Detailed information for compound 337270

Basic information

Technical information
  • TDR Targets ID: 337270
  • Name: 2-methoxy-5-[(Z)-2-(3,4,5-trimethylphenyl)eth enyl]phenol
  • MW: 268.35 | Formula: C18H20O2
  • H donors: 1 H acceptors: 1 LogP: 4.9 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1O)/C=C\c1cc(C)c(c(c1)C)C
  • InChi: 1S/C18H20O2/c1-12-9-16(10-13(2)14(12)3)6-5-15-7-8-18(20-4)17(19)11-15/h5-11,19H,1-4H3/b6-5-
  • InChiKey: RYPSSPOIYQFPDK-WAYWQWQTSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-methoxy-5-[(Z)-2-(3,4,5-trimethylphenyl)vinyl]phenol

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens tubulin, beta 1 class VI Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis tubulin, beta 4A class IVa Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta-4 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum ko:K07375 tubulin beta, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei gambiense beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Giardia lamblia Beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Giardia lamblia Beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei gambiense beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Entamoeba histolytica tubulin family protein Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi beta-tubulin, identical Get druggable targets OG5_126611 All targets in OG5_126611
Neospora caninum hypothetical protein Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin beta 1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Entamoeba histolytica tubulin family protein Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin alpha chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Babesia bovis tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Toxoplasma gondii beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi Tubulin beta-1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Theileria parva tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin beta 4A class IVa Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin beta 1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin beta-2A chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Toxoplasma gondii beta-1 tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma congolense beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta-7 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Cryptosporidium parvum tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta-1 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) BEN-1 protein Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Giardia lamblia Beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin beta-1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Cryptosporidium hominis beta-catenin-like repeat protein Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum ko:K07375 tubulin beta, putative Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium vivax tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium yoelii tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium berghei tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma cruzi beta tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium falciparum tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta-1 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin gamma chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Neospora caninum hypothetical protein Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Toxoplasma gondii beta-tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) BEN-1 protein Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin beta-4 chain Get druggable targets OG5_126611 All targets in OG5_126611
Neospora caninum hypothetical protein Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum tubulin gamma chain tubulin, beta 1 class VI 451 aa 438 aa 32.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0078 0.2964 0.2964
