Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Leishmania major | beta tubulin | Curated by TDR Targets | References |
Leishmania major | epsilon tubulin, putative | Curated by TDR Targets | References |
Leishmania major | beta tubulin | Curated by TDR Targets | References |
Leishmania major | beta tubulin | Curated by TDR Targets | References |
Leishmania major | alpha tubulin | Curated by TDR Targets | References |
Leishmania major | delta tubulin, putative | Curated by TDR Targets | References |
Leishmania major | beta tubulin | Curated by TDR Targets | References |
Leishmania major | alpha tubulin | Curated by TDR Targets | References |
Leishmania major | alpha tubulin | Curated by TDR Targets | References |
Leishmania major | beta tubulin | Curated by TDR Targets | References |
Leishmania major | beta tubulin | Curated by TDR Targets | References |
Leishmania major | alpha tubulin | Curated by TDR Targets | References |
Leishmania major | alpha tubulin | Curated by TDR Targets | References |
Leishmania major | alpha tubulin | Curated by TDR Targets | References |
Leishmania major | alpha tubulin | Curated by TDR Targets | References |
Leishmania major | beta tubulin | Curated by TDR Targets | References |
Leishmania major | beta tubulin | Curated by TDR Targets | References |
Leishmania major | gamma-tubulin | Curated by TDR Targets | References |
Leishmania major | beta tubulin | Curated by TDR Targets | References |
Leishmania major | alpha tubulin | Curated by TDR Targets | References |
Leishmania major | alpha tubulin | Curated by TDR Targets | References |
Leishmania major | beta tubulin | Curated by TDR Targets | References |
Leishmania major | zeta tubulin, putative | Curated by TDR Targets | References |
Leishmania major | DNA topoisomerase IB, large subunit | Curated by TDR Targets | References |
Leishmania major | beta tubulin | Curated by TDR Targets | References |
Leishmania major | alpha tubulin | Curated by TDR Targets | References |
Leishmania major | alpha tubulin | Curated by TDR Targets | References |
Leishmania major | beta tubulin | Curated by TDR Targets | References |
Leishmania major | beta tubulin | Curated by TDR Targets | References |
Leishmania major | beta tubulin | Curated by TDR Targets | References |
Leishmania major | beta tubulin | Curated by TDR Targets | References |
Leishmania major | alpha tubulin | Curated by TDR Targets | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | tubulin gamma chain | alpha tubulin | 451 aa | 457 aa | 30.9 % |
Plasmodium falciparum | tubulin gamma chain | alpha tubulin | 451 aa | 457 aa | 30.9 % |
Plasmodium falciparum | tubulin gamma chain | alpha tubulin | 451 aa | 457 aa | 30.9 % |
Plasmodium falciparum | tubulin gamma chain | beta tubulin | 443 aa | 438 aa | 33.6 % |
Plasmodium falciparum | tubulin epsilon chain, putative | gamma-tubulin | 447 aa | 479 aa | 28.2 % |
Plasmodium falciparum | tubulin gamma chain | alpha tubulin | 451 aa | 457 aa | 30.9 % |
Plasmodium falciparum | tubulin gamma chain | alpha tubulin | 451 aa | 457 aa | 30.9 % |
Plasmodium falciparum | tubulin gamma chain | alpha tubulin | 451 aa | 457 aa | 30.9 % |
Plasmodium falciparum | tubulin gamma chain | alpha tubulin | 451 aa | 457 aa | 30.9 % |
Plasmodium falciparum | tubulin gamma chain | beta tubulin | 443 aa | 438 aa | 33.6 % |
Plasmodium falciparum | tubulin gamma chain | alpha tubulin | 451 aa | 457 aa | 30.9 % |
Plasmodium falciparum | tubulin gamma chain | beta tubulin | 443 aa | 438 aa | 33.6 % |
Plasmodium falciparum | tubulin gamma chain | beta tubulin | 443 aa | 438 aa | 33.6 % |
Plasmodium falciparum | tubulin gamma chain | beta tubulin | 443 aa | 438 aa | 33.6 % |
Plasmodium falciparum | tubulin gamma chain | beta tubulin | 443 aa | 438 aa | 33.6 % |
Plasmodium falciparum | tubulin gamma chain | beta tubulin | 443 aa | 438 aa | 33.6 % |
Plasmodium falciparum | tubulin gamma chain | beta tubulin | 443 aa | 438 aa | 33.6 % |
Trypanosoma brucei | epsilon tubulin | epsilon tubulin, putative | 470 aa | 488 aa | 68.0 % |
Plasmodium falciparum | tubulin gamma chain | beta tubulin | 443 aa | 438 aa | 33.6 % |
Plasmodium falciparum | tubulin gamma chain | beta tubulin | 443 aa | 438 aa | 33.6 % |
Plasmodium falciparum | tubulin gamma chain | alpha tubulin | 451 aa | 457 aa | 30.9 % |
Plasmodium falciparum | tubulin gamma chain | alpha tubulin | 451 aa | 457 aa | 30.9 % |
Plasmodium falciparum | tubulin gamma chain | beta tubulin | 443 aa | 438 aa | 33.6 % |
Plasmodium falciparum | tubulin gamma chain | beta tubulin | 443 aa | 438 aa | 33.6 % |
Plasmodium falciparum | tubulin gamma chain | beta tubulin | 443 aa | 438 aa | 33.6 % |
Plasmodium falciparum | tubulin gamma chain | alpha tubulin | 451 aa | 457 aa | 30.9 % |
Plasmodium falciparum | tubulin gamma chain | beta tubulin | 443 aa | 438 aa | 33.6 % |
Plasmodium falciparum | tubulin gamma chain | beta tubulin | 443 aa | 438 aa | 33.6 % |
