Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | heat shock protein 90, putative | 0.0195 | 0.5044 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0053 | 0.0996 | 0.1975 |
Loa Loa (eye worm) | TAR-binding protein | 0.0071 | 0.1504 | 0.2081 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.094 | 0.094 |
Mycobacterium ulcerans | lipase LipD | 0.0041 | 0.0627 | 0.0903 |
Onchocerca volvulus | 0.0041 | 0.0627 | 0.0297 | |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0034 | 0.043 | 0.043 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0021 | 0.0075 | 0.0108 |
Trichomonas vaginalis | heat shock protein, putative | 0.0048 | 0.0852 | 0.1204 |
Loa Loa (eye worm) | RNA binding protein | 0.0071 | 0.1504 | 0.2081 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0262 | 0.6943 | 0.6943 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0032 | 0.0394 | 0.0394 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0.6943 | 1 |
Schistosoma mansoni | endoplasmin | 0.0052 | 0.0942 | 0.0942 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.0075 | 0.0075 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0034 | 0.0452 | 0.0651 |
Echinococcus granulosus | GPCR family 2 | 0.0034 | 0.0452 | 0.0452 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0041 | 0.0632 | 0.0632 |
Brugia malayi | Pre-SET motif family protein | 0.0234 | 0.615 | 0.8858 |
Echinococcus multilocularis | heat shock protein | 0.0052 | 0.0942 | 0.0942 |
Echinococcus granulosus | heat shock protein 90 | 0.0052 | 0.0942 | 0.0942 |
Echinococcus granulosus | heat shock protein heat shock protein 90 alpha | 0.0044 | 0.073 | 0.073 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0074 | 0.1589 | 0.2289 |
Loa Loa (eye worm) | heat shock protein 90 | 0.0052 | 0.0942 | 0.1262 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0041 | 0.0627 | 0.0627 |
Mycobacterium ulcerans | beta-lactamase | 0.0041 | 0.0627 | 0.0903 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0034 | 0.0452 | 0.0452 |
Echinococcus multilocularis | endoplasmin | 0.0048 | 0.0852 | 0.0852 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0262 | 0.6943 | 0.6943 |
Echinococcus multilocularis | tar DNA binding protein | 0.0071 | 0.1504 | 0.1504 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0262 | 0.6943 | 0.6943 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0627 | 0.0804 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0041 | 0.0627 | 0.0887 |
Echinococcus multilocularis | glycoprotein Antigen 5 | 0.0262 | 0.6943 | 0.6943 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0259 | 0.6853 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0.6943 | 1 |
Brugia malayi | hypothetical protein | 0.0028 | 0.0281 | 0.0404 |
Trypanosoma brucei | Heat shock protein 83, putative | 0.0052 | 0.0942 | 0.9459 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0028 | 0.0281 | 0.0556 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0041 | 0.0627 | 0.0627 |
Brugia malayi | Trypsin-like protease protein 5 | 0.0262 | 0.6943 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0632 | 0.6417 |
Trypanosoma brucei | heat shock protein 90, putative | 0.0052 | 0.0942 | 0.9459 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0627 | 0.0804 |
Echinococcus multilocularis | subfamily S1A unassigned peptidase (S01 family) | 0.0262 | 0.6943 | 0.6943 |
Trichomonas vaginalis | heat shock protein, putative | 0.0037 | 0.0539 | 0.0762 |
Leishmania major | heat shock protein 83-1 | 0.0052 | 0.0942 | 0.9459 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0041 | 0.0627 | 0.0903 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0052 | 0.0942 | 0.9459 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0053 | 0.0996 | 0.0996 |
Leishmania major | heat shock protein 83-1 | 0.0052 | 0.0942 | 0.9459 |
Giardia lamblia | Grp94/Hsp90 | 0.0048 | 0.0852 | 0.9041 |
Onchocerca volvulus | 0.0041 | 0.0627 | 0.0297 | |
Mycobacterium leprae | PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) | 0.0048 | 0.0852 | 0.0829 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0034 | 0.0452 | 0.0548 |
