Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | CMGC family protein kinase | 0.0158 | 0.3414 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0158 | 0.3414 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0158 | 0.3414 | 0.3239 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.012 | 0.2401 | 0.3572 |
Brugia malayi | beta-lactamase family protein | 0.004 | 0.0259 | 0.0759 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0265 | 0.6255 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0158 | 0.3414 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0259 | 0.0759 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.004 | 0.0259 | 0.0759 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.012 | 0.2401 | 0.7032 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0259 | 0.0759 |
Onchocerca volvulus | 0.004 | 0.0259 | 0.5 | |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0158 | 0.3414 | 0.3239 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0158 | 0.3414 | 0.5262 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.012 | 0.2401 | 0.8054 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0158 | 0.3414 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0045 | 0.0413 | 0.0358 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.012 | 0.2401 | 0.8054 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0158 | 0.3414 | 0.5312 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0253 | 0.5943 | 1 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0125 | 0.2541 | 0.3806 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0368 | 0.1078 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.004 | 0.0259 | 0.0105 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.004 | 0.0259 | 0.0759 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.004 | 0.0259 | 0.0759 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0158 | 0.3414 | 0.3239 |
Loa Loa (eye worm) | beta-lactamase | 0.004 | 0.0259 | 0.0759 |
Toxoplasma gondii | hypothetical protein | 0.0043 | 0.0342 | 0.0261 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.012 | 0.2401 | 0.2199 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0158 | 0.3414 | 0.3239 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0158 | 0.3414 | 0.5312 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0158 | 0.3414 | 0.5312 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0158 | 0.3414 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0139 | 0.2918 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0158 | 0.3414 | 0.5312 |
Onchocerca volvulus | 0.004 | 0.0259 | 0.5 | |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0158 | 0.3414 | 0.5262 |
Brugia malayi | beta-lactamase | 0.004 | 0.0259 | 0.0759 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0158 | 0.3414 | 1 |
Onchocerca volvulus | 0.004 | 0.0259 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0259 | 0.0759 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0265 | 0.6255 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0259 | 0.0759 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0158 | 0.3414 | 1 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.012 | 0.2401 | 0.2199 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.004 | 0.0259 | 0.0105 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.012 | 0.2401 | 0.6788 |
Trypanosoma brucei | hypothetical protein, conserved | 0.004 | 0.0259 | 0.0105 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0158 | 0.3414 | 0.5312 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0259 | 0.0759 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.012 | 0.2401 | 0.7032 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0265 | 0.6255 | 1 |
Trypanosoma brucei | protein kinase, putative | 0.0158 | 0.3414 | 0.5312 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.012 | 0.2401 | 0.3768 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0125 | 0.2541 | 0.3871 |
Mycobacterium leprae | Probable lipase LipE | 0.004 | 0.0259 | 0.5 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.004 | 0.0259 | 0.0759 |
Brugia malayi | MAP kinase sur-1 | 0.0158 | 0.3414 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0125 | 0.2541 | 0.3871 |
Mycobacterium leprae | conserved hypothetical protein | 0.004 | 0.0259 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.004 | 0.0259 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.004 | 0.0259 | 0.0759 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0139 | 0.2918 | 0.4678 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0044 | 0.0368 | 0.1078 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0044 | 0.0368 | 0.1078 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0259 | 0.0759 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0265 | 0.6255 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0044 | 0.0368 | 0.1078 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0158 | 0.3414 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.012 | 0.2401 | 0.8054 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.