Plasmodium falciparum | tubulin gamma chain | alpha tubulin | 451 aa | 457 aa | 30.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Tubulin alpha-2 chain | 0.0471 | 0.6434 | 0.6144 |
Schistosoma mansoni | tubulin subunit alpha | 0.0471 | 0.6434 | 0.6144 |
Trichomonas vaginalis | tubulin, putative | 0.0625 | 1 | 1 |
Plasmodium vivax | tubulin alpha chain, putative | 0.0471 | 0.6434 | 0.6144 |
Leishmania major | beta tubulin | 0.0625 | 1 | 1 |
Trypanosoma brucei | tubulin gamma chain | 0.0384 | 0.4422 | 0.3969 |
Leishmania major | alpha tubulin | 0.0471 | 0.6434 | 0.6144 |
Echinococcus granulosus | tubulin alpha | 0.0351 | 0.3666 | 0.3151 |
Giardia lamblia | Beta tubulin | 0.0625 | 1 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0625 | 1 | 1 |
Leishmania major | alpha tubulin | 0.0471 | 0.6434 | 0.6144 |
Echinococcus multilocularis | tubulin subunit beta | 0.0625 | 1 | 1 |
Echinococcus multilocularis | tubulin alpha | 0.0351 | 0.3666 | 0.3151 |
Trypanosoma brucei | alpha tubulin | 0.0471 | 0.6434 | 0.6144 |
Leishmania major | beta tubulin | 0.0625 | 1 | 1 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0351 | 0.3666 | 0.3659 |
Leishmania major | alpha tubulin | 0.0471 | 0.6434 | 0.6144 |
Entamoeba histolytica | tubulin alpha-1 chain | 0.0471 | 0.6434 | 0.3607 |
Echinococcus granulosus | tubulin subunit TubB | 0.0471 | 0.6434 | 0.6144 |
Echinococcus granulosus | tubulin alpha chain | 0.0471 | 0.6434 | 0.6144 |
Trypanosoma brucei | alpha tubulin | 0.0471 | 0.6434 | 0.6144 |
Schistosoma mansoni | tubulin subunit beta | 0.0625 | 1 | 1 |
Leishmania major | beta tubulin | 0.0625 | 1 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0625 | 1 | 1 |
Trichomonas vaginalis | tubulin alpha-1 chain, putative | 0.031 | 0.2699 | 0.2691 |
Loa Loa (eye worm) | tubulin alpha-2 chain | 0.0471 | 0.6434 | 0.6144 |
Leishmania major | alpha tubulin | 0.0471 | 0.6434 | 0.6144 |
Echinococcus granulosus | tubulin beta 4A class IVa | 0.0625 | 1 | 1 |
Echinococcus multilocularis | tubulin alpha chain | 0.0471 | 0.6434 | 0.6144 |
Echinococcus granulosus | beta tubulin | 0.0625 | 1 | 1 |
Loa Loa (eye worm) | tubulin alpha chain | 0.0471 | 0.6434 | 0.6144 |
Giardia lamblia | Beta tubulin | 0.0625 | 1 | 1 |
Leishmania major | gamma-tubulin | 0.0384 | 0.4422 | 0.3969 |
Echinococcus granulosus | peroxisome assembly protein 26 | 0.0471 | 0.6434 | 0.6144 |
Leishmania major | zeta tubulin, putative | 0.0498 | 0.7065 | 0.6826 |
Plasmodium falciparum | alpha tubulin 1 | 0.0471 | 0.6434 | 0.6144 |
Echinococcus granulosus | tubulin subunit beta | 0.0625 | 1 | 1 |
Schistosoma mansoni | tubulin subunit gamma | 0.0384 | 0.4422 | 0.3969 |
Loa Loa (eye worm) | tubulin gamma chain | 0.0384 | 0.4422 | 0.3969 |
Trypanosoma cruzi | tubulin gamma chain | 0.0384 | 0.4422 | 0.3969 |
Loa Loa (eye worm) | tubulin alpha chain | 0.0471 | 0.6434 | 0.6144 |
Brugia malayi | Tubulin alpha chain | 0.0471 | 0.6434 | 0.6144 |
Leishmania major | beta tubulin | 0.0625 | 1 | 1 |
Trypanosoma brucei | beta tubulin | 0.0625 | 1 | 1 |
Brugia malayi | beta-tubulin, identical | 0.0625 | 1 | 1 |
Trypanosoma cruzi | epsilon tubulin, putative | 0.0384 | 0.4411 | 0.3957 |
Echinococcus multilocularis | tubulin subunit TubB | 0.0471 | 0.6434 | 0.6144 |
Plasmodium vivax | tubulin epsilon chain, putative | 0.0384 | 0.4411 | 0.3957 |
Giardia lamblia | Alpha-tubulin | 0.0471 | 0.6434 | 0.6434 |
Leishmania major | beta tubulin | 0.0625 | 1 | 1 |
Echinococcus multilocularis | tubulin alpha 3 chain | 0.0471 | 0.6434 | 0.6144 |
Echinococcus multilocularis | tubulin alpha 3 chain | 0.0471 | 0.6434 | 0.6144 |
Loa Loa (eye worm) | alpha-tubulin | 0.0471 | 0.6434 | 0.6144 |
Schistosoma mansoni | tubulin subunit epsilon | 0.0384 | 0.4411 | 0.3957 |
Echinococcus multilocularis | Tubulin alpha 1 chain | 0.0471 | 0.6434 | 0.6144 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0471 | 0.6434 | 0.643 |
Echinococcus multilocularis | tubulin alpha 1C chain | 0.0471 | 0.6434 | 0.6144 |
Loa Loa (eye worm) | alpha-tubulin | 0.0471 | 0.6434 | 0.6144 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0471 | 0.6434 | 0.643 |
Leishmania major | alpha tubulin | 0.0471 | 0.6434 | 0.6144 |
Leishmania major | alpha tubulin | 0.0471 | 0.6434 | 0.6144 |
Schistosoma mansoni | alpha tubulin | 0.0471 | 0.6434 | 0.6144 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0625 | 1 | 1 |
Trypanosoma cruzi | tubulin delta chain | 0.0363 | 0.3926 | 0.3432 |
Brugia malayi | alpha-tubulin | 0.0471 | 0.6434 | 0.6144 |
Trypanosoma brucei | zeta tubulin | 0.0498 | 0.7065 | 0.6826 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0471 | 0.6434 | 0.643 |
Plasmodium vivax | tubulin alpha chain, putative | 0.0471 | 0.6434 | 0.6144 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0625 | 1 | 1 |
Trypanosoma brucei | beta tubulin | 0.0625 | 1 | 1 |
Leishmania major | alpha tubulin | 0.0471 | 0.6434 | 0.6144 |
Loa Loa (eye worm) | tubulin beta-1 chain | 0.0625 | 1 | 1 |
Leishmania major | beta tubulin | 0.0625 | 1 | 1 |