Brugia malayi | Trypsin family protein | 0.0262 | 0.6943 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0028 | 0.0281 | 0.2817 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.0281 | 0.0556 |
Brugia malayi | RNA binding protein | 0.0071 | 0.1504 | 0.2167 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0041 | 0.0627 | 0.0915 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0041 | 0.0627 | 0.0887 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0041 | 0.0627 | 0.0804 |
Trichomonas vaginalis | heat shock protein, putative | 0.003 | 0.0326 | 0.0462 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0021 | 0.0075 | 0.0884 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0028 | 0.0281 | 0.0556 |
Echinococcus multilocularis | Peptidase S1 S6, chymotrypsin Hap | 0.0262 | 0.6943 | 0.6943 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.1504 | 0.1504 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0053 | 0.0996 | 0.1453 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0262 | 0.6943 | 0.6943 |
Toxoplasma gondii | heat shock protein HSP90 | 0.0052 | 0.0942 | 0.1868 |
Trypanosoma brucei | heat shock protein, putative | 0.0052 | 0.0942 | 0.9459 |
Echinococcus granulosus | subfamily S1A unassigned peptidase S01 family | 0.0262 | 0.6943 | 0.6943 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0632 | 0.0632 |
Onchocerca volvulus | 0.0267 | 0.7072 | 1 | |
Mycobacterium tuberculosis | Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) | 0.0048 | 0.0852 | 0.1243 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0136 | 0.3337 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.0052 | 0.0942 | 0.9459 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 0.094 | 0.094 |
Brugia malayi | hypothetical protein | 0.0139 | 0.3421 | 0.4927 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.3421 | 0.4872 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.1504 | 0.1504 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0041 | 0.0627 | 0.6296 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0021 | 0.0075 | 0.0075 |
Trypanosoma brucei | trypanothione reductase | 0.0053 | 0.0996 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0041 | 0.0627 | 0.0903 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0051 | 0.094 | 0.1258 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0053 | 0.0996 | 0.0996 |
Leishmania major | heat shock protein 83-1 | 0.0052 | 0.0942 | 0.9459 |
Leishmania major | hypothetical protein, conserved | 0.0041 | 0.0627 | 0.6296 |
Leishmania major | heat shock protein 83-1 | 0.0052 | 0.0942 | 0.9459 |
Brugia malayi | Chymotrypsin-like protease CTRL-1 precursor | 0.0262 | 0.6943 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0021 | 0.0075 | 0.0108 |
Echinococcus granulosus | Mastin | 0.0262 | 0.6943 | 0.6943 |
Brugia malayi | Hsp90 protein | 0.0034 | 0.0449 | 0.0646 |
Plasmodium vivax | heat shock protein 90, putative | 0.0034 | 0.0449 | 0.0889 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0.6943 | 1 |
Schistosoma mansoni | heat shock protein | 0.0034 | 0.0449 | 0.0449 |
Onchocerca volvulus | Heat shock protein 75 kDa, mitochondrial homolog | 0.0034 | 0.0449 | 0.0028 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0262 | 0.6943 | 0.6943 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0234 | 0.615 | 0.8845 |
Leishmania major | heat shock protein 83-1 | 0.0052 | 0.0942 | 0.9459 |
Leishmania major | trypanothione reductase | 0.0053 | 0.0996 | 1 |
Trichomonas vaginalis | heat shock protein, putative | 0.0052 | 0.0942 | 0.1332 |
Brugia malayi | Endoplasmin precursor | 0.0052 | 0.0942 | 0.1357 |
Brugia malayi | beta-lactamase family protein | 0.0041 | 0.0627 | 0.0903 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0041 | 0.0627 | 0.0915 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0.6943 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.094 | 0.094 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0041 | 0.0627 | 0.0887 |
Leishmania major | heat shock protein 83-1 | 0.0052 | 0.0942 | 0.9459 |
Treponema pallidum | heat shock protein 90 | 0.0048 | 0.0852 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.3421 | 0.4872 |
