Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | DNA gyrase (type II topoisomerase), subunit A | Starlite/ChEMBL | References |
Escherichia coli | DNA gyrase, subunit B | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.4161 | 0.6423 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.0153 | 0.378 | 0.3378 |
Loa Loa (eye worm) | hypothetical protein | 0.0215 | 0.614 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.4161 | 0.6423 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0075 | 0.0847 | 1 |
Plasmodium falciparum | histone deacetylase 1 | 0.0075 | 0.0847 | 0.0255 |
Trypanosoma brucei | histone deacetylase 1 | 0.0075 | 0.0847 | 0.2721 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0109 | 0.2115 | 0.3296 |
Echinococcus multilocularis | histone deacetylase 1 | 0.0075 | 0.0847 | 0.0434 |
Mycobacterium leprae | Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0152 | 0.3728 | 0.6072 |
Toxoplasma gondii | peptidase family M13 protein | 0.0215 | 0.614 | 0.589 |
Echinococcus granulosus | endothelin converting enzyme 1 | 0.0215 | 0.614 | 1 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0075 | 0.0847 | 0.0434 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.0075 | 0.0847 | 0.0434 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0075 | 0.0847 | 1 |
Brugia malayi | Hypothetical zinc metalloproteinase T16A9.4 | 0.0215 | 0.614 | 1 |
Brugia malayi | Histone deacetylase 1 | 0.0075 | 0.0847 | 0.0434 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0075 | 0.0847 | 0.0434 |
Echinococcus granulosus | histone deacetylase 1 | 0.0075 | 0.0847 | 0.0434 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0215 | 0.614 | 1 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0075 | 0.0847 | 0.2721 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.2041 | 0.2591 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.4161 | 0.6423 |
Schistosoma mansoni | Nep2 peptidase (M13 family) | 0.0109 | 0.2115 | 0.3296 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0121 | 0.2591 | 1 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.0075 | 0.0847 | 0.0255 |
Echinococcus multilocularis | histone deacetylase 3 | 0.0075 | 0.0847 | 0.0434 |
Plasmodium vivax | histone deacetylase 1, putative | 0.0075 | 0.0847 | 0.0255 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.402 | 0.6168 |
Giardia lamblia | Histone deacetylase | 0.0075 | 0.0847 | 1 |
Plasmodium falciparum | DNA gyrase subunit B | 0.0153 | 0.378 | 0.3378 |
Schistosoma mansoni | histone deacetylase | 0.0075 | 0.0847 | 0.1184 |
Entamoeba histolytica | histone deacetylase, putative | 0.0075 | 0.0847 | 1 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.0075 | 0.0847 | 0.0255 |
Leishmania major | histone deacetylase, putative | 0.0075 | 0.0847 | 0.2721 |
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | 0.0109 | 0.2115 | 0.3296 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0159 | 0.402 | 0.6168 |
Trypanosoma brucei | DNA topoisomerase ii | 0.0121 | 0.2591 | 1 |
Leishmania major | histone deacetylase, putative | 0.0075 | 0.0847 | 0.2721 |
Schistosoma mansoni | histone deacetylase | 0.0075 | 0.0847 | 0.1184 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0153 | 0.378 | 0.2419 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0088 | 0.1347 | 0.0788 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.4161 | 0.6423 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0075 | 0.0847 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0121 | 0.2591 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0075 | 0.0847 | 1 |
Brugia malayi | histone deacetylase 3 (HD3) | 0.0075 | 0.0847 | 0.0434 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0075 | 0.0847 | 1 |
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.0215 | 0.614 | 0.3794 |
Echinococcus granulosus | histone deacetylase 3 | 0.0075 | 0.0847 | 0.0434 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0159 | 0.402 | 0.6168 |
Schistosoma mansoni | neprilysin-2 (M13 family) | 0.0109 | 0.2115 | 0.3296 |
Schistosoma mansoni | DNA topoisomerase II | 0.0069 | 0.0607 | 0.0785 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0075 | 0.0847 | 0.2721 |
Loa Loa (eye worm) | hypothetical protein | 0.0215 | 0.614 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0215 | 0.614 | 1 |
Brugia malayi | Peptidase family M13 containing protein | 0.0215 | 0.614 | 1 |
Mycobacterium ulcerans | zinc metalloprotease | 0.0215 | 0.614 | 0.3794 |
Mycobacterium leprae | probable zinc metalloprotease | 0.0215 | 0.614 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.402 | 0.6168 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.0121 | 0.2591 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0075 | 0.0847 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.4161 | 0.6423 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0075 | 0.0847 | 1 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0075 | 0.0847 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.402 | 0.6168 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.4161 | 0.6423 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0075 | 0.0847 | 1 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0109 | 0.2115 | 0.3296 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0847 | 0.0434 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.402 | 0.6168 |
Onchocerca volvulus | 0.0107 | 0.2041 | 1 | |
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.0215 | 0.614 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.078 mg/L | Inhibition of Escherichia coli DNA gyrase preincubated for 5 mins at 37 degC before addition of relaxed pBR322 as substrate by supercoiling assay | ChEMBL. | 26363871 |
MIC (functional) | = 0.006 mg/L | Antibacterial activity against Escherichia coli 177 assessed as growth inhibition at 128 to 0.002 mg/L incubated for 18 hrs at 37 degC by agar dilution method | ChEMBL. | 26363871 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.