Detailed information for compound 571120

Basic information

Technical information
  • TDR Targets ID: 571120
  • Name: 6-(chloromethyl)pteridine-2,4-diamine
  • MW: 210.624 | Formula: C7H7ClN6
  • H donors: 2 H acceptors: 4 LogP: -0.45 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: ClCc1cnc2c(n1)c(N)nc(n2)N
  • InChi: 1S/C7H7ClN6/c8-1-3-2-11-6-4(12-3)5(9)13-7(10)14-6/h2H,1H2,(H4,9,10,11,13,14)
  • InChiKey: IHJBYRAXZVHUGF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • [2-amino-6-(chloromethyl)pteridin-4-yl]amine
  • 2,4-diamino-6-chloromethylpteridine
  • 2,4-Pteridinediamine, 6-(chloromethyl)-
  • 2,4-Dcmpt

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Leishmania major dihydrofolate reductase-thymidylate synthase Curated by TDR Targets References
Leishmania major pteridine reductase 1 Curated by TDR Targets References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Neospora caninum Bifunctional dihydrofolate reductase-thymidylate synthase, related Get druggable targets OG5_127385 All targets in OG5_127385
Plasmodium berghei bifunctional dihydrofolate reductase-thymidylate synthase, putative Get druggable targets OG5_127385 All targets in OG5_127385
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) Get druggable targets OG5_127385 All targets in OG5_127385
Echinococcus granulosus thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative Get druggable targets OG5_127385 All targets in OG5_127385
Leishmania donovani pteridine reductase 1 Get druggable targets OG5_133937 All targets in OG5_133937
Plasmodium knowlesi bifunctional dihydrofolate reductase-thymidylate synthase, putative Get druggable targets OG5_127385 All targets in OG5_127385
Leishmania infantum pteridine reductase 1 Get druggable targets OG5_133937 All targets in OG5_133937
Brugia malayi thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Cryptosporidium parvum dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Leishmania braziliensis pteridine reductase 1 Get druggable targets OG5_133937 All targets in OG5_133937
Candida albicans Thymidylate synthase capable of functional substitution for S. cerevisiae CDC21 (YOR074C) Get druggable targets OG5_127385 All targets in OG5_127385
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Echinococcus multilocularis thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127385 All targets in OG5_127385
Leishmania major pteridine reductase 1 Get druggable targets OG5_133937 All targets in OG5_133937
Leishmania mexicana pteridine reductase 1 Get druggable targets OG5_133937 All targets in OG5_133937
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Leishmania mexicana dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Cryptosporidium hominis chain A, crystal structure of Dhfr Get druggable targets OG5_127385 All targets in OG5_127385
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Theileria parva dihydrofolate reductase-thymidylate synthase, putative Get druggable targets OG5_127385 All targets in OG5_127385
Leishmania donovani dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Schistosoma japonicum ko:K00560 thymidylate synthase [EC2.1.1.45], putative Get druggable targets OG5_127385 All targets in OG5_127385
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Onchocerca volvulus Get druggable targets OG5_127385 All targets in OG5_127385
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) Get druggable targets OG5_127385 All targets in OG5_127385
Plasmodium yoelii thymidylate synthase, putative Get druggable targets OG5_127385 All targets in OG5_127385
Mycobacterium ulcerans thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Leishmania infantum dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Trypanosoma brucei pteridine reductase 1 Get druggable targets OG5_133937 All targets in OG5_133937
Leishmania major dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Trypanosoma congolense pteridine reductase 1 Get druggable targets OG5_133937 All targets in OG5_133937