Onchocerca volvulus | 0.0262 | 0.6943 | 0.9805 | |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0122 | 0.2949 | 0.4303 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 0.094 | 0.094 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0262 | 0.6943 | 0.6943 |
Echinococcus multilocularis | enteropeptidase | 0.0262 | 0.6943 | 0.6943 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0052 | 0.0942 | 0.9459 |
Mycobacterium ulcerans | heat shock protein 90 | 0.0048 | 0.0852 | 0.1227 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0041 | 0.0627 | 0.0915 |
Echinococcus multilocularis | GPCR, family 2 | 0.0034 | 0.0452 | 0.0452 |
Mycobacterium tuberculosis | Conserved protein | 0.0041 | 0.0627 | 0.0915 |
Leishmania major | heat shock protein 83-1 | 0.0052 | 0.0942 | 0.9459 |
Toxoplasma gondii | heat shock protein 90, putative | 0.0052 | 0.0942 | 0.1868 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.1504 | 0.1504 |
Trypanosoma brucei | heat shock protein, putative | 0.0052 | 0.0942 | 0.9459 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0041 | 0.0627 | 0.0915 |
Brugia malayi | Trypsin family protein | 0.0262 | 0.6943 | 1 |
Loa Loa (eye worm) | trypsin family protein | 0.0262 | 0.6943 | 1 |
Echinococcus multilocularis | heat shock protein 90 | 0.0044 | 0.073 | 0.073 |
Trypanosoma brucei | heat shock protein, putative | 0.0052 | 0.0942 | 0.9459 |
Plasmodium falciparum | glutathione reductase | 0.0053 | 0.0996 | 0.1975 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0452 | 0.0452 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.1504 | 0.1504 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0034 | 0.0452 | 0.0452 |
Toxoplasma gondii | Hsp90 domain-containing protein | 0.0195 | 0.5044 | 1 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.0075 | 0.0149 |
Onchocerca volvulus | 0.0041 | 0.0627 | 0.0297 | |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0041 | 0.0627 | 0.0627 |
Trypanosoma brucei | heat shock protein 84, putative | 0.0034 | 0.0449 | 0.4504 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0034 | 0.043 | 0.043 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0136 | 0.3337 | 0.4869 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0632 | 0.6417 |
Plasmodium vivax | endoplasmin, putative | 0.0052 | 0.0942 | 0.1868 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.094 | 0.094 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0041 | 0.0627 | 0.0915 |
Schistosoma mansoni | heat shock protein | 0.0052 | 0.0942 | 0.0942 |
Echinococcus multilocularis | heat shock protein 90 | 0.0052 | 0.0942 | 0.0942 |
Plasmodium vivax | SET domain protein, putative | 0.0034 | 0.043 | 0.0852 |
Brugia malayi | beta-lactamase family protein | 0.0041 | 0.0627 | 0.0903 |
Plasmodium vivax | heat shock protein, putative | 0.0195 | 0.5044 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0053 | 0.0996 | 0.1975 |
Giardia lamblia | Heat shock protein HSP 90-alpha | 0.0052 | 0.0942 | 1 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0034 | 0.043 | 0.043 |
Leishmania major | heat shock protein 83-1 | 0.0052 | 0.0942 | 0.9459 |
Schistosoma mansoni | hypothetical protein | 0.0262 | 0.6943 | 0.6943 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0452 | 0.0452 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0041 | 0.0627 | 0.6296 |
Echinococcus granulosus | endoplasmin | 0.0048 | 0.0852 | 0.0852 |
Loa Loa (eye worm) | beta-lactamase | 0.0041 | 0.0627 | 0.0804 |
Mycobacterium ulcerans | hypothetical protein | 0.0041 | 0.0627 | 0.0903 |
Leishmania major | hypothetical protein, conserved | 0.0028 | 0.0281 | 0.2817 |
Mycobacterium tuberculosis | Conserved protein | 0.0041 | 0.0627 | 0.0915 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0052 | 0.0942 | 0.9459 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0021 | 0.0075 | 0.0756 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0021 | 0.0075 | 0.0075 |
Echinococcus granulosus | transmembrane protease serine 3 | 0.0262 | 0.6943 | 0.6943 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0627 | 0.0804 |
Trypanosoma brucei | heat shock protein, putative | 0.0052 | 0.0942 | 0.9459 |
Wolbachia endosymbiont of Brugia malayi | heat shock protein 90 | 0.0048 | 0.0852 | 1 |
