Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0144 | 0.0189 | 0.0174 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.3209 | 0.5076 | 1 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0039 | 0.0021 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.3209 | 0.5076 | 1 |
Echinococcus granulosus | geminin | 0.0168 | 0.0227 | 0.0213 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.3209 | 0.5076 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3209 | 0.5076 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.064 | 0.098 | 0.098 |
Echinococcus multilocularis | thymidylate synthase | 0.064 | 0.098 | 0.0967 |
Echinococcus multilocularis | geminin | 0.0168 | 0.0227 | 0.0213 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 0.0227 | 0.0213 |
Brugia malayi | thymidylate synthase | 0.064 | 0.098 | 0.098 |
Brugia malayi | beta-NAC-like protein | 0.0035 | 0.0014 | 0.0014 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.064 | 0.098 | 0.0967 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0305 | 0.0445 | 1 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0039 | 0.0021 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.064 | 0.098 | 0.0967 |
Loa Loa (eye worm) | acetyltransferase | 0.0144 | 0.0189 | 0.0189 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.064 | 0.098 | 0.056 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0042 | 0.0027 | 0.0282 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.014 | 0.0182 | 0.0168 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0039 | 0.0021 | 0.0013 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0305 | 0.0445 | 0.085 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3209 | 0.5076 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 0.0227 | 0.0213 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0042 | 0.0027 | 0.0024 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0144 | 0.0189 | 0.0174 |
Brugia malayi | hypothetical protein | 0.0305 | 0.0445 | 0.0445 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0042 | 0.0027 | 0.0012 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0042 | 0.0027 | 0.0024 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0042 | 0.0027 | 0.0024 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.3209 | 0.5076 | 1 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0042 | 0.0027 | 0.0282 |
Onchocerca volvulus | 0.064 | 0.098 | 0.5 | |
Loa Loa (eye worm) | ICD-1 protein | 0.0035 | 0.0014 | 0.0014 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0144 | 0.0189 | 0.0189 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 9.35 uM | Cytotoxicity against human KB cells after 72 hrs by SRB assay | ChEMBL. | 24553146 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 24553146 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.