Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | Curated by TDR Targets | References |
Mycobacterium tuberculosis | DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | Curated by TDR Targets | References |
Leishmania major | mitochondrial DNA topoisomerase II | Curated by TDR Targets | References |
Leishmania major | DNA topoisomerase ii | Curated by TDR Targets | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma cruzi | DNA topoisomerase II, putative | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 714 aa | 649 aa | 26.5 % |
Trypanosoma brucei | DNA topoisomerase II beta, putative | mitochondrial DNA topoisomerase II | 1236 aa | 1047 aa | 35.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0152 | 0.241 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0298 | 0.5622 | 0.5622 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0238 | 0.43 | 0.4216 |
Schistosoma mansoni | eyes absent homolog | 0.0086 | 0.097 | 0.1984 |
Brugia malayi | hypothetical protein | 0.0149 | 0.2353 | 0.224 |
Giardia lamblia | DNA topoisomerase II | 0.0224 | 0.4001 | 0.5 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0141 | 0.2176 | 0.2176 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0497 | 1 | 1 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0217 | 0.386 | 0.386 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0497 | 1 | 1 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0238 | 0.43 | 0.4216 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0187 | 0.3185 | 0.4533 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0497 | 1 | 1 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.0251 | 0.4603 | 0.4788 |
Echinococcus granulosus | muscleblind protein | 0.0158 | 0.256 | 0.245 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.1134 | 0.1003 |
Brugia malayi | Muscleblind-like protein | 0.0158 | 0.256 | 0.245 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.0311 | 0.5911 | 0.4773 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.097 | 0.0836 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0238 | 0.43 | 0.4216 |
Plasmodium falciparum | DNA gyrase subunit B | 0.0251 | 0.4603 | 0.3998 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.256 | 0.245 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0238 | 0.43 | 0.4216 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0217 | 0.386 | 0.386 |
Brugia malayi | Probable DNA topoisomerase II | 0.0238 | 0.43 | 0.4216 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0051 | 0.0201 | 0.0201 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0183 | 0.3097 | 1 |
Plasmodium falciparum | DNA gyrase subunit A | 0.0354 | 0.6863 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.2714 | 0.6183 |
Schistosoma mansoni | DNA topoisomerase II | