Detailed information for compound 1835779

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 218.338 | Formula: C14H22N2
  • H donors: 1 H acceptors: 0 LogP: 2.25 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(CCCNC1Cc2c(C1)cccc2)C
  • InChi: 1S/C14H22N2/c1-16(2)9-5-8-15-14-10-12-6-3-4-7-13(12)11-14/h3-4,6-7,14-15H,5,8-11H2,1-2H3
  • InChiKey: RGYUJOJKLQDQJZ-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0034 0.0247 0.0666
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0034 0.0247 0.0247
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0155 0.0155
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0314 0.3708 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0018 0.0043 0.0082
Entamoeba histolytica transcription factor BTF3, putative 0.0037 0.0283 0.9552
Entamoeba histolytica hypothetical protein 0.0038 0.0296 1
Trypanosoma brucei heat shock protein, putative 0.0034 0.0251 0.0251
Echinococcus multilocularis dna polymerase kappa 0.002 0.0078 0.0078
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0087 0.0907 0.0907
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0216 0.0415
Entamoeba histolytica hypothetical protein 0.0025 0.0132 0.4441
Trichomonas vaginalis set domain proteins, putative 0.025 0.2919 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0078 0.0078
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0118 0.1285 0.2471
Leishmania major heat shock protein 83-1 0.0034 0.0251 0.025
Plasmodium falciparum heat shock protein 90 0.0034 0.0251 0.0675
Brugia malayi Pre-SET motif family protein 0.0031 0.0216 0.0216
Brugia malayi Smad1 0.0018 0.0043 0.0043
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.0247 0.0247
Brugia malayi MH1 domain containing protein 0.0018 0.0043 0.0043
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0155 0.0155
Giardia lamblia Heat shock protein HSP 90-alpha 0.0027 0.0164 0.4987
Leishmania major heat shock protein 83-1 0.0034 0.0251 0.025
Schistosoma mansoni apoptosis regulator bax 0.0087 0.0907 0.1744
Brugia malayi MH1 domain containing protein 0.0018 0.0043 0.0043
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0314 0.3708 1
Echinococcus granulosus heat shock protein 90 0.0034 0.0251 0.025
Onchocerca volvulus 0.0031 0.0216 0.074
Schistosoma mansoni Smad4 0.0018 0.0043 0.0082
Plasmodium falciparum importin beta, putative 0.003 0.0203 0.0546
Leishmania major importin beta-1 subunit, putative 0.0025 0.0132 0.0131
Trypanosoma brucei heat shock protein, putative 0.0034 0.0251 0.0251
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0078 0.0078
Plasmodium vivax SET domain protein, putative 0.0031 0.0216 0.0582
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0155 0.0419
Brugia malayi Endoplasmin precursor 0.0034 0.0251 0.025
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0296 0.0296
Onchocerca volvulus 0.0118 0.1285 0.4404
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0078 0.0078
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0078 0.0078
Schistosoma mansoni hypothetical protein 0.0087 0.0907 0.1744
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0027 0.0155 0.0155
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0246 0.0246
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0078 0.0078
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0078 0.0078
Echinococcus multilocularis neuropeptide receptor A26 0.0488 0.5864 0.5864
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0078 0.0078
Schistosoma mansoni ran 0.0022 0.0103 0.0198
Schistosoma mansoni hypothetical protein 0.0034 0.0246 0.0473
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0027 0.0164 0.5
Echinococcus granulosus endoplasmin 0.0027 0.0164 0.0164
Brugia malayi MH2 domain containing protein 0.0018 0.0043 0.0043
Plasmodium vivax heat shock protein 86, putative 0.0034 0.0251 0.0675
Leishmania major DNA polymerase kappa, putative 0.002 0.0078 0.0078
Loa Loa (eye worm) isocitrate dehydrogenase 0.0034 0.0247 0.0247
Brugia malayi hypothetical protein 0.0038 0.0296 0.0296
Leishmania major heat shock protein 83-1 0.0034 0.0251 0.025
Echinococcus multilocularis geminin 0.0179 0.2039 0.2039
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0078 0.0268
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0087 0.0907 0.0907
Trypanosoma brucei unspecified product 0.002 0.0078 0.0078
