Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0048 | 0.066 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0044 | 0.0361 | 0.0361 |
Onchocerca volvulus | Cathepsin L homolog | 0.0044 | 0.0361 | 1 |
Onchocerca volvulus | 0.0044 | 0.0361 | 1 | |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.013 | 0.6411 | 0.6411 |
Echinococcus granulosus | cathepsin b | 0.013 | 0.6411 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0044 | 0.0361 | 0.0563 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0044 | 0.0361 | 0.0563 |
Brugia malayi | Cathepsin L-like precursor | 0.0044 | 0.0361 | 0.0563 |
Echinococcus granulosus | cathepsin l1 | 0.0044 | 0.0361 | 0.0563 |
Brugia malayi | cathepsin B-like cysteine proteinase | 0.013 | 0.6411 | 1 |
Echinococcus multilocularis | cathepsin b | 0.013 | 0.6411 | 1 |
Echinococcus granulosus | cathepsin b | 0.013 | 0.6411 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.013 | 0.6411 | 0.6411 |
Onchocerca volvulus | 0.0044 | 0.0361 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.0044 | 0.0361 | 0.0563 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.013 | 0.6411 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0117 | 0.5479 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0044 | 0.0361 | 0.0563 |
Giardia lamblia | Dipeptidyl-peptidase I precursor | 0.0076 | 0.2606 | 0.2084 |
Onchocerca volvulus | 0.0044 | 0.0361 | 1 | |
Giardia lamblia | Encystation-specific protease | 0.0076 | 0.2606 | 0.2084 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0044 | 0.0361 | 0.0563 |
Loa Loa (eye worm) | hypothetical protein | 0.013 | 0.6411 | 1 |
Loa Loa (eye worm) | fibroinase | 0.0044 | 0.0361 | 0.0563 |
Loa Loa (eye worm) | cysteine protease | 0.0044 | 0.0361 | 0.0563 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0361 | 0.0563 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0044 | 0.0361 | 0.0361 |
Onchocerca volvulus | 0.0044 | 0.0361 | 1 | |
Brugia malayi | Papain family cysteine protease containing protein | 0.0044 | 0.0361 | 0.0563 |
Echinococcus multilocularis | cathepsin b | 0.013 | 0.6411 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0044 | 0.0361 | 0.0563 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.013 | 0.6411 | 0.6411 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0044 | 0.0361 | 0.5 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0048 | 0.066 | 0.066 |
Plasmodium falciparum | dipeptidyl aminopeptidase 3 | 0.0076 | 0.2606 | 0.2329 |
Brugia malayi | Cathepsin L-like precursor | 0.0044 | 0.0361 | 0.0563 |
Echinococcus multilocularis | cysteine protease | 0.0044 | 0.0361 | 0.0563 |
Brugia malayi | Cathepsin L-like precursor | 0.0044 | 0.0361 | 0.0563 |
Plasmodium vivax | dipeptidyl aminopeptidase 3, putative | 0.0076 | 0.2606 | 0.2329 |
Brugia malayi | Cathepsin L-like precursor | 0.0044 | 0.0361 | 0.0563 |
Loa Loa (eye worm) | cathepsin B | 0.0048 | 0.066 | 0.103 |
Toxoplasma gondii | cathepsin B | 0.0048 | 0.066 | 0.031 |
Onchocerca volvulus | Cathepsin F homolog | 0.0044 | 0.0361 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0048 | 0.066 | 0.0585 |
Onchocerca volvulus | Cathepsin L homolog | 0.0044 | 0.0361 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0044 | 0.0361 | 0.0563 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0044 | 0.0361 | 0.0563 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0044 | 0.0361 | 0.0563 |
Onchocerca volvulus | 0.0044 | 0.0361 | 1 | |
Onchocerca volvulus | 0.0044 | 0.0361 | 1 | |
Toxoplasma gondii | cathepsin CPC2 | 0.0076 | 0.2606 | 0.2329 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.013 | 0.6411 | 0.6411 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0044 | 0.0361 | 0.0563 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0044 | 0.0361 | 0.0563 |
Giardia lamblia | Dipeptidyl-peptidase I precursor | 0.0076 | 0.2606 | 0.2084 |
Onchocerca volvulus | 0.0044 | 0.0361 | 1 | |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0048 | 0.066 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0044 | 0.0361 | 0.5 |
Loa Loa (eye worm) | ctsf protein | 0.0044 | 0.0361 | 0.0563 |
Entamoeba histolytica | cysteine protease, putative | 0.0044 | 0.0361 | 0.5 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0048 | 0.066 | 0.0495 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.