Babesia bovis dihydrofolate reductase/thymidilate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Loa Loa (eye worm) thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Trypanosoma brucei gambiense dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Candida albicans Thymidylate synthase capable of functional substitution for S. cerevisiae CDC21 (YOR074C) Get druggable targets OG5_127385 All targets in OG5_127385
Leishmania braziliensis dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase pteridine reductase 1 288 aa 281 aa 25.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0053 0.0486 0.0898
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0444 0.1455
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0046 0.0072
Loa Loa (eye worm) hypothetical protein 0.0035 0.0256 0.0472
Onchocerca volvulus 0.0231 0.2782 0.5012
Mycobacterium ulcerans beta-lactamase 0.0035 0.0256 0.1466
Leishmania major pteridine reductase 1 0.0238 0.2873 1
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0176 0.0325
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0444 0.1881
Brugia malayi Pre-SET motif family protein 0.0029 0.0178 0.0329
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0256 0.0793
Echinococcus granulosus dna polymerase kappa 0.0019 0.0046 0.0072
Mycobacterium ulcerans aldehyde dehydrogenase 0.0118 0.1325 0.8931
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0256 0.0793
Onchocerca volvulus 0.0054 0.0499 0.0618
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0256 0.0665
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0444 0.082
Mycobacterium ulcerans aldehyde dehydrogenase 0.0118 0.1325 0.8931
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0046 0.0046
Mycobacterium tuberculosis Conserved protein 0.0035 0.0256 0.0793
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0046 0.0046
Schistosoma mansoni hypothetical protein 0.0503 0.6295 1
Schistosoma mansoni intermediate filament proteins 0.0054 0.0499 0.0793
Echinococcus granulosus survival motor neuron protein 1 0.023 0.2777 0.4411
Echinococcus multilocularis muscleblind protein 0.0435 0.5414 0.5414
Mycobacterium tuberculosis Hypothetical protein 0.0062 0.06 0.2092
Echinococcus multilocularis lamin dm0 0.0054 0.0499 0.0499
Loa Loa (eye worm) hypothetical protein 0.0435 0.5414 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0178 0.0283
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0054 0.0499 0.0922
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0046 0.5
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.013 0.1478 0.5407
Schistosoma mansoni lamin 0.0054 0.0499 0.0793
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0256 0.0768
Loa Loa (eye worm) hypothetical protein 0.0025 0.012 0.0221
Brugia malayi hypothetical protein 0.0431 0.5373 0.9924
Brugia malayi beta-lactamase 0.0035 0.0256 0.0472
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0444 0.1428
Loa Loa (eye worm) hypothetical protein 0.023 0.2777 0.5128
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0053 0.0486 0.3075
Brugia malayi ImpB/MucB/SamB family protein 0.0044 0.0366 0.0676
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0046 0.0072
Brugia malayi hypothetical protein 0.0016 0.0008 0.0014
Toxoplasma gondii aldehyde dehydrogenase 0.0118 0.1325 0.5904
Trypanosoma cruzi DNA polymerase eta, putative 0.0044 0.0366 0.1514
Loa Loa (eye worm) beta-lactamase 0.0035 0.0256 0.0472
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.1304 0.2409
Brugia malayi Pre-SET motif family protein 0.0203 0.242 0.447
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0183 0.2162 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0256 0.0406
Mycobacterium tuberculosis Conserved protein 0.0035 0.0256 0.0793
Plasmodium vivax SET domain protein, putative 0.0029 0.0178 0.0286