Echinococcus multilocularis heat shock protein 90 0.0027 0.0164 0.0164
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.0247 0.0247
Schistosoma mansoni endoplasmin 0.0034 0.0251 0.0482
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0434 0.5202 1
Brugia malayi RNA, U transporter 1 0.0087 0.0897 0.0897
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0103 0.0278
Brugia malayi hypothetical protein 0.0027 0.0155 0.0155
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0078 0.0078
Treponema pallidum heat shock protein 90 0.0027 0.0164 0.5
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0078 0.0078
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0103 0.0103
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0078 0.0078
Loa Loa (eye worm) Smad1 0.0018 0.0043 0.0043
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.052 0.1783
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0107 0.1154 0.1154
Echinococcus multilocularis transcription factor btf3 0.0037 0.0283 0.0283
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0423 0.0814
Schistosoma mansoni hypothetical protein 0.0179 0.2039 0.3919
Entamoeba histolytica hypothetical protein 0.0038 0.0296 1
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0078 0.0078
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0423 0.0423
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0216 0.0415
Leishmania major DNA polymerase eta, putative 0.002 0.0078 0.0078
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0246 0.0246
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0423 0.0423
Toxoplasma gondii isocitrate dehydrogenase 0.0034 0.0247 0.0666
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0325 0.3845 0.3845
Schistosoma mansoni hypothetical protein 0.0073 0.0734 0.1411
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0034 0.0247 0.0475
Echinococcus granulosus heat shock protein 90 0.0027 0.0164 0.0164
Trypanosoma cruzi transcription factor btf3, putative 0.0037 0.0283 0.0283
Brugia malayi Dihydrofolate reductase 0.0434 0.5202 0.5202
Echinococcus granulosus importin subunit beta 1 0.003 0.0203 0.0203
Brugia malayi Pre-SET motif family protein 0.022 0.2544 0.2543
Loa Loa (eye worm) MH2 domain-containing protein 0.0018 0.0043 0.0043
Echinococcus granulosus geminin 0.0179 0.2039 0.2039
Echinococcus granulosus snurportin 1 0.0325 0.3845 0.3845
Schistosoma mansoni hypothetical protein 0.0087 0.0907 0.1744
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0078 0.0078
Toxoplasma gondii isocitrate dehydrogenase 0.0034 0.0247 0.0666
Loa Loa (eye worm) hypothetical protein 0.002 0.0078 0.0078
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0132 0.045
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0078 0.0078
Echinococcus granulosus mothers against decapentaplegic 5 0.0018 0.0043 0.0043
Schistosoma mansoni hypothetical protein 0.0038 0.0296 0.0569
Leishmania major heat shock protein 83-1 0.0034 0.0251 0.025
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0027 0.0164 0.0164
Loa Loa (eye worm) hypothetical protein 0.003 0.0203 0.0203
Schistosoma mansoni smad1 5 8 and 0.0018 0.0043 0.0082
Trypanosoma brucei heat shock protein, putative 0.0034 0.0251 0.0251
Echinococcus multilocularis thymidylate synthase 0.0118 0.1285 0.1285
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0078 0.0078
Mycobacterium ulcerans thymidylate synthase 0.0118 0.1285 0.2356
Loa Loa (eye worm) heat shock protein 90 0.0034 0.0251 0.025
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0283 0.0968
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0034 0.0247 0.0247
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0132 0.045
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0103 0.0103
Schistosoma mansoni DNA polymerase eta 0.002 0.0078 0.015
Plasmodium falciparum endoplasmin, putative 0.0021 0.0087 0.0233
Trypanosoma brucei heat shock protein 90, putative 0.0034 0.0251 0.0251
Brugia malayi Importin beta-1 subunit 0.003 0.0203 0.0203
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0103 0.0103
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0103 0.0103
Echinococcus multilocularis dihydrofolate reductase 0.0434 0.5202 0.5202
Chlamydia trachomatis dihydrofolate reductase 0.0434 0.5202 0.5
Trichomonas vaginalis heat shock protein, putative 0.0021 0.0087 0.0296
