Detailed information for compound 1839721

Basic information

Technical information
  • TDR Targets ID: 1839721
  • Name: 2-(3,4-dihydroxy-5-methoxyphenyl)-3,5,7-trihy droxychromen-4-one
  • MW: 332.262 | Formula: C16H12O8
  • H donors: 5 H acceptors: 6 LogP: 2.14 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(cc(c1O)O)c1oc2cc(O)cc(c2c(=O)c1O)O
  • InChi: 1S/C16H12O8/c1-23-11-3-6(2-9(19)13(11)20)16-15(22)14(21)12-8(18)4-7(17)5-10(12)24-16/h2-5,17-20,22H,1H3
  • InChiKey: CFYMYCCYMJIYAB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-(3,4-dihydroxy-5-methoxy-phenyl)-3,5,7-trihydroxy-chromen-4-one
  • 2-(3,4-dihydroxy-5-methoxyphenyl)-3,5,7-trihydroxy-4-chromenone
  • 2-(3,4-dihydroxy-5-methoxy-phenyl)-3,5,7-trihydroxy-chromone
  • 53472-37-0
  • 3'-O-Methylmyricetin
  • C12633
  • Laricitrin

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) heat shock protein 90 0.0045 0.1871 0.2734
Leishmania major heat shock protein 83-1 0.0045 0.1871 1
Mycobacterium ulcerans heat shock protein 90 0.0042 0.1693 0.5
Trypanosoma brucei heat shock protein, putative 0.0045 0.1871 1
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0042 0.1693 0.5
Entamoeba histolytica hypothetical protein 0.0037 0.1335 0.4511
Leishmania major heat shock protein 83-1 0.0045 0.1871 1
Leishmania major heat shock protein 83-1 0.0045 0.1871 1
Entamoeba histolytica hypothetical protein 0.0037 0.1335 0.4511
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.2986 0.4362
Brugia malayi MH2 domain containing protein 0.0122 0.6845 1
Trypanosoma cruzi heat shock protein, putative 0.003 0.0894 0.4226
Loa Loa (eye worm) hypothetical protein 0.0035 0.1209 0.1767
Leishmania major heat shock protein 83-1 0.0045 0.1871 1
Brugia malayi heat shock protein 90 0.0045 0.1871 0.2734
Echinococcus multilocularis endoplasmin 0.0042 0.1693 0.5669
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0042 0.1693 0.817
Leishmania major heat shock protein 83-1 0.0045 0.1871 1
Loa Loa (eye worm) RNA binding protein 0.0062 0.2986 0.4362
Leishmania major heat shock protein 83-1 0.0045 0.1871 1
Trichomonas vaginalis heat shock protein, putative 0.0042 0.1693 0.8533
Trypanosoma brucei heat shock protein, putative 0.0045 0.1871 1
Leishmania major heat shock protein 83-1 0.0045 0.1871 1
Schistosoma mansoni heat shock protein 0.003 0.0894 0.2993
Plasmodium vivax heat shock protein 86, putative 0.0045 0.1871 0.1074
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.2986 0.4362
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.003 0.0894 0.5
Trichomonas vaginalis heat shock protein, putative 0.0045 0.1871 1
Echinococcus granulosus heat shock protein 0.0045 0.1871 0.6268
Leishmania major heat shock protein 83-1 0.0045 0.1871 1
Plasmodium falciparum heat shock protein 90 0.0045 0.1871 0.1305
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.1335 0.447
Trypanosoma cruzi Heat shock protein 83, putative 0.0045 0.1871 1
Trypanosoma cruzi heat shock protein 85, putative 0.0045 0.1871 1
Brugia malayi RNA binding protein 0.0062 0.2986 0.4362
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.2251 0.3289
Schistosoma mansoni heat shock protein 0.0045 0.1871 0.6268
Loa Loa (eye worm) MH2 domain-containing protein 0.0122 0.6845 1
Giardia lamblia Heat shock protein HSP 90-alpha 0.0045 0.1871 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.1335 0.447
Leishmania major heat shock protein 83-1 0.0045 0.1871 1
Plasmodium vivax endoplasmin, putative 0.0045 0.1871 0.1074
Trypanosoma cruzi heat shock protein 90, putative 0.0045 0.1871 1
Trypanosoma cruzi heat shock protein 90, putative 0.0038 0.1451 0.7515
Schistosoma mansoni tar DNA-binding protein 0.0062 0.2986 1
Trypanosoma brucei heat shock protein, putative 0.0045 0.1871 1
Toxoplasma gondii heat shock protein HSP90 0.0045 0.1871 0.1074
Echinococcus multilocularis tar DNA binding protein 0.0062 0.2986 1
Entamoeba histolytica heat shock protein 90, putative 0.0045 0.1871 1
Echinococcus granulosus endoplasmin 0.0042 0.1693 0.5669
