Detailed information for compound 549058

Basic information

Technical information
  • TDR Targets ID: 549058
  • Name: 3-morpholinooxadiazol-3-ium-5-amine chloride
  • MW: 206.63 | Formula: C6H11ClN4O2
  • H donors: 1 H acceptors: 1 LogP: 1.17 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1on[n+](c1)N1CCOCC1.[Cl-]
  • InChi: 1S/C6H11N4O2.ClH/c7-6-5-10(8-12-6)9-1-3-11-4-2-9;/h5H,1-4,7H2;1H/q+1;/p-1
  • InChiKey: ZRFWHHCXSSACAW-UHFFFAOYSA-M  


Substructure search Similarity search

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Synonyms

  • 3-morpholino-5-oxadiazol-3-iumamine chloride
  • 3-morpholin-4-yl-1,2,3-oxadiazol-3-ium-5-amine chloride
  • (3-morpholinooxadiazol-3-ium-5-yl)amine chloride
  • 3-morpholin-4-yloxadiazol-3-ium-5-amine chloride
  • 16142-27-1
  • 33876-97-0
  • 25800-18-4
  • SIN-1 HCl
  • Sydnone imine, 3-morpholino-, monohydrochloride
  • 3-Morpholinosydnone imine hydrochloride
  • 3-Morpholinosydnonimine, HCl

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Leishmania major cathepsin L-like protease Curated by TDR Targets References
Leishmania major cathepsin L-like protease Curated by TDR Targets References
Leishmania major cathepsin L-like protease Curated by TDR Targets References
Leishmania major cathepsin L-like protease Curated by TDR Targets References
Leishmania major iron superoxide dismutase, putative Curated by TDR Targets References
Leishmania major cathepsin L-like protease Curated by TDR Targets References
Leishmania major cathepsin L-like protease Curated by TDR Targets References
Leishmania major cathepsin L-like protease Curated by TDR Targets References
Leishmania major iron superoxide dismutase, putative Curated by TDR Targets References
Leishmania major cathepsin L-like protease Curated by TDR Targets References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense iron superoxide dismutase A, mitochondrial Get druggable targets OG5_126676 All targets in OG5_126676
Brugia malayi Superoxide dismutase, mitochondrial precursor, putative Get druggable targets OG5_126676 All targets in OG5_126676
Leishmania braziliensis iron superoxide dismutase Get druggable targets OG5_126676 All targets in OG5_126676
Mycobacterium leprae Probable superoxide dismutase SodA Get druggable targets OG5_126676 All targets in OG5_126676
Onchocerca volvulus Superoxide dismutase [Mn], mitochondrial homolog Get druggable targets OG5_126676 All targets in OG5_126676
Trypanosoma cruzi iron superoxide dismutase, putative Get druggable targets OG5_126676 All targets in OG5_126676
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi iron superoxide dismutase A, mitochondrial Get druggable targets OG5_126676 All targets in OG5_126676
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei iron superoxide dismutase Get druggable targets OG5_126676 All targets in OG5_126676
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum iron superoxide dismutase, putative Get druggable targets OG5_126676 All targets in OG5_126676
Neospora caninum superoxide dismutase Get druggable targets OG5_126676 All targets in OG5_126676
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii Iron/manganese superoxide dismutases, putative Get druggable targets OG5_126676 All targets in OG5_126676
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum superoxide dismutase [Fe] Get druggable targets OG5_126676 All targets in OG5_126676
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii superoxide dismutase SOD3 Get druggable targets OG5_126676 All targets in OG5_126676
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax superoxide dismutase [Fe], putative Get druggable targets OG5_126676 All targets in OG5_126676
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Superoxide dismutase (EC 1.15.1.1), related Get druggable targets OG5_126676 All targets in OG5_126676
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis iron superoxide dismutase, putative Get druggable targets OG5_126676 All targets in OG5_126676
Toxoplasma gondii superoxide dismutase Get druggable targets OG5_126676 All targets in OG5_126676
Schistosoma japonicum ko:K04564 superoxide dismutase, Fe-Mn family [EC1.15.1.1A], putative Get druggable targets OG5_126676 All targets in OG5_126676
Leishmania mexicana iron superoxide dismutase, putative Get druggable targets OG5_126676 All targets in OG5_126676
Mycobacterium tuberculosis Superoxide dismutase [FE] SodA Get druggable targets OG5_126676 All targets in OG5_126676
Leishmania donovani iron superoxide dismutase, putative Get druggable targets OG5_126676 All targets in OG5_126676
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi iron superoxide dismutase, putative Get druggable targets OG5_126676 All targets in OG5_126676
Leishmania major iron superoxide dismutase, putative Get druggable targets OG5_126676 All targets in OG5_126676
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense iron superoxide dismutase Get druggable targets OG5_126676 All targets in OG5_126676
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum iron superoxide dismutase Get druggable targets OG5_126676 All targets in OG5_126676
Mycobacterium ulcerans superoxide dismutase [Fe] SodA Get druggable targets OG5_126676 All targets in OG5_126676
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Chlamydia trachomatis superoxide dismutase Get druggable targets OG5_126676 All targets in OG5_126676
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis iron superoxide dismutase A, putative Get druggable targets OG5_126676 All targets in OG5_126676