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0155 0.0419
Echinococcus granulosus dna polymerase eta 0.002 0.0078 0.0078
Leishmania major heat shock protein 83-1 0.0034 0.0251 0.025
Echinococcus multilocularis heat shock protein 0.0034 0.0251 0.025
Leishmania major GTP-binding protein, putative 0.0022 0.0103 0.0103
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0087 0.0907 0.0907
Brugia malayi latrophilin 2 splice variant baaae 0.0073 0.0734 0.0734
Trypanosoma cruzi Heat shock protein 83, putative 0.0034 0.0251 0.025
Toxoplasma gondii NAC domain-containing protein 0.0037 0.0283 0.0762
Plasmodium vivax endoplasmin, putative 0.0034 0.0251 0.0675
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0078 0.015
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0103 0.0103
Trypanosoma cruzi transcription factor btf3, putative 0.0037 0.0283 0.0283
Onchocerca volvulus 0.025 0.2919 1
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0103 0.1456
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0296 0.0569
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0056 0.052 0.052
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0246 0.0246
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0283 0.0968
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0078 0.0078
Trypanosoma brucei heat shock protein, putative 0.0034 0.0251 0.0251
Mycobacterium ulcerans heat shock protein 90 0.0027 0.0164 0.0168
Loa Loa (eye worm) hypothetical protein 0.0107 0.1154 0.1154
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0078 0.0078
Trypanosoma cruzi heat shock protein 85, putative 0.0027 0.0164 0.0164
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0078 0.0078
Trypanosoma cruzi heat shock protein 90, putative 0.0027 0.0164 0.0164
Loa Loa (eye worm) apoptosis regulator protein 0.0087 0.0907 0.0907
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0078 0.0078
Echinococcus granulosus transcription factor btf3 0.0037 0.0283 0.0283
Leishmania major heat shock protein 83-1 0.0034 0.0251 0.025
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0314 0.3708 0.3708
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0423 0.0814
Leishmania major heat shock protein 83-1 0.0034 0.0251 0.025
Schistosoma mansoni hypothetical protein 0.0179 0.2039 0.3919
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0423 0.0814
Trypanosoma cruzi heat shock protein 90, putative 0.0034 0.0251 0.025
Echinococcus multilocularis Smad4 0.0018 0.0043 0.0043
Leishmania major heat shock protein 83-1 0.0034 0.0251 0.025
Trypanosoma brucei heat shock protein 90, putative 0.0034 0.0251 0.0251
Echinococcus granulosus Smad4 0.0018 0.0043 0.0043
Echinococcus granulosus dihydrofolate reductase 0.0434 0.5202 0.5202
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0423 0.0423
Leishmania major basic transcription factor 3a, putative 0.0037 0.0283 0.0283
Loa Loa (eye worm) hypothetical protein 0.0034 0.0246 0.0246
Plasmodium vivax importin-beta 2, putative 0.003 0.0203 0.0546
Trypanosoma brucei heat shock protein, putative 0.0034 0.0251 0.0251
Echinococcus multilocularis endoplasmin 0.0027 0.0164 0.0164
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0203 0.0546
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0078 0.0078
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0314 0.3708 1
Leishmania major heat shock protein 83-1 0.0034 0.0251 0.025
Echinococcus granulosus neuropeptide s receptor 0.0488 0.5864 0.5864
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0034 0.0247 0.0247
Brugia malayi beta-NAC-like protein 0.0037 0.0283 0.0283
Loa Loa (eye worm) transcription factor SMAD2 0.0257 0.3006 0.3006
Brugia malayi dihydrofolate reductase family protein 0.0434 0.5202 0.5202
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0216 0.0582
Schistosoma mansoni importin beta-1 0.003 0.0203 0.0389
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0216 0.0216
Echinococcus multilocularis importin subunit beta 1 0.003 0.0203 0.0203
Brugia malayi heat shock protein 90 0.0034 0.0251 0.025
Echinococcus multilocularis heat shock protein 90 0.0034 0.0251 0.025
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0078 0.2639
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0087 0.0907 0.0907
Entamoeba histolytica heat shock protein 90, putative 0.0034 0.0251 0.8467
Loa Loa (eye worm) hypothetical protein 0.0073 0.0734 0.0734