Trichomonas vaginalis | set domain proteins, putative | 0.0267 | 0.7072 | 1 |
Leishmania major | lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative | 0.0048 | 0.0852 | 0.8552 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 0.094 | 0.094 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0.0075 | 0.0756 |
Plasmodium vivax | glutathione reductase, putative | 0.0053 | 0.0996 | 0.1975 |
Loa Loa (eye worm) | heat shock protein 75 | 0.0034 | 0.0449 | 0.0544 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0139 | 0.3447 | 0.491 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0109 | 0.2569 | 0.37 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0262 | 0.6943 | 0.6943 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0034 | 0.043 | 0.043 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0071 | 0.1504 | 0.2167 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.0281 | 0.2817 |
Mycobacterium tuberculosis | Probable reductase | 0.0122 | 0.2949 | 0.4303 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.0075 | 0.0075 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0122 | 0.2949 | 0.4303 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0051 | 0.094 | 0.1353 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0021 | 0.0075 | 0.0799 |
Entamoeba histolytica | heat shock protein 90, putative | 0.0052 | 0.0942 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0052 | 0.0942 | 0.9459 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0041 | 0.0627 | 0.6296 |
Leishmania major | heat shock protein 83-1 | 0.0052 | 0.0942 | 0.9459 |
Onchocerca volvulus | 0.0262 | 0.6943 | 0.9805 | |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0021 | 0.0075 | 0.0884 |
Trypanosoma cruzi | Heat shock protein 83, putative | 0.0052 | 0.0942 | 0.9459 |
Trypanosoma brucei | heat shock protein, putative | 0.0052 | 0.0942 | 0.9459 |
Trichomonas vaginalis | heat shock protein, putative | 0.0044 | 0.073 | 0.1032 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0.0075 | 0.0106 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0262 | 0.6943 | 0.6943 |
Schistosoma mansoni | endoplasmin | 0.0052 | 0.0942 | 0.0942 |
Toxoplasma gondii | exonuclease III APE | 0.0021 | 0.0075 | 0.0149 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0034 | 0.043 | 0.043 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0.0075 | 0.0756 |
Brugia malayi | hypothetical protein | 0.0262 | 0.6943 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0034 | 0.043 | 0.043 |
Leishmania major | heat shock protein 83-1 | 0.0052 | 0.0942 | 0.9459 |
Trypanosoma brucei | heat shock protein 90, putative | 0.0052 | 0.0942 | 0.9459 |
Brugia malayi | Trypsin family protein | 0.0262 | 0.6943 | 1 |
Brugia malayi | heat shock protein 90 | 0.0052 | 0.0942 | 0.1357 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0044 | 0.073 | 0.7326 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0281 | 0.0299 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0262 | 0.6943 | 0.6943 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0452 | 0.0452 |
Entamoeba histolytica | 90 kDa heat shock protein, putative | 0.0034 | 0.0449 | 0.4307 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0627 | 0.0804 |
Brugia malayi | beta-lactamase | 0.0041 | 0.0627 | 0.0903 |
Trypanosoma brucei | heat shock protein, putative | 0.0052 | 0.0942 | 0.9459 |
Echinococcus multilocularis | Mastin | 0.0262 | 0.6943 | 0.6943 |
Echinococcus granulosus | heat shock protein 75 kDa mitochondrial | 0.0034 | 0.0449 | 0.0449 |
Mycobacterium tuberculosis | Conserved protein | 0.0041 | 0.0627 | 0.0915 |
Schistosoma mansoni | hypothetical protein | 0.0074 | 0.1589 | 0.1589 |
Toxoplasma gondii | ABC1 family protein | 0.0041 | 0.0627 | 0.1243 |
Entamoeba histolytica | heat shock protein 90, putative | 0.0052 | 0.0942 | 1 |
Plasmodium vivax | heat shock protein 86, putative | 0.0052 | 0.0942 | 0.1868 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0034 | 0.0452 | 0.0651 |
Loa Loa (eye worm) | glutathione reductase | 0.0053 | 0.0996 | 0.1341 |
Leishmania major | heat shock protein 83-1 | 0.0052 | 0.0942 | 0.9459 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0034 | 0.0452 | 0.0452 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0122 | 0.2949 | 0.4303 |