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.2964 0.2964
Loa Loa (eye worm) hypothetical protein 0.0078 0.2964 0.2964
Trichomonas vaginalis tubulin beta chain, putative 0.003 0 0.5
Schistosoma mansoni neuropeptide receptor 0.0078 0.2964 0.2964
Echinococcus granulosus carbonic anhydrase II 0.0192 1 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0078 0.2964 0.2964
Echinococcus multilocularis rhodopsin orphan GPCR 0.0078 0.2964 0.2964
Echinococcus granulosus orexin receptor type 2 0.0078 0.2964 0.2964
Loa Loa (eye worm) hypothetical protein 0.009 0.3725 0.3725
Brugia malayi RE15519p 0.0078 0.2964 0.2964
Echinococcus multilocularis allatostatin A receptor 0.0078 0.2964 0.2964
Brugia malayi G-protein coupled receptor 0.0078 0.2964 0.2964
Trichomonas vaginalis tubulin alpha chain, putative 0.003 0 0.5
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0078 0.2964 0.2964
Echinococcus granulosus rhodopsin orphan GPCR 0.0078 0.2964 0.2964
Brugia malayi hypothetical protein 0.0078 0.2964 0.2964
Brugia malayi putative neuropeptide receptor NPR1 0.0078 0.2964 0.2964
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0078 0.2964 0.2964
Loa Loa (eye worm) hypothetical protein 0.0078 0.2964 0.2964
Loa Loa (eye worm) hypothetical protein 0.0078 0.2964 0.2964
Echinococcus granulosus 7tm_1 domain containing protein 0.0078 0.2964 0.2964
Echinococcus granulosus neuropeptide receptor 0.0078 0.2964 0.2964
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.009 0.3725 0.3725
Giardia lamblia Beta tubulin 0.003 0 0.5
Echinococcus multilocularis neuropeptide Y receptor 0.0078 0.2964 0.2964
Loa Loa (eye worm) G-protein coupled receptor 0.0078 0.2964 0.2964
Schistosoma mansoni neuropeptide F-like receptor 0.0078 0.2964 0.2964
Brugia malayi hypothetical protein 0.0078 0.2964 0.2964
Echinococcus multilocularis rhodopsin orphan GPCR 0.0078 0.2964 0.2964
Echinococcus granulosus alpha 1A adrenergic receptor 0.0078 0.2964 0.2964
Loa Loa (eye worm) hypothetical protein 0.0078 0.2964 0.2964
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.2964 0.2964
Brugia malayi Dopamine receptor protein 1 0.0078 0.2964 0.2964
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0078 0.2964 0.2964
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.2964 0.2964
Echinococcus granulosus peptide allatostatin:somatostatin 0.0078 0.2964 0.2964
Loa Loa (eye worm) hypothetical protein 0.009 0.3725 0.3725
Echinococcus multilocularis rhodopsin orphan GPCR 0.0078 0.2964 0.2964
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0078 0.2964 0.2964
Loa Loa (eye worm) hypothetical protein 0.0078 0.2964 0.2964
Echinococcus granulosus neuropeptides capa receptor 0.0078 0.2964 0.2964
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0078 0.2964 0.2964
Brugia malayi follicle stimulating hormone receptor 0.0078 0.2964 0.2964
Echinococcus granulosus neuropeptide Y receptor 0.0078 0.2964 0.2964
Loa Loa (eye worm) hypothetical protein 0.0078 0.2964 0.2964
Loa Loa (eye worm) hypothetical protein 0.0078 0.2964 0.2964
Schistosoma mansoni amine GPCR 0.0078 0.2964 0.2964
Brugia malayi hypothetical protein 0.0078 0.2964 0.2964
Giardia lamblia Beta tubulin 0.003 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0078 0.2964 0.2964
Echinococcus granulosus rhodopsin orphan GPCR 0.0078 0.2964 0.2964
Schistosoma mansoni neuropeptide receptor 0.0078 0.2964 0.2964
Schistosoma mansoni carbonic anhydrase-related 0.009 0.3725 0.3725
Trichomonas vaginalis tubulin epsilon chain, putative 0.003 0 0.5
Echinococcus granulosus hypothetical protein 0.0078 0.2964 0.2964
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0078 0.2964 0.2964
Loa Loa (eye worm) hypothetical protein 0.0078 0.2964 0.2964
Loa Loa (eye worm) hypothetical protein 0.0078 0.2964 0.2964
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0078 0.2964 0.2964
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0078 0.2964 0.2964