Plasmodium falciparum basic transcription factor 3b, putative 0.0037 0.0283 0.0762
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0434 0.5202 1
Schistosoma mansoni hypothetical protein 0.0325 0.3845 0.7392
Trichomonas vaginalis ran, putative 0.0022 0.0103 0.0354
Echinococcus granulosus neuropeptide receptor A26 0.0488 0.5864 0.5864
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0246 0.0246
Plasmodium vivax basic transcription factor 3b, putative 0.0037 0.0283 0.0762
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0216 0.0415
Toxoplasma gondii heat shock protein HSP90 0.0034 0.0251 0.0675
Leishmania major heat shock protein 83-1 0.0034 0.0251 0.025
Trypanosoma brucei transcription factor BTF3, putative 0.0037 0.0283 0.0283
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0103 0.0278
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0216 0.0216
Echinococcus multilocularis dna polymerase eta 0.002 0.0078 0.0078
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.022 0.2544 0.2543
Schistosoma mansoni transcription factor btf3 0.0037 0.0283 0.0543
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0246 0.0246
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0155 0.0419
Leishmania major heat shock protein 83-1 0.0034 0.0251 0.025
Trichomonas vaginalis endoplasmin, putative 0.0021 0.0087 0.0296
Brugia malayi isocitrate dehydrogenase 0.0034 0.0247 0.0247
Schistosoma mansoni smad 0.0018 0.0043 0.0082
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0078 0.0078
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0107 0.1154 0.1154
Entamoeba histolytica hypothetical protein 0.0038 0.0296 1
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0027 0.0164 0.0168
Trypanosoma cruzi heat shock protein 90, putative 0.002 0.0077 0.0077
Echinococcus multilocularis smad 0.0018 0.0043 0.0043
Echinococcus granulosus TGF beta signal transducer SmadC 0.0018 0.0043 0.0043
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0164 0.0562
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0203 0.0203
Schistosoma mansoni heat shock protein 0.0034 0.0251 0.0482
Trypanosoma cruzi heat shock protein 85, putative 0.0034 0.0251 0.025
Schistosoma mansoni dihydrofolate reductase 0.0434 0.5202 1
Brugia malayi Isocitrate dehydrogenase 0.0034 0.0247 0.0247
Echinococcus multilocularis snurportin 1 0.0325 0.3845 0.3845
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0423 0.0423
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0203 0.0203
Leishmania major heat shock protein 83-1 0.0034 0.0251 0.025
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0202 0.0202
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0103 0.0278
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0155 0.0155
Schistosoma mansoni smad1 5 8 and 0.0018 0.0043 0.0082
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0434 0.5202 1
Entamoeba histolytica heat shock protein 90, putative 0.0034 0.0251 0.8467
Toxoplasma gondii heat shock protein 90, putative 0.0034 0.0251 0.0675
Trypanosoma brucei Heat shock protein 83, putative 0.0034 0.0251 0.0251
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.0247 0.0247
Schistosoma mansoni heat shock protein 0.0034 0.0251 0.0482
Schistosoma mansoni hypothetical protein 0.0034 0.0246 0.0473
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0155 0.0419
Echinococcus granulosus smad 0.0018 0.0043 0.0043
Echinococcus granulosus dna polymerase kappa 0.002 0.0078 0.0078
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.0247 0.0247
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0018 0.0043 0.0043
Schistosoma mansoni hypothetical protein 0.0087 0.0907 0.1744
Trichomonas vaginalis heat shock protein, putative 0.0034 0.0251 0.0858
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0103 0.0103
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0103 0.0103
Brugia malayi MH2 domain containing protein 0.0257 0.3006 0.3006
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0087 0.0907 0.1744
Brugia malayi thymidylate synthase 0.0118 0.1285 0.1285
Echinococcus granulosus heat shock protein 0.0034 0.0251 0.025
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0423 0.0423
Trypanosoma brucei heat shock protein, putative 0.0034 0.0251 0.0251
Leishmania major heat shock protein 83-1 0.0034 0.0251 0.025