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0176 0.0325
Schistosoma mansoni aldehyde dehydrogenase 0.0118 0.1325 0.2105
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0046 0.0084
Schistosoma mansoni DNA polymerase eta 0.0044 0.0366 0.0581
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0256 0.0768
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0256 0.0472
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0183 0.2162 1
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0444 0.0444
Brugia malayi Muscleblind-like protein 0.0435 0.5414 1
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0444 0.0705
Echinococcus granulosus muscleblind protein 0.0435 0.5414 0.86
Echinococcus granulosus geminin 0.0503 0.6295 1
Schistosoma mansoni aldehyde dehydrogenase 0.0118 0.1325 0.2105
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0118 0.1325 0.1325
Loa Loa (eye worm) intermediate filament protein 0.0054 0.0499 0.0922
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0444 0.1455
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0118 0.1325 0.2105
Echinococcus multilocularis Protein lozenge 0.0054 0.0502 0.0502
Trypanosoma brucei protein kinase, putative 0.005 0.0444 0.1428
Echinococcus multilocularis lamin 0.0054 0.0499 0.0499
Echinococcus multilocularis dihydrofolate reductase 0.0053 0.0486 0.0486
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0062 0.06 0.262
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0229 0.0422
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.012 0.0351
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.1304 0.2409
Schistosoma mansoni dihydrofolate reductase 0.0053 0.0486 0.0772
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0444 0.1881
Brugia malayi beta-lactamase family protein 0.0035 0.0256 0.0472
Echinococcus granulosus thymidylate synthase 0.013 0.1478 0.2348
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0444 0.0444
Brugia malayi dihydrofolate reductase family protein 0.0053 0.0486 0.0898
Mycobacterium ulcerans lipase LipD 0.0035 0.0256 0.1466
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0256 0.0793
Echinococcus multilocularis thymidylate synthase 0.013 0.1478 0.1478
Loa Loa (eye worm) dihydrofolate reductase 0.0053 0.0486 0.0898
Schistosoma mansoni hypothetical protein 0.0033 0.0229 0.0363
Onchocerca volvulus 0.0054 0.0499 0.0618
Schistosoma mansoni survival motor neuron protein 0.0047 0.0409 0.065
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0256 0.0406
Chlamydia trachomatis dihydrofolate reductase 0.0053 0.0486 0.5
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0444 0.1586
Onchocerca volvulus 0.0035 0.0256 0.0149
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0256 0.0256
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0444 0.1408
Trypanosoma cruzi DNA polymerase eta, putative 0.0031 0.0199 0.0723
Echinococcus multilocularis dna polymerase eta 0.0044 0.0366 0.0366
Loa Loa (eye worm) thymidylate synthase 0.013 0.1478 0.2731
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0165 0.0261
Mycobacterium ulcerans hypothetical protein 0.0035 0.0256 0.1466
Toxoplasma gondii ABC1 family protein 0.0035 0.0256 0.0665
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0139 0.0139
Loa Loa (eye worm) hypothetical protein 0.0035 0.0256 0.0472
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0444 0.1455
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0444 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0426 0.0786
Brugia malayi MH2 domain containing protein 0.0116 0.1304 0.2409
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.012 0.0266
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.06 0.2026
Loa Loa (eye worm) hypothetical protein 0.0435 0.5414 1
Brugia malayi Intermediate filament tail domain containing protein 0.0054 0.0499 0.0922
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0053 0.0486 0.1885
Loa Loa (eye worm) hypothetical protein 0.0026 0.0139 0.0257
