Detailed information for compound 573463

Basic information

Technical information
  • TDR Targets ID: 573463
  • Name: (2S)-2-[[4-[(2-amino-4-oxo-1H-quinazolin-6-yl )methyl-formyl-amino]benzoyl]amino]pentanedio ic acid
  • MW: 467.431 | Formula: C22H21N5O7
  • H donors: 5 H acceptors: 9 LogP: 1.34 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=CN(c1ccc(cc1)C(=O)N[C@H](C(=O)O)CCC(=O)O)Cc1ccc2c(c1)c(O)nc(n2)N
  • InChi: 1S/C22H21N5O7/c23-22-25-16-6-1-12(9-15(16)20(32)26-22)10-27(11-28)14-4-2-13(3-5-14)19(31)24-17(21(33)34)7-8-18(29)30/h1-6,9,11,17H,7-8,10H2,(H,24,31)(H,29,30)(H,33,34)(H3,23,25,26,32)/t17-/m0/s1
  • InChiKey: QHUBQNFYSLRYQG-KRWDZBQOSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2S)-2-[[[4-[(2-amino-4-oxo-1H-quinazolin-6-yl)methyl-formylamino]phenyl]-oxomethyl]amino]pentanedioic acid
  • (2S)-2-[[4-[(2-azanyl-4-oxo-1H-quinazolin-6-yl)methyl-methanoyl-amino]phenyl]carbonylamino]pentanedioic acid
  • (2S)-2-[[4-[(2-amino-4-keto-1H-quinazolin-6-yl)methyl-formyl-amino]benzoyl]amino]glutaric acid
  • (2S)-2-[[4-[(2-amino-4-oxo-1H-quinazolin-6-yl)methyl-formylamino]benzoyl]amino]pentanedioic acid
  • 10-formyl-5,8-dideazafolate
  • (2S)-2-[[4-[(2-amino-4-oxo-1H-quinazolin-6-yl)methyl-methanoyl-amino]phenyl]carbonylamino]pentanedioic acid
  • N-(4-(((2-Amino-1,4-dihydro-4-oxo-6-quinazolinyl)methyl)formylamino)benzoyl)-L-glutamic acid
  • NSC 278167
  • 10-Fddf
  • 10-Formyl-5,8-dideazafolic acid
  • L-Glutamic acid, N-(4-(((2-amino-1,4-dihydro-4-oxo-6-quinazolinyl)methyl)formylamino)benzoyl)-

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Leishmania major pteridine reductase 1 Curated by TDR Targets References
Leishmania major dihydrofolate reductase-thymidylate synthase Curated by TDR Targets References
Enterococcus faecium Dihydrofolate reductase Starlite/ChEMBL References
Rattus norvegicus Dihydrofolate reductase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Cryptosporidium hominis chain A, crystal structure of Dhfr Get druggable targets OG5_127385 All targets in OG5_127385
Loa Loa (eye worm) dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127385 All targets in OG5_127385
Loa Loa (eye worm) thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Candida albicans Thymidylate synthase capable of functional substitution for S. cerevisiae CDC21 (YOR074C) Get druggable targets OG5_127385 All targets in OG5_127385
Leishmania infantum pteridine reductase 1 Get druggable targets OG5_133937 All targets in OG5_133937
Leishmania mexicana pteridine reductase 1 Get druggable targets OG5_133937 All targets in OG5_133937
Schistosoma japonicum ko:K00287 dihydrofolate reductase [EC1.5.1.3], putative Get druggable targets OG5_128410 All targets in OG5_128410
Leishmania major pteridine reductase 1 Get druggable targets OG5_133937 All targets in OG5_133937
Mycobacterium ulcerans thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Trypanosoma brucei gambiense dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Schistosoma mansoni dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Brugia malayi Dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Candida albicans dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Chlamydia trachomatis dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Trypanosoma brucei pteridine reductase 1 Get druggable targets OG5_133937 All targets in OG5_133937
Brugia malayi thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Echinococcus granulosus dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Echinococcus multilocularis dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) Get druggable targets OG5_127385 All targets in OG5_127385
Candida albicans Thymidylate synthase capable of functional substitution for S. cerevisiae CDC21 (YOR074C) Get druggable targets OG5_127385 All targets in OG5_127385
Theileria parva dihydrofolate reductase-thymidylate synthase, putative Get druggable targets OG5_127385 All targets in OG5_127385
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) Get druggable targets OG5_127385 All targets in OG5_127385
Leishmania braziliensis dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Leishmania donovani pteridine reductase 1 Get druggable targets OG5_133937 All targets in OG5_133937
Leishmania major dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Leishmania mexicana dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Plasmodium knowlesi bifunctional dihydrofolate reductase-thymidylate synthase, putative Get druggable targets OG5_127385 All targets in OG5_127385
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) Get druggable targets OG5_128410 All targets in OG5_128410
Cryptosporidium parvum dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Schistosoma japonicum ko:K00560 thymidylate synthase [EC2.1.1.45], putative Get druggable targets OG5_127385 All targets in OG5_127385
Mycobacterium ulcerans dihydrofolate reductase DfrA Get druggable targets OG5_128410 All targets in OG5_128410
Onchocerca volvulus Get druggable targets OG5_127385 All targets in OG5_127385
Candida albicans dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Leishmania braziliensis pteridine reductase 1 Get druggable targets OG5_133937 All targets in OG5_133937
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) Get druggable targets OG5_128410 All targets in OG5_128410
Trypanosoma congolense pteridine reductase 1 Get druggable targets OG5_133937 All targets in OG5_133937
Echinococcus multilocularis thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Neospora caninum Bifunctional dihydrofolate reductase-thymidylate synthase, related Get druggable targets OG5_127385 All targets in OG5_127385
Echinococcus granulosus thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Plasmodium yoelii thymidylate synthase, putative Get druggable targets OG5_127385 All targets in OG5_127385
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Leishmania infantum dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative Get druggable targets OG5_127385 All targets in OG5_127385
Candida albicans hypothetical protein Get druggable targets OG5_128410 All targets in OG5_128410
Brugia malayi dihydrofolate reductase family protein Get druggable targets OG5_128410 All targets in OG5_128410
Plasmodium berghei bifunctional dihydrofolate reductase-thymidylate synthase, putative Get druggable targets OG5_127385 All targets in OG5_127385
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Leishmania donovani dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Babesia bovis dihydrofolate reductase/thymidilate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   187 aa 186 aa 37.1 %
Leishmania major dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   187 aa 172 aa 36.0 %
Babesia bovis dihydrofolate reductase/thymidilate synthase Dihydrofolate reductase   187 aa 191 aa 31.9 %
Cryptosporidium hominis chain A, crystal structure of Dhfr Dihydrofolate reductase   187 aa 182 aa 34.1 %
Trypanosoma brucei gambiense dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   187 aa 210 aa 30.0 %
Leishmania donovani dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   187 aa 172 aa 36.0 %
Leishmania mexicana dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   187 aa 172 aa 33.7 %
Theileria parva dihydrofolate reductase-thymidylate synthase, putative Dihydrofolate reductase   187 aa 193 aa 32.1 %
Onchocerca volvulus Putative dihydrofolate reductase Dihydrofolate reductase   167 aa 167 aa 27.5 %