Candida albicans hypothetical protein Get druggable targets OG5_126676 All targets in OG5_126676
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani iron superoxide dismutase, putative Get druggable targets OG5_126676 All targets in OG5_126676
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major iron superoxide dismutase Get druggable targets OG5_126676 All targets in OG5_126676
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii superoxide dismutase SOD2 Get druggable targets OG5_126676 All targets in OG5_126676
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani iron superoxide dismutase A, mitochondrial Get druggable targets OG5_126676 All targets in OG5_126676
Plasmodium knowlesi superoxide dismutase [Fe], putative Get druggable targets OG5_126676 All targets in OG5_126676
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum iron superoxide dismutase, putative Get druggable targets OG5_126676 All targets in OG5_126676
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus manganese superoxide dismutase Get druggable targets OG5_126676 All targets in OG5_126676
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana iron superoxide dismutase, putative Get druggable targets OG5_126676 All targets in OG5_126676
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana iron superoxide dismutase Get druggable targets OG5_126676 All targets in OG5_126676
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense iron superoxide dismutase Get druggable targets OG5_126676 All targets in OG5_126676
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Superoxide dismutase [Mn], mitochondrial homolog Get druggable targets OG5_126676 All targets in OG5_126676
Trypanosoma brucei iron superoxide dismutase Get druggable targets OG5_126676 All targets in OG5_126676
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi iron superoxide dismutase, putative Get druggable targets OG5_126676 All targets in OG5_126676
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva iron-dependent superoxide dismutase, putative Get druggable targets OG5_126676 All targets in OG5_126676
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense iron superoxide dismutase, putative Get druggable targets OG5_126676 All targets in OG5_126676
Trichomonas vaginalis superoxide dismutase [fe], putative Get druggable targets OG5_126676 All targets in OG5_126676
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Wolbachia endosymbiont of Brugia malayi superoxide dismutase, SodA Get druggable targets OG5_126676 All targets in OG5_126676
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum superoxide dismutase Get druggable targets OG5_126676 All targets in OG5_126676
Trypanosoma brucei gambiense iron superoxide dismutase, putative Get druggable targets OG5_126676 All targets in OG5_126676
Trypanosoma cruzi iron superoxide dismutase A, mitochondrial Get druggable targets OG5_126676 All targets in OG5_126676
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni superoxide dismutase [mn] Get druggable targets OG5_126676 All targets in OG5_126676
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi iron superoxide dismutase, putative Get druggable targets OG5_126676 All targets in OG5_126676
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica iron-containing superoxide dismutase Get druggable targets OG5_126676 All targets in OG5_126676
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Babesia bovis superoxide dismutase, putative Get druggable targets OG5_126676 All targets in OG5_126676
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei iron superoxide dismutase A, mitochondrial Get druggable targets OG5_126676 All targets in OG5_126676
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126676 All targets in OG5_126676
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans likely mitochondrial manganese-containing superoxide dismutase similar to S. cerevisiae SOD2 (YHR008C) Get druggable targets OG5_126676 All targets in OG5_126676
Trichomonas vaginalis superoxide dismutase [mn], putative Get druggable targets OG5_126676 All targets in OG5_126676
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis superoxide dismutase [fe], putative Get druggable targets OG5_126676 All targets in OG5_126676
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis manganese superoxide dismutase Get druggable targets OG5_126676 All targets in OG5_126676
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei superoxide dismutase [Fe], putative Get druggable targets OG5_126676 All targets in OG5_126676
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis superoxide dismutase, putative Get druggable targets OG5_126676 All targets in OG5_126676
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major iron superoxide dismutase, putative Get druggable targets OG5_126676 All targets in OG5_126676
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis superoxide dismutase Get druggable targets OG5_126676 All targets in OG5_126676
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis iron superoxide dismutase, putative Get druggable targets OG5_126676 All targets in OG5_126676
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense iron superoxide dismutase, putative Get druggable targets OG5_126676 All targets in OG5_126676
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis superoxide dismutase [fe], putative Get druggable targets OG5_126676 All targets in OG5_126676
Trichomonas vaginalis superoxide dismutase, putative Get druggable targets OG5_126676 All targets in OG5_126676