Loa Loa (eye worm) | beta-tubulin | 0.0625 | 1 | 1 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0384 | 0.4411 | 0.4405 |
Plasmodium falciparum | tubulin gamma chain | 0.0384 | 0.4422 | 0.3969 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0625 | 1 | 1 |
Echinococcus multilocularis | tubulin alpha chain | 0.0471 | 0.6434 | 0.6144 |
Echinococcus multilocularis | hypothetical protein | 0.0471 | 0.6434 | 0.6144 |
Loa Loa (eye worm) | alpha-tubulin isotype 2 | 0.031 | 0.2699 | 0.2105 |
Leishmania major | alpha tubulin | 0.0471 | 0.6434 | 0.6144 |
Echinococcus multilocularis | beta tubulin | 0.0625 | 1 | 1 |
Echinococcus multilocularis | tubulin, beta 4A class IVa | 0.0625 | 1 | 1 |
Echinococcus multilocularis | tubulin alpha chain | 0.0471 | 0.6434 | 0.6144 |
Echinococcus multilocularis | tubulin alpha chain | 0.0471 | 0.6434 | 0.6144 |
Leishmania major | alpha tubulin | 0.0471 | 0.6434 | 0.6144 |
Echinococcus granulosus | tubulin beta 1 chain | 0.0625 | 1 | 1 |
Echinococcus multilocularis | tubulin alpha chain | 0.0471 | 0.6434 | 0.6144 |
Plasmodium vivax | tubulin gamma chain, putative | 0.0384 | 0.4422 | 0.3969 |
Leishmania major | alpha tubulin | 0.0471 | 0.6434 | 0.6144 |
Echinococcus multilocularis | Tubulin alpha 1 chain | 0.0471 | 0.6434 | 0.6144 |
Entamoeba histolytica | tubulin family protein | 0.0625 | 1 | 1 |
Giardia lamblia | Gamma tubulin | 0.0384 | 0.4422 | 0.4422 |
Toxoplasma gondii | alpha-tubulin I, putative | 0.0471 | 0.6434 | 0.6434 |
Leishmania major | beta tubulin | 0.0625 | 1 | 1 |
Plasmodium falciparum | tubulin epsilon chain, putative | 0.0384 | 0.4411 | 0.3957 |
Leishmania major | delta tubulin, putative | 0.0363 | 0.3926 | 0.3432 |
Trypanosoma brucei | tubulin delta chain | 0.0363 | 0.3926 | 0.3432 |
Echinococcus multilocularis | tubulin gamma 1 chain | 0.0384 | 0.4422 | 0.3969 |
Trypanosoma brucei | beta tubulin | 0.0351 | 0.3666 | 0.3151 |
Schistosoma mansoni | tubulin subunit alpha | 0.0471 | 0.6434 | 0.6144 |
Toxoplasma gondii | DNA topoisomerase I, putative | 0.0226 | 0.0753 | 0.0753 |
Schistosoma mansoni | tubulin subunit beta | 0.0625 | 1 | 1 |
Leishmania major | beta tubulin | 0.0625 | 1 | 1 |
Toxoplasma gondii | tubulin/FtsZ family, GTPase domain-containing protein | 0.0363 | 0.3926 | 0.3926 |
Leishmania major | epsilon tubulin, putative | 0.0384 | 0.4411 | 0.3957 |
Entamoeba histolytica | tubulin alpha chain, putative | 0.0471 | 0.6434 | 0.3607 |
Echinococcus multilocularis | tubulin epsilon chain | 0.0384 | 0.4411 | 0.3957 |
Echinococcus granulosus | tubulin alpha 1C chain | 0.0471 | 0.6434 | 0.6144 |
Echinococcus granulosus | tubulin alpha 3 chain | 0.0471 | 0.6434 | 0.6144 |
Schistosoma mansoni | tubulin subunit beta | 0.0625 | 1 | 1 |
Toxoplasma gondii | alpha tubulin TUBA1 | 0.0471 | 0.6434 | 0.6434 |
Trypanosoma cruzi | zeta tubulin, putative | 0.0498 | 0.7065 | 0.6826 |
Leishmania major | beta tubulin | 0.0625 | 1 | 1 |
Echinococcus granulosus | tubulin alpha 3 chain | 0.0471 | 0.6434 | 0.6144 |
Echinococcus granulosus | tubulin gamma 1 chain | 0.0384 | 0.4422 | 0.3969 |
Echinococcus granulosus | tubulin alpha chain | 0.0471 | 0.6434 | 0.6144 |
Echinococcus multilocularis | beta tubulin | 0.0625 | 1 | 1 |
Trypanosoma brucei | epsilon tubulin | 0.0351 | 0.3666 | 0.3151 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0625 | 1 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0625 | 1 | 1 |
Trypanosoma brucei | zeta tubulin, putative | 0.0498 | 0.7065 | 0.6826 |
Trypanosoma cruzi | beta tubulin, putative | 0.0625 | 1 | 1 |
Leishmania major | beta tubulin | 0.0625 | 1 | 1 |
Brugia malayi | Tubulin gamma chain | 0.0384 | 0.4422 | 0.3969 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0471 | 0.6434 | 0.643 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0625 | 1 | 1 |
Leishmania major | beta tubulin | 0.0625 | 1 | 1 |
Echinococcus granulosus | tubulin alpha chain | 0.0471 | 0.6434 | 0.6144 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0384 | 0.4422 | 0.4416 |
Trypanosoma brucei | beta tubulin | 0.0625 | 1 | 1 |
Leishmania major | beta tubulin | 0.0625 | 1 | 1 |
Entamoeba histolytica | tubulin family protein | 0.0625 | 1 | 1 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0471 | 0.6434 | 0.643 |
Echinococcus granulosus | Tubulin alpha 1 chain | 0.0471 | 0.6434 | 0.6144 |
Loa Loa (eye worm) | tubulin beta-2A chain | 0.0625 | 1 | 1 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0625 | 1 | 1 |
Plasmodium falciparum | tubulin beta chain | 0.0625 | 1 | 1 |
Giardia lamblia | Beta tubulin | 0.0625 | 1 | 1 |
Giardia lamblia | Alpha-tubulin | 0.0471 | 0.6434 | 0.6434 |
Loa Loa (eye worm) | BEN-1 protein | 0.0625 | 1 | 1 |
Schistosoma mansoni | tubulin subunit alpha | 0.0471 | 0.6434 | 0.6144 |
Trypanosoma brucei | alpha tubulin | 0.0471 | 0.6434 | 0.6144 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0625 | 1 | 1 |
Brugia malayi | tubulin alpha chain - mouse | 0.0471 | 0.6434 | 0.6144 |
