Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0042 | 0.012 | 0.0079 |
Schistosoma mansoni | methyltransferase-related | 0.0048 | 0.0352 | 1 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0163 | 0.4848 | 0.6445 |
Leishmania major | hypothetical protein, conserved | 0.0048 | 0.0352 | 1 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0153 | 0.4464 | 0.5912 |
Loa Loa (eye worm) | fatty acid synthase | 0.0157 | 0.459 | 0.5273 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0153 | 0.4464 | 0.5688 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.01 | 0.237 | 0.3113 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0124 | 0.3337 | 0.4437 |
Mycobacterium ulcerans | thioesterase TesA | 0.0132 | 0.3641 | 0.4813 |
Trypanosoma brucei | beta-ketoacyl-ACP synthase | 0.004 | 0.0041 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0042 | 0.012 | 1 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.0286 | 0.9634 | 1 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0153 | 0.4464 | 0.4441 |
Mycobacterium ulcerans | polyketide synthase | 0.0153 | 0.4464 | 0.5912 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0042 | 0.012 | 0.2522 |
Plasmodium falciparum | 3-oxoacyl-acyl-carrier protein synthase I/II | 0.004 | 0.0041 | 0.5 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0132 | 0.3641 | 0.4527 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0154 | 0.4482 | 0.5959 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0042 | 0.012 | 1 |
Mycobacterium tuberculosis | Polyketide synthetase MbtD (polyketide synthase) | 0.0049 | 0.039 | 0.0519 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.0232 | 0.7522 | 1 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.0232 | 0.7522 | 1 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0163 | 0.4848 | 0.6445 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.0232 | 0.7522 | 1 |
Mycobacterium ulcerans | polyketide synthase | 0.0163 | 0.4848 | 0.6426 |
Trypanosoma cruzi | beta-ketoacyl synthase family protein, putative | 0.004 | 0.0041 | 0.5 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0148 | 0.4266 | 0.4897 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0163 | 0.4848 | 0.6229 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.01 | 0.237 | 0.3113 |
Mycobacterium ulcerans | fatty acid synthase Fas | 0.005 | 0.0431 | 0.0522 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0048 | 0.0352 | 0.5 |
Chlamydia trachomatis | 3-oxoacyl-ACP synthase | 0.004 | 0.0041 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0042 | 0.012 | 0.0091 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0042 | 0.012 | 0.2522 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.01 | 0.237 | 0.2734 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0153 | 0.4464 | 0.5912 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0042 | 0.012 | 1 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0153 | 0.4464 | 0.5935 |
Brugia malayi | AMP-binding enzyme family protein | 0.0049 | 0.039 | 0.035 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.004 | 0.0041 | 0.5 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0154 | 0.4482 | 0.5959 |
Mycobacterium ulcerans | thioesterase | 0.0132 | 0.3641 | 0.4813 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0049 | 0.0407 | 0.0541 |
Toxoplasma gondii | AMP-binding enzyme domain-containing protein | 0.008 | 0.1614 | 0.3272 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0153 | 0.4464 | 0.5688 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0122 | 0.3256 | 0.4298 |
Mycobacterium ulcerans | polyketide synthase MbtD | 0.0049 | 0.039 | 0.0467 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0048 | 0.0352 | 0.0468 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0163 | 0.4848 | 0.6229 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0153 | 0.4464 | 0.5935 |
Brugia malayi | AMP-binding enzyme family protein | 0.0148 | 0.4266 | 0.4242 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0163 | 0.4848 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0042 | 0.012 | 0.2522 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0122 | 0.3256 | 0.3984 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.1745 | 0.1976 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0153 | 0.4464 | 0.5912 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.009 | 0.2004 | 0.2665 |
Loa Loa (eye worm) | acyl carrier protein | 0.0073 | 0.1332 | 0.1497 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0122 | 0.3256 | 0.4298 |
Brugia malayi | Methyltransferase-like protein 4 | 0.0048 | 0.0352 | 0.0312 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.0232 | 0.7522 | 1 |
Onchocerca volvulus | 0.0276 | 0.925 | 0.9285 | |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0103 | 0.25 | 0.5115 |
Giardia lamblia | Methyltransferase like 2 | 0.0048 | 0.0352 | 0.5 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.0064 | 0.099 | 0.1316 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0132 | 0.3641 | 0.4841 |
Mycobacterium tuberculosis | Probable fatty acid synthase Fas (fatty acid synthetase) | 0.005 | 0.0431 | 0.0574 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0163 | 0.4848 | 0.6229 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0153 | 0.4464 | 0.5912 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0163 | 0.4848 | 0.6426 |
Plasmodium vivax | 3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative | 0.004 | 0.0041 | 0.5 |
Trypanosoma cruzi | beta-ketoacyl synthase family protein, putative | 0.004 | 0.0041 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0042 | 0.012 | 1 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0163 | 0.4848 | 0.6445 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0114 | 0.2931 | 0.3896 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0148 | 0.4266 | 0.5671 |
Mycobacterium tuberculosis | Conserved protein | 0.0048 | 0.0352 | 0.0468 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0113 | 0.289 | 0.5927 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0163 | 0.4848 | 0.6426 |
Loa Loa (eye worm) | hypothetical protein | 0.0261 | 0.8668 | 1 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0153 | 0.4464 | 0.5935 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
LD50 (ADMET) | > 1000 mg kg-1 | Acute toxicity in po dosed Mus musculus ICR (mouse) assessed as mortality measured after 14 days | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.