Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | cyclin dependent kinase 9 | 0.0279 | 0.1013 | 0.0401 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0352 | 0.1674 | 0.1674 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0927 | 0.6883 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0352 | 0.1674 | 0.1108 |
Loa Loa (eye worm) | thymidylate synthase | 0.0352 | 0.1674 | 0.1108 |
Echinococcus granulosus | thymidylate synthase | 0.0352 | 0.1674 | 0.1108 |
Echinococcus granulosus | cyclin dependent kinase 9 | 0.0279 | 0.1013 | 0.0401 |
Brugia malayi | cyclin-dependent kinase 9 | 0.0238 | 0.0637 | 0.0637 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0927 | 0.6883 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0927 | 0.6883 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0927 | 0.6883 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.0352 | 0.1674 | 0.1108 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0927 | 0.6883 | 0.5 |
Brugia malayi | thymidylate synthase | 0.0352 | 0.1674 | 0.1674 |
Onchocerca volvulus | 0.0352 | 0.1674 | 0.5 | |
Entamoeba histolytica | protein kinase domain containing protein | 0.0238 | 0.0637 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0927 | 0.6883 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 128 uM | Anticancer activity against human HeLa cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay | ChEMBL. | 25086915 |
MIC (functional) | > 128 ug ml-1 | Antimicrobial activity against Candida albicans after 24 hrs by broth microdilution method | ChEMBL. | 24447849 |
MIC (functional) | > 128 ug ml-1 | Antimicrobial activity against Escherichia coli after 24 hrs by broth microdilution method | ChEMBL. | 24447849 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.