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Superoxide dismutase (EC 1.15.1.1), related Get druggable targets OG5_126676 All targets in OG5_126676
Onchocerca volvulus Superoxide dismutase [Mn], mitochondrial homolog Get druggable targets OG5_126676 All targets in OG5_126676
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans likely mitochondrial manganese-containing superoxide dismutase similar to S. cerevisiae SOD2 (YHR008C) Get druggable targets OG5_126676 All targets in OG5_126676
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Giardia lamblia Cathepsin L-like protease cathepsin L-like protease 443 aa 386 aa 24.1 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin L-like protease 348 aa 343 aa 28.6 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin L-like protease 348 aa 343 aa 29.1 %
Plasmodium falciparum superoxide dismutase [Fe] iron superoxide dismutase, putative 195 aa 196 aa 46.4 %
Plasmodium falciparum superoxide dismutase [Fe] iron superoxide dismutase, putative 208 aa 194 aa 46.4 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin L-like protease 348 aa 343 aa 29.4 %
Giardia lamblia Cathepsin L precursor cathepsin L-like protease 443 aa 387 aa 23.0 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin L-like protease 348 aa 343 aa 29.1 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin L-like protease 348 aa 343 aa 29.1 %
Giardia lamblia Cathepsin L precursor cathepsin L-like protease 443 aa 387 aa 23.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica cysteine proteinase 1, putative 0.0109 0.0282 0.4199
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.043 0.1372 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0212 0.0632 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0212 0.0632 1
Giardia lamblia Cathepsin B precursor 0.0039 0.0044 0.5
Onchocerca volvulus Superoxide dismutase [Mn], mitochondrial homolog 0.008 0.0184 0.2383
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0034 0.0034
Brugia malayi Papain family cysteine protease containing protein 0.0039 0.0044 0.0361
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0113 0.0296 0.0296
Leishmania major cathepsin L-like protease 0.0212 0.0632 0.4468
Trypanosoma cruzi cruzipain precursor, putative 0.007 0.0149 0.086
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0039 0.0044 0.0044
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0212 0.0632 1
Echinococcus granulosus cathepsin l1 0.0142 0.0394 0.0394
Brugia malayi calpain family protein 1 0.0062 0.0123 0.1008
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0039 0.0044 0.0044
Trichomonas vaginalis superoxide dismutase [fe], putative 0.008 0.0184 0.2506
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0212 0.0632 1
Loa Loa (eye worm) hypothetical protein 0.008 0.0184 0.151
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0039 0.0044 0.0162
Giardia lamblia Cathepsin B precursor 0.0039 0.0044 0.5
Onchocerca volvulus Superoxide dismutase [Mn], mitochondrial homolog 0.0055 0.0097 0.0908
Echinococcus multilocularis tumor protein p63 0.0361 0.1136 0.1136
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0039 0.0044 0.0044
Plasmodium vivax vivapain-3 0.0109 0.0282 0.4054
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0055 0.0098 0.0807
Giardia lamblia Cysteine protease 0.0039 0.0044 0.5
Onchocerca volvulus 0.0212 0.0632 1
Entamoeba histolytica cysteine proteinase, putative 0.0109 0.0282 0.4199
Trypanosoma brucei iron superoxide dismutase 0.008 0.0184 0.112
Loa Loa (eye worm) hypothetical protein 0.0039 0.0044 0.0361
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0109 0.0282 0.4151
Brugia malayi Cathepsin L-like precursor 0.0212 0.0632 0.5185
Trypanosoma cruzi cysteine peptidase, putative 0.043 0.1372 1
Brugia malayi TAR-binding protein 0.0131 0.0357 0.293
Toxoplasma gondii cathepsin B 0.0039 0.0044 0.0162
Onchocerca volvulus Huntingtin homolog 0.0119 0.0314 0.4593
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0039 0.0044 0.0162
Trypanosoma cruzi iron superoxide dismutase, putative 0.008 0.0184 0.112
Brugia malayi hypothetical protein 0.0119 0.0314 0.2576
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0212 0.0632 1
Onchocerca volvulus 0.0053 0.009 0.0787
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0113 0.0296 0.0296
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0039 0.0044 0.0044
Leishmania major iron superoxide dismutase, putative 0.008 0.0184 0.112
Trypanosoma cruzi cysteine peptidase, putative 0.043 0.1372 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.043 0.1372 1
Giardia lamblia Cathepsin B precursor 0.0039 0.0044 0.5
Brugia malayi Intermediate filament tail domain containing protein 0.0055 0.0098 0.0807
Entamoeba histolytica cysteine protease, putative 0.0212 0.0632 1
Loa Loa (eye worm) hypothetical protein 0.007 0.0149 0.1225
Echinococcus multilocularis cathepsin L 0.0109 0.0282 0.0282
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0027 0.0001 0.0001
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0034 0.0034
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0113 0.0296 0.0296
Brugia malayi Cathepsin L-like precursor 0.0212 0.0632 0.5185
Echinococcus multilocularis cysteine protease 0.0212 0.0632 0.0632
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0039 0.0044 0.0044
Onchocerca volvulus Cathepsin L homolog 0.0212 0.0632 1
Plasmodium falciparum superoxide dismutase [Fe] 0.0046 0.0066 0.0372
Schistosoma mansoni superoxide dismutase [mn] 0.008 0.0184 0.0184
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0039 0.0044 0.5
Brugia malayi latrophilin 2 splice variant baaae 0.0245 0.0743 0.6097