Echinococcus multilocularis | tubulin alpha 1C chain | 0.0471 | 0.6434 | 0.6144 |
Leishmania major | beta tubulin | 0.0625 | 1 | 1 |
Loa Loa (eye worm) | BEN-1 protein | 0.0625 | 1 | 1 |
Leishmania major | beta tubulin | 0.0625 | 1 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0625 | 1 | 1 |
Echinococcus granulosus | tubulin alpha 1C chain | 0.0471 | 0.6434 | 0.6144 |
Leishmania major | beta tubulin | 0.0625 | 1 | 1 |
Echinococcus multilocularis | tubulin beta 1 chain | 0.0625 | 1 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0625 | 1 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0625 | 1 | 1 |
Plasmodium falciparum | alpha tubulin 2 | 0.0471 | 0.6434 | 0.6144 |
Echinococcus granulosus | Tubulin alpha 1 chain | 0.0471 | 0.6434 | 0.6144 |
Loa Loa (eye worm) | tubulin alpha-3 chain | 0.0281 | 0.2023 | 0.1374 |
Trypanosoma cruzi | tubulin delta chain | 0.0363 | 0.3926 | 0.3432 |
Echinococcus granulosus | tubulin alpha chain | 0.0471 | 0.6434 | 0.6144 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0471 | 0.6434 | 0.643 |
Loa Loa (eye worm) | hypothetical protein | 0.0281 | 0.2023 | 0.1374 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0625 | 1 | 1 |
Trypanosoma brucei | epsilon tubulin | 0.0384 | 0.4411 | 0.3957 |
Trichomonas vaginalis | tubulin alpha-1 chain, putative | 0.0281 | 0.2023 | 0.2014 |
Echinococcus granulosus | beta tubulin | 0.0625 | 1 | 1 |
Schistosoma mansoni | alpha tubulin | 0.0471 | 0.6434 | 0.6144 |
Trypanosoma brucei | alpha tubulin | 0.0471 | 0.6434 | 0.6144 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0625 | 1 | 1 |
Loa Loa (eye worm) | tubulin alpha 2 | 0.031 | 0.2699 | 0.2105 |
Loa Loa (eye worm) | tubulin beta-4 chain | 0.0625 | 1 | 1 |
Brugia malayi | tubulin alpha-2 chain | 0.0471 | 0.6434 | 0.6144 |
Schistosoma mansoni | tubulin subunit beta | 0.0625 | 1 | 1 |
Trypanosoma cruzi | alpha tubulin, putative | 0.0471 | 0.6434 | 0.6144 |
Plasmodium vivax | tubulin beta chain, putative | 0.0625 | 1 | 1 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0471 | 0.6434 | 0.643 |
Leishmania major | beta tubulin | 0.0625 | 1 | 1 |
Echinococcus granulosus | alpha tubulin | 0.0471 | 0.6434 | 0.6144 |
Leishmania major | alpha tubulin | 0.0471 | 0.6434 | 0.6144 |
Trypanosoma cruzi | zeta tubulin, putative | 0.0498 | 0.7065 | 0.6826 |
Leishmania major | beta tubulin | 0.0625 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0471 | 0.6434 | 0.6144 |
Schistosoma mansoni | alpha tubulin | 0.0471 | 0.6434 | 0.6144 |
Trypanosoma cruzi | epsilon tubulin, putative | 0.0384 | 0.4411 | 0.3957 |
Trypanosoma brucei | beta tubulin | 0.0625 | 1 | 1 |
Loa Loa (eye worm) | tubulin beta chain | 0.0625 | 1 | 1 |
Echinococcus multilocularis | Tubulin alpha 1 chain | 0.0471 | 0.6434 | 0.6144 |
Trypanosoma brucei | epsilon tubulin | 0.0384 | 0.4411 | 0.3957 |
Echinococcus granulosus | tubulin alpha chain | 0.0471 | 0.6434 | 0.6144 |
Echinococcus granulosus | Tubulin alpha 1 chain | 0.0471 | 0.6434 | 0.6144 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0625 | 1 | 1 |
Toxoplasma gondii | beta tubulin | 0.0625 | 1 | 1 |
Toxoplasma gondii | beta-tubulin, putative | 0.0625 | 1 | 1 |
Toxoplasma gondii | beta-1 tubulin, putative | 0.0625 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.031 | 0.2699 | 0.2105 |
Toxoplasma gondii | tubulin/FtsZ family, GTPase domain-containing protein | 0.0351 | 0.3666 | 0.3666 |
Leishmania major | beta tubulin | 0.0625 | 1 | 1 |
Echinococcus multilocularis | peroxisome assembly protein 26 | 0.0471 | 0.6434 | 0.6144 |
Trichomonas vaginalis | tubulin alpha-1 chain, putative | 0.0471 | 0.6434 | 0.643 |
Loa Loa (eye worm) | tubulin alpha 2 | 0.031 | 0.2699 | 0.2105 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0471 | 0.6434 | 0.643 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0625 | 1 | 1 |
Brugia malayi | Tubulin alpha-2 chain | 0.0471 | 0.6434 | 0.6144 |
Echinococcus granulosus | tubulin epsilon chain | 0.0384 | 0.4411 | 0.3957 |
Leishmania major | alpha tubulin | 0.0471 | 0.6434 | 0.6144 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | 0 | Toxicity in BALB/c mouse erythrocytes assessed as hemolysis at 6.25 ug/ml after 2 hrs | ChEMBL. | 18177008 |
Activity (functional) | = 4 % | Antileishmanial activity against Leishmania donovani LCR-L133 promastigotes at 1 mg/ml after 24 hrs relative to control | ChEMBL. | No reference |
Activity (functional) | = 20 % | Antileishmanial activity against Leishmania donovani LCR-L133 promastigotes at 1 mg/ml after 48 hrs relative to control | ChEMBL. | No reference |
Activity (functional) | = 28 % | Antileishmanial activity against Leishmania donovani LCR-L133 promastigotes at 10 mg/ml after 24 hrs relative to control | ChEMBL. | No reference |
Activity (functional) | = 39 % | Antileishmanial activity against Leishmania donovani LCR-L133 promastigotes at 1 mg/ml after 72 hrs relative to control | ChEMBL. | No reference |
Activity (functional) | = 40 % | Antiparasitic activity against Leishmania braziliensis assessed as lysis of parasite at 100 ug/mL | ChEMBL. | 8759169 |