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0256 0.0754
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0178 0.0178
Loa Loa (eye worm) hypothetical protein 0.0035 0.0256 0.0472
Onchocerca volvulus 0.0431 0.5373 1
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0183 0.2162 0.7483
Loa Loa (eye worm) hypothetical protein 0.0431 0.5373 0.9924
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0256 0.0768
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0444 0.0705
Loa Loa (eye worm) runx1 0.0054 0.0502 0.0927
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.012 0.0351
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.242 0.447
Leishmania major hypothetical protein, conserved 0.0025 0.012 0.0263
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0256 0.0768
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0224 0.2696 1
Echinococcus multilocularis musashi 0.0054 0.0499 0.0499
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0256 0.0793
Echinococcus multilocularis geminin 0.0503 0.6295 0.6295
Loa Loa (eye worm) hypothetical protein 0.0033 0.0229 0.0422
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0031 0.0199 0.0385
Brugia malayi beta-lactamase family protein 0.0035 0.0256 0.0472
Schistosoma mansoni lozenge 0.0054 0.0502 0.0797
Loa Loa (eye worm) hypothetical protein 0.0035 0.0256 0.0472
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0444 0.1455
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0444 0.1881
Brugia malayi hypothetical protein 0.0062 0.06 0.1108
Trypanosoma brucei pteridine reductase 1 0.0235 0.2833 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0178 0.0283
Loa Loa (eye worm) hypothetical protein 0.0035 0.0256 0.0472
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0256 0.0406
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0178 0.0286
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0118 0.1325 0.4829
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0178 0.0283
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0256 0.0793
Trypanosoma brucei DNA polymerase eta, putative 0.0044 0.0366 0.1149
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0256 0.0993
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0256 0.0793
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0183 0.2162 0.7591
Echinococcus granulosus dihydrofolate reductase 0.0053 0.0486 0.0772
Schistosoma mansoni lamin 0.0054 0.0499 0.0793
Brugia malayi Dihydrofolate reductase 0.0053 0.0486 0.0898
Echinococcus granulosus intermediate filament protein 0.0054 0.0499 0.0793
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0256 0.1466
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0053 0.0486 0.1662
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0426 0.0786
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0046 0.0072
Trichomonas vaginalis set domain proteins, putative 0.0231 0.2782 1
Echinococcus multilocularis muscleblind protein 1 0.0435 0.5414 0.5414
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.013 0.1478 0.2348
Onchocerca volvulus 0.013 0.1478 0.2503
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0256 0.0768
Loa Loa (eye worm) hypothetical protein 0.0431 0.5373 0.9924
Brugia malayi hypothetical protein 0.0025 0.012 0.0221
Leishmania major hypothetical protein, conserved 0.0035 0.0256 0.0743
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0118 0.1325 0.4525
Echinococcus granulosus lamin dm0 0.0054 0.0499 0.0793
Loa Loa (eye worm) hypothetical protein 0.0054 0.0499 0.0922
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0046 0.0084
Echinococcus granulosus lamin 0.0054 0.0499 0.0793
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0256 0.1466
Mycobacterium tuberculosis Conserved protein 0.0035 0.0256 0.0793
Onchocerca volvulus 0.0035 0.0256 0.0149
Schistosoma mansoni hypothetical protein 0.0047 0.0409 0.065