Loa Loa (eye worm) RNA binding protein 0.0131 0.0357 0.293
Schistosoma mansoni cathepsin s 0.007 0.0149 0.0149
Echinococcus granulosus cathepsin l cysteine peptidase 0.0212 0.0632 0.0632
Giardia lamblia Cathepsin L-like protease 0.0039 0.0044 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0212 0.0632 1
Echinococcus multilocularis cathepsin b 0.0039 0.0044 0.0044
Entamoeba histolytica cysteine protease, putative 0.0109 0.0282 0.4199
Schistosoma mansoni lamin 0.0055 0.0098 0.0098
Entamoeba histolytica cysteine proteinase 2 0.0109 0.0282 0.4199
Brugia malayi cathepsin L precursor 0.0039 0.0044 0.0361
Echinococcus granulosus calpain A 0.0066 0.0134 0.0134
Loa Loa (eye worm) hypothetical protein 0.0119 0.0314 0.2576
Brugia malayi Papain family cysteine protease containing protein 0.0039 0.0044 0.0361
Echinococcus multilocularis cysteine protease 0.0212 0.0632 0.0632
Plasmodium vivax vivapain-1 0.0109 0.0282 0.4054
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0066 0.0134 0.0134
Loa Loa (eye worm) hypothetical protein 0.0054 0.0095 0.0779
Giardia lamblia Cathepsin L precursor 0.0039 0.0044 0.5
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0039 0.0044 0.0244
Brugia malayi Cathepsin L-like precursor 0.0212 0.0632 0.5185
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0039 0.0044 0.0044
Giardia lamblia Cathepsin B precursor 0.0039 0.0044 0.5
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0359 0.1128 0.9257
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0039 0.0044 0.0361
Brugia malayi cathepsin L-like precursor 0.0142 0.0394 0.3229
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.043 0.1372 1
Leishmania major iron superoxide dismutase, putative 0.008 0.0184 0.112
Onchocerca volvulus 0.0212 0.0632 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0039 0.0044 0.0162
Giardia lamblia Cathepsin L precursor 0.0039 0.0044 0.5
Trichomonas vaginalis superoxide dismutase, putative 0.008 0.0184 0.2506
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0034 0.0281
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0039 0.0044 0.5
Loa Loa (eye worm) hypothetical protein 0.0062 0.0123 0.1008
Brugia malayi Cathepsin L-like precursor 0.0212 0.0632 0.5185
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0212 0.0632 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0212 0.0632 1
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0044 0.0162
Onchocerca volvulus 0.0212 0.0632 1
Brugia malayi calpain family protein 1 0.0062 0.0123 0.1008
Entamoeba histolytica cysteine protease, putative 0.0109 0.0282 0.4199
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0039 0.0044 0.0162
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0212 0.0632 1
Entamoeba histolytica cysteine protease, putative 0.0109 0.0282 0.4199
Entamoeba histolytica cysteine protease, putative 0.0109 0.0282 0.4199
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0786 0.2579 0.2579
Schistosoma mansoni alpha-glucosidase 0.0141 0.0389 0.0389
Schistosoma mansoni cathepsin C 0.0039 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0039 0.0044 0.0361
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0212 0.0632 0.0632
Entamoeba histolytica cysteine proteinase, putative 0.0109 0.0282 0.4199
Leishmania major superoxide dismutase, putative 0.0046 0.0066 0.0236
Entamoeba histolytica cysteine protease, putative 0.0109 0.0282 0.4199
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0109 0.0282 0.1854
Brugia malayi fibroinase precursor 0.0039 0.0044 0.0361
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0109 0.0282 0.4151
Loa Loa (eye worm) hypothetical protein 0.0044 0.006 0.049
Loa Loa (eye worm) hypothetical protein 0.0359 0.1128 0.9257
Echinococcus granulosus cathepsin b 0.0039 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0142 0.0394 0.3229
Schistosoma mansoni alpha-glucosidase 0.0141 0.0389 0.0389
Brugia malayi Cathepsin L-like precursor 0.0142 0.0394 0.3229
Onchocerca volvulus 0.0055 0.0098 0.0926
Loa Loa (eye worm) fibroinase 0.0212 0.0632 0.5185
Schistosoma mansoni lamin 0.0055 0.0098 0.0098
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0212 0.0632 1
Onchocerca volvulus Cathepsin L homolog 0.0212 0.0632 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0039 0.0044 0.0044
Loa Loa (eye worm) ctsf protein 0.0212 0.0632 0.5185
Trypanosoma cruzi major cysteine proteinase, putative 0.0039 0.0044 0.0073
Brugia malayi intermediate filament protein 0.0055 0.0098 0.0807
Loa Loa (eye worm) hypothetical protein 0.0245 0.0743 0.6097
Brugia malayi Cathepsin L-like cysteine proteinase 0.0142 0.0394 0.3229
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0212 0.0632 1
Leishmania major iron superoxide dismutase 0.008 0.0184 0.112
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0034 0.0281
Onchocerca volvulus Superoxide dismutase [Mn], mitochondrial homolog 0.008 0.0184 0.2383
Trypanosoma cruzi cysteine peptidase, putative 0.0212 0.0632 0.4468
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0062 0.0123 0.0123
Echinococcus multilocularis GPCR, family 2 0.0113 0.0296 0.0296
Brugia malayi Latrophilin receptor protein 2 0.0113 0.0296 0.2429
Loa Loa (eye worm) hypothetical protein 0.0027 0.0001 0.0011
Loa Loa (eye worm) hypothetical protein 0.0053 0.009 0.074
Echinococcus multilocularis lysosomal alpha glucosidase 0.0164 0.0467 0.0467
Echinococcus multilocularis cathepsin L cysteine protease 0.0212 0.0632 0.0632
Onchocerca volvulus 0.0212 0.0632 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0039 0.0044 0.0361
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0109 0.0282 0.0282