Plasmodium falciparum carbonic anhydrase 0.009 0.3725 1
Onchocerca volvulus 0.0078 0.2964 0.5
Brugia malayi larval opioid receptor 0.0078 0.2964 0.2964
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0078 0.2964 0.2964
Schistosoma mansoni hypothetical protein 0.009 0.3725 0.3725
Onchocerca volvulus 0.0078 0.2964 0.5
Echinococcus granulosus neuropeptide receptor 0.0078 0.2964 0.2964
Echinococcus granulosus biogenic amine 5HT receptor 0.0078 0.2964 0.2964
Plasmodium vivax tubulin beta chain, putative 0.003 0 0.5
Echinococcus granulosus serotonin receptor 0.0078 0.2964 0.2964
Echinococcus granulosus dro:myosuppressin receptor 0.0078 0.2964 0.2964
Schistosoma mansoni biogenic amine receptor 0.0078 0.2964 0.2964
Entamoeba histolytica tubulin family protein 0.003 0 0.5
Onchocerca volvulus 0.0078 0.2964 0.5
Schistosoma mansoni neuropeptide F-like receptor 0.0078 0.2964 0.2964
Loa Loa (eye worm) hypothetical protein 0.0078 0.2964 0.2964
Loa Loa (eye worm) hypothetical protein 0.0078 0.2964 0.2964
Giardia lamblia Beta tubulin 0.003 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0078 0.2964 0.2964
Trichomonas vaginalis tubulin epsilon chain, putative 0.003 0 0.5
Schistosoma mansoni hypothetical protein 0.0078 0.2964 0.2964
Echinococcus granulosus G protein coupled receptor 139 0.0078 0.2964 0.2964
Echinococcus granulosus rhodopsin orphan GPCR 0.0078 0.2964 0.2964
Schistosoma mansoni biogenic amine (5HT) receptor 0.0078 0.2964 0.2964
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0078 0.2964 0.2964
Echinococcus granulosus neuropeptides capa receptor 0.0078 0.2964 0.2964
Echinococcus multilocularis fmrfamide receptor 0.0078 0.2964 0.2964
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0078 0.2964 0.2964
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.2964 0.2964
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0192 1 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0078 0.2964 0.2964
Echinococcus multilocularis rhodopsin orphan GPCR 0.0078 0.2964 0.2964
Onchocerca volvulus 0.0078 0.2964 0.5
Onchocerca volvulus 0.0078 0.2964 0.5
Echinococcus granulosus g-protein coupled receptor 0.0078 0.2964 0.2964
Onchocerca volvulus 0.0078 0.2964 0.5
Loa Loa (eye worm) hypothetical protein 0.0078 0.2964 0.2964
Loa Loa (eye worm) hypothetical protein 0.0078 0.2964 0.2964
Echinococcus multilocularis carbonic anhydrase 0.009 0.3725 0.3725
Loa Loa (eye worm) hypothetical protein 0.0078 0.2964 0.2964
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0078 0.2964 0.2964
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0078 0.2964 0.2964
Echinococcus granulosus neuropeptide receptor A26 0.0078 0.2964 0.2964
Echinococcus granulosus rhodopsin orphan GPCR 0.0078 0.2964 0.2964
Schistosoma mansoni amine GPCR 0.0078 0.2964 0.2964
Onchocerca volvulus 0.0078 0.2964 0.5
Echinococcus granulosus tm gpcr rhodopsin 0.0078 0.2964 0.2964
Loa Loa (eye worm) melatonin receptor type 1A 0.0078 0.2964 0.2964
Echinococcus multilocularis G protein coupled receptor 139 0.0078 0.2964 0.2964
Echinococcus granulosus rhodopsin orphan GPCR 0.0078 0.2964 0.2964
Onchocerca volvulus 0.0078 0.2964 0.5
Loa Loa (eye worm) carbonic anhydrase 3 0.0192 1 1
Brugia malayi Melatonin receptor type 1A 0.0078 0.2964 0.2964
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.009 0.3725 0.3725
Schistosoma mansoni carbonic anhydrase-related 0.009 0.3725 0.3725
Onchocerca volvulus Neuropeptide F receptor homolog 0.0078 0.2964 0.5
Schistosoma mansoni alpha-1 adrenergic receptor 0.0078 0.2964 0.2964
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.009 0.3725 0.3725
Loa Loa (eye worm) hypothetical protein 0.0078 0.2964 0.2964
Schistosoma mansoni biogenic amine receptor 0.0078 0.2964 0.2964
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0078 0.2964 0.2964
Schistosoma mansoni biogenic amine receptor 0.0078 0.2964 0.2964