Loa Loa (eye worm) hypothetical protein 0.0035 0.0256 0.0472
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0256 0.0993
Loa Loa (eye worm) hypothetical protein 0.0025 0.0126 0.0233
Loa Loa (eye worm) hypothetical protein 0.0048 0.0426 0.0786
Brugia malayi thymidylate synthase 0.013 0.1478 0.2731
Leishmania major DNA polymerase eta, putative 0.0031 0.0199 0.0541
Onchocerca volvulus 0.0047 0.0409 0.0445
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0183 0.2162 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0178 0.0178
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0444 0.1881
Loa Loa (eye worm) hypothetical protein 0.0029 0.0178 0.0329
Brugia malayi intermediate filament protein 0.0054 0.0499 0.0922
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0444 0.0705
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.013 0.1478 1
Echinococcus multilocularis survival motor neuron protein 1 0.023 0.2777 0.2777
Schistosoma mansoni hypothetical protein 0.0503 0.6295 1
Echinococcus granulosus dna polymerase eta 0.0044 0.0366 0.0581
Loa Loa (eye worm) hypothetical protein 0.0025 0.0126 0.0233
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0409 0.0756
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0426 0.0786
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0256 0.0793
Onchocerca volvulus 0.0035 0.0256 0.0149
Loa Loa (eye worm) hypothetical protein 0.0044 0.0366 0.0676
Brugia malayi MAP kinase sur-1 0.005 0.0444 0.082
Mycobacterium ulcerans aldehyde dehydrogenase 0.0118 0.1325 0.8931
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0178 0.0283
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0139 0.0221
Brugia malayi hypothetical protein 0.023 0.2777 0.5128
Trichomonas vaginalis esterase, putative 0.0035 0.0256 0.0768
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0183 0.2162 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0256 0.0472
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0178 0.0283
Mycobacterium ulcerans thymidylate synthase 0.013 0.1478 1
Leishmania major DNA polymerase eta, putative 0.0044 0.0366 0.1133
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0444 0.1408

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Targets
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania major 25954  
Annotator: aaronjr@u.washington.edu Comment: Drug: 700-47-0; Drug: 704-61-0; Drug: 708-74-7; Drug: 945-24-4; Drug: 1026-36-4; Drug: 1597-01-9; Drug: 1899-40-7; Drug: 2432-24-8; Drug: 2440-80-4; Drug: 3977-17-1; Drug: 5774-32-3; Drug: 6954-23-0; Drug: 6973-01-9; Drug: 7319-50-8; Drug: 14684-54-9; Drug: 17005-34-4; Drug: 17005-35-5; Drug: 19152-86-4; Drug: 26398-12-9; Drug: 34244-78-5; Drug: 34244-80-9; Drug: 36804-91-8; Drug: 38713-63-2; Drug: 38713-64-3; Drug: 38713-65-4; Drug: 47066-05-7; Drug: 50691-65-1; Drug: 51395-54-1; Drug: 51583-00-7; Drug: 52128-15-1; Drug: 53219-56-0; Drug: 53274-34-3; Drug: 54798-36-6; Drug: 58091-86-4; Drug: 61267-65-0; Drug: 61267-67-2; Drug: 73978-42-4; Drug: 73978-43-5; Drug: 73978-44-6; Drug: 89977-50-4; Drug: 104422-58-4; Drug: 104422-59-5; Drug: 107174-41-4; Drug: 160602-03-9; Drug: 160602-12-0; Drug: 200127-49-7; Drug: 200127-50-0; Drug: 200127-51-1; Drug: 200127-52-2; Drug: 200127-53-3; Drug: 200127-54-4; Drug: 200127-55-5; Drug: 200127-57-7; Drug: 200127-58-8; Drug: 200127-59-9; Drug: 200127-60-2; Drug: 200127-61-3; Drug: 200127-62-4; Drug: 200127-63-5. chemical inhibition with DHFR and PTR1 inhibitors leads to slow growth of Leishmania sp. in cell assay; References: 9371081 9398595
catalytic activity (GO:0003824) decreased (PATO:0000468) in vitro (MI:0492) inferred from specific protein inhibition (ECO:0000020) Leishmania major 25954  