Loa Loa (eye worm) MH2 domain-containing protein 0.0257 0.3006 0.3006
Leishmania major heat shock protein 83-1 0.0034 0.0251 0.025
Entamoeba histolytica Ran family GTPase 0.0022 0.0103 0.3488
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0034 0.0247 0.0247
Echinococcus multilocularis GPCR, family 2 0.0034 0.0246 0.0246
Trypanosoma cruzi heat shock protein 85, putative 0.0034 0.0251 0.025
Entamoeba histolytica hypothetical protein 0.0038 0.0296 1
Loa Loa (eye worm) endoplasmin 0.0034 0.0251 0.025
Entamoeba histolytica hypothetical protein 0.0037 0.0283 0.9552
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0314 0.3708 0.3708
Leishmania major hypothetical protein, conserved 0.0027 0.0155 0.0155
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0164 0.0562
Loa Loa (eye worm) ICD-1 protein 0.0037 0.0283 0.0283
Leishmania major heat shock protein 83-1 0.0034 0.0251 0.025
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0132 0.0131
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0118 0.1285 0.2356
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0034 0.0247 0.033
Echinococcus multilocularis mothers against decapentaplegic 5 0.0018 0.0043 0.0043
Echinococcus multilocularis isocitrate dehydrogenase 0.0034 0.0247 0.0247
Giardia lamblia Heat shock protein HSP 90-alpha 0.0034 0.0251 1
Schistosoma mansoni hypothetical protein 0.0034 0.0246 0.0473
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0283 0.0968
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0164 0.0562
Giardia lamblia Grp94/Hsp90 0.0027 0.0164 0.4987
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0132 0.045
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0078 0.0078
Schistosoma mansoni ran 0.0022 0.0103 0.0198
Loa Loa (eye worm) hypothetical protein 0.0031 0.0216 0.0216
Trypanosoma brucei heat shock protein, putative 0.0034 0.0251 0.0251
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0078 0.0078
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0078 0.0078
Brugia malayi MH2 domain containing protein 0.0018 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0087 0.0907 0.0907
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0314 0.3708 0.3708
Schistosoma mansoni endoplasmin 0.0034 0.0251 0.0482
Echinococcus granulosus GPCR family 2 0.0034 0.0246 0.0246
Loa Loa (eye worm) MH1 domain-containing protein 0.0018 0.0043 0.0043
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0296 0.0296
Echinococcus granulosus thymidylate synthase 0.0118 0.1285 0.1285
Brugia malayi Calcitonin receptor-like protein seb-1 0.0107 0.1154 0.1154
Trypanosoma brucei heat shock protein, putative 0.0034 0.0251 0.0251
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0216 0.0216
Mycobacterium tuberculosis Hypothetical protein 0.0056 0.052 0.0863
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.0247 0.0247
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0078 0.015
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0087 0.0907 0.0907
Schistosoma mansoni smad1 5 8 and 0.0018 0.0043 0.0082
Brugia malayi hypothetical protein 0.0056 0.052 0.052
Leishmania major heat shock protein 83-1 0.0034 0.0251 0.025
Brugia malayi hypothetical protein 0.0017 0.0039 0.0039
Loa Loa (eye worm) thymidylate synthase 0.0118 0.1285 0.1285
Loa Loa (eye worm) dihydrofolate reductase 0.0434 0.5202 0.5202
Trypanosoma cruzi heat shock protein 85, putative 0.0034 0.0251 0.025
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0216 0.0415
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0246 0.0246
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0078 0.0268
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0246 0.0246
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0078 0.0078
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0118 0.1285 0.2226
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.0247 0.0247
Schistosoma mansoni hypothetical protein 0.0034 0.0246 0.0473
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0027 0.0164 0.0164
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0034 0.0247 0.0666
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0423 0.0423
Leishmania major heat shock protein 83-1 0.0034 0.0251 0.025
Echinococcus multilocularis neuropeptide s receptor 0.0488 0.5864 0.5864

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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