Trichomonas vaginalis heat shock protein, putative 0.0033 0.1073 0.345
Schistosoma mansoni hypothetical protein 0.0035 0.1209 0.405
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.003 0.0894 0.2993
Trypanosoma brucei Heat shock protein 83, putative 0.0045 0.1871 1
Schistosoma mansoni heat shock protein 0.0045 0.1871 0.6268
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0042 0.1693 0.5
Loa Loa (eye worm) hypothetical protein 0.0051 0.2251 0.3289
Loa Loa (eye worm) endoplasmin 0.0045 0.1871 0.2734
Leishmania major heat shock protein 83-1 0.0045 0.1871 1
Entamoeba histolytica hypothetical protein 0.0037 0.1335 0.4511
Leishmania major heat shock protein 83-1 0.0045 0.1871 1
Loa Loa (eye worm) TAR-binding protein 0.0062 0.2986 0.4362
Brugia malayi hypothetical protein 0.0037 0.1335 0.195
Schistosoma mansoni hypothetical protein 0.0037 0.1335 0.447
Trypanosoma cruzi heat shock protein 85, putative 0.0045 0.1871 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.2986 1
Trypanosoma brucei heat shock protein, putative 0.0045 0.1871 1
Leishmania major heat shock protein 83-1 0.0045 0.1871 1
Schistosoma mansoni endoplasmin 0.0045 0.1871 0.6268
Trichomonas vaginalis endoplasmin, putative 0.0033 0.1073 0.345
Treponema pallidum heat shock protein 90 0.0042 0.1693 0.5
Schistosoma mansoni tar DNA-binding protein 0.0062 0.2986 1
Echinococcus multilocularis heat shock protein 90 0.0038 0.1451 0.4858
Schistosoma mansoni endoplasmin 0.0045 0.1871 0.6268
Leishmania major heat shock protein 83-1 0.0045 0.1871 1
Plasmodium falciparum endoplasmin, putative 0.0033 0.1073 0.045
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.2251 0.3289
Trichomonas vaginalis heat shock protein, putative 0.0042 0.1693 0.8533
Echinococcus multilocularis heat shock protein 0.0045 0.1871 0.6268
Trypanosoma cruzi heat shock protein 85, putative 0.0038 0.1451 0.7515
Schistosoma mansoni tar DNA-binding protein 0.0062 0.2986 1
Trypanosoma brucei heat shock protein 90, putative 0.0045 0.1871 1
Leishmania major heat shock protein 83-1 0.0045 0.1871 1
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0042 0.1693 0.5
Trypanosoma brucei heat shock protein 90, putative 0.0045 0.1871 1
Brugia malayi Endoplasmin precursor 0.0045 0.1871 0.2734
Entamoeba histolytica hypothetical protein 0.0037 0.1335 0.4511
Entamoeba histolytica heat shock protein 90, putative 0.0045 0.1871 1
Echinococcus granulosus tar DNA binding protein 0.0062 0.2986 1
Leishmania major heat shock protein 83-1 0.0045 0.1871 1
Trypanosoma brucei heat shock protein, putative 0.0045 0.1871 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.2986 1
Loa Loa (eye worm) transcription factor SMAD2 0.0122 0.6845 1
Giardia lamblia Grp94/Hsp90 0.0042 0.1693 0.5748
Trypanosoma brucei heat shock protein, putative 0.0045 0.1871 1
Toxoplasma gondii heat shock protein 90, putative 0.0045 0.1871 0.1074
Echinococcus granulosus heat shock protein 90 0.0045 0.1871 0.6268
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.1335 0.447
Brugia malayi Hsp90 protein 0.003 0.0894 0.1305
Echinococcus granulosus heat shock protein 90 0.0038 0.1451 0.4858
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.003 0.0894 0.2993
Trichomonas vaginalis heat shock protein, putative 0.0038 0.1451 0.655
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0038 0.1451 0.4858
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.1209 0.1767
Trypanosoma cruzi heat shock protein 85, putative 0.0045 0.1871 1
Leishmania major heat shock protein 83-1 0.0045 0.1871 1
Trypanosoma brucei heat shock protein, putative 0.0045 0.1871 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.2251 0.3289
Brugia malayi TAR-binding protein 0.0062 0.2986 0.4362
Trypanosoma brucei heat shock protein, putative 0.0045 0.1871 1
Loa Loa (eye worm) heat shock protein 75 0.003 0.0894 0.1305
Leishmania major heat shock protein 83-1 0.0045 0.1871 1
Echinococcus multilocularis heat shock protein 90 0.0045 0.1871 0.6268

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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