Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0124 | 0.2719 | 0.4585 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0058 | 0.1011 | 0.1011 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0249 | 0.593 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0124 | 0.2719 | 0.2719 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0251 | 0.5968 | 0.5968 |
Brugia malayi | hypothetical protein | 0.0059 | 0.1048 | 0.1048 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.1011 | 0.1011 |
Loa Loa (eye worm) | thymidylate synthase | 0.0124 | 0.2719 | 0.2719 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0543 | 0.0543 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0001 | 0.0001 |
Brugia malayi | Dihydrofolate reductase | 0.0249 | 0.593 | 0.593 |
Echinococcus granulosus | thymidylate synthase | 0.0124 | 0.2719 | 0.2719 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0018 | 0.0001 | 0.0001 |
Schistosoma mansoni | dihydrofolate reductase | 0.0249 | 0.593 | 0.593 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0249 | 0.593 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.0543 | 0.0543 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0059 | 0.1048 | 0.1767 |
Brugia malayi | thymidylate synthase | 0.0124 | 0.2719 | 0.2719 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0249 | 0.593 | 0.593 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0001 | 0.0001 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0251 | 0.5968 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0001 | 0.0001 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0138 | 0.3073 | 0.3073 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0059 | 0.1048 | 0.1048 |
Brugia malayi | isocitrate dehydrogenase | 0.0018 | 0.0001 | 0.0001 |
Brugia malayi | Isocitrate dehydrogenase | 0.0018 | 0.0001 | 0.0001 |
Echinococcus granulosus | dihydrofolate reductase | 0.0249 | 0.593 | 0.593 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0001 | 0.0001 |
Brugia malayi | MH2 domain containing protein | 0.0138 | 0.3073 | 0.3073 |
Onchocerca volvulus | 0.0124 | 0.2719 | 0.5 | |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0018 | 0.0001 | 0.0001 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0039 | 0.0543 | 0.0543 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0249 | 0.593 | 0.593 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0018 | 0.0001 | 0.0001 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0249 | 0.593 | 0.5 |
Brugia malayi | dihydrofolate reductase family protein | 0.0249 | 0.593 | 0.593 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0058 | 0.1011 | 0.1011 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0018 | 0.0001 | 0.0001 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0251 | 0.5968 | 0.5968 |
Echinococcus multilocularis | thymidylate synthase | 0.0124 | 0.2719 | 0.2719 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0058 | 0.1011 | 0.1011 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0251 | 0.5968 | 0.5968 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0251 | 0.5968 | 0.5968 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0138 | 0.3073 | 0.3073 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0251 | 0.5968 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0249 | 0.593 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.