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   187 aa 210 aa 30.0 %
Cryptosporidium parvum dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   187 aa 182 aa 33.5 %
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   167 aa 155 aa 29.7 %
Leishmania braziliensis dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   187 aa 172 aa 34.3 %
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase pteridine reductase 1 288 aa 281 aa 25.3 %
Neospora caninum Bifunctional dihydrofolate reductase-thymidylate synthase, related Dihydrofolate reductase   187 aa 187 aa 35.8 %
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative Dihydrofolate reductase   187 aa 209 aa 29.2 %
Plasmodium yoelii thymidylate synthase, putative Dihydrofolate reductase   187 aa 212 aa 27.8 %
Plasmodium knowlesi bifunctional dihydrofolate reductase-thymidylate synthase, putative Dihydrofolate reductase   187 aa 209 aa 29.2 %
Plasmodium knowlesi glutamine-dependent NAD(+) synthetase, putative Dihydrofolate reductase   167 aa 160 aa 18.8 %
Plasmodium berghei bifunctional dihydrofolate reductase-thymidylate synthase, putative Dihydrofolate reductase   187 aa 211 aa 28.4 %
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   187 aa 202 aa 29.2 %
Leishmania infantum dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   187 aa 172 aa 36.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.004 0.0161 0.073
Loa Loa (eye worm) hypothetical protein 0.0033 0.0118 0.0247
Loa Loa (eye worm) hypothetical protein 0.0033 0.0118 0.0247
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0337 0.0797
Brugia malayi beta-lactamase 0.0037 0.0142 0.0306
Loa Loa (eye worm) melatonin receptor type 1A 0.0033 0.0118 0.0247
Brugia malayi aspartic protease BmAsp-2, identical 0.0079 0.043 0.0944
Schistosoma mansoni cathepsin D (A01 family) 0.0911 0.6132 0.6129
Loa Loa (eye worm) hypothetical protein 0.004 0.0161 0.034
Mycobacterium tuberculosis Conserved protein 0.0037 0.0142 0.0154
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.0089 0.0182
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0033 0.0118 0.0186
Echinococcus multilocularis fmrfamide receptor 0.0033 0.0118 0.0186
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0066 0.0145
Loa Loa (eye worm) hypothetical protein 0.0033 0.0118 0.0247
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0142 0.0154
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0041 0.0084
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0079 0.043 0.0423
Loa Loa (eye worm) hypothetical protein 0.0079 0.043 0.0937
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0033 0.0118 0.0112
Echinococcus granulosus rhodopsin orphan GPCR 0.0033 0.0118 0.0219
Schistosoma mansoni hypothetical protein 0.0339 0.2211 0.2206
Loa Loa (eye worm) hypothetical protein 0.0033 0.0118 0.0247
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0041 0.0084
Loa Loa (eye worm) hypothetical protein 0.0022 0.0041 0.0077
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0142 0.0154
Echinococcus multilocularis g protein coupled receptor 0.0033 0.0118 0.0186
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0079 0.043 0.0423
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0049 0.0102
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0033 0.0118 0.0112
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0041 0.0035
Leishmania major cathepsin L-like protease 0.0065 0.0337 0.0805
Loa Loa (eye worm) hypothetical protein 0.0033 0.0118 0.0247
Brugia malayi acetyltransferase, GNAT family protein 0.0159 0.0976 0.2153
Echinococcus multilocularis neuropeptides capa receptor 0.0033 0.0118 0.0186
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0142 0.0225
Loa Loa (eye worm) hypothetical protein 0.0037 0.0142 0.0299
Loa Loa (eye worm) hypothetical protein 0.004 0.0161 0.034
Loa Loa (eye worm) G-protein coupled receptor 0.0033 0.0118 0.0247
Wolbachia endosymbiont of Brugia malayi phosphoribosylamine--glycine ligase 0.0359 0.2353 1
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0142 0.0809
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0118 0.0112
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0033 0.0118 0.0219
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0041 0.0058
Wolbachia endosymbiont of Brugia malayi phosphoribosylaminoimidazole synthetase 0.0079 0.0433 0.1578
Schistosoma mansoni importin beta-1 0.0032 0.0107 0.01
Plasmodium falciparum histone acetyltransferase GCN5 0.0043 0.0182 0.0428
Mycobacterium ulcerans thymidylate synthase 0.0324 0.2113 0.4674
Schistosoma mansoni neuropeptide F-like receptor 0.0033 0.0118 0.0112
Echinococcus granulosus dro:myosuppressin receptor 0.0033 0.0118 0.0219
Brugia malayi hypothetical protein 0.0033 0.0118 0.0254
Schistosoma mansoni peroxidasin 0.004 0.0161 0.0154
Echinococcus multilocularis G protein coupled receptor 139 0.0033 0.0118 0.0186
Echinococcus multilocularis dro:myosuppressin receptor 0.0033 0.0118 0.0186
Brugia malayi steroid hormone receptor 0.0022 0.0041 0.0084
Brugia malayi hypothetical protein 0.0079 0.043 0.0944
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0195 0.0314
Echinococcus granulosus hypothetical protein 0.0033 0.0118 0.0219
Echinococcus granulosus neuropeptide receptor A26 0.0033 0.0118 0.0219
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0892 0.6006 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0195 0.0418
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0033 0.0118 0.0186
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0033 0.0118 0.0219
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0107 0.0236
Brugia malayi hypothetical protein 0.0033 0.0118 0.0254
Loa Loa (eye worm) beta-lactamase 0.0037 0.0142 0.0299
Leishmania major GTP-binding protein, putative 0.0023 0.0049 0.0104
Loa Loa (eye worm) hypothetical protein 0.0075 0.0407 0.0886
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0154 0.0947 0.2293
Schistosoma mansoni hypothetical protein 0.0035 0.0129 0.0122
Brugia malayi hypothetical protein 0.0154 0.0947 0.2089
Echinococcus multilocularis survival motor neuron protein 1 0.0229 0.1462 0.2426
Brugia malayi Eukaryotic aspartyl protease family protein 0.0079 0.043 0.0944
Brugia malayi nuclear receptor NHR-88 0.0022 0.0041 0.0084
Brugia malayi neuropeptide F receptor 0.0033 0.0118 0.0254
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0033 0.0118 0.0112
Schistosoma mansoni hypothetical protein 0.0047 0.021 0.0203
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0041 0.0077
Echinococcus multilocularis tumor protein p63 0.0372 0.2438 0.4053
Trichomonas vaginalis bromodomain-containing protein, putative 0.0047 0.0209 0.121
Echinococcus granulosus neuropeptides capa receptor 0.0033 0.0118 0.0219
Brugia malayi G protein-coupled receptor F59B2.13 0.0033 0.0118 0.0254
Plasmodium falciparum plasmepsin IX 0.0158 0.0974 0.2359
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0047 0.0209 0.0493
Leishmania major cytochrome p450-like protein 0.0018 0.001 0.0009
Schistosoma mansoni amine GPCR 0.0033 0.0118 0.0112
Brugia malayi Dihydrofolate reductase 0.0676 0.452 1
Loa Loa (eye worm) dihydrofolate reductase 0.0676 0.452 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0161 0.034
Loa Loa (eye worm) hypothetical protein 0.004 0.0161 0.034
Loa Loa (eye worm) acetyltransferase 0.0159 0.0976 0.2148
Echinococcus multilocularis microtubule associated protein 2 0.0759 0.5094 0.8481
Plasmodium vivax plasmepsin IV, putative 0.0261 0.1678 0.4074
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0041 0.0077
Brugia malayi hypothetical protein 0.0033 0.0118 0.0254
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0079 0.043 0.1032
Loa Loa (eye worm) hypothetical protein 0.0033 0.0118 0.0247
Schistosoma mansoni hypothetical protein 0.0033 0.0118 0.0112
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0142 0.0314
Brugia malayi G-protein coupled receptor 0.0033 0.0118 0.0254
Onchocerca volvulus 0.0054 0.0262 0.1214
Loa Loa (eye worm) transcription factor SMAD2 0.0122 0.0727 0.1595
Schistosoma mansoni peroxidasin 0.004 0.0161 0.0154
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0041 0.0068
Loa Loa (eye worm) TYRA-2 protein 0.0033 0.0118 0.0247
Plasmodium falciparum importin beta, putative 0.0032 0.0107 0.0244
Plasmodium vivax aspartyl protease, putative 0.0158 0.0974 0.2359
Loa Loa (eye worm) hypothetical protein 0.0033 0.0118 0.0247
Echinococcus multilocularis geminin 0.0185 0.116 0.1922
Loa Loa (eye worm) hypothetical protein 0.0033 0.0118 0.0247
Brugia malayi Serotonin receptor 0.0033 0.0118 0.0254
Echinococcus multilocularis sex peptide receptor 0.0033 0.0118 0.0186
Onchocerca volvulus 0.0033 0.0118 0.0529
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0041 0.0084
Mycobacterium tuberculosis Probable phosphoribosylformylglycinamidine CYCLO-ligase PurM (AIRS) (phosphoribosyl-aminoimidazole synthetase) (air synthase) 0.0079 0.0433 0.0809
Loa Loa (eye worm) hypothetical protein 0.0022 0.0041 0.0077
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0033 0.0118 0.0186
Loa Loa (eye worm) hypothetical protein 0.0033 0.0118 0.0247
Echinococcus granulosus serotonin receptor 0.0033 0.0118 0.0219
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0066 0.0353
Toxoplasma gondii ABC1 family protein 0.0037 0.0142 0.0329
Echinococcus granulosus neuropeptide receptor 0.0033 0.0118 0.0219
Loa Loa (eye worm) MH2 domain-containing protein 0.0122 0.0727 0.1595
Loa Loa (eye worm) hypothetical protein 0.0037 0.0142 0.0299
Brugia malayi Cathepsin L-like precursor 0.0017 0.0007 0.0007
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0142 0.0809
Plasmodium vivax aspartyl proteinase, putative 0.0079 0.043 0.1032
Schistosoma mansoni hypothetical protein 0.0185 0.116 0.1154
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0261 0.1678 1
Echinococcus multilocularis fmrfamide receptor 0.0033 0.0118 0.0186
Echinococcus granulosus g-protein coupled receptor 0.0033 0.0118 0.0219
Echinococcus granulosus 7tm_1 domain containing protein 0.0033 0.0118 0.0219
Onchocerca volvulus Peroxidasin homolog 0.004 0.0161 0.073
Loa Loa (eye worm) G-protein coupled receptor 0.0033 0.0118 0.0247
Loa Loa (eye worm) hypothetical protein 0.011 0.0646 0.1416
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0142 0.0329
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0041 0.0084
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0041 0.0084
Mycobacterium tuberculosis Hypothetical protein 0.0154 0.0947 0.1965
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0033 0.0118 0.0186
Onchocerca volvulus 0.0047 0.021 0.0965
Plasmodium falciparum selenide water dikinase, putative 0.0027 0.0074 0.0163
Echinococcus multilocularis allatostatin A receptor 0.0033 0.0118 0.0186
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0049 0.0104
Echinococcus granulosus peroxidasin 0.004 0.0161 0.0302
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0107 0.0167
Loa Loa (eye worm) blistered cuticle protein 3 0.004 0.0161 0.034
Plasmodium vivax aspartyl protease, putative 0.0158 0.0974 0.2359
Echinococcus granulosus tm gpcr rhodopsin 0.0033 0.0118 0.0219
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0033 0.0118 0.0186
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0007 0.0007
Mycobacterium leprae PROBABLE PHOSPHORIBOSYLAMINE--GLYCINE LIGASE PURD (GARS) (GLYCINAMIDE RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE SYNT 0.0359 0.2353 0.5206
Schistosoma mansoni coup transcription factor 0.0022 0.0041 0.0035
Brugia malayi Cathepsin L-like precursor 0.0017 0.0007 0.0007
Entamoeba histolytica hypothetical protein 0.0026 0.0066 0.3356
Loa Loa (eye worm) hypothetical protein 0.0037 0.0142 0.0299
Plasmodium falciparum plasmepsin IV 0.0261 0.1678 0.4074
Onchocerca volvulus 0.0079 0.043 0.2009
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0142 0.0809
Schistosoma mansoni neuropeptide receptor 0.0033 0.0118 0.0112
Brugia malayi Animal haem peroxidase family protein 0.004 0.0161 0.0348
Echinococcus granulosus g protein coupled receptor 0.0033 0.0118 0.0219
Loa Loa (eye worm) neuropeptide F receptor 0.0033 0.0118 0.0247
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0079 0.043 0.0423
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0676 0.452 1
Schistosoma mansoni amine GPCR 0.0033 0.0118 0.0112
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0337 0.0797
Onchocerca volvulus Bile acid receptor homolog 0.0022 0.0041 0.0164
Loa Loa (eye worm) hypothetical protein 0.0022 0.0041 0.0077
Loa Loa (eye worm) hypothetical protein 0.004 0.0161 0.034
Schistosoma mansoni hypothetical protein 0.0035 0.0129 0.0122
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0118 0.0112
Echinococcus multilocularis neuropeptide s receptor 0.0033 0.0118 0.0186
Brugia malayi RNA, U transporter 1 0.009 0.0508 0.1117
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.0129 0.0203
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0041 0.0058
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0041 0.0077
Schistosoma mansoni dihydrofolate reductase 0.0676 0.452 0.4516
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0033 0.0118 0.0112
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0041 0.0035
Loa Loa (eye worm) animal heme peroxidase 0.004 0.0161 0.034
Onchocerca volvulus 0.0063 0.0323 0.15
Toxoplasma gondii aspartyl protease ASP1 0.0261 0.1678 0.4074
Loa Loa (eye worm) hypothetical protein 0.0033 0.0118 0.0247
Echinococcus granulosus histone acetyltransferase KAT2B 0.0047 0.0209 0.0397
Mycobacterium leprae PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE II PURL (FGAM SYNTHASE II) 0.0027 0.0074 0.0163
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0079 0.043 0.0937
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.0118 0.0186
Loa Loa (eye worm) hypothetical protein 0.0033 0.0118 0.0247
Loa Loa (eye worm) hypothetical protein 0.0033 0.0118 0.0247
Echinococcus granulosus neuropeptide FF receptor 2 0.0033 0.0118 0.0219
Onchocerca volvulus 0.0033 0.0118 0.0529
Onchocerca volvulus 0.0033 0.0118 0.0529
Loa Loa (eye worm) thymidylate synthase 0.0324 0.2113 0.4666
Entamoeba histolytica Ran family GTPase 0.0023 0.0049 0.2428
Mycobacterium tuberculosis Conserved protein 0.0037 0.0142 0.0154
Loa Loa (eye worm) hypothetical protein 0.004 0.0161 0.034
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0324 0.2113 0.2107
Loa Loa (eye worm) hypothetical protein 0.0033 0.0118 0.0247
Echinococcus granulosus neuropeptide receptor 0.0033 0.0118 0.0219
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0041 0.0077
Schistosoma mansoni opsin-like receptor 0.0033 0.0118 0.0112
Echinococcus granulosus somatostatin receptor 0.0033 0.0118 0.0219
Brugia malayi Animal haem peroxidase family protein 0.004 0.0161 0.0348
Trypanosoma cruzi cruzipain precursor, putative 0.0065 0.0337 0.0805
Plasmodium falciparum plasmepsin VII 0.0079 0.043 0.1032
Trichomonas vaginalis esterase, putative 0.0037 0.0142 0.0809
