Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | tm gpcr rhodopsin | Get druggable targets OG5_145685 | All targets in OG5_145685 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | Get druggable targets OG5_145685 | All targets in OG5_145685 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.3115 | 0.5303 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0556 | 0.0823 | 0.0823 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0087 | 0.0002 | 0.0002 |
Onchocerca volvulus | Netrin receptor homolog | 0.0127 | 0.0072 | 0.0655 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0717 | 0.1106 | 0.1106 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.0072 | 0.0072 |
Echinococcus granulosus | thymidylate synthase | 0.0717 | 0.1106 | 0.1106 |
Schistosoma mansoni | retinoblastoma-binding protein 4 (rbbp4) | 0.0127 | 0.0072 | 0.0072 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.0072 | 0.0072 |
Echinococcus multilocularis | Ankyrin | 0.0127 | 0.0072 | 0.0072 |
Schistosoma mansoni | tyrosine kinase | 0.0567 | 0.0843 | 0.0843 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.3115 | 0.5303 | 0.5 |
Echinococcus multilocularis | netrin receptor unc 5 | 0.0127 | 0.0072 | 0.0072 |
Brugia malayi | Death domain containing protein | 0.0127 | 0.0072 | 0.0072 |
Brugia malayi | Protein kinase domain containing protein | 0.0128 | 0.0075 | 0.0075 |
Schistosoma mansoni | netrin receptor unc5 | 0.0127 | 0.0072 | 0.0072 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.1003 | 0.1606 | 0.1606 |
Echinococcus granulosus | Ankyrin | 0.0127 | 0.0072 | 0.0072 |
Brugia malayi | hypothetical protein | 0.0341 | 0.0448 | 0.0448 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0127 | 0.0072 | 0.0072 |
Echinococcus multilocularis | ankyrin repeat and death domain containing protein | 0.0127 | 0.0072 | 0.0072 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0717 | 0.1106 | 0.0689 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.3115 | 0.5303 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.3115 | 0.5303 | 1 |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.0567 | 0.0843 | 0.0843 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3115 | 0.5303 | 0.5 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.1003 | 0.1606 | 0.1606 |
Echinococcus granulosus | netrin receptor unc 5 | 0.0127 | 0.0072 | 0.0072 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0127 | 0.0072 | 0.0072 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3115 | 0.5303 | 0.5 |
Brugia malayi | Uncoordinated protein 44 | 0.0127 | 0.0072 | 0.0072 |
Echinococcus granulosus | ankyrin repeat and death domain containing protein | 0.0127 | 0.0072 | 0.0072 |
Schistosoma mansoni | ankyrin 23/unc44 | 0.0127 | 0.0072 | 0.0072 |
Loa Loa (eye worm) | thymidylate synthase | 0.0717 | 0.1106 | 0.1106 |
Schistosoma mansoni | hypothetical protein | 0.0127 | 0.0072 | 0.0072 |
Onchocerca volvulus | 0.0717 | 0.1106 | 1 | |
Brugia malayi | thymidylate synthase | 0.0717 | 0.1106 | 0.1106 |
Echinococcus granulosus | death domain containing protein | 0.0127 | 0.0072 | 0.0072 |
Echinococcus multilocularis | thymidylate synthase | 0.0717 | 0.1106 | 0.1106 |
Echinococcus granulosus | tyrosine protein kinase shark | 0.0567 | 0.0843 | 0.0843 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0341 | 0.0448 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 50 nM | Displacement of [3H]LSD from human cloned 5-HT6 receptor expressed in HeLa cells | ChEMBL. | 24495863 |
Inhibition (binding) | Antagonist activity at human cloned 5-HT6 receptor expressed in HeLa cells assessed as inhibition of 5-HT-stimulated conversion of [alpha-33P]ATP to [33P]cAMP | ChEMBL. | 24495863 | |
T1/2 (ADMET) | = 4.1 min | Half life in human liver microsomes at 0.5 uM in presence of NADPH | ChEMBL. | 24495863 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.