Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | DNA gyrase (type II topoisomerase), subunit A | Starlite/ChEMBL | References |
Escherichia coli | DNA gyrase, subunit B | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0069 | 0.0607 | 0.5 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0069 | 0.0607 | 0.5 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0069 | 0.0607 | 0.5 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0069 | 0.0607 | 0.5 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0069 | 0.0607 | 0.5 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.0153 | 0.378 | 0.3378 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0069 | 0.0607 | 0.5 |
Schistosoma mansoni | DNA topoisomerase II | 0.0069 | 0.0607 | 0.5 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0069 | 0.0607 | 0.5 |
Brugia malayi | Probable DNA topoisomerase II | 0.0069 | 0.0607 | 0.5 |
Giardia lamblia | DNA topoisomerase II | 0.0064 | 0.0426 | 0.5 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0069 | 0.0607 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0121 | 0.2591 | 1 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0069 | 0.0607 | 0.5 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0153 | 0.378 | 0.2419 |
Plasmodium falciparum | DNA gyrase subunit B | 0.0153 | 0.378 | 0.3378 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0088 | 0.1347 | 0.0788 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0121 | 0.2591 | 1 |
Trypanosoma brucei | DNA topoisomerase ii | 0.0121 | 0.2591 | 1 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.0121 | 0.2591 | 1 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0069 | 0.0607 | 0.5 |
Mycobacterium leprae | Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0152 | 0.3728 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.12 mg/L | Inhibition of Escherichia coli DNA gyrase preincubated for 5 mins at 37 degC before addition of relaxed pBR322 as substrate by supercoiling assay | ChEMBL. | 26363871 |
MIC (functional) | = 0.004 mg/L | Antibacterial activity against Escherichia coli 177 assessed as growth inhibition at 128 to 0.002 mg/L incubated for 18 hrs at 37 degC by agar dilution method | ChEMBL. | 26363871 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.