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0033 0.0118 0.0247
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0118 0.0112
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0041 0.0084
Leishmania major hypothetical protein, conserved 0.0026 0.0066 0.0145
Onchocerca volvulus Peroxidasin homolog 0.004 0.0161 0.073
Echinococcus granulosus survival motor neuron protein 1 0.0229 0.1462 0.286
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0107 0.0244
Echinococcus multilocularis G-protein coupled receptor, putative 0.0033 0.0118 0.0186
Loa Loa (eye worm) pigment dispersing factor receptor c 0.011 0.0646 0.1416
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0159 0.0976 0.097
Echinococcus granulosus orexin receptor type 2 0.0033 0.0118 0.0219
Echinococcus granulosus rhodopsin orphan GPCR 0.0033 0.0118 0.0219
Loa Loa (eye worm) hypothetical protein 0.0033 0.0118 0.0247
Onchocerca volvulus 0.0033 0.0118 0.0529
Brugia malayi hypothetical protein 0.0033 0.0118 0.0254
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0066 0.0136
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0033 0.0118 0.0186
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0268 0.1728 0.1722
Loa Loa (eye worm) hypothetical protein 0.0022 0.0041 0.0077
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0195 0.0314
Chlamydia trachomatis dihydrofolate reductase 0.0676 0.452 0.5
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0041 0.0068
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0033 0.0118 0.0254
Brugia malayi nuclear hormone receptor 0.0022 0.0041 0.0084
Schistosoma mansoni myosin xvIII 0.0033 0.0118 0.0112
Plasmodium vivax aspartyl protease, putative 0.0079 0.043 0.1032
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0041 0.0084
Onchocerca volvulus 0.0037 0.0142 0.0642
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0047 0.0209 0.0493
Onchocerca volvulus 0.0166 0.1029 0.4854
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0676 0.452 1
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0615 0.4107 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0107 0.0236
Onchocerca volvulus 0.004 0.0161 0.073
Onchocerca volvulus 0.0033 0.0118 0.0529
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0033 0.0118 0.0219
Brugia malayi RE15519p 0.0033 0.0118 0.0254
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0337 0.0805
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0041 0.0035
Brugia malayi beta-lactamase family protein 0.0037 0.0142 0.0306
Trypanosoma cruzi selenophosphate synthetase, putative 0.0027 0.0074 0.0163
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0142 0.0154
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0033 0.0118 0.0529
Plasmodium vivax selenophosphate synthetase, putative 0.0027 0.0074 0.0163
Brugia malayi hypothetical protein 0.0033 0.0118 0.0254
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.0118 0.0186
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0142 0.0321
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.0041 0.0058
Onchocerca volvulus 0.0033 0.0118 0.0529
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0033 0.0118 0.0254
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0041 0.0084
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0142 0.0154
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0041 0.0058
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0033 0.0118 0.0186
Brugia malayi MH2 domain containing protein 0.0122 0.0727 0.1601
Plasmodium falciparum plasmepsin V 0.0079 0.043 0.1032
Brugia malayi putative neuropeptide receptor 0.0033 0.0118 0.0254
Echinococcus granulosus 7TM GPCR rhodopsin 0.0033 0.0118 0.0219
Toxoplasma gondii aspartyl protease ASP3 0.0158 0.0974 0.2359
Echinococcus granulosus G protein coupled receptor 139 0.0033 0.0118 0.0219
Loa Loa (eye worm) hypothetical protein 0.0033 0.0118 0.0247
Plasmodium falciparum plasmepsin VI 0.0261 0.1678 0.4074
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0041 0.0058
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0195 0.0425
Loa Loa (eye worm) hypothetical protein 0.0022 0.0041 0.0077
Plasmodium falciparum plasmepsin VIII, putative 0.0079 0.043 0.1032
Loa Loa (eye worm) selenium donor protein 0.0027 0.0074 0.0148
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0079 0.043 0.0423
Onchocerca volvulus 0.004 0.0161 0.073
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0049 0.0094
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0142 0.0314
Loa Loa (eye worm) aspartyl protease 6 0.0079 0.043 0.0937
Trypanosoma cruzi cytochrome P450, putative 0.0018 0.001 0.0009
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0129 0.0277
Schistosoma mansoni amine GPCR 0.0033 0.0118 0.0112
Brugia malayi Calcitonin receptor-like protein seb-1 0.011 0.0646 0.1423
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0041 0.0035
Brugia malayi Animal haem peroxidase family protein 0.004 0.0161 0.0348
Schistosoma mansoni biogenic amine (5HT) receptor 0.0033 0.0118 0.0112
Schistosoma mansoni neuropeptide receptor 0.0033 0.0118 0.0112
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0041 0.0084
Loa Loa (eye worm) hypothetical protein 0.0033 0.0118 0.0247
Loa Loa (eye worm) neuropeptide F receptor 0.0033 0.0118 0.0247
Brugia malayi Animal haem peroxidase family protein 0.004 0.0161 0.0348
Echinococcus granulosus selenide water dikinase 0.0027 0.0074 0.0131
Onchocerca volvulus 0.0033 0.0118 0.0529
Loa Loa (eye worm) hypothetical protein 0.0166 0.1029 0.2265
Loa Loa (eye worm) hypothetical protein 0.0033 0.0118 0.0247
Echinococcus multilocularis somatostatin receptor 0.0033 0.0118 0.0186
Echinococcus granulosus dihydrofolate reductase 0.0676 0.452 0.8872
Loa Loa (eye worm) hypothetical protein 0.0032 0.0107 0.0222
Onchocerca volvulus 0.0079 0.043 0.2009
Brugia malayi Cathepsin L-like precursor 0.0017 0.0007 0.0007
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0615 0.4107 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0018 0.001 0.0008
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0033 0.0118 0.0219
Onchocerca volvulus Chorion peroxidase homolog 0.004 0.0161 0.073
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0159 0.0976 0.1616
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0033 0.0118 0.0247
Brugia malayi hypothetical protein 0.0033 0.0118 0.0254
Plasmodium vivax importin-beta 2, putative 0.0032 0.0107 0.0244
Onchocerca volvulus 0.0033 0.0118 0.0529
Echinococcus granulosus tm gpcr rhodopsin 0.0033 0.0118 0.0219
Leishmania major selenophosphate synthetase, putative 0.0027 0.0074 0.0163
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.0118 0.0186
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0142 0.0299
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0033 0.0118 0.0186
Loa Loa (eye worm) hypothetical protein 0.0022 0.0041 0.0077
Echinococcus multilocularis serotonin receptor 0.0033 0.0118 0.0186
Brugia malayi Dopamine receptor protein 2 0.0033 0.0118 0.0254
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0049 0.0071
Loa Loa (eye worm) hypothetical protein 0.0033 0.0118 0.0247
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.0118 0.0186
Schistosoma mansoni hypothetical protein 0.0185 0.116 0.1154
Loa Loa (eye worm) hypothetical protein 0.0261 0.1678 0.3702
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0041 0.0058
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0066 0.0145
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0615 0.4107 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0033 0.0118 0.0529