Annotator: aaronjr@u.washington.edu Comment: Drug: 700-47-0; Drug: 704-61-0; Drug: 708-74-7; Drug: 945-24-4; Drug: 1026-36-4; Drug: 1597-01-9; Drug: 1899-40-7; Drug: 2432-24-8; Drug: 2440-80-4; Drug: 3977-17-1; Drug: 5774-32-3; Drug: 6954-23-0; Drug: 6973-01-9; Drug: 7319-50-8; Drug: 14684-54-9; Drug: 17005-34-4; Drug: 17005-35-5; Drug: 19152-86-4; Drug: 26398-12-9; Drug: 34244-78-5; Drug: 34244-80-9; Drug: 36804-91-8; Drug: 38713-63-2; Drug: 38713-64-3; Drug: 38713-65-4; Drug: 47066-05-7; Drug: 50691-65-1; Drug: 51395-54-1; Drug: 51583-00-7; Drug: 52128-15-1; Drug: 53219-56-0; Drug: 53274-34-3; Drug: 54798-36-6; Drug: 58091-86-4; Drug: 61267-65-0; Drug: 61267-67-2; Drug: 73978-42-4; Drug: 73978-43-5; Drug: 73978-44-6; Drug: 89977-50-4; Drug: 104422-58-4; Drug: 104422-59-5; Drug: 107174-41-4; Drug: 160602-03-9; Drug: 160602-12-0; Drug: 200127-49-7; Drug: 200127-50-0; Drug: 200127-51-1; Drug: 200127-52-2; Drug: 200127-53-3; Drug: 200127-54-4; Drug: 200127-55-5; Drug: 200127-57-7; Drug: 200127-58-8; Drug: 200127-59-9; Drug: 200127-60-2; Drug: 200127-61-3; Drug: 200127-62-4; Drug: 200127-63-5. chemical inhibition with DHFR and PTR1 inhibitors leads to reduced enzyme activity in vitro; References: 9371081 9398595
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania major 21977  
Annotator: aaronjr@u.washington.edu Comment: Drug: 700-47-0; Drug: 704-61-0; Drug: 708-74-7; Drug: 945-24-4; Drug: 1026-36-4; Drug: 1597-01-9; Drug: 1899-40-7; Drug: 2432-24-8; Drug: 2440-80-4; Drug: 3977-17-1; Drug: 5774-32-3; Drug: 6954-23-0; Drug: 6973-01-9; Drug: 7319-50-8; Drug: 14684-54-9; Drug: 17005-34-4; Drug: 17005-35-5; Drug: 19152-86-4; Drug: 26398-12-9; Drug: 34244-78-5; Drug: 34244-80-9; Drug: 36804-91-8; Drug: 38713-63-2; Drug: 38713-64-3; Drug: 38713-65-4; Drug: 47066-05-7; Drug: 50691-65-1; Drug: 51395-54-1; Drug: 51583-00-7; Drug: 52128-15-1; Drug: 53219-56-0; Drug: 53274-34-3; Drug: 54798-36-6; Drug: 58091-86-4; Drug: 61267-65-0; Drug: 61267-67-2; Drug: 73978-42-4; Drug: 73978-43-5; Drug: 73978-44-6; Drug: 89977-50-4; Drug: 104422-58-4; Drug: 104422-59-5; Drug: 107174-41-4; Drug: 160602-03-9; Drug: 160602-12-0; Drug: 200127-49-7; Drug: 200127-50-0; Drug: 200127-51-1; Drug: 200127-52-2; Drug: 200127-53-3; Drug: 200127-54-4; Drug: 200127-55-5; Drug: 200127-57-7; Drug: 200127-58-8; Drug: 200127-59-9; Drug: 200127-60-2; Drug: 200127-61-3; Drug: 200127-62-4; Drug: 200127-63-5. chemical inhibition with DHFR and PTR1 inhibitors leads to slow growth of Leishmania sp. in cell assay; References: 9371081 9398595
catalytic activity (GO:0003824) decreased (PATO:0000468) in vitro (MI:0492) inferred from specific protein inhibition (ECO:0000020) Leishmania major 21977  
Annotator: aaronjr@u.washington.edu Comment: Drug: 700-47-0; Drug: 704-61-0; Drug: 708-74-7; Drug: 945-24-4; Drug: 1026-36-4; Drug: 1597-01-9; Drug: 1899-40-7; Drug: 2432-24-8; Drug: 2440-80-4; Drug: 3977-17-1; Drug: 5774-32-3; Drug: 6954-23-0; Drug: 6973-01-9; Drug: 7319-50-8; Drug: 14684-54-9; Drug: 17005-34-4; Drug: 17005-35-5; Drug: 19152-86-4; Drug: 26398-12-9; Drug: 34244-78-5; Drug: 34244-80-9; Drug: 36804-91-8; Drug: 38713-63-2; Drug: 38713-64-3; Drug: 38713-65-4; Drug: 47066-05-7; Drug: 50691-65-1; Drug: 51395-54-1; Drug: 51583-00-7; Drug: 52128-15-1; Drug: 53219-56-0; Drug: 53274-34-3; Drug: 54798-36-6; Drug: 58091-86-4; Drug: 61267-65-0; Drug: 61267-67-2; Drug: 73978-42-4; Drug: 73978-43-5; Drug: 73978-44-6; Drug: 89977-50-4; Drug: 104422-58-4; Drug: 104422-59-5; Drug: 107174-41-4; Drug: 160602-03-9; Drug: 160602-12-0; Drug: 200127-49-7; Drug: 200127-50-0; Drug: 200127-51-1; Drug: 200127-52-2; Drug: 200127-53-3; Drug: 200127-54-4; Drug: 200127-55-5; Drug: 200127-57-7; Drug: 200127-58-8; Drug: 200127-59-9; Drug: 200127-60-2; Drug: 200127-61-3; Drug: 200127-62-4; Drug: 200127-63-5. chemical inhibition with DHFR and PTR1 inhibitors leads to reduced enzyme activity in vitro; References: 9371081 9398595

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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Bibliographic References

2 literature references were collected for this gene.

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