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0192 1 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.2964 0.2964
Echinococcus granulosus fmrfamide receptor 0.0078 0.2964 0.2964
Loa Loa (eye worm) hypothetical protein 0.0078 0.2964 0.2964
Echinococcus granulosus tachykinin peptides receptor 99D 0.0078 0.2964 0.2964
Loa Loa (eye worm) hypothetical protein 0.0078 0.2964 0.2964
Brugia malayi hypothetical protein 0.0078 0.2964 0.2964
Echinococcus granulosus neuropeptide s receptor 0.0078 0.2964 0.2964
Onchocerca volvulus 0.0078 0.2964 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.2964 0.2964
Loa Loa (eye worm) hypothetical protein 0.0078 0.2964 0.2964
Schistosoma mansoni biogenic amine (5HT) receptor 0.0078 0.2964 0.2964
Echinococcus multilocularis G-protein coupled receptor, putative 0.0078 0.2964 0.2964
Schistosoma mansoni hypothetical protein 0.0078 0.2964 0.2964
Echinococcus granulosus rhodopsin orphan GPCR 0.0078 0.2964 0.2964
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0078 0.2964 0.2964
Schistosoma mansoni histamine h1 receptor 0.0078 0.2964 0.2964
Echinococcus granulosus carbonic anhydrase 0.009 0.3725 0.3725
Loa Loa (eye worm) hypothetical protein 0.0078 0.2964 0.2964
Loa Loa (eye worm) hypothetical protein 0.0078 0.2964 0.2964
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0078 0.2964 0.2964
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0078 0.2964 0.2964
Echinococcus granulosus g protein coupled receptor 0.0078 0.2964 0.2964
Loa Loa (eye worm) hypothetical protein 0.0078 0.2964 0.2964
Onchocerca volvulus 0.0078 0.2964 0.5
Brugia malayi neuropeptide F receptor 0.0078 0.2964 0.2964
Echinococcus multilocularis carbonic anhydrase 0.009 0.3725 0.3725
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0078 0.2964 0.2964
Brugia malayi Dopamine receptor 0.0078 0.2964 0.2964
Echinococcus multilocularis neuropeptides capa receptor 0.0078 0.2964 0.2964
Schistosoma mansoni opsin-like receptor 0.0078 0.2964 0.2964
Echinococcus multilocularis neuropeptide Y receptor 0.0078 0.2964 0.2964
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0078 0.2964 0.2964
Onchocerca volvulus 0.0078 0.2964 0.5
Echinococcus multilocularis carbonic anhydrase II 0.0192 1 1
Brugia malayi hypothetical protein 0.0078 0.2964 0.2964
Echinococcus multilocularis serotonin receptor 0.0078 0.2964 0.2964
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0078 0.2964 0.2964
Schistosoma mansoni neuropeptide f receptor 76f 0.0078 0.2964 0.2964
Echinococcus multilocularis g protein coupled receptor 0.0078 0.2964 0.2964
Echinococcus multilocularis neuropeptides capa receptor 0.0078 0.2964 0.2964
Trichomonas vaginalis tubulin, putative 0.003 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0078 0.2964 0.2964
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0078 0.2964 0.2964
Loa Loa (eye worm) hypothetical protein 0.0078 0.2964 0.2964
Loa Loa (eye worm) hypothetical protein 0.0078 0.2964 0.2964
Toxoplasma gondii hypothetical protein 0.009 0.3725 1
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0192 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.2964 0.2964
Echinococcus granulosus carbonic anhydrase 0.009 0.3725 0.3725
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0078 0.2964 0.2964
Echinococcus multilocularis carbonic anhydrase 0.009 0.3725 0.3725
Brugia malayi AKH receptor 0.0078 0.2964 0.2964
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0078 0.2964 0.2964
Brugia malayi G-protein coupled receptor 0.0078 0.2964 0.2964
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0078 0.2964 0.5
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0078 0.2964 0.2964
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0078 0.2964 0.2964
Brugia malayi sulfakinin receptor protein 0.0078 0.2964 0.2964
Brugia malayi hypothetical protein 0.0078 0.2964 0.2964
Echinococcus multilocularis rhodopsin orphan GPCR 0.0078 0.2964 0.2964
