Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | DNA gyrase (type II topoisomerase), subunit A | Starlite/ChEMBL | References |
Escherichia coli | DNA gyrase, subunit B | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0847 | 0.0434 |
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | 0.0109 | 0.2115 | 0.3296 |
Brugia malayi | Hypothetical zinc metalloproteinase T16A9.4 | 0.0215 | 0.614 | 1 |
Onchocerca volvulus | 0.0107 | 0.2041 | 1 | |
Trypanosoma brucei | histone deacetylase 1 | 0.0075 | 0.0847 | 0.2721 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0121 | 0.2591 | 1 |
Mycobacterium leprae | Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0152 | 0.3728 | 0.6072 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0215 | 0.614 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0215 | 0.614 | 1 |
Schistosoma mansoni | neprilysin-2 (M13 family) | 0.0109 | 0.2115 | 0.3296 |
Mycobacterium leprae | probable zinc metalloprotease | 0.0215 | 0.614 | 1 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0075 | 0.0847 | 1 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.0153 | 0.378 | 0.3378 |
Brugia malayi | Histone deacetylase 1 | 0.0075 | 0.0847 | 0.0434 |
Schistosoma mansoni | histone deacetylase | 0.0075 | 0.0847 | 0.1184 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.4161 | 0.6423 |
Plasmodium falciparum | histone deacetylase 1 | 0.0075 | 0.0847 | 0.0255 |
Leishmania major | histone deacetylase, putative | 0.0075 | 0.0847 | 0.2721 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0121 | 0.2591 | 1 |
Echinococcus granulosus | endothelin converting enzyme 1 | 0.0215 | 0.614 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.4161 | 0.6423 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.0121 | 0.2591 | 1 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0075 | 0.0847 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0075 | 0.0847 | 1 |
Brugia malayi | Peptidase family M13 containing protein | 0.0215 | 0.614 | 1 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0153 | 0.378 | 0.2419 |
Echinococcus multilocularis | histone deacetylase 1 | 0.0075 | 0.0847 | 0.0434 |
Echinococcus granulosus | histone deacetylase 1 | 0.0075 | 0.0847 | 0.0434 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0075 | 0.0847 | 0.0434 |
Schistosoma mansoni | DNA topoisomerase II | 0.0069 | 0.0607 | 0.0785 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0075 | 0.0847 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.4161 | 0.6423 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.0075 | 0.0847 | 0.0255 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0075 | 0.0847 | 0.0434 |
Loa Loa (eye worm) | hypothetical protein | 0.0215 | 0.614 | 1 |
Plasmodium vivax | histone deacetylase 1, putative | 0.0075 | 0.0847 | 0.0255 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0075 | 0.0847 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.402 | 0.6168 |
Toxoplasma gondii | peptidase family M13 protein | 0.0215 | 0.614 | 0.589 |
Plasmodium falciparum | DNA gyrase subunit B | 0.0153 | 0.378 | 0.3378 |
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.0215 | 0.614 | 0.3794 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0159 | 0.402 | 0.6168 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.4161 | 0.6423 |
Leishmania major | histone deacetylase, putative | 0.0075 | 0.0847 | 0.2721 |
Loa Loa (eye worm) | hypothetical protein | 0.0215 | 0.614 | 1 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0088 | 0.1347 | 0.0788 |
Echinococcus granulosus | histone deacetylase 3 | 0.0075 | 0.0847 | 0.0434 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0075 | 0.0847 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.402 | 0.6168 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0109 | 0.2115 | 0.3296 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.402 | 0.6168 |
Schistosoma mansoni | histone deacetylase | 0.0075 | 0.0847 | 0.1184 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0159 | 0.402 | 0.6168 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0075 | 0.0847 | 1 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0075 | 0.0847 | 0.2721 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.0075 | 0.0847 | 0.0255 |
Giardia lamblia | Histone deacetylase | 0.0075 | 0.0847 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.4161 | 0.6423 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0075 | 0.0847 | 0.2721 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.2041 | 0.2591 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.402 | 0.6168 |
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.0215 | 0.614 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0075 | 0.0847 | 1 |
Brugia malayi | histone deacetylase 3 (HD3) | 0.0075 | 0.0847 | 0.0434 |
Mycobacterium ulcerans | zinc metalloprotease | 0.0215 | 0.614 | 0.3794 |
Schistosoma mansoni | Nep2 peptidase (M13 family) | 0.0109 | 0.2115 | 0.3296 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0109 | 0.2115 | 0.3296 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0075 | 0.0847 | 1 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.0075 | 0.0847 | 0.0434 |
Entamoeba histolytica | histone deacetylase, putative | 0.0075 | 0.0847 | 1 |
Echinococcus multilocularis | histone deacetylase 3 | 0.0075 | 0.0847 | 0.0434 |
Trypanosoma brucei | DNA topoisomerase ii | 0.0121 | 0.2591 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.4161 | 0.6423 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.33 mg/L | Inhibition of Escherichia coli DNA gyrase preincubated for 5 mins at 37 degC before addition of relaxed pBR322 as substrate by supercoiling assay | ChEMBL. | 26363871 |
MIC (functional) | = 0.038 mg/L | Antibacterial activity against Escherichia coli 177 assessed as growth inhibition at 128 to 0.002 mg/L incubated for 18 hrs at 37 degC by agar dilution method | ChEMBL. | 26363871 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.