Echinococcus granulosus histone acetyltransferase KAT2B 0.0154 0.0946 0.1845
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0041 0.0084
Onchocerca volvulus 0.0033 0.0118 0.0529
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0118 0.0112
Onchocerca volvulus 0.0033 0.0118 0.0529
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0118 0.0112
Schistosoma mansoni opsin-like receptor 0.0033 0.0118 0.0112
Schistosoma mansoni ran 0.0023 0.0049 0.0043
Echinococcus multilocularis neuropeptide receptor 0.0033 0.0118 0.0186
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0033 0.0118 0.0112
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0033 0.0118 0.0112
Schistosoma mansoni cathepsin D (A01 family) 0.0911 0.6132 0.6129
Schistosoma mansoni adenoreceptor 0.0033 0.0118 0.0112
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.011 0.0646 0.1423
Onchocerca volvulus Peroxidase homolog 0.004 0.0161 0.073
Brugia malayi hypothetical protein 0.0079 0.043 0.0944
Schistosoma mansoni hypothetical protein 0.0033 0.0118 0.0112
Leishmania major cathepsin L-like protease 0.0065 0.0337 0.0805
Brugia malayi Dopamine receptor protein 1 0.0033 0.0118 0.0254
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0033 0.0118 0.0112
Trypanosoma cruzi selenophosphate synthetase, putative 0.0027 0.0074 0.0163
Onchocerca volvulus 0.0037 0.0142 0.0642
Loa Loa (eye worm) hypothetical protein 0.0033 0.0118 0.0247
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0615 0.4107 1
Brugia malayi Cathepsin L-like precursor 0.0017 0.0007 0.0007
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0041 0.0068
Brugia malayi Dopamine receptor 0.0033 0.0118 0.0254
Brugia malayi Importin beta-1 subunit 0.0032 0.0107 0.0229
Mycobacterium ulcerans phosphoribosylformylglycinamidine synthase II 0.0027 0.0074 0.0163
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0337 0.0797
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0033 0.0118 0.0186
Schistosoma mansoni growth hormone secretagogue receptor 0.0033 0.0118 0.0112
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0033 0.0118 0.0112
Schistosoma mansoni histamine h1 receptor 0.0033 0.0118 0.0112
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0049 0.0104
Loa Loa (eye worm) animal heme peroxidase 0.004 0.0161 0.034
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0615 0.4107 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0041 0.0068
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0022 0.0041 0.0164
Onchocerca volvulus Peroxidase homolog 0.004 0.0161 0.073
Loa Loa (eye worm) hypothetical protein 0.0033 0.0118 0.0247
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0033 0.0118 0.0112
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0142 0.0306
Schistosoma mansoni hypothetical protein 0.0033 0.0118 0.0112
Loa Loa (eye worm) hypothetical protein 0.0033 0.0118 0.0247
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0195 0.0189
Echinococcus granulosus biogenic amine 5HT receptor 0.0033 0.0118 0.0219
Echinococcus granulosus tachykinin peptides receptor 99D 0.0033 0.0118 0.0219
Brugia malayi hypothetical protein 0.0033 0.0118 0.0254
Echinococcus granulosus geminin 0.0185 0.116 0.2267
Loa Loa (eye worm) hypothetical protein 0.0033 0.0118 0.0247
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0041 0.0035
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0033 0.0118 0.0247
Brugia malayi hypothetical protein 0.0033 0.0118 0.0254
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0033 0.0118 0.0112
Loa Loa (eye worm) hypothetical protein 0.004 0.0161 0.034
Loa Loa (eye worm) hypothetical protein 0.004 0.0161 0.034
Schistosoma mansoni survival motor neuron protein 0.0047 0.021 0.0203
Loa Loa (eye worm) animal heme peroxidase 0.004 0.0161 0.034
Schistosoma mansoni neuropeptide receptor 0.0033 0.0118 0.0112
Echinococcus granulosus neuropeptide s receptor 0.0033 0.0118 0.0219
Loa Loa (eye worm) hypothetical protein 0.0033 0.0118 0.0247
Giardia lamblia Histone acetyltransferase GCN5 0.0043 0.0182 1
Brugia malayi hypothetical protein 0.0166 0.1029 0.2271
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0337 0.0797
Onchocerca volvulus 0.0079 0.0433 0.2025
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0324 0.2113 0.4674
Onchocerca volvulus 0.0324 0.2113 1
Onchocerca volvulus 0.0037 0.0142 0.0642
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0079 0.043 0.0423
Trichomonas vaginalis conserved hypothetical protein 0.0154 0.0947 0.5628
Echinococcus multilocularis g-protein coupled receptor 0.0033 0.0118 0.0186
Echinococcus multilocularis neuropeptide receptor A26 0.0033 0.0118 0.0186
Echinococcus multilocularis GPCR, family 2 0.0035 0.0129 0.0203
Loa Loa (eye worm) hypothetical protein 0.0035 0.0129 0.027
Brugia malayi G-protein coupled receptor 0.0033 0.0118 0.0254
Echinococcus granulosus snurportin 1 0.0339 0.2211 0.4333
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.0118 0.0186
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0041 0.0035
Plasmodium falciparum plasmepsin III 0.0079 0.043 0.1032
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0066 0.0145
Brugia malayi latrophilin 2 splice variant baaae 0.0075 0.0407 0.0893
Toxoplasma gondii aspartyl protease 0.0079 0.043 0.1032
Mycobacterium ulcerans phosphoribosylaminoimidazole synthetase 0.0079 0.0433 0.0959
Loa Loa (eye worm) hypothetical protein 0.0033 0.0118 0.0247
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0041 0.0068
Schistosoma mansoni opsin-like receptor 0.0033 0.0118 0.0112
Brugia malayi larval opioid receptor 0.0033 0.0118 0.0254
Loa Loa (eye worm) hypothetical protein 0.0033 0.0118 0.0247
Mycobacterium tuberculosis Conserved protein 0.0037 0.0142 0.0154
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.006 0.0298 0.071
Echinococcus granulosus neuropeptides capa receptor 0.0033 0.0118 0.0219
Loa Loa (eye worm) hypothetical protein 0.0037 0.0142 0.0299
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.0118 0.0186
Brugia malayi Peroxidasin 0.004 0.0161 0.0348
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0049 0.0104
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0041 0.0084
Echinococcus multilocularis snurportin 1 0.0339 0.2211 0.3675
Trichomonas vaginalis ran, putative 0.0023 0.0049 0.0255
Loa Loa (eye worm) hypothetical protein 0.0033 0.0118 0.0247
Loa Loa (eye worm) hypothetical protein 0.0033 0.0118 0.0247
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.0118 0.0186
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0337 0.0797
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0142 0.0135
Loa Loa (eye worm) hypothetical protein 0.004 0.0161 0.034
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0337 0.0797
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0142 0.0154
Echinococcus granulosus thymidylate synthase 0.0324 0.2113 0.414
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0033 0.0118 0.0247
Brugia malayi thymidylate synthase 0.0324 0.2113 0.467
Schistosoma mansoni neuropeptide f receptor 76f 0.0033 0.0118 0.0112
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0041 0.0068
Brugia malayi Serotonin receptor 0.0033 0.0118 0.0254
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0079 0.043 0.0423
Echinococcus multilocularis orexin receptor type 2 0.0033 0.0118 0.0186
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0142 0.0809
Echinococcus granulosus fmrfamide receptor 0.0033 0.0118 0.0219