Loa Loa (eye worm) TAR-binding protein 0.0131 0.0357 0.293
Brugia malayi Superoxide dismutase, mitochondrial precursor, putative 0.008 0.0184 0.151
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0212 0.0632 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.043 0.1372 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0109 0.0282 0.1854
Toxoplasma gondii cathepsin CPL 0.0212 0.0632 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.043 0.1372 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0039 0.0044 0.0073
Entamoeba histolytica cysteine protease, putative 0.0039 0.0044 0.0244
Giardia lamblia Cathepsin L precursor 0.0039 0.0044 0.5
Entamoeba histolytica cysteine protease, putative 0.0109 0.0282 0.4199
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0212 0.0632 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0109 0.0282 0.0282
Schistosoma mansoni hypothetical protein 0.0113 0.0296 0.0296
Leishmania major cathepsin L-like protease 0.043 0.1372 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0359 0.1128 0.9257
Schistosoma mansoni hypothetical protein 0.0035 0.0029 0.0029
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0113 0.0296 0.2429
Loa Loa (eye worm) transcription factor SMAD2 0.0385 0.1219 1
Trypanosoma cruzi iron superoxide dismutase A, mitochondrial 0.008 0.0184 0.112
Giardia lamblia Cathepsin L precursor 0.0039 0.0044 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.043 0.1372 1
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.007 0.0149 0.1225
Entamoeba histolytica cysteine protease, putative 0.0039 0.0044 0.0244
Brugia malayi Cathepsin L-like precursor 0.0142 0.0394 0.3229
Schistosoma mansoni microtubule-associated protein tau 0.2971 1 1
Trypanosoma cruzi cysteine proteinase, putative 0.0109 0.0282 0.1854
Plasmodium vivax unspecified product 0.007 0.0149 0.1791
Toxoplasma gondii superoxide dismutase 0.008 0.0184 0.2506
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0039 0.0044 0.0044
Toxoplasma gondii cathepsin CPC2 0.0039 0.0044 0.0162
Giardia lamblia Cathepsin B precursor 0.0039 0.0044 0.5
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0357 0.0357
Brugia malayi cathepsin F-like cysteine proteinase 0.007 0.0149 0.1225
Trypanosoma cruzi superoxide dismutase, putative 0.0046 0.0066 0.0236
Entamoeba histolytica cysteine proteinase, putative 0.0109 0.0282 0.4199
Entamoeba histolytica hypothetical protein 0.0039 0.0044 0.0244
Leishmania major cathepsin L-like protease 0.0212 0.0632 0.4468
Trypanosoma cruzi superoxide dismutase, putative 0.0046 0.0066 0.0236
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0357 0.0357
Echinococcus multilocularis cathepsin L 0.0039 0.0044 0.0044
Echinococcus granulosus lamin dm0 0.0055 0.0098 0.0098
Trypanosoma cruzi iron superoxide dismutase, putative 0.008 0.0184 0.112
Toxoplasma gondii superoxide dismutase SOD3 0.008 0.0184 0.2506
Trypanosoma brucei superoxide dismutase, putative 0.0046 0.0066 0.0236
Brugia malayi Papain family cysteine protease containing protein 0.0039 0.0044 0.0361
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0039 0.0044 0.0361
Echinococcus granulosus cathepsin L 0.0109 0.0282 0.0282
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.043 0.1372 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0212 0.0632 1
Schistosoma mansoni cathepsin F (C01 family) 0.0142 0.0394 0.0394
Brugia malayi Calcitonin receptor-like protein seb-1 0.0359 0.1128 0.9257
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0357 0.0357
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0212 0.0632 1
Brugia malayi cathepsin L-like cysteine proteinase 0.0039 0.0044 0.0361
Trypanosoma cruzi superoxide dismutase, putative 0.0046 0.0066 0.0236
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0212 0.0632 1
Giardia lamblia Cathepsin B precursor 0.0039 0.0044 0.5
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0131 0.0357 0.293
Onchocerca volvulus 0.0044 0.006 0.0269
Trypanosoma cruzi cysteine peptidase, putative 0.0109 0.0282 0.1854
Onchocerca volvulus Cathepsin F homolog 0.0212 0.0632 1
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0066 0.0134 0.0134
Brugia malayi Papain family cysteine protease containing protein 0.0109 0.0282 0.2316
Schistosoma mansoni hypothetical protein 0.0245 0.0743 0.0743
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0164 0.0467 0.383
Entamoeba histolytica cysteine protease, putative 0.0109 0.0282 0.4199
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0066 0.0134 0.0134
Entamoeba histolytica cysteine protease, putative 0.0109 0.0282 0.4199
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.036 0.1134 0.8218
Giardia lamblia Cysteine protease 0.0039 0.0044 0.5
Giardia lamblia Cathepsin B precursor 0.0039 0.0044 0.5
Loa Loa (eye worm) intermediate filament protein 0.0055 0.0098 0.0807
Trichomonas vaginalis superoxide dismutase, putative 0.008 0.0184 0.2506
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0039 0.0044 0.0162
Loa Loa (eye worm) calpain family protein 1 0.0044 0.006 0.049
Echinococcus multilocularis calpain family protein 1, d 0.0044 0.006 0.006
Echinococcus granulosus cathepsin l1 0.0212 0.0632 0.0632
Schistosoma mansoni cathepsin B (C01 family) 0.0039 0.0044 0.0044
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0212 0.0632 1
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0357 0.0357
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0034 0.0083
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.043 0.1372 1
Echinococcus granulosus cysteine protease 0.0109 0.0282 0.0282
