Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | chemokine (C-C motif) receptor 2 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.1308 | 0.1512 |
Schistosoma mansoni | tar DNA-binding protein | 0.0041 | 0.0129 | 0.0438 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.014 | 0.4798 | 0.6357 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0132 | 0.4411 | 0.5834 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0197 | 0.7485 | 1 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0197 | 0.7485 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0197 | 0.7485 | 1 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.0197 | 0.7498 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0197 | 0.7485 | 1 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0106 | 0.3191 | 0.4155 |
Brugia malayi | AMP-binding enzyme family protein | 0.0041 | 0.0088 | 0.0088 |
Mycobacterium tuberculosis | Polyketide synthetase MbtD (polyketide synthase) | 0.0041 | 0.0088 | 0.0052 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0132 | 0.4411 | 0.5834 |
Brugia malayi | jmjC domain containing protein | 0.0047 | 0.0385 | 0.0385 |
Toxoplasma gondii | AMP-binding enzyme domain-containing protein | 0.0067 | 0.1323 | 0.2758 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.0053 | 0.0693 | 0.0864 |
Schistosoma mansoni | tar DNA-binding protein | 0.0041 | 0.0129 | 0.0438 |
Echinococcus multilocularis | tar DNA binding protein | 0.0041 | 0.0129 | 0.0309 |
Schistosoma mansoni | tar DNA-binding protein | 0.0041 | 0.0129 | 0.0438 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0096 | 0.272 | 0.3552 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.011 | 0.337 | 0.4398 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0197 | 0.7485 | 1 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0123 | 0.4001 | 0.5305 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0197 | 0.7485 | 0.5 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.014 | 0.4798 | 0.6376 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0087 | 0.2296 | 0.2981 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.0197 | 0.7498 | 1 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0095 | 0.2653 | 0.3495 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.008 | 0.195 | 0.2253 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.0238 | 0.9421 | 1 |
Loa Loa (eye worm) | acyl carrier protein | 0.0061 | 0.1039 | 0.12 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0047 | 0.0385 | 0.1313 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0132 | 0.4411 | 0.5856 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0127 | 0.4167 | 1 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0132 | 0.4411 | 0.581 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.014 | 0.4798 | 0.6376 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0086 | 0.2218 | 0.4622 |
Schistosoma mansoni | methyltransferase-related | 0.004 | 0.0049 | 0.0167 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.014 | 0.4798 | 0.6357 |
Mycobacterium ulcerans | polyketide synthase | 0.0132 | 0.4411 | 0.5834 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0047 | 0.0385 | 0.0445 |
Giardia lamblia | Methyltransferase like 2 | 0.004 | 0.0049 | 0.0066 |
Schistosoma mansoni | tar DNA-binding protein | 0.0041 | 0.0129 | 0.0438 |
Loa Loa (eye worm) | RNA binding protein | 0.0041 | 0.0129 | 0.0149 |
Brugia malayi | RNA binding protein | 0.0041 | 0.0129 | 0.0129 |
Loa Loa (eye worm) | TAR-binding protein | 0.0041 | 0.0129 | 0.0149 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0087 | 0.2296 | 0.2981 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.0197 | 0.7498 | 1 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0047 | 0.0385 | 0.0925 |
Loa Loa (eye worm) | fatty acid synthase | 0.013 | 0.4328 | 0.5 |
Mycobacterium ulcerans | thioesterase | 0.011 | 0.337 | 0.443 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0108 | 0.3273 | 0.4329 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0132 | 0.4411 | 0.5834 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.011 | 0.337 | 0.4459 |
Leishmania major | hypothetical protein, conserved | 0.004 | 0.0049 | 0.5 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0096 | 0.272 | 0.3515 |
Brugia malayi | jmjC domain containing protein | 0.0127 | 0.4167 | 0.4167 |
Onchocerca volvulus | 0.023 | 0.9033 | 0.9588 | |
Echinococcus granulosus | tar DNA binding protein | 0.0041 | 0.0129 | 0.0309 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0197 | 0.7485 | 0.5 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0087 | 0.2296 | 0.2941 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0047 | 0.0385 | 0.0925 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0054 | 0.0717 | 0.1721 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0197 | 0.7485 | 1 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.014 | 0.4798 | 0.6337 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0197 | 0.7485 | 1 |
Brugia malayi | TAR-binding protein | 0.0041 | 0.0129 | 0.0129 |
Mycobacterium ulcerans | polyketide synthase | 0.014 | 0.4798 | 0.6357 |
Loa Loa (eye worm) | hypothetical protein | 0.0222 | 0.8655 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0041 | 0.0129 | 0.0438 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0197 | 0.7485 | 0.5 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0096 | 0.272 | 0.3585 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0127 | 0.4167 | 1 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0132 | 0.4411 | 0.4411 |
Brugia malayi | Methyltransferase-like protein 4 | 0.004 | 0.0049 | 0.0049 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0041 | 0.0129 | 0.0129 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0128 | 0.4219 | 0.5599 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0106 | 0.3191 | 0.4188 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0047 | 0.0385 | 0.1313 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0197 | 0.7485 | 1 |
Mycobacterium ulcerans | thioesterase TesA | 0.011 | 0.337 | 0.443 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0132 | 0.4411 | 0.5856 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0106 | 0.3191 | 0.4188 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.014 | 0.4798 | 0.6337 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0075 | 0.1717 | 0.224 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.014 | 0.4798 | 0.6337 |
Mycobacterium ulcerans | fatty acid synthase Fas | 0.0041 | 0.0129 | 0.0056 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0045 | 0.0314 | 0.0356 |
Onchocerca volvulus | 0.0123 | 0.4001 | 0.4247 | |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.1666 | 0.1925 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.0197 | 0.7498 | 1 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0094 | 0.2612 | 0.5443 |
Schistosoma mansoni | jumonji domain containing protein | 0.0101 | 0.2934 | 1 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0132 | 0.4411 | 0.581 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.014 | 0.4798 | 0.6376 |
Mycobacterium tuberculosis | Probable fatty acid synthase Fas (fatty acid synthetase) | 0.0041 | 0.0129 | 0.0108 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0041 | 0.0129 | 0.0149 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0123 | 0.4001 | 0.4622 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0128 | 0.4219 | 0.5599 |
Echinococcus granulosus | jumonji domain containing protein | 0.0054 | 0.0717 | 0.1721 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0197 | 0.7485 | 1 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0132 | 0.4411 | 0.5856 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0132 | 0.4411 | 0.5834 |
Brugia malayi | AMP-binding enzyme family protein | 0.0123 | 0.4001 | 0.4001 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.014 | 0.4798 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.