Brugia malayi hypothetical protein 0.0078 0.2964 0.2964
Schistosoma mansoni opsin-like receptor 0.0078 0.2964 0.2964
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.009 0.3725 0.3725
Schistosoma mansoni myosin xvIII 0.0078 0.2964 0.2964
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0192 1 1
Onchocerca volvulus 0.0078 0.2964 0.5
Loa Loa (eye worm) hypothetical protein 0.0078 0.2964 0.2964
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0078 0.2964 0.2964
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0078 0.2964 0.2964
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0078 0.2964 0.2964
Echinococcus multilocularis somatostatin receptor 0.0078 0.2964 0.2964
Echinococcus granulosus 7TM GPCR rhodopsin 0.0078 0.2964 0.2964
Loa Loa (eye worm) TYRA-2 protein 0.0078 0.2964 0.2964
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0078 0.2964 0.2964
Loa Loa (eye worm) hypothetical protein 0.009 0.3725 0.3725
Loa Loa (eye worm) hypothetical protein 0.0078 0.2964 0.2964
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0078 0.2964 0.2964
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0078 0.2964 0.2964
Brugia malayi hypothetical protein 0.0078 0.2964 0.2964
Echinococcus granulosus tm gpcr rhodopsin 0.0078 0.2964 0.2964
Brugia malayi hypothetical protein 0.0078 0.2964 0.2964
Trypanosoma brucei carbonic anhydrase-like protein 0.0192 1 1
Echinococcus multilocularis serotonin receptor 0.0078 0.2964 0.2964
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.2964 0.2964
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0078 0.2964 0.2964
Echinococcus multilocularis rhodopsin orphan GPCR 0.0078 0.2964 0.2964
Schistosoma mansoni hypothetical protein 0.0078 0.2964 0.2964
Loa Loa (eye worm) hypothetical protein 0.0078 0.2964 0.2964
Loa Loa (eye worm) hypothetical protein 0.0078 0.2964 0.2964
Echinococcus granulosus neuropeptide Y receptor 0.0078 0.2964 0.2964
Echinococcus granulosus biogenic amine 5HT receptor 0.0078 0.2964 0.2964
Brugia malayi ORL1-like opioid receptor 0.0078 0.2964 0.2964
Echinococcus multilocularis orexin receptor type 2 0.0078 0.2964 0.2964
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.2964 0.2964
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0192 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.2964 0.2964
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0078 0.2964 0.2964
Brugia malayi hypothetical protein 0.0078 0.2964 0.2964
Echinococcus granulosus sex peptide receptor 0.0078 0.2964 0.2964
Schistosoma mansoni amine GPCR 0.0078 0.2964 0.2964
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.009 0.3725 0.3725
Onchocerca volvulus 0.0078 0.2964 0.5
Echinococcus granulosus tm gpcr rhodopsin 0.0078 0.2964 0.2964
Schistosoma mansoni neuropeptide receptor 0.0078 0.2964 0.2964
Schistosoma mansoni adenoreceptor 0.0078 0.2964 0.2964
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0078 0.2964 0.2964
Loa Loa (eye worm) hypothetical protein 0.0078 0.2964 0.2964
Brugia malayi Dopamine receptor protein 2 0.0078 0.2964 0.2964
Brugia malayi Tachykinin-like peptides receptor 99D 0.0078 0.2964 0.2964
Brugia malayi GnHR receptor homolog 0.0078 0.2964 0.2964
Brugia malayi G protein-coupled receptor 0.0078 0.2964 0.2964
Echinococcus multilocularis neuropeptide receptor 0.0078 0.2964 0.2964
Echinococcus granulosus somatostatin receptor 0.0078 0.2964 0.2964
Schistosoma mansoni growth hormone secretagogue receptor 0.0078 0.2964 0.2964
Loa Loa (eye worm) hypothetical protein 0.0078 0.2964 0.2964
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0078 0.2964 0.2964
Echinococcus multilocularis neuropeptide receptor A26 0.0078 0.2964 0.2964
Loa Loa (eye worm) neuropeptide F receptor 0.0078 0.2964 0.2964
Echinococcus multilocularis neuropeptide FF receptor 2 0.0078 0.2964 0.2964
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0078 0.2964 0.2964
Echinococcus multilocularis g protein coupled receptor 0.0078 0.2964 0.2964
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0078 0.2964 0.2964
Echinococcus multilocularis sex peptide receptor 0.0078 0.2964 0.2964
Brugia malayi Serotonin receptor 0.0078 0.2964 0.2964
Loa Loa (eye worm) hypothetical protein 0.0078 0.2964 0.2964
Onchocerca volvulus 0.0078 0.2964 0.5
Schistosoma mansoni carbonic anhydrase-related 0.009 0.3725 0.3725
Echinococcus multilocularis neuropeptide s receptor 0.0078 0.2964 0.2964
Echinococcus granulosus g protein coupled receptor 0.0078 0.2964 0.2964
Echinococcus granulosus carbonic anhydrase 0.009 0.3725 0.3725
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0078 0.2964 0.2964
Loa Loa (eye worm) hypothetical protein 0.0078 0.2964 0.2964
Echinococcus multilocularis rhodopsin orphan GPCR 0.0078 0.2964 0.2964
Loa Loa (eye worm) neuropeptide F receptor 0.0078 0.2964 0.2964
Loa Loa (eye worm) hypothetical protein 0.0078 0.2964 0.2964
Schistosoma mansoni opsin-like receptor 0.0078 0.2964 0.2964
Echinococcus multilocularis g-protein coupled receptor 0.0078 0.2964 0.2964
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.009 0.3725 0.3725
Trichomonas vaginalis tubulin gamma chain, putative 0.003 0 0.5
Echinococcus multilocularis g protein coupled receptor 0.0078 0.2964 0.2964
Loa Loa (eye worm) hypothetical protein 0.0078 0.2964 0.2964
Brugia malayi Serotonin receptor 0.0078 0.2964 0.2964
Echinococcus granulosus allatostatin A receptor 0.0078 0.2964 0.2964
Onchocerca volvulus 0.0078 0.2964 0.5
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0078 0.2964 0.2964
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0078 0.2964 0.2964
Schistosoma mansoni amine GPCR 0.0078 0.2964 0.2964
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0192 1 1
Brugia malayi neuropeptide F receptor 0.0078 0.2964 0.2964
Schistosoma mansoni neuropeptide receptor 0.0078 0.2964 0.2964
Echinococcus granulosus g protein coupled receptor 0.0078 0.2964 0.2964
Loa Loa (eye worm) hypothetical protein 0.0078 0.2964 0.2964
Loa Loa (eye worm) hypothetical protein 0.0078 0.2964 0.2964
Loa Loa (eye worm) hypothetical protein 0.0078 0.2964 0.2964
Echinococcus multilocularis neuropeptide receptor 0.0078 0.2964 0.2964
Loa Loa (eye worm) hypothetical protein 0.0078 0.2964 0.2964
Echinococcus multilocularis dro:myosuppressin receptor 0.0078 0.2964 0.2964
Leishmania major carbonic anhydrase-like protein 0.0192 1 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0078 0.2964 0.2964
Echinococcus multilocularis fmrfamide receptor 0.0078 0.2964 0.2964
Loa Loa (eye worm) G-protein coupled receptor 0.0078 0.2964 0.2964
Schistosoma mansoni carbonic anhydrase 0.009 0.3725 0.3725
Echinococcus multilocularis rhodopsin orphan GPCR 0.0078 0.2964 0.2964
Onchocerca volvulus 0.0078 0.2964 0.5
Loa Loa (eye worm) hypothetical protein 0.0078 0.2964 0.2964
Loa Loa (eye worm) hypothetical protein 0.0078 0.2964 0.2964
Loa Loa (eye worm) hypothetical protein 0.0078 0.2964 0.2964
Onchocerca volvulus 0.0078 0.2964 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0078 0.2964 0.2964
Schistosoma mansoni hypothetical protein 0.0078 0.2964 0.2964
Schistosoma mansoni amine GPCR 0.0078 0.2964 0.2964
Brugia malayi putative neuropeptide receptor 0.0078 0.2964 0.2964
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0078 0.2964 0.2964
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0078 0.2964 0.2964
Entamoeba histolytica tubulin family protein 0.003 0 0.5

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 0.02 uM Cytotoxicity against human K562 cells ChEMBL. No reference
IC50 (binding) = 0.12 uM Concentration required for 50% inhibition of tubulin polymerization ChEMBL. 15658859
IC50 (binding) = 0.12 uM Concentration required for 50% inhibition of tubulin polymerization ChEMBL. 15658859

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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