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0142 0.0394 0.6012
Plasmodium vivax superoxide dismutase [Fe], putative 0.0046 0.0066 0.0372
Brugia malayi MH2 domain containing protein 0.0385 0.1219 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0212 0.0632 1
Trypanosoma brucei iron superoxide dismutase 0.008 0.0184 0.112
Giardia lamblia Cysteine protease 0.0039 0.0044 0.5
Trichomonas vaginalis superoxide dismutase [fe], putative 0.008 0.0184 0.2506
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0039 0.0044 0.0044
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0039 0.0044 0.0361
Echinococcus multilocularis calpain A 0.0066 0.0134 0.0134
Echinococcus multilocularis lamin dm0 0.0055 0.0098 0.0098
Loa Loa (eye worm) hypothetical protein 0.0113 0.0296 0.2429
Loa Loa (eye worm) hypothetical protein 0.0039 0.0044 0.0361
Trypanosoma cruzi iron superoxide dismutase, putative 0.008 0.0184 0.112
Loa Loa (eye worm) hypothetical protein 0.0039 0.0044 0.0361
Loa Loa (eye worm) MH2 domain-containing protein 0.0385 0.1219 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0044 0.0361
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0039 0.0044 0.0162
Echinococcus multilocularis cathepsin b 0.0039 0.0044 0.0044
Entamoeba histolytica cysteine protease, putative 0.0039 0.0044 0.0244
Echinococcus multilocularis cathepsin L cysteine protease 0.0212 0.0632 0.0632
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0039 0.0044 0.0044
Mycobacterium leprae Probable superoxide dismutase SodA 0.008 0.0184 0.5
Trypanosoma cruzi cruzipain precursor, putative 0.043 0.1372 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0039 0.0044 0.0162
Toxoplasma gondii cathepsin CPC1 0.0039 0.0044 0.0162
Plasmodium vivax vivapain-2 0.0212 0.0632 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0039 0.0044 0.0162
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0212 0.0632 1
Trypanosoma cruzi cysteine proteinase, putative 0.0109 0.0282 0.1854
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0357 0.0357
Entamoeba histolytica cysteine protease, putative 0.0109 0.0282 0.4199
Trichomonas vaginalis superoxide dismutase [mn], putative 0.008 0.0184 0.2506
Onchocerca volvulus 0.0212 0.0632 1
Echinococcus multilocularis microtubule associated protein 2 0.2971 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0212 0.0632 1
Chlamydia trachomatis superoxide dismutase 0.008 0.0184 0.5
Brugia malayi cytoplasmic intermediate filament protein 0.003 0.0011 0.0093
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0029 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0044 0.0162
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0039 0.0044 0.5
Loa Loa (eye worm) cathepsin B 0.0039 0.0044 0.0361
Plasmodium vivax vivapain-2 0.0212 0.0632 1
Echinococcus granulosus cathepsin L cysteine protease 0.0109 0.0282 0.0282
Brugia malayi hypothetical protein 0.0035 0.0029 0.024
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0212 0.0632 1
Loa Loa (eye worm) hypothetical protein 0.0142 0.0394 0.3229
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0029 0.0029
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.009 0.009
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0212 0.0632 0.0632
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.003 0.0011 0.0093
Echinococcus granulosus intermediate filament protein 0.0055 0.0098 0.0098
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0039 0.0044 0.0162
Leishmania major cathepsin L-like protease 0.0212 0.0632 0.4468
Echinococcus multilocularis lysosomal alpha glucosidase 0.0164 0.0467 0.0467
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.007 0.0149 0.1225
Echinococcus multilocularis tar DNA binding protein 0.0131 0.0357 0.0357
Trichomonas vaginalis iron superoxide dismutase A, putative 0.008 0.0184 0.2506
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0212 0.0632 0.5185
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0039 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0142 0.0394 0.3229
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0039 0.0044 0.0162
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0212 0.0632 0.5185
Mycobacterium tuberculosis Superoxide dismutase [FE] SodA 0.008 0.0184 0.5
Entamoeba histolytica cysteine protease, putative 0.0109 0.0282 0.4199
Schistosoma mansoni intermediate filament proteins 0.0055 0.0098 0.0098
Brugia malayi RNA recognition motif domain containing protein 0.0131 0.0357 0.293
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0034 0.0083
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0039 0.0044 0.0044
Entamoeba histolytica cysteine protease, putative 0.0109 0.0282 0.4199
Leishmania major superoxide dismutase, putative 0.0046 0.0066 0.0236
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0109 0.0282 0.1854
Entamoeba histolytica cysteine protease, putative 0.0039 0.0044 0.0244
Echinococcus granulosus cathepsin b 0.0039 0.0044 0.0044
Trypanosoma cruzi cysteine peptidase, putative 0.043 0.1372 1
Onchocerca volvulus 0.0212 0.0632 1
Trypanosoma brucei cysteine peptidase C (CPC) 0.0039 0.0044 0.0073
Schistosoma mansoni hypothetical protein 0.0113 0.0296 0.0296
Echinococcus granulosus GPCR family 2 0.0113 0.0296 0.0296
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0212 0.0632 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.043 0.1372 1
Echinococcus multilocularis musashi 0.0055 0.0098 0.0098
Giardia lamblia Cathepsin L precursor 0.0039 0.0044 0.5
Onchocerca volvulus 0.0055 0.0098 0.0926
Loa Loa (eye worm) hypothetical protein 0.007 0.0149 0.1225
Brugia malayi cathepsin B-like cysteine proteinase 0.0039 0.0044 0.0361
