Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | muscleblind protein 1 | 0.0151 | 0.1997 | 0.1966 |
Echinococcus multilocularis | muscleblind protein | 0.0151 | 0.1997 | 0.1966 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.0185 | 0.0564 |
Echinococcus multilocularis | lamin | 0.0027 | 0.0185 | 0.0147 |
Onchocerca volvulus | 0.0049 | 0.05 | 0.1013 | |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0202 | 0.2743 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0047 | 0.048 | 0.0468 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0295 | 0.4112 | 1 |
Schistosoma mansoni | lamin | 0.0027 | 0.0185 | 0.0173 |
Schistosoma mansoni | zinc finger protein | 0.002 | 0.0076 | 0.0063 |
Echinococcus multilocularis | musashi | 0.0027 | 0.0185 | 0.0147 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.1997 | 0.6077 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.0724 | 0.0712 |
Schistosoma mansoni | intermediate filament proteins | 0.0027 | 0.0185 | 0.0173 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0389 | 0.1184 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.0724 | 0.0712 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0202 | 0.2743 | 0.8347 |
Echinococcus multilocularis | zinc finger protein | 0.002 | 0.0076 | 0.0037 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0202 | 0.2743 | 1 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0202 | 0.2743 | 1 |
Onchocerca volvulus | Huntingtin homolog | 0.0124 | 0.1599 | 0.4552 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.003 | 0.0228 | 0.0266 |
Brugia malayi | hypothetical protein | 0.0016 | 0.0027 | 0.0082 |
Brugia malayi | PHD-finger family protein | 0.0025 | 0.0155 | 0.0471 |
Echinococcus multilocularis | tar DNA binding protein | 0.0064 | 0.0724 | 0.0688 |
Onchocerca volvulus | 0.0239 | 0.3292 | 1 | |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0023 | 0.012 | 0.0082 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.0185 | 0.0564 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0202 | 0.2743 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0064 | 0.0724 | 0.2202 |
Trypanosoma brucei | protein kinase, putative | 0.0202 | 0.2743 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0124 | 0.1599 | 0.4867 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0144 | 0.1899 | 0.5 |
Onchocerca volvulus | Huntingtin homolog | 0.0124 | 0.1599 | 0.4552 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.0185 | 0.0147 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0036 | 0.0318 | 0.0281 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.0185 | 0.0564 |
Onchocerca volvulus | 0.003 | 0.0228 | 0.0137 | |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0159 | 0.0537 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0202 | 0.2743 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0833 | 0.2535 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0295 | 0.4112 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0159 | 0.5 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0018 | 0.0048 | 0.0145 |
Echinococcus multilocularis | geminin | 0.0171 | 0.2294 | 0.2264 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.0159 | 0.0537 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0159 | 0.0485 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.003 | 0.0228 | 0.0216 |
Brugia malayi | Pre-SET motif family protein | 0.003 | 0.0228 | 0.0694 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0029 | 0.0212 | 0.0174 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.0185 | 0.0147 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.0185 | 0.0564 |
Schistosoma mansoni | lamin | 0.0027 | 0.0185 | 0.0173 |
Brugia malayi | Muscleblind-like protein | 0.0151 | 0.1997 | 0.6077 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0202 | 0.2743 | 1 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0049 | 0.05 | 0.1522 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0017 | 0.0039 | 0.0026 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0417 | 0.127 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0295 | 0.4112 | 1 |
Brugia malayi | TAR-binding protein | 0.0064 | 0.0724 | 0.2202 |
Trichomonas vaginalis | set domain proteins, putative | 0.0239 | 0.3292 | 0.4011 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.0724 | 0.0712 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0239 | 0.3286 | 0.326 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0354 | 0.1078 |
Loa Loa (eye worm) | TAR-binding protein | 0.0064 | 0.0724 | 0.2202 |
Brugia malayi | MAP kinase sur-1 | 0.0202 | 0.2743 | 0.8347 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0295 | 0.4112 | 0.5 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0036 | 0.0318 | 0.0281 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0202 | 0.2743 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0295 | 0.4112 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0295 | 0.4112 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0159 | 0.5 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0021 | 0.0092 | 0.0279 |
Loa Loa (eye worm) | hypothetical protein | 0.0239 | 0.3286 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0064 | 0.0724 | 0.2202 |
Schistosoma mansoni | hypothetical protein | 0.0021 | 0.0092 | 0.0079 |
Brugia malayi | hypothetical protein | 0.0239 | 0.3286 | 1 |
Brugia malayi | hypothetical protein | 0.0124 | 0.1599 | 0.4867 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.2294 | 0.2284 |
Brugia malayi | Bromodomain containing protein | 0.0076 | 0.0896 | 0.2727 |
Loa Loa (eye worm) | hypothetical protein | 0.0124 | 0.1599 | 0.4867 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0159 | 0.0485 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.1997 | 0.6077 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0295 | 0.4112 | 1 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0144 | 0.1899 | 0.5 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0239 | 0.3286 | 0.326 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0017 | 0.0039 | 0.0026 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.05 | 0.0488 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0228 | 0.0216 |
Echinococcus granulosus | muscleblind protein | 0.0151 | 0.1997 | 0.1966 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0202 | 0.2743 | 0.2715 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.2294 | 0.2284 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.0724 | 0.0712 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0144 | 0.1899 | 0.5 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.006 | 0.067 | 0.0634 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.0724 | 0.0712 |
Brugia malayi | Bromodomain containing protein | 0.0039 | 0.0353 | 0.1074 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0202 | 0.2743 | 0.2715 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0047 | 0.048 | 0.0444 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.0159 | 0.0537 |
Loa Loa (eye worm) | RNA binding protein | 0.0064 | 0.0724 | 0.2202 |
Brugia malayi | Pre-SET motif family protein | 0.021 | 0.2867 | 0.8723 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0295 | 0.4112 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0064 | 0.0724 | 0.0688 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0185 | 0.0564 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0047 | 0.048 | 0.0468 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.006 | 0.067 | 0.0634 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.048 | 0.1462 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.003 | 0.0228 | 0.019 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0295 | 0.4112 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0295 | 0.4112 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0295 | 0.4112 | 1 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0295 | 0.4112 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0178 | 0.0542 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.021 | 0.2867 | 0.8723 |
Echinococcus granulosus | zinc finger protein | 0.002 | 0.0076 | 0.0037 |
Plasmodium vivax | SET domain protein, putative | 0.003 | 0.0228 | 1 |
Schistosoma mansoni | survival motor neuron protein | 0.0049 | 0.05 | 0.0488 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.0185 | 0.0147 |
Echinococcus granulosus | lamin | 0.0027 | 0.0185 | 0.0147 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0047 | 0.048 | 0.0444 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0202 | 0.2743 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0202 | 0.2743 | 0.2715 |
Brugia malayi | RNA binding protein | 0.0064 | 0.0724 | 0.2202 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0202 | 0.2743 | 0.2734 |
Echinococcus granulosus | geminin | 0.0171 | 0.2294 | 0.2264 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0023 | 0.012 | 0.0107 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0023 | 0.012 | 0.0082 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0159 | 0.0537 |
Schistosoma mansoni | bromodomain containing protein | 0.0064 | 0.0723 | 0.0711 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0202 | 0.2743 | 0.2715 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI (functional) | = 16.8 % | Antibacterial activity against Escherichia coli DH5[alpha] assessed as growth inhibition at late exponential phase at 200 uM after 16 hrs | ChEMBL. | 24525002 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.