Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.7982 | 0.5011 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 1.1038 | 0.8087 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 1.1038 | 0.8087 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 1.1038 | 0.8087 | 0.8087 |
Brugia malayi | Dihydrofolate reductase | 1.1038 | 0.8087 | 1 |
Brugia malayi | dihydrofolate reductase family protein | 1.1038 | 0.8087 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.7982 | 0.5011 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.7982 | 0.5011 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 1.1038 | 0.8087 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 1.1038 | 0.8087 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 1.1038 | 0.8087 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 1.1038 | 0.8087 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 1.1038 | 0.8087 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.7982 | 0.5011 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.7982 | 0.5011 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.7982 | 0.5011 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 3.1 % | Cytotoxicity against human A549 cells at 25 ug/ml by MTT assay | ChEMBL. | 24445312 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.