Plasmodium falciparum superoxide dismutase [Fe] 0.008 0.0184 0.2383
Leishmania major cysteine peptidase A (CPA) 0.0212 0.0632 0.4468
Loa Loa (eye worm) cysteine protease 0.0212 0.0632 0.5185
Giardia lamblia Cysteine protease 0.0039 0.0044 0.5
Giardia lamblia Encystation-specific protease 0.0039 0.0044 0.5
Schistosoma mansoni cathepsin F (C01 family) 0.0212 0.0632 0.0632
Brugia malayi Cathepsin L-like precursor 0.0212 0.0632 0.5185
Wolbachia endosymbiont of Brugia malayi superoxide dismutase, SodA 0.008 0.0184 0.5
Brugia malayi Cathepsin L-like precursor 0.007 0.0149 0.1225
Trypanosoma brucei iron superoxide dismutase C, mitochondrial 0.0046 0.0066 0.0236
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0113 0.0296 0.0296
Brugia malayi Papain family cysteine protease containing protein 0.0212 0.0632 0.5185
Brugia malayi Cathepsin L-like precursor 0.0212 0.0632 0.5185
Schistosoma mansoni alpha glucosidase 0.0036 0.0034 0.0034
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0039 0.0044 0.0162
Loa Loa (eye worm) hypothetical protein 0.0212 0.0632 0.5185
Echinococcus granulosus lamin 0.0055 0.0098 0.0098
Trypanosoma cruzi iron superoxide dismutase, putative 0.0055 0.0097 0.0472
Brugia malayi Papain family cysteine protease containing protein 0.0109 0.0282 0.2316
Leishmania major cathepsin L-like protease 0.043 0.1372 1
Giardia lamblia Hypothetical protein 0.0039 0.0044 0.5
Echinococcus granulosus cathepsin L cysteine proteinase 0.0212 0.0632 0.0632
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0142 0.0394 0.6012
Onchocerca volvulus Huntingtin homolog 0.0119 0.0314 0.4593
Loa Loa (eye worm) calpain family protein 1 0.0062 0.0123 0.1008
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0212 0.0632 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0039 0.0044 0.0162
Giardia lamblia Hypothetical protein 0.0039 0.0044 0.5
Trypanosoma brucei iron superoxide dismutase A, mitochondrial 0.008 0.0184 0.112
Brugia malayi cathepsin Z-like cysteine proteinase 0.0039 0.0044 0.0361
Leishmania major cathepsin L-like protease 0.043 0.1372 1
Schistosoma mansoni hypothetical protein 0.0113 0.0296 0.0296
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0109 0.0282 0.0282
Entamoeba histolytica cysteine proteinase, putative 0.0212 0.0632 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.043 0.1372 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.043 0.1372 1
Onchocerca volvulus 0.0095 0.0232 0.3205
Trypanosoma cruzi major cysteine proteinase, putative 0.0257 0.0784 0.5605
Entamoeba histolytica cysteine proteinase, putative 0.0109 0.0282 0.4199
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0039 0.0044 0.0162
Entamoeba histolytica cysteine protease, putative 0.0109 0.0282 0.4199
Trypanosoma cruzi cysteine protease, putative 0.0109 0.0282 0.1854
Echinococcus multilocularis lamin 0.0055 0.0098 0.0098
Loa Loa (eye worm) hypothetical protein 0.0062 0.0123 0.1008
Echinococcus granulosus cathepsin L 0.0039 0.0044 0.0044
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0066 0.0134 0.0134
Leishmania major cathepsin L-like protease 0.0212 0.0632 0.4468
Brugia malayi cathepsin F-like cysteine proteinase 0.0039 0.0044 0.0361
Trypanosoma cruzi cysteine peptidase, putative 0.007 0.0149 0.086
Giardia lamblia Cathepsin B precursor 0.0039 0.0044 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0212 0.0632 1
Trichomonas vaginalis superoxide dismutase [fe], putative 0.008 0.0184 0.2506
Schistosoma mansoni hypothetical protein 0.0113 0.0296 0.0296
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0039 0.0044 0.0073
Entamoeba histolytica cysteine protease, putative 0.0039 0.0044 0.0244
Schistosoma mansoni cathepsin S (C01 family) 0.0039 0.0044 0.0044
Entamoeba histolytica iron-containing superoxide dismutase 0.008 0.0184 0.2568
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0212 0.0632 1
Giardia lamblia Cathepsin L precursor 0.0039 0.0044 0.5
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0027 0.0001 0.0001
Plasmodium vivax unspecified product 0.0109 0.0282 0.4054
Echinococcus granulosus tumor protein p63 0.0361 0.1136 0.1136
Toxoplasma gondii preprocathepsin c precursor, putative 0.0039 0.0044 0.0162
Giardia lamblia Cathepsin L-like protease 0.0039 0.0044 0.5
Echinococcus granulosus manganese superoxide dismutase 0.008 0.0184 0.0184
Schistosoma mansoni cathepsin F (C01 family) 0.0212 0.0632 0.0632
Entamoeba histolytica cysteine proteinase, putative 0.0142 0.0394 0.6045
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0039 0.0044 0.0244
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0039 0.0044 0.0044
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0039 0.0044 0.0162
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0039 0.0044 0.0162
Brugia malayi Glycosyl hydrolases family 31 protein 0.0164 0.0467 0.383
Mycobacterium ulcerans superoxide dismutase [Fe] SodA 0.008 0.0184 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0212 0.0632 1
Onchocerca volvulus 0.0142 0.0394 0.5946
Entamoeba histolytica cysteine protease, putative 0.0039 0.0044 0.0244
Loa Loa (eye worm) hypothetical protein 0.0055 0.0098 0.0807
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0039 0.0044 0.5
Toxoplasma gondii superoxide dismutase SOD2 0.008 0.0184 0.2506
Entamoeba histolytica cysteine protease, putative 0.0109 0.0282 0.4199
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0212 0.0632 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0113 0.0296 0.2429
Plasmodium vivax superoxide dismutase [Fe], putative 0.008 0.0184 0.2383