Echinococcus granulosus | enteropeptidase | 0.0262 | 0.6943 | 0.6943 |
Leishmania major | heat shock protein 83-1 | 0.0052 | 0.0942 | 0.9459 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0034 | 0.043 | 0.043 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0262 | 0.6943 | 0.6943 |
Trypanosoma cruzi | heat shock protein, putative | 0.0034 | 0.0449 | 0.4504 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0041 | 0.0632 | 0.0632 |
Toxoplasma gondii | heat shock protein 75, putative | 0.0034 | 0.0449 | 0.0889 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.1589 | 0.2204 |
Brugia malayi | Thioredoxin reductase | 0.0053 | 0.0996 | 0.1435 |
Brugia malayi | TAR-binding protein | 0.0071 | 0.1504 | 0.2167 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0452 | 0.0548 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0053 | 0.0996 | 0.1975 |
Plasmodium falciparum | heat shock protein 90, putative | 0.003 | 0.0326 | 0.0647 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0071 | 0.1504 | 0.2081 |
Leishmania major | heat shock protein 83-1 | 0.0052 | 0.0942 | 0.9459 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0627 | 0.0804 |
Brugia malayi | Trypsin family protein | 0.0262 | 0.6943 | 1 |
Loa Loa (eye worm) | endoplasmin | 0.0052 | 0.0942 | 0.1262 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0262 | 0.6943 | 0.6943 |
Echinococcus granulosus | glycoprotein Antigen 5 | 0.0262 | 0.6943 | 0.6943 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0109 | 0.2569 | 0.3631 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0041 | 0.0627 | 0.0627 |
Schistosoma mansoni | hypothetical protein | 0.0262 | 0.6943 | 0.6943 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0262 | 0.6943 | 0.6943 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.2569 | 0.3631 |
Echinococcus granulosus | Peptidase S1 S6 chymotrypsin Hap | 0.0262 | 0.6943 | 0.6943 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.043 | 0.0516 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0262 | 0.6943 | 0.6943 |
Echinococcus multilocularis | transmembrane protease serine 3 | 0.0262 | 0.6943 | 0.6943 |
Echinococcus multilocularis | heat shock protein 75 kDa, mitochondrial | 0.0034 | 0.0449 | 0.0449 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0262 | 0.6943 | 0.6943 |
Schistosoma mansoni | heat shock protein | 0.0052 | 0.0942 | 0.0942 |
Brugia malayi | MH2 domain containing protein | 0.0139 | 0.3447 | 0.4965 |
Onchocerca volvulus | 0.0262 | 0.6943 | 0.9805 | |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0021 | 0.0075 | 0.011 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0041 | 0.0632 | 0.0632 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.0281 | 0.0556 |
Leishmania major | heat shock protein, putative | 0.0034 | 0.0449 | 0.4504 |
Echinococcus granulosus | heat shock protein 90 | 0.0044 | 0.073 | 0.073 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0139 | 0.3447 | 0.491 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.0075 | 0.0149 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0109 | 0.2569 | 0.37 |
Onchocerca volvulus | Huntingtin homolog | 0.0139 | 0.3421 | 0.4503 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0262 | 0.6943 | 0.6943 |
Plasmodium vivax | hypothetical protein, conserved | 0.0041 | 0.0627 | 0.1243 |
Brugia malayi | glutathione reductase | 0.0053 | 0.0996 | 0.1435 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0262 | 0.6943 | 0.6943 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0041 | 0.0627 | 0.0915 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0.0075 | 0.0106 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0034 | 0.0452 | 0.0452 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.0022 | 0.0087 | 0.0878 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0262 | 0.6943 | 0.6943 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0041 | 0.0627 | 0.0887 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0041 | 0.0627 | 0.0903 |
Trichomonas vaginalis | esterase, putative | 0.0041 | 0.0627 | 0.0887 |
Onchocerca volvulus | 0.0262 | 0.6943 | 0.9805 | |
