Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.015 | 0.2022 | 0.2022 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0164 | 0.3182 | 0.3182 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.015 | 0.2022 | 0.2022 |
Brugia malayi | Cathepsin L-like precursor | 0.0164 | 0.3182 | 0.3182 |
Echinococcus multilocularis | RUN | 0.015 | 0.2022 | 0.2022 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.3182 | 0.1454 |
Onchocerca volvulus | 0.0164 | 0.3182 | 0.1454 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0164 | 0.3182 | 0.3182 |
Brugia malayi | cathepsin L-like precursor | 0.0164 | 0.3182 | 0.3182 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.015 | 0.2022 | 0.2022 |
Echinococcus granulosus | RUN | 0.015 | 0.2022 | 0.2022 |
Brugia malayi | Cathepsin L-like precursor | 0.0164 | 0.3182 | 0.3182 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0164 | 0.3182 | 0.3182 |
Plasmodium falciparum | LCCL domain-containing protein | 0.015 | 0.2022 | 0.2022 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.015 | 0.2022 | 0.2022 |
Brugia malayi | hypothetical protein | 0.015 | 0.2022 | 0.2022 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0164 | 0.3182 | 0.3182 |
Echinococcus granulosus | cathepsin l1 | 0.0164 | 0.3182 | 0.3182 |
Schistosoma mansoni | rab6-interacting | 0.015 | 0.2022 | 0.2022 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.015 | 0.2022 | 0.2022 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.015 | 0.2022 | 0.2022 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0164 | 0.3182 | 0.3182 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.015 | 0.2022 | 0.2022 |
Schistosoma mansoni | loxhd1 | 0.015 | 0.2022 | 0.2022 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.015 | 0.2022 | 0.2022 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.3182 | 0.1454 |
Schistosoma mansoni | rab6-interacting | 0.015 | 0.2022 | 0.2022 |
Schistosoma mansoni | hypothetical protein | 0.015 | 0.2022 | 0.2022 |
Schistosoma mansoni | polycystin 1-related | 0.015 | 0.2022 | 0.2022 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.3182 | 0.1454 |
Schistosoma mansoni | lipoxygenase | 0.015 | 0.2022 | 0.2022 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0164 | 0.3182 | 0.3182 |
Brugia malayi | Doublecortin family protein | 0.015 | 0.2022 | 0.2022 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
FC (binding) | = 0.06 | Induction of HEXIM1 protein expression in human LNCAP cells at 100 uM after 24 hrs by Western blotting analysis relative to control | ChEMBL. | 24503105 |
FC (binding) | = 1.88 | Induction of HEXIM1 protein expression in human LNCAP cells at 500 uM after 24 hrs by Western blotting analysis relative to control | ChEMBL. | 24503105 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.