Brugia malayi G protein-coupled receptor 0.0033 0.0118 0.0254
Entamoeba histolytica acetyltransferase, GNAT family 0.0043 0.0182 1
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0337 0.0805
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0041 0.0035
Echinococcus granulosus neuropeptide Y receptor 0.0033 0.0118 0.0219
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0041 0.0058
Brugia malayi ecdysteroid receptor 0.0022 0.0041 0.0084
Loa Loa (eye worm) hypothetical protein 0.0033 0.0118 0.0247
Schistosoma mansoni amine GPCR 0.0033 0.0118 0.0112
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0047 0.0209 0.0493
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0142 0.0314
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0195 0.0189
Schistosoma mansoni hypothetical protein 0.0033 0.0118 0.0112
Brugia malayi sulfakinin receptor protein 0.0033 0.0118 0.0254
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0339 0.2211 0.4884
Echinococcus multilocularis g protein coupled receptor 0.0033 0.0118 0.0186
Loa Loa (eye worm) hypothetical protein 0.0033 0.0118 0.0247
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0261 0.1678 0.3284
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0118 0.0112
Brugia malayi Cathepsin L-like precursor 0.0017 0.0007 0.0007
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0041 0.0068
Onchocerca volvulus 0.0022 0.0041 0.0164
Schistosoma mansoni amine GPCR 0.0033 0.0118 0.0112
Brugia malayi AKH receptor 0.0033 0.0118 0.0254
Schistosoma mansoni ran 0.0023 0.0049 0.0043
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0041 0.0084
Schistosoma mansoni microtubule-associated protein tau 0.0759 0.5094 0.5091
Loa Loa (eye worm) hypothetical protein 0.0033 0.0118 0.0247
Echinococcus granulosus rhodopsin orphan GPCR 0.0033 0.0118 0.0219
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0142 0.0329
Echinococcus multilocularis neuropeptide Y receptor 0.0033 0.0118 0.0186
Brugia malayi GnHR receptor homolog 0.0033 0.0118 0.0254
Loa Loa (eye worm) hypothetical protein 0.0229 0.1462 0.3224
Schistosoma mansoni biogenic amine receptor 0.0033 0.0118 0.0112
Brugia malayi dihydrofolate reductase family protein 0.0676 0.452 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0195 0.0371
Echinococcus granulosus peptide allatostatin:somatostatin 0.0033 0.0118 0.0219
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0118 0.0112
Onchocerca volvulus 0.0033 0.0118 0.0529
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.0129 0.024
Brugia malayi Cytochrome P450 family protein 0.0018 0.001 0.0015
Plasmodium falciparum plasmepsin I 0.0261 0.1678 0.4074
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0049 0.0104
Echinococcus multilocularis neuropeptide receptor 0.0033 0.0118 0.0186
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0066 0.0145
Echinococcus multilocularis neuropeptides capa receptor 0.0033 0.0118 0.0186
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0337 0.0805
Echinococcus multilocularis g protein coupled receptor 0.0033 0.0118 0.0186
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0142 0.0154
Brugia malayi hypothetical protein 0.004 0.0161 0.0348
Loa Loa (eye worm) hypothetical protein 0.0022 0.0041 0.0077
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0041 0.0077
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0041 0.0035
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0018 0.001 0.0023
Leishmania major importin beta-1 subunit, putative 0.0026 0.0066 0.0144
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0195 0.0371
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0033 0.0118 0.0186
Brugia malayi hypothetical protein 0.0033 0.0118 0.0254
Brugia malayi neuropeptide F receptor 0.0033 0.0118 0.0254
Brugia malayi follicle stimulating hormone receptor 0.0033 0.0118 0.0254
Brugia malayi putative neuropeptide receptor NPR1 0.0033 0.0118 0.0254
Plasmodium falciparum plasmepsin II 0.0261 0.1678 0.4074
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0033 0.0118 0.0219
Echinococcus multilocularis 0.0027 0.0074 0.0111
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0033 0.0118 0.0254
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0615 0.4107 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0033 0.0118 0.0186
Echinococcus granulosus rhodopsin orphan GPCR 0.0033 0.0118 0.0219
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.0118 0.0186
Mycobacterium ulcerans beta-lactamase 0.0037 0.0142 0.0314
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0261 0.1678 0.4074
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0041 0.0077
Schistosoma mansoni alpha-1 adrenergic receptor 0.0033 0.0118 0.0112
Loa Loa (eye worm) hypothetical protein 0.0079 0.043 0.0937
Brugia malayi aspartic protease BmAsp-1, identical 0.0079 0.043 0.0944
Mycobacterium ulcerans hypothetical protein 0.0037 0.0142 0.0314
Loa Loa (eye worm) hypothetical protein 0.0033 0.0118 0.0247
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0047 0.0209 0.121
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0041 0.0084
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0066 0.0353
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0066 0.0353
Echinococcus granulosus allatostatin A receptor 0.0033 0.0118 0.0219
Schistosoma mansoni hypothetical protein 0.0035 0.0129 0.0122
Loa Loa (eye worm) hypothetical protein 0.0033 0.0118 0.0247
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0132
Loa Loa (eye worm) hypothetical protein 0.0033 0.0118 0.0247
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0142 0.0135
Onchocerca volvulus 0.0033 0.0118 0.0529
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0041 0.0084
Leishmania major cathepsin L-like protease 0.0065 0.0337 0.0805
Echinococcus granulosus rhodopsin orphan GPCR 0.0033 0.0118 0.0219
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0337 0.0797
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0041 0.0068
Loa Loa (eye worm) hypothetical protein 0.0033 0.0118 0.0247
Brugia malayi beta-lactamase family protein 0.0037 0.0142 0.0306
Plasmodium vivax plasmepsin V, putative 0.0079 0.043 0.1032
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0041 0.0035
Loa Loa (eye worm) hypothetical protein 0.0033 0.0118 0.0247
Echinococcus granulosus g protein coupled receptor 0.0033 0.0118 0.0219
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0066 0.0145
Brugia malayi Cathepsin L-like precursor 0.0017 0.0007 0.0007
Schistosoma mansoni hypothetical protein 0.0035 0.0129 0.0122
Brugia malayi Tachykinin-like peptides receptor 99D 0.0033 0.0118 0.0254
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0066 0.0144
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0041 0.0077
Echinococcus granulosus GPCR family 2 0.0035 0.0129 0.024
Brugia malayi Cytochrome P450 family protein 0.0029 0.0089 0.019
Onchocerca volvulus 0.0033 0.0118 0.0529
Leishmania major pteridine reductase 1 0.0238 0.1519 0.3688
Brugia malayi ORL1-like opioid receptor 0.0033 0.0118 0.0254
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0041 0.0035
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.021 0.0457
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0261 0.1678 0.1672
Loa Loa (eye worm) hypothetical protein 0.004 0.0161 0.034
Onchocerca volvulus Protein ultraspiracle homolog 0.0022 0.0041 0.0164
Echinococcus granulosus microtubule associated protein 2 0.0759 0.5094 1
Brugia malayi Melatonin receptor type 1A 0.0033 0.0118 0.0254
Schistosoma mansoni selinide water dikinase 0.0027 0.0074 0.0067