Activity (functional) | = 40 % | Antiparasitic activity against Leishmania donovani assessed as lysis of parasite at 100 ug/mL | ChEMBL. | 8759169 |
Activity (functional) | = 40 % | Antileishmanial activity against Leishmania donovani LCR-L133 promastigotes at 10 mg/ml after 48 hrs relative to control | ChEMBL. | No reference |
Activity (functional) | = 42 % | Antileishmanial activity against Leishmania donovani LCR-L133 promastigotes at 10 mg/ml after 72 hrs relative to control | ChEMBL. | No reference |
Activity (functional) | = 50 % | Antiplasmodial activity against Leishmania braziliensis MHOM/BR/2000/CP13396 infected Rhesus monkey assessed as relapse in parasite-induced skin lesions at 5 mg/kg, intramuscular daily for 21 days administered 9 weeks post infection | ChEMBL. | 19822700 |
Activity (functional) | = 70 % | Antileishmanial activity against Leishmania donovani LCR-L133 promastigotes at 100 mg/ml after 24 hrs relative to control | ChEMBL. | No reference |
Activity (functional) | = 74 % | Antileishmanial activity against Leishmania donovani LCR-L133 promastigotes at 100 mg/ml after 48 hrs relative to control | ChEMBL. | No reference |
Activity (functional) | = 76 % | Antileishmanial activity against Leishmania donovani LCR-L133 promastigotes at 100 mg/ml after 72 hrs relative to control | ChEMBL. | No reference |
Activity (functional) | > 80 % | Toxicity against BALB/c mouse macrophages assessed as cell viability | ChEMBL. | 17888668 |
Activity (functional) | > 100 ug ml-1 | Antileishmanial against Leishmania brasiliensis 2903 promastigote assessed as total lysis of parasites after 48 hrs | ChEMBL. | 8699188 |
Activity (functional) | > 100 ug ml-1 | Antileishmanial against Leishmania donovani promastigote PP-75 assessed as total lysis of parasites after 48 hrs | ChEMBL. | 8699188 |
CC50 (ADMET) | = 273.1 uM | Cytotoxicity against mouse L929 cells after 72 hrs by trypan blue assay | ChEMBL. | 26076227 |
IC50 (functional) | 0 | Antileishmanial activity against Leishmania chagasi promastigotes infected in hamster after 48 hrs by MTT assay | ChEMBL. | 18177008 |
IC50 (functional) | = 30 mg/ml | Antileishmanial activity against Leishmania major MRHO/IR/75/ER promastigotes by MTT assay | ChEMBL. | 18321711 |
IC50 (functional) | = 30 mg/ml | Antileishmanial activity against Leishmania major MRHO/IR/75/ER promastigote infected in BALB/c mouse peritoneal macrophage after 24 hrs by MTT assay | ChEMBL. | 20074836 |
IC50 (functional) | = 30 mg/ml | Antileishmanial activity against promastigotes form of Leishmania major MRHO/IR/75/ER after 72 hrs by MTT assay | ChEMBL. | 21501907 |
IC50 (functional) | = 30 mg/ml | Antileishmanial activity against promastigotes form of Leishmania major MRHO/IR/75/ER after 48 hrs by MTT assay | ChEMBL. | 21501907 |
IC50 (functional) | = 35 mg/ml | Antileishmanial activity against promastigotes form of Leishmania major MRHO/IR/75/ER after 24 hrs by MTT assay | ChEMBL. | 21501907 |
IC50 (functional) | = 68.3 mM | Antileishmanial activity against promastigotes of Leishmania major MHOM/1L/80/ER by MTT assay | ChEMBL. | 22336386 |
IC50 (functional) | = 21 ug ml-1 | Antileishmanial activity against Leishmania chagasi intracellular amastigotes infected in hamster macrophages after 48 hrs by MTT assay | ChEMBL. | 18177008 |
IC50 (ADMET) | > 1000 ug ml-1 | Cytotoxicity against human macrophages after 48 hrs by MTT assay | ChEMBL. | 18177008 |
IC50 (functional) | = 7.15 uM | In vitro anti protozoal activity against Leishmania infantum strain MHOM-ET-67/L82 was determined | ChEMBL. | 15203133 |
IC50 (functional) | = 18 uM | Antileishmanial activity against promastigote form of Leishmania infantum MCAN/ES/2001/UCM-10 after 72 hrs by haemocytometric analysis | ChEMBL. | 23395967 |
IC50 (functional) | = 25.61 uM | Antileishmanial activity against extracellular Leishmania braziliensis promastigotes after 72 hrs | ChEMBL. | 19489596 |
IC50 (functional) | = 81.97 uM | Antileishmanial activity against promastigote form of Leishmania major MRHO/IR/75/ER after 24 hrs by MTT assay | ChEMBL. | 18485538 |
IC50 (functional) | < 81.97 uM | Antiprotozoal activity against Leishmania major promastigote forms | ChEMBL. | 25137491 |
IC50 (functional) | = 96.4 uM | Antileishmanial activity against Leishmania donovani MHOM/IN/00/LEM138 infected in mouse BMDM cells assessed as reduction in intracellular amastigotes after 48 hrs | ChEMBL. | 26076227 |
IC50 (functional) | = 144.4 uM | Antileishmanial activity against Leishmania infantum MHOM/ES/2007/DP532JFJ infected in mouse BMDM cells assessed as reduction in intracellular amastigotes after 48 hrs | ChEMBL. | 26076227 |
IC50 (functional) | = 182.7 uM | Antiparasitic activity against promastigote form of Leishmania mexicana MHOM/BZ/61/M379 after 24 hrs by haemocytometer | ChEMBL. | 25576738 |
IC90 (functional) | > 100 ug | Antileishmanial activity against Leishmania (Viannia) braziliensis 2904 after 48 hrs | ChEMBL. | 1919589 |
