Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0329 | 0.4058 | 1 |
Trypanosoma cruzi | cysteine protease, putative | 0.0169 | 0.1304 | 0.2757 |
Onchocerca volvulus | 0.022 | 0.218 | 0.2452 | |
Loa Loa (eye worm) | ctsf protein | 0.0329 | 0.4058 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0329 | 0.4058 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0329 | 0.4058 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0329 | 0.4058 | 0.3167 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0185 | 0.157 | 0.0967 |
Leishmania major | cathepsin L-like protease | 0.0329 | 0.4058 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0329 | 0.4058 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0329 | 0.4058 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0329 | 0.4058 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0329 | 0.4058 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0329 | 0.4058 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0329 | 0.4058 | 1 |
Onchocerca volvulus | 0.0329 | 0.4058 | 1 | |
Plasmodium vivax | unspecified product | 0.0169 | 0.1304 | 0.2757 |
Giardia lamblia | Kinase, PLK | 0.0185 | 0.157 | 0.5 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0185 | 0.157 | 0.0306 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0185 | 0.157 | 0.157 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0329 | 0.4058 | 0.3167 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0329 | 0.4058 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0169 | 0.1304 | 0.2757 |
Leishmania major | cathepsin L-like protease | 0.0329 | 0.4058 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0185 | 0.157 | 0.0967 |
Brugia malayi | cathepsin L-like precursor | 0.022 | 0.218 | 0.5061 |
Onchocerca volvulus | 0.0329 | 0.4058 | 1 | |
Onchocerca volvulus | 0.0329 | 0.4058 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0329 | 0.4058 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0329 | 0.4058 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0329 | 0.4058 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0329 | 0.4058 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0329 | 0.4058 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0329 | 0.4058 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.022 | 0.218 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0329 | 0.4058 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0329 | 0.4058 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.022 | 0.218 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0329 | 0.4058 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0329 | 0.4058 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0329 | 0.4058 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0329 | 0.4058 | 0.3167 |
Loa Loa (eye worm) | fibroinase | 0.0329 | 0.4058 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0329 | 0.4058 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0329 | 0.4058 | 1 |
Schistosoma mansoni | cathepsin s | 0.0109 | 0.0255 | 0.0255 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0169 | 0.1304 | 0.2757 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0329 | 0.4058 | 0.3167 |
Brugia malayi | Cathepsin L-like precursor | 0.0329 | 0.4058 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0329 | 0.4058 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0329 | 0.4058 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0329 | 0.4058 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0329 | 0.4058 | 1 |
Leishmania major | cathepsin L-like protease | 0.0329 | 0.4058 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0329 | 0.4058 | 1 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0185 | 0.157 | 0.3457 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0329 | 0.4058 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0329 | 0.4058 | 1 |
Leishmania major | cathepsin L-like protease | 0.0329 | 0.4058 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0329 | 0.4058 | 0.4058 |
Loa Loa (eye worm) | hypothetical protein | 0.022 | 0.218 | 0.5061 |
Loa Loa (eye worm) | hypothetical protein | 0.022 | 0.218 | 0.5061 |
Leishmania major | cathepsin L-like protease | 0.0329 | 0.4058 | 1 |
Leishmania major | cathepsin L-like protease | 0.0329 | 0.4058 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0169 | 0.1304 | 0.1304 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0185 | 0.157 | 0.3457 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0169 | 0.1304 | 0.2757 |
Entamoeba histolytica | cysteine protease, putative | 0.0329 | 0.4058 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0185 | 0.157 | 0.0967 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0329 | 0.4058 | 1 |
Onchocerca volvulus | 0.0329 | 0.4058 | 1 | |
Entamoeba histolytica | cysteine proteinase, putative | 0.022 | 0.218 | 0.3182 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0185 | 0.157 | 0.0967 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.022 | 0.218 | 0.218 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0329 | 0.4058 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0329 | 0.4058 | 0.3167 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0329 | 0.4058 | 1 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0185 | 0.157 | 0.0306 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0329 | 0.4058 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0329 | 0.4058 | 0.3167 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0329 | 0.4058 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0329 | 0.4058 | 1 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0185 | 0.157 | 0.3457 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0329 | 0.4058 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0329 | 0.4058 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0329 | 0.4058 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0329 | 0.4058 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0329 | 0.4058 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0329 | 0.4058 | 1 |
Plasmodium vivax | vivapain-2 | 0.0329 | 0.4058 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0329 | 0.4058 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.022 | 0.218 | 0.5061 |
Leishmania major | cathepsin L-like protease | 0.0329 | 0.4058 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0329 | 0.4058 | 1 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0185 | 0.157 | 0.0967 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0329 | 0.4058 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0185 | 0.157 | 0.0967 |
Onchocerca volvulus | 0.0329 | 0.4058 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0329 | 0.4058 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0169 | 0.1304 | 0.1304 |
Echinococcus multilocularis | cysteine protease | 0.0329 | 0.4058 | 0.3167 |
Plasmodium vivax | vivapain-3 | 0.0169 | 0.1304 | 0.2757 |
Onchocerca volvulus | 0.0329 | 0.4058 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0329 | 0.4058 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.0329 | 0.4058 | 0.5 |
Plasmodium vivax | vivapain-1 | 0.0169 | 0.1304 | 0.2757 |
Loa Loa (eye worm) | cysteine protease | 0.0329 | 0.4058 | 1 |
Onchocerca volvulus | 0.0329 | 0.4058 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0329 | 0.4058 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0329 | 0.4058 | 0.4058 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0185 | 0.157 | 0.0967 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.022 | 0.218 | 0.5061 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0185 | 0.157 | 0.3457 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0329 | 0.4058 | 0.3167 |
Plasmodium vivax | vivapain-2 | 0.0329 | 0.4058 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0329 | 0.4058 | 1 |
Leishmania major | cathepsin L-like protease | 0.0329 | 0.4058 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0329 | 0.4058 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0329 | 0.4058 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0329 | 0.4058 | 0.3167 |
Leishmania major | cysteine peptidase A (CPA) | 0.0329 | 0.4058 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0329 | 0.4058 | 1 |
Trypanosoma brucei | polo-like protein kinase | 0.0185 | 0.157 | 0.0967 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0329 | 0.4058 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.022 | 0.218 | 0.5061 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0169 | 0.1304 | 0.2757 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0169 | 0.1304 | 0.1304 |
Brugia malayi | Cathepsin L-like precursor | 0.022 | 0.218 | 0.5061 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0185 | 0.157 | 0.0967 |
Brugia malayi | Cathepsin L-like precursor | 0.022 | 0.218 | 0.5061 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0329 | 0.4058 | 1 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0169 | 0.1304 | 0.2757 |
Onchocerca volvulus | Cathepsin F homolog | 0.0329 | 0.4058 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0329 | 0.4058 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0329 | 0.4058 | 1 |
Trypanosoma cruzi | cysteine peptidase (N-terminal), putative | 0.0169 | 0.1304 | 0.2757 |
Brugia malayi | Cathepsin L-like precursor | 0.0329 | 0.4058 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.022 | 0.218 | 0.1008 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
FC (binding) | = 2.14 | Induction of HEXIM1 protein expression in human LNCAP cells at 500 uM after 24 hrs by Western blotting analysis relative to control | ChEMBL. | 24503105 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.