Loa Loa (eye worm) hypothetical protein 0.0033 0.0118 0.0247
Loa Loa (eye worm) hypothetical protein 0.004 0.0161 0.034
Loa Loa (eye worm) hypothetical protein 0.0033 0.0118 0.0247
Brugia malayi hypothetical protein 0.0229 0.1462 0.3229
Mycobacterium leprae Probable lipase LipE 0.0037 0.0142 0.0314
Echinococcus granulosus tm gpcr rhodopsin 0.0033 0.0118 0.0219
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0049 0.0095
Schistosoma mansoni hypothetical protein 0.0075 0.0407 0.04
Echinococcus multilocularis serotonin receptor 0.0033 0.0118 0.0186
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0195 0.0189
Schistosoma mansoni biogenic amine (5HT) receptor 0.0033 0.0118 0.0112
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.0129 0.024
Echinococcus multilocularis peroxidasin 0.004 0.0161 0.0256
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0041 0.0068
Loa Loa (eye worm) hypothetical protein 0.004 0.0161 0.034
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0041 0.0084
Echinococcus multilocularis thymidylate synthase 0.0324 0.2113 0.3511
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0118 0.0112
Loa Loa (eye worm) hypothetical protein 0.004 0.0161 0.034
Mycobacterium ulcerans phosphoribosylamine--glycine ligase 0.0359 0.2353 0.5206
Schistosoma mansoni memapsin-2 (A01 family) 0.0079 0.043 0.0423
Echinococcus granulosus importin subunit beta 1 0.0032 0.0107 0.0197
Onchocerca volvulus 0.0033 0.0118 0.0529
Schistosoma mansoni cellular tumor antigen P53 0.0054 0.0262 0.0256
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0041 0.0058
Onchocerca volvulus 0.0033 0.0118 0.0529
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0261 0.1678 0.2785
Trypanosoma cruzi cytochrome P450, putative 0.0018 0.001 0.0009
Brugia malayi Animal haem peroxidase family protein 0.004 0.0161 0.0348
Echinococcus granulosus neuropeptide Y receptor 0.0033 0.0118 0.0219
Brugia malayi selenium donor protein 0.0027 0.0074 0.0155
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0118 0.0112
Loa Loa (eye worm) cytochrome P450 family protein 0.0018 0.001 0.0008
Schistosoma mansoni neuropeptide F-like receptor 0.0033 0.0118 0.0112
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0033 0.0118 0.0112
Echinococcus granulosus rhodopsin orphan GPCR 0.0033 0.0118 0.0219
Schistosoma mansoni biogenic amine receptor 0.0033 0.0118 0.0112
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0235 0.1503 0.3214
Loa Loa (eye worm) hypothetical protein 0.0033 0.0118 0.0247
Trypanosoma brucei Selenophosphate synthetase 2 0.0027 0.0074 0.0154
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0337 0.0797
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0041 0.0084
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0079 0.043 0.0423
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0033 0.0118 0.0254
Echinococcus granulosus g protein coupled receptor 0.0033 0.0118 0.0219
Loa Loa (eye worm) hypothetical protein 0.0037 0.0142 0.0299
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0049 0.0104
Onchocerca volvulus 0.0033 0.0118 0.0529
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0676 0.452 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.0033 0.0118 0.0186
Echinococcus granulosus biogenic amine 5HT receptor 0.0033 0.0118 0.0219
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0041 0.0035
Mycobacterium leprae PROBABLE PHOSPHORIBOSYLFORMYLGLYCINAMIDINE CYCLO-LIGASE PURM (AIRS) (PHOSPHORIBOSYL-AMINOIMIDAZOLE SYNTHETASE) (AIR SYNTHASE) 0.0079 0.0433 0.0959
Loa Loa (eye worm) hypothetical protein 0.0033 0.0118 0.0247
Loa Loa (eye worm) hypothetical protein 0.0054 0.0262 0.0566
Trypanosoma cruzi major cysteine proteinase, putative 0.0051 0.0241 0.0571
Echinococcus granulosus alpha 1A adrenergic receptor 0.0033 0.0118 0.0219
Schistosoma mansoni biogenic amine receptor 0.0033 0.0118 0.0112
Loa Loa (eye worm) hypothetical protein 0.0033 0.0118 0.0247
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0033 0.0118 0.0219
Loa Loa (eye worm) hypothetical protein 0.0033 0.0118 0.0247
Onchocerca volvulus Dual oxidase homolog 0.004 0.0161 0.073
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0337 0.0797
Plasmodium falciparum plasmepsin X 0.0158 0.0974 0.2359
Brugia malayi Pepsin A precursor 0.0079 0.043 0.0944
Onchocerca volvulus 0.0033 0.0118 0.0529
Mycobacterium ulcerans lipase LipD 0.0037 0.0142 0.0314
Plasmodium vivax aspartyl proteinase, putative 0.0261 0.1678 0.4074
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0142 0.0809
Leishmania major hypothetical protein, conserved 0.0037 0.0142 0.0329
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.0129 0.0203
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0129 0.0277
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0261 0.1678 0.3702
Loa Loa (eye worm) hypothetical protein 0.0022 0.0041 0.0077
Loa Loa (eye worm) hypothetical protein 0.0033 0.0118 0.0247
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0066 0.0145
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0041 0.0077
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0033 0.0118 0.0112
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0033 0.0118 0.0254
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0079 0.043 0.0423
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0337 0.0797
Echinococcus granulosus sex peptide receptor 0.0033 0.0118 0.0219
Echinococcus multilocularis dihydrofolate reductase 0.0676 0.452 0.7524
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0041 0.0058
Loa Loa (eye worm) CYP4Cod1 0.0018 0.001 0.0008
Schistosoma mansoni neuropeptide receptor 0.0033 0.0118 0.0112
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0324 0.2113 0.4586
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0033 0.0118 0.0186
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0041 0.0035
Loa Loa (eye worm) hypothetical protein 0.0033 0.0118 0.0247
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0049 0.0084
Loa Loa (eye worm) hypothetical protein 0.0033 0.0118 0.0247
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0033 0.0118 0.0186
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0142 0.0329
Brugia malayi hypothetical protein 0.0033 0.0118 0.0254
Echinococcus granulosus tumor protein p63 0.0372 0.2438 0.4779
Echinococcus multilocularis neuropeptide Y receptor 0.0033 0.0118 0.0186
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0129 0.027
Mycobacterium tuberculosis Probable phosphoribosylamine--glycine ligase PurD (GARS) (glycinamide ribonucleotide synthetase) (phosphoribosylglycinamide synt 0.0052 0.0249 0.0395
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0142 0.0266
Brugia malayi Blistered cuticle protein 3 0.004 0.0161 0.0348
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0033 0.0118 0.0186
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0337 0.0797
Loa Loa (eye worm) animal heme peroxidase 0.004 0.0161 0.034
Echinococcus granulosus rhodopsin orphan GPCR 0.0033 0.0118 0.0219
Toxoplasma gondii selenide, water dikinase 0.0027 0.0074 0.0163
Loa Loa (eye worm) hypothetical protein 0.004 0.0161 0.034
Brugia malayi Cytochrome P450 family protein 0.0018 0.001 0.0015
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0142 0.0154
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0033 0.0118 0.0247
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0033 0.0118 0.0112
Loa Loa (eye worm) hypothetical protein 0.0033 0.0118 0.0247
