Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | aspartyl protease, putative | 0.0533 | 0.0436 | 0.1281 |
Plasmodium falciparum | plasmepsin X | 0.0533 | 0.0436 | 0.1281 |
Plasmodium falciparum | plasmepsin IV | 0.0533 | 0.0436 | 0.1281 |
Brugia malayi | hypothetical protein | 0.0533 | 0.0436 | 0.0761 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.3943 | 0.3406 | 1 |
Brugia malayi | hypothetical protein | 0.0537 | 0.044 | 0.0767 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0004 | 0.0004 |
Plasmodium vivax | plasmepsin V, putative | 0.0533 | 0.0436 | 0.1281 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0533 | 0.0436 | 0.0436 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.6615 | 0.5733 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0004 | 1 |
Plasmodium falciparum | plasmepsin I | 0.0533 | 0.0436 | 0.1281 |
Loa Loa (eye worm) | hypothetical protein | 0.0533 | 0.0436 | 0.0761 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.3943 | 0.3406 | 1 |
Loa Loa (eye worm) | aspartic protease BmAsp-2 | 0.0533 | 0.0436 | 0.0761 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0004 | 1 |
Toxoplasma gondii | eukaryotic aspartyl protease superfamily protein | 0.0533 | 0.0436 | 0.1281 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0533 | 0.0436 | 0.0436 |
Brugia malayi | Pepsin A precursor | 0.0533 | 0.0436 | 0.0761 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.0004 | 0.0006 |
Echinococcus multilocularis | thymidylate synthase | 0.1129 | 0.0955 | 0.1666 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0533 | 0.0436 | 0.0436 |
Toxoplasma gondii | aspartyl proteinase (eimepsin), putative | 0.0533 | 0.0436 | 0.1281 |
Toxoplasma gondii | aspartyl protease ASP1 | 0.0533 | 0.0436 | 0.1281 |
Loa Loa (eye worm) | aspartic protease BmAsp-1 | 0.0533 | 0.0436 | 0.0761 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0004 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.6615 | 0.5733 | 1 |
Plasmodium falciparum | plasmepsin V | 0.0533 | 0.0436 | 0.1281 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.0004 | 0.0006 |
Brugia malayi | Dihydrofolate reductase | 0.6615 | 0.5733 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1129 | 0.0955 | 0.0955 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0004 | 0.0006 |
Toxoplasma gondii | aspartyl protease | 0.0533 | 0.0436 | 0.1281 |
Onchocerca volvulus | 0.1129 | 0.0955 | 1 | |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0533 | 0.0436 | 0.0436 |
Plasmodium falciparum | plasmepsin IX | 0.0533 | 0.0436 | 0.1281 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0533 | 0.0436 | 0.1281 |
Plasmodium falciparum | plasmepsin II | 0.0533 | 0.0436 | 0.1281 |
Schistosoma mansoni | dihydrofolate reductase | 0.6615 | 0.5733 | 0.5733 |
Plasmodium falciparum | plasmepsin VII | 0.0533 | 0.0436 | 0.1281 |
Plasmodium falciparum | plasmepsin VI | 0.0533 | 0.0436 | 0.1281 |
Brugia malayi | Eukaryotic aspartyl protease family protein | 0.0533 | 0.0436 | 0.0761 |
Plasmodium vivax | aspartyl protease, putative | 0.0533 | 0.0436 | 0.1281 |
Plasmodium vivax | plasmepsin IV, putative | 0.0533 | 0.0436 | 0.1281 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3943 | 0.3406 | 1 |
Trichomonas vaginalis | Clan AA, family A1, cathepsin D-like aspartic peptidase | 0.0533 | 0.0436 | 0.9919 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0533 | 0.0436 | 0.0436 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0537 | 0.044 | 0.1291 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0533 | 0.0436 | 0.0436 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0533 | 0.0436 | 0.0436 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3943 | 0.3406 | 1 |
Echinococcus granulosus | cathepsin d lysosomal aspartyl protease | 0.0533 | 0.0436 | 0.0761 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.3943 | 0.3406 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0004 | 1 |
Brugia malayi | aspartic protease BmAsp-1, identical | 0.0533 | 0.0436 | 0.0761 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.0004 | 0.0004 |
Brugia malayi | thymidylate synthase | 0.1129 | 0.0955 | 0.1666 |
Brugia malayi | aspartic protease BmAsp-2, identical | 0.0533 | 0.0436 | 0.0761 |
Plasmodium vivax | aspartyl protease, putative | 0.0533 | 0.0436 | 0.1281 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.1129 | 0.0955 | 0.0974 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0537 | 0.044 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.6615 | 0.5733 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0533 | 0.0436 | 0.0761 |
Brugia malayi | hypothetical protein | 0.0533 | 0.0436 | 0.0761 |
Loa Loa (eye worm) | thymidylate synthase | 0.1129 | 0.0955 | 0.1666 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0533 | 0.0436 | 0.0436 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0533 | 0.0436 | 0.1281 |
Toxoplasma gondii | aspartyl protease ASP3 | 0.0533 | 0.0436 | 0.1281 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.6615 | 0.5733 | 1 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0533 | 0.0436 | 0.0436 |
Plasmodium falciparum | plasmepsin III | 0.0533 | 0.0436 | 0.1281 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.6615 | 0.5733 | 1 |
Brugia malayi | dihydrofolate reductase family protein | 0.6615 | 0.5733 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.6615 | 0.5733 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.1129 | 0.0955 | 0.1666 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0533 | 0.0436 | 0.0436 |
Loa Loa (eye worm) | aspartyl protease 6 | 0.0533 | 0.0436 | 0.0761 |
Plasmodium falciparum | plasmepsin VIII, putative | 0.0533 | 0.0436 | 0.1281 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0533 | 0.0436 | 0.0436 |
Echinococcus multilocularis | cathepsin d (lysosomal aspartyl protease) | 0.0533 | 0.0436 | 0.0761 |
Loa Loa (eye worm) | hypothetical protein | 0.0533 | 0.0436 | 0.0761 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.3943 | 0.3406 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.6615 | 0.5733 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IZ (functional) | = 7 mm | Antibacterial activity against Escherichia coli at 10 mg/ml by cup-plate technique | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.