Leishmania major | heat shock protein 83-1 | 0.0052 | 0.0942 | 0.9459 |
Plasmodium falciparum | heat shock protein 90 | 0.0052 | 0.0942 | 0.1868 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0136 | 0.3337 | 0.4869 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.0044 | 0.073 | 0.7326 |
Giardia lamblia | Heat shock protein HSP 90-alpha | 0.0044 | 0.073 | 0.7745 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0.6943 | 1 |
Brugia malayi | hypothetical protein | 0.0041 | 0.0632 | 0.091 |
Onchocerca volvulus | 0.0262 | 0.6943 | 0.9805 | |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 0.094 | 0.094 |
Trypanosoma brucei | heat shock protein, putative | 0.0052 | 0.0942 | 0.9459 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0262 | 0.6943 | 0.6943 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0053 | 0.0996 | 0.1341 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0632 | 0.6417 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0136 | 0.3337 | 0.4869 |
Trichomonas vaginalis | heat shock protein, putative | 0.0048 | 0.0852 | 0.1204 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.0281 | 0.2817 |
Leishmania major | heat shock protein 83-1 | 0.0052 | 0.0942 | 0.9459 |
Brugia malayi | Pre-SET motif family protein | 0.0034 | 0.043 | 0.0619 |
Mycobacterium ulcerans | hypothetical protein | 0.0262 | 0.6943 | 1 |
Plasmodium falciparum | endoplasmin, putative | 0.0037 | 0.0539 | 0.1068 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0122 | 0.2949 | 0.4303 |
Echinococcus granulosus | tar DNA binding protein | 0.0071 | 0.1504 | 0.1504 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0122 | 0.2949 | 0.4303 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.1504 | 0.1504 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0034 | 0.043 | 0.0852 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0021 | 0.0075 | 0.0756 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0452 | 0.0452 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0262 | 0.6943 | 0.6943 |
Onchocerca volvulus | 0.0262 | 0.6943 | 0.9805 | |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0041 | 0.0627 | 0.0887 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0632 | 0.6417 |
Leishmania major | heat shock protein 83-1 | 0.0052 | 0.0942 | 0.9459 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0053 | 0.0996 | 1 |
Trichomonas vaginalis | endoplasmin, putative | 0.0037 | 0.0539 | 0.0762 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0122 | 0.2949 | 0.8568 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0627 | 0.0804 |
Echinococcus granulosus | heat shock protein | 0.0052 | 0.0942 | 0.0942 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0.6943 | 1 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.0052 | 0.0942 | 0.9459 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0.6943 | 1 |
Onchocerca volvulus | Huntingtin homolog | 0.0139 | 0.3421 | 0.4503 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0041 | 0.0627 | 0.0915 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 18.01 % | Analgesic activity in Mus musculus balb/cj (mouse) assessed as preference to open arm at 30 mg/kg, ip measured after 30 min by elevated pluze maze test | ChEMBL. | No reference |
Activity (functional) | = 40.31 % | Antidepressant activity in Mus musculus (mouse) assessed as increase in mobile phase at 30 mg/kg, ip measured after 30 min by tail suspension test | ChEMBL. | No reference |
Inhibition (functional) | = 50.48 % | Antidepressant activity in Mus musculus (mouse) assessed as decrease in immobility at 30 mg/kg, ip measured after 30 min by despair swim test | ChEMBL. | No reference |
TIME (functional) | = 46.31 s | Analgesic activity in Mus musculus balb/cj (mouse) assessed as time spent in open arm at 30 mg/kg, ip measured after 30 min by elevated pluze maze test (Rvb = 12.25 +/- 0.02 sec) | ChEMBL. | No reference |
Time (functional) | = 185.9 s | Analgesic activity in Mus musculus Swiss (mouse) assessed as time spent in light chamber at 30 mg/kg, ip measured after 30 min by light and dark model test (Rvb = 130.2 +/- 0.01 sec) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.