Loa Loa (eye worm) hypothetical protein 0.0037 0.0142 0.0299
Trypanosoma brucei pteridine reductase 1 0.0235 0.1498 0.3631
Brugia malayi hypothetical protein 0.0026 0.0066 0.0139

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.012 uM Inhibition of rat liver dihydrofolate reductase using dihydrofolate as substrate ChEMBL. 850245
IC50 (binding) = 0.3 uM Inhibition of Streptococcus faecium dihydrofolate reductase using dihydrofolate as substrate ChEMBL. 850245
Inhibition (functional) = 0 % GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. ChEMBL. 20485427
Inhibition (functional) = 2 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 2.98 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 4.17 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 6.36 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 93 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 94 % GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition frequency index (IFI) (functional) = 0 Inhibition Frequency Index (IFI) GSK. 20485427
Percent growth inhibition (functional) = -5 % Percent inhibition of HepG2 growth (at 10 uM) GSK. 20485427
Percent growth inhibition (functional) = 2 % Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 93 % Percent inhibition of P. falciparum 3D7 growth (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 94 % Percent inhibition of P. falciparum Dd2 growth (at 2 uM) GSK. 20485427
Survival (functional) = 25 % Antitumor activity against mouse L1210 cells allografted in mouse assessed as increase in survival at 100 mg/kg administered on day 1 to 5 relative to control ChEMBL. 850245
XC50 (functional) = 6.75 XC50 determination of P. falciparum 3D7 growth GSK. 20485427
XC50 (functional) = 0.17884 uM GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. ChEMBL. 20485427

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Targets
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania major 25954  
Annotator: aaronjr@u.washington.edu Comment: Drug: 700-47-0; Drug: 704-61-0; Drug: 708-74-7; Drug: 945-24-4; Drug: 1026-36-4; Drug: 1597-01-9; Drug: 1899-40-7; Drug: 2432-24-8; Drug: 2440-80-4; Drug: 3977-17-1; Drug: 5774-32-3; Drug: 6954-23-0; Drug: 6973-01-9; Drug: 7319-50-8; Drug: 14684-54-9; Drug: 17005-34-4; Drug: 17005-35-5; Drug: 19152-86-4; Drug: 26398-12-9; Drug: 34244-78-5; Drug: 34244-80-9; Drug: 36804-91-8; Drug: 38713-63-2; Drug: 38713-64-3; Drug: 38713-65-4; Drug: 47066-05-7; Drug: 50691-65-1; Drug: 51395-54-1; Drug: 51583-00-7; Drug: 52128-15-1; Drug: 53219-56-0; Drug: 53274-34-3; Drug: 54798-36-6; Drug: 58091-86-4; Drug: 61267-65-0; Drug: 61267-67-2; Drug: 73978-42-4; Drug: 73978-43-5; Drug: 73978-44-6; Drug: 89977-50-4; Drug: 104422-58-4; Drug: 104422-59-5; Drug: 107174-41-4; Drug: 160602-03-9; Drug: 160602-12-0; Drug: 200127-49-7; Drug: 200127-50-0; Drug: 200127-51-1; Drug: 200127-52-2; Drug: 200127-53-3; Drug: 200127-54-4; Drug: 200127-55-5; Drug: 200127-57-7; Drug: 200127-58-8; Drug: 200127-59-9; Drug: 200127-60-2; Drug: 200127-61-3; Drug: 200127-62-4; Drug: 200127-63-5. chemical inhibition with DHFR and PTR1 inhibitors leads to slow growth of Leishmania sp. in cell assay; References: 9371081 9398595
catalytic activity (GO:0003824) decreased (PATO:0000468) in vitro (MI:0492) inferred from specific protein inhibition (ECO:0000020) Leishmania major 25954  
Annotator: aaronjr@u.washington.edu Comment: Drug: 700-47-0; Drug: 704-61-0; Drug: 708-74-7; Drug: 945-24-4; Drug: 1026-36-4; Drug: 1597-01-9; Drug: 1899-40-7; Drug: 2432-24-8; Drug: 2440-80-4; Drug: 3977-17-1; Drug: 5774-32-3; Drug: 6954-23-0; Drug: 6973-01-9; Drug: 7319-50-8; Drug: 14684-54-9; Drug: 17005-34-4; Drug: 17005-35-5; Drug: 19152-86-4; Drug: 26398-12-9; Drug: 34244-78-5; Drug: 34244-80-9; Drug: 36804-91-8; Drug: 38713-63-2; Drug: 38713-64-3; Drug: 38713-65-4; Drug: 47066-05-7; Drug: 50691-65-1; Drug: 51395-54-1; Drug: 51583-00-7; Drug: 52128-15-1; Drug: 53219-56-0; Drug: 53274-34-3; Drug: 54798-36-6; Drug: 58091-86-4; Drug: 61267-65-0; Drug: 61267-67-2; Drug: 73978-42-4; Drug: 73978-43-5; Drug: 73978-44-6; Drug: 89977-50-4; Drug: 104422-58-4; Drug: 104422-59-5; Drug: 107174-41-4; Drug: 160602-03-9; Drug: 160602-12-0; Drug: 200127-49-7; Drug: 200127-50-0; Drug: 200127-51-1; Drug: 200127-52-2; Drug: 200127-53-3; Drug: 200127-54-4; Drug: 200127-55-5; Drug: 200127-57-7; Drug: 200127-58-8; Drug: 200127-59-9; Drug: 200127-60-2; Drug: 200127-61-3; Drug: 200127-62-4; Drug: 200127-63-5. chemical inhibition with DHFR and PTR1 inhibitors leads to reduced enzyme activity in vitro; References: 9371081 9398595
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania major 21977  
Annotator: aaronjr@u.washington.edu Comment: Drug: 700-47-0; Drug: 704-61-0; Drug: 708-74-7; Drug: 945-24-4; Drug: 1026-36-4; Drug: 1597-01-9; Drug: 1899-40-7; Drug: 2432-24-8; Drug: 2440-80-4; Drug: 3977-17-1; Drug: 5774-32-3; Drug: 6954-23-0; Drug: 6973-01-9; Drug: 7319-50-8; Drug: 14684-54-9; Drug: 17005-34-4; Drug: 17005-35-5; Drug: 19152-86-4; Drug: 26398-12-9; Drug: 34244-78-5; Drug: 34244-80-9; Drug: 36804-91-8; Drug: 38713-63-2; Drug: 38713-64-3; Drug: 38713-65-4; Drug: 47066-05-7; Drug: 50691-65-1; Drug: 51395-54-1; Drug: 51583-00-7; Drug: 52128-15-1; Drug: 53219-56-0; Drug: 53274-34-3; Drug: 54798-36-6; Drug: 58091-86-4; Drug: 61267-65-0; Drug: 61267-67-2; Drug: 73978-42-4; Drug: 73978-43-5; Drug: 73978-44-6; Drug: 89977-50-4; Drug: 104422-58-4; Drug: 104422-59-5; Drug: 107174-41-4; Drug: 160602-03-9; Drug: 160602-12-0; Drug: 200127-49-7; Drug: 200127-50-0; Drug: 200127-51-1; Drug: 200127-52-2; Drug: 200127-53-3; Drug: 200127-54-4; Drug: 200127-55-5; Drug: 200127-57-7; Drug: 200127-58-8; Drug: 200127-59-9; Drug: 200127-60-2; Drug: 200127-61-3; Drug: 200127-62-4; Drug: 200127-63-5. chemical inhibition with DHFR and PTR1 inhibitors leads to slow growth of Leishmania sp. in cell assay; References: 9371081 9398595
catalytic activity (GO:0003824) decreased (PATO:0000468) in vitro (MI:0492) inferred from specific protein inhibition (ECO:0000020) Leishmania major 21977  
Annotator: aaronjr@u.washington.edu Comment: Drug: 700-47-0; Drug: 704-61-0; Drug: 708-74-7; Drug: 945-24-4; Drug: 1026-36-4; Drug: 1597-01-9; Drug: 1899-40-7; Drug: 2432-24-8; Drug: 2440-80-4; Drug: 3977-17-1; Drug: 5774-32-3; Drug: 6954-23-0; Drug: 6973-01-9; Drug: 7319-50-8; Drug: 14684-54-9; Drug: 17005-34-4; Drug: 17005-35-5; Drug: 19152-86-4; Drug: 26398-12-9; Drug: 34244-78-5; Drug: 34244-80-9; Drug: 36804-91-8; Drug: 38713-63-2; Drug: 38713-64-3; Drug: 38713-65-4; Drug: 47066-05-7; Drug: 50691-65-1; Drug: 51395-54-1; Drug: 51583-00-7; Drug: 52128-15-1; Drug: 53219-56-0; Drug: 53274-34-3; Drug: 54798-36-6; Drug: 58091-86-4; Drug: 61267-65-0; Drug: 61267-67-2; Drug: 73978-42-4; Drug: 73978-43-5; Drug: 73978-44-6; Drug: 89977-50-4; Drug: 104422-58-4; Drug: 104422-59-5; Drug: 107174-41-4; Drug: 160602-03-9; Drug: 160602-12-0; Drug: 200127-49-7; Drug: 200127-50-0; Drug: 200127-51-1; Drug: 200127-52-2; Drug: 200127-53-3; Drug: 200127-54-4; Drug: 200127-55-5; Drug: 200127-57-7; Drug: 200127-58-8; Drug: 200127-59-9; Drug: 200127-60-2; Drug: 200127-61-3; Drug: 200127-62-4; Drug: 200127-63-5. chemical inhibition with DHFR and PTR1 inhibitors leads to reduced enzyme activity in vitro; References: 9371081 9398595

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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Bibliographic References

3 literature references were collected for this gene.

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