IC90 (functional) | > 100 ug | Antileishmanial activity against Leishmania donovani infantum LEM 209 after 48 hrs | ChEMBL. | 1919589 |
Inhibition (functional) | = 26 % | Antileishmanial activity against Leishmania donovani LD-1/MHOM/SD/00-1S in mouse peritoneal macrophages at 80 ug/mL after 48 hrs relative to control | ChEMBL. | 17888668 |
Inhibition (functional) | = 26 % | Antileishmanial activity against Leishmania donovani LD-1/MHOM/SD/00-1S in mouse peritoneal macrophages at 80 ug/mL after 48 hrs relative to control | ChEMBL. | 17888668 |
Inhibition (functional) | = 28.2 % | Antileishmanial activity against Leishmania amazonensis MHOM/BR/75-josefa in mouse peritoneal macrophages at 80 ug/mL after 48 hrs relative to control | ChEMBL. | 17888668 |
Inhibition (functional) | = 30 % | Antileishmanial activity against promastigote form of Leishmania infantum MCAN/ES/2001/UCM-10 infected in J774.2 cells assessed as inhibition of number of amastigotes per host cell at IC25 concentration incubated for 12 hrs followed by compound washout measured after 48 hrs by microscopic analysis | ChEMBL. | 23395967 |
Inhibition (functional) | = 32 % | Antileishmanial activity against Leishmania mexicana MHOM/MX/00/Tab3 infected in BALB/c mouse macrophage assessed as growth inhibition at 1 ug/ml after 6 days by hemocytometer | ChEMBL. | 18694950 |
Inhibition (functional) | = 33 % | Antileishmanial activity against Leishmania mexicana MNYC/BZ/62/M379 infected in BALB/c mouse macrophage assessed as growth inhibition at 1 ug/ml after 6 days by hemocytometer | ChEMBL. | 18694950 |
Inhibition (functional) | = 54 % | Antileishmanial activity against Leishmania mexicana MHOM/MX/00/Tab3 infected in BALB/c mouse macrophage assessed as growth inhibition at 10 ug/ml after 6 days by hemocytometer | ChEMBL. | 18694950 |
Inhibition (functional) | = 69 % | Antileishmanial activity against Leishmania mexicana MNYC/BZ/62/M379 infected in BALB/c mouse macrophage assessed as growth inhibition at 10 ug/ml after 6 days by hemocytometer | ChEMBL. | 18694950 |
Inhibition (functional) | = 77 % | Antileishmanial activity against Leishmania mexicana MHOM/MX/00/Tab3 infected in BALB/c mouse macrophage assessed as growth inhibition at 25 ug/ml after 6 days by hemocytometer | ChEMBL. | 18694950 |
Inhibition (functional) | = 93 % | Antileishmanial activity against Leishmania mexicana MNYC/BZ/62/M379 infected in BALB/c mouse macrophage assessed as growth inhibition at 25 ug/ml after 6 days by hemocytometer | ChEMBL. | 18694950 |
LC50 (ADMET) | > 1000 ug ml-1 | Cytotoxicity against Homo sapiens (human) U937 cells assessed as cell viability after 72 hr by MTT assay | ChEMBL. | No reference |
LC50 (ADMET) | = 6 uM | Cytotoxicity against human U937 cells assessed as cell viability after 72 hrs by MTT assay | ChEMBL. | 26218652 |
LC50 (functional) | = 182.68 uM | Antimicrobial activity against Leishmania mexicana MHOM/BZ/61/M379 after 24 hrs by haemocytometry | ChEMBL. | 25899334 |
Suppression (functional) | = 42 % | Antileishmanial activity against Leishmania donovani infections in hamsters (at 13 mg/kg). | ChEMBL. | 6827535 |
Suppression (functional) | = 91.3 % | Antileishmanial activity against Leishmania donovani infections in hamsters (104 mg/kg) | ChEMBL. | 6827535 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Leishmania infantum | ChEMBL23 | 15203133 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Targets |
---|---|---|---|---|---|---|
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | amastigote (BTO:0000062) | inferred from bioassay (ECO:0000094) | Leishmania mexicana | 26882 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | amastigote (BTO:0000062) | inferred from bioassay (ECO:0000094) | Leishmania mexicana | 26953 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | amastigote (BTO:0000062) | inferred from bioassay (ECO:0000094) | Leishmania mexicana | 29919 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | amastigote (BTO:0000062) | inferred from bioassay (ECO:0000094) | Leishmania mexicana | 25756 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | amastigote (BTO:0000062) | inferred from bioassay (ECO:0000094) | Leishmania mexicana | 29777 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | amastigote (BTO:0000062) | inferred from bioassay (ECO:0000094) | Leishmania mexicana | 25113 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | amastigote (BTO:0000062) | inferred from bioassay (ECO:0000094) | Leishmania mexicana | 29099 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | amastigote (BTO:0000062) | inferred from bioassay (ECO:0000094) | Leishmania mexicana | 28601 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | amastigote (BTO:0000062) | inferred from bioassay (ECO:0000094) | Leishmania mexicana | 24472 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | amastigote (BTO:0000062) | inferred from bioassay (ECO:0000094) | Leishmania mexicana | 21739 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | amastigote (BTO:0000062) | inferred from bioassay (ECO:0000094) | Leishmania mexicana | 28044 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | amastigote (BTO:0000062) | inferred from bioassay (ECO:0000094) | Leishmania mexicana | 21309 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | amastigote (BTO:0000062) | inferred from bioassay (ECO:0000094) | Leishmania mexicana | 24440 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | amastigote (BTO:0000062) | inferred from bioassay (ECO:0000094) | Leishmania mexicana | 20919 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | amastigote (BTO:0000062) | inferred from bioassay (ECO:0000094) | Leishmania mexicana | 22594 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | amastigote (BTO:0000062) | inferred from bioassay (ECO:0000094) | Leishmania mexicana | 23453 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | amastigote (BTO:0000062) | inferred from bioassay (ECO:0000094) | Leishmania mexicana | 21545 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | amastigote (BTO:0000062) | inferred from bioassay (ECO:0000094) | Leishmania mexicana | 29554 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | amastigote (BTO:0000062) | inferred from bioassay (ECO:0000094) | Leishmania mexicana | 29031 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | amastigote (BTO:0000062) | inferred from bioassay (ECO:0000094) | Leishmania mexicana | 23905 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | amastigote (BTO:0000062) | inferred from bioassay (ECO:0000094) | Leishmania mexicana | 21179 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | amastigote (BTO:0000062) | inferred from bioassay (ECO:0000094) | Leishmania mexicana | 25450 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | amastigote (BTO:0000062) | inferred from bioassay (ECO:0000094) | Leishmania mexicana | 22205 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | amastigote (BTO:0000062) | inferred from bioassay (ECO:0000094) | Leishmania mexicana | 27459 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | amastigote (BTO:0000062) | inferred from bioassay (ECO:0000094) | Leishmania mexicana | 26961 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | amastigote (BTO:0000062) | inferred from bioassay (ECO:0000094) | Leishmania mexicana | 22252 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | amastigote (BTO:0000062) | inferred from bioassay (ECO:0000094) | Leishmania mexicana | 23996 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | amastigote (BTO:0000062) | inferred from bioassay (ECO:0000094) | Leishmania mexicana | 23078 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | amastigote (BTO:0000062) | inferred from bioassay (ECO:0000094) | Leishmania mexicana | 20827 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | amastigote (BTO:0000062) | inferred from bioassay (ECO:0000094) | Leishmania mexicana | 28024 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | amastigote (BTO:0000062) | inferred from bioassay (ECO:0000094) | Leishmania mexicana | 28324 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania infantum | 26882 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania infantum | 26953 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania infantum | 29919 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania infantum | 25756 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania infantum | 29777 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania infantum | 25113 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania infantum | 29099 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania infantum | 28601 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania infantum | 24472 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania infantum | 21739 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania infantum | 28044 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania infantum | 21309 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania infantum | 24440 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania infantum | 20919 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania infantum | 22594 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania infantum | 23453 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania infantum | 21545 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania infantum | 29554 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania infantum | 29031 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania infantum | 23905 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania infantum | 21179 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania infantum | 25450 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania infantum | 22205 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania infantum | 27459 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania infantum | 26961 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania infantum | 22252 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania infantum | 23996 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania infantum | 23078 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania infantum | 20827 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania infantum | 28024 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania infantum | 28324 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania mexicana | 26882 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania mexicana | 26953 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania mexicana | 29919 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania mexicana | 25756 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania mexicana | 29777 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania mexicana | 25113 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania mexicana | 29099 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania mexicana | 28601 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania mexicana | 24472 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania mexicana | 21739 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania mexicana | 28044 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania mexicana | 21309 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania mexicana | 24440 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania mexicana | 20919 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania mexicana | 22594 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania mexicana | 23453 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania mexicana | 21545 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania mexicana | 29554 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania mexicana | 29031 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania mexicana | 23905 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania mexicana | 21179 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania mexicana | 25450 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania mexicana | 22205 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania mexicana | 27459 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania mexicana | 26961 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania mexicana | 22252 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania mexicana | 23996 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania mexicana | 23078 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania mexicana | 20827 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania mexicana | 28024 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania mexicana | 28324 |
Annotator: | aaronjr@u.washington.edu | Comment: | Drug: 209345-04-0; Drug: 58915-19-8; Drug: 209345-05-1; Drug: 218935-77-4; Drug: 268749-50-4. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied | References: | 16918078 | |
chromosomal_structural_element (SO:0000628) | biosynthetic process (GO:0009058) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania panamensis | 23578 |
Annotator: | crowther@u.washington.edu | Comment: | Drug: 16037-91-5. chemical inhibition with topoisomerase inhibitors leads to generation of cleavable complex; unclear as to which topoisomerase II gene/enzyme was studied | References: | 9687395 | |
catalytic activity (GO:0003824) | decreased (PATO:0000468) | in vitro (MI:0492) | inferred from specific protein inhibition (ECO:0000020) | Leishmania donovani | 23578 | |
Annotator: | crowther@u.washington.edu | Comment: | Drug: 16037-91-5 (Sodium stibogluconate). chemical inhibition with topoisomerase inhibitors reduced topoisomerase I activity; | References: | 15562618 | |
viability (PATO:0000169) | decreased (PATO:0000468) | single cell organism (CARO:0000064) | promastigote (BTO:0001124) | inferred from bioassay (ECO:0000094) | Leishmania donovani | 23578 |
Annotator: | crowther@u.washington.edu | Comment: | Drug: 16037-91-5 (Sodium stibogluconate). chemical inhibition with topoisomerase inhibitors leads to cytotoxicity; | References: | 15562618 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | amastigote (BTO:0000062) | host (GO:0018995) | Leishmania panamensis | 23578 |
Annotator: | crowther@u.washington.edu | Comment: | Drug: (16037-91-5 (pentostam). chemical inhibition with topoisomerase inhibitors leads to slow growth in vivo (hamsters); | References: | 15678803 | |
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | amastigote (BTO:0000062) | inferred from bioassay (ECO:0000094) | Leishmania panamensis | 23578 |
Annotator: | crowther@u.washington.edu | Comment: | Drug: (16037-91-5 (pentostam). chemical inhibition with topoisomerase inhibitors leads to slow growth in vivo (hamsters); | References: | 15678803 |
531 literature references were collected for this gene.