched 1 | 0.0051 | 0.0546 | 0.0585 |
Schistosoma mansoni | hypothetical protein | 0.0056 | 0.0726 | 0.0726 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0045 | 0.0295 | 0.0317 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0101 | 0.2523 | 0.2704 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.015 | 0.4429 | 0.4748 |
Echinococcus multilocularis | expressed conserved protein | 0.0098 | 0.2405 | 0.2578 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.0231 | 0.0231 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0616 | 0.0616 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | > 1000 ug ml-1 | Antimicrobial activity against Escherichia coli ATCC 25922 after 18 hrs by microdilution method | ChEMBL. | 24440302 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.