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0212 0.0632 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0039 0.0044 0.0162
Brugia malayi RNA binding protein 0.0131 0.0357 0.293
Loa Loa (eye worm) papain family cysteine protease containing protein 0.007 0.0149 0.1225
Echinococcus granulosus tar DNA binding protein 0.0131 0.0357 0.0357
Plasmodium falciparum cysteine proteinase falcipain 1 0.0109 0.0282 0.4054
Loa Loa (eye worm) hypothetical protein 0.0119 0.0314 0.2576
Echinococcus granulosus lysosomal alpha glucosidase 0.0164 0.0467 0.0467
Loa Loa (eye worm) hypothetical protein 0.0039 0.0044 0.0361
Brugia malayi cathepsin Z-like cysteine proteinase 0.0039 0.0044 0.0361
Trypanosoma cruzi iron superoxide dismutase A, mitochondrial 0.008 0.0184 0.112
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0039 0.0044 0.0162
Loa Loa (eye worm) hypothetical protein 0.0044 0.006 0.049
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0039 0.0044 0.0162
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0039 0.0044 0.0073
Echinococcus multilocularis manganese superoxide dismutase 0.008 0.0184 0.0184
Onchocerca volvulus 0.0212 0.0632 1
Trypanosoma cruzi superoxide dismutase, putative 0.0046 0.0066 0.0236
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0039 0.0044 0.0044
Leishmania major cathepsin L-like protease 0.0212 0.0632 0.4468
Loa Loa (eye worm) hypothetical protein 0.0039 0.0044 0.0361
Entamoeba histolytica cysteine proteinase, putative 0.0212 0.0632 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Targets
catalytic activity (GO:0003824) decreased (PATO:0000468) in vitro (MI:0492) inferred from enzyme assay (ECO:0000005) Leishmania infantum 23838  
Annotator: aaronjr@u.washington.edu Comment: Drug: 67776-06-1; Drug: 138472-01-2. chemical inhibition with NO-donor inhibitors leads to reduced enzyme activity in vitro; References: 11342060 14975759
catalytic activity (GO:0003824) decreased (PATO:0000468) in vitro (MI:0492) inferred from enzyme assay (ECO:0000005) Leishmania infantum 28263  
Annotator: aaronjr@u.washington.edu Comment: Drug: 67776-06-1; Drug: 138472-01-2. chemical inhibition with NO-donor inhibitors leads to reduced enzyme activity in vitro; References: 11342060 14975759
catalytic activity (GO:0003824) decreased (PATO:0000468) in vitro (MI:0492) inferred from enzyme assay (ECO:0000005) Leishmania infantum 25858  
Annotator: aaronjr@u.washington.edu Comment: Drug: 67776-06-1; Drug: 138472-01-2. chemical inhibition with NO-donor inhibitors leads to reduced enzyme activity in vitro; References: 11342060 14975759
catalytic activity (GO:0003824) decreased (PATO:0000468) in vitro (MI:0492) inferred from enzyme assay (ECO:0000005) Leishmania infantum 21112  
Annotator: aaronjr@u.washington.edu Comment: Drug: 67776-06-1; Drug: 138472-01-2. chemical inhibition with NO-donor inhibitors leads to reduced enzyme activity in vitro; References: 11342060 14975759
catalytic activity (GO:0003824) decreased (PATO:0000468) in vitro (MI:0492) inferred from enzyme assay (ECO:0000005) Leishmania infantum 26564  
Annotator: aaronjr@u.washington.edu Comment: Drug: 67776-06-1; Drug: 138472-01-2. chemical inhibition with NO-donor inhibitors leads to reduced enzyme activity in vitro; References: 11342060 14975759
catalytic activity (GO:0003824) decreased (PATO:0000468) in vitro (MI:0492) inferred from enzyme assay (ECO:0000005) Leishmania infantum 24534  
Annotator: aaronjr@u.washington.edu Comment: Drug: 67776-06-1; Drug: 138472-01-2. chemical inhibition with NO-donor inhibitors leads to reduced enzyme activity in vitro; References: 11342060 14975759
catalytic activity (GO:0003824) decreased (PATO:0000468) in vitro (MI:0492) inferred from enzyme assay (ECO:0000005) Leishmania infantum 25675  
Annotator: aaronjr@u.washington.edu Comment: Drug: 67776-06-1; Drug: 138472-01-2. chemical inhibition with NO-donor inhibitors leads to reduced enzyme activity in vitro; References: 11342060 14975759
catalytic activity (GO:0003824) decreased (PATO:0000468) in vitro (MI:0492) inferred from enzyme assay (ECO:0000005) Leishmania infantum 21404  
Annotator: aaronjr@u.washington.edu Comment: Drug: 67776-06-1; Drug: 138472-01-2. chemical inhibition with NO-donor inhibitors leads to reduced enzyme activity in vitro; References: 11342060 14975759
growth (GO:0040007) drug insensitive (PATO:0000528) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from over expression (ECO:0000120) Leishmania chagasi 21145  
Annotator: crowther@u.washington.edu Comment: overexpression of recombinant enzyme confers resistance to superoxide dismutase inhibitors References: 9497044
growth (GO:0040007) drug insensitive (PATO:0000528) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from over expression (ECO:0000120) Leishmania chagasi 26774  
Annotator: crowther@u.washington.edu Comment: overexpression of recombinant enzyme confers resistance to superoxide dismutase inhibitors References: 9497044
growth (GO:0040007) drug insensitive (PATO:0000528) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania chagasi 21145  
Annotator: crowther@u.washington.edu Comment: overexpression of recombinant enzyme confers resistance to superoxide dismutase inhibitors References: 9497044
growth (GO:0040007) drug insensitive (PATO:0000528) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania chagasi 26774  
Annotator: crowther@u.washington.edu Comment: overexpression of recombinant enzyme confers resistance to superoxide dismutase inhibitors References: 9497044

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

9 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.