Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | tubulin beta 4A class IVa | 0.0605 | 0.5 | 0.5 |
Echinococcus multilocularis | tubulin, beta 4A class IVa | 0.0605 | 0.5 | 0.5 |
Plasmodium falciparum | tubulin beta chain | 0.0605 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0605 | 0.5 | 0.5 |
Entamoeba histolytica | tubulin family protein | 0.0605 | 0.5 | 0.5 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0605 | 0.5 | 0.5 |
Giardia lamblia | Beta tubulin | 0.0605 | 0.5 | 0.5 |
Giardia lamblia | Beta tubulin | 0.0605 | 0.5 | 0.5 |
Giardia lamblia | Beta tubulin | 0.0605 | 0.5 | 0.5 |
Loa Loa (eye worm) | tubulin beta-4 chain | 0.0605 | 0.5 | 0.5 |
Trypanosoma brucei | beta tubulin | 0.0605 | 0.5 | 0.5 |
Schistosoma mansoni | tubulin subunit beta | 0.0605 | 0.5 | 0.5 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0605 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0605 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0605 | 0.5 | 0.5 |
Plasmodium vivax | tubulin beta chain, putative | 0.0605 | 0.5 | 0.5 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0605 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0605 | 0.5 | 0.5 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0605 | 0.5 | 0.5 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0605 | 0.5 | 0.5 |
Toxoplasma gondii | beta tubulin | 0.0605 | 0.5 | 0.5 |
Echinococcus granulosus | tubulin subunit beta | 0.0605 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0605 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0605 | 0.5 | 0.5 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0605 | 0.5 | 0.5 |
Echinococcus multilocularis | tubulin beta 1 chain | 0.0605 | 0.5 | 0.5 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0605 | 0.5 | 0.5 |
Loa Loa (eye worm) | beta-tubulin | 0.0605 | 0.5 | 0.5 |
Trypanosoma cruzi | beta tubulin, putative | 0.0605 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0605 | 0.5 | 0.5 |
Trypanosoma brucei | beta tubulin | 0.0605 | 0.5 | 0.5 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0605 | 0.5 | 0.5 |
Toxoplasma gondii | beta-1 tubulin, putative | 0.0605 | 0.5 | 0.5 |
Schistosoma mansoni | tubulin subunit beta | 0.0605 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0605 | 0.5 | 0.5 |
Trypanosoma brucei | beta tubulin | 0.0605 | 0.5 | 0.5 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0605 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0605 | 0.5 | 0.5 |
Echinococcus granulosus | beta tubulin | 0.0605 | 0.5 | 0.5 |
Echinococcus granulosus | tubulin beta 1 chain | 0.0605 | 0.5 | 0.5 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0605 | 0.5 | 0.5 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0605 | 0.5 | 0.5 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0605 | 0.5 | 0.5 |
Brugia malayi | beta-tubulin, identical | 0.0605 | 0.5 | 0.5 |
Loa Loa (eye worm) | BEN-1 protein | 0.0605 | 0.5 | 0.5 |
Schistosoma mansoni | tubulin subunit beta | 0.0605 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0605 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0605 | 0.5 | 0.5 |
Trichomonas vaginalis | tubulin, putative | 0.0605 | 0.5 | 0.5 |
Echinococcus multilocularis | tubulin subunit beta | 0.0605 | 0.5 | 0.5 |
Entamoeba histolytica | tubulin family protein | 0.0605 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0605 | 0.5 | 0.5 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0605 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0605 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0605 | 0.5 | 0.5 |
Schistosoma mansoni | tubulin subunit beta | 0.0605 | 0.5 | 0.5 |
Trypanosoma brucei | beta tubulin | 0.0605 | 0.5 | 0.5 |
Loa Loa (eye worm) | tubulin beta-2A chain | 0.0605 | 0.5 | 0.5 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0605 | 0.5 | 0.5 |
Loa Loa (eye worm) | BEN-1 protein | 0.0605 | 0.5 | 0.5 |
Schistosoma mansoni | tubulin subunit beta | 0.0605 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0605 | 0.5 | 0.5 |
Echinococcus multilocularis | beta tubulin | 0.0605 | 0.5 | 0.5 |
Schistosoma mansoni | tubulin subunit beta | 0.0605 | 0.5 | 0.5 |
Toxoplasma gondii | beta-tubulin, putative | 0.0605 | 0.5 | 0.5 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0605 | 0.5 | 0.5 |
Loa Loa (eye worm) | tubulin beta chain | 0.0605 | 0.5 | 0.5 |
Echinococcus granulosus | beta tubulin | 0.0605 | 0.5 | 0.5 |
Loa Loa (eye worm) | tubulin beta-1 chain | 0.0605 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0605 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0605 | 0.5 | 0.5 |
Echinococcus multilocularis | beta tubulin | 0.0605 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0605 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Anticonvulsant activity in Mus musculus (mouse) assessed as protection against maximal electroshock-induced seizures at 100 mg/kg, ip administered 30 min prior to electroshock-challenge measured at 0.5 hr | ChEMBL. | No reference | |
Activity (ADMET) | Neurotoxicity against Mus musculus (mouse) at 100 mg/kg, ip measured at 4 hr by rotarod test | ChEMBL. | No reference | |
Activity (ADMET) | Neurotoxicity against Mus musculus (mouse) at 100 mg/kg, ip measured at 0.5 hr by rotarod test | ChEMBL. | No reference | |
Activity (functional) | Anticonvulsant activity in Mus musculus (mouse) assessed as protection against maximal electroshock-induced seizures at 100 mg/kg, ip administered 30 min prior to electroshock-challenge measured at 4 hr | ChEMBL. | No reference | |
ED50 (functional) | = 78.3 mg kg-1 | Anticonvulsant activity in ip dosed Mus musculus (mouse) assessed as protection against maximal electroshock-induced seizures administered 30 min prior to electroshock-challenge measured at 4 hr | ChEMBL. | No reference |
Ratio TD50/ED50 | = 2.2 | Protective index, ratio of TD50 for neurotoxicity to ED50 for anticonvulsant activity in mouse | ChEMBL. | No reference |
TD50 (ADMET) | = 169.7 mg kg-1 | Neurotoxicity against ip dosed Mus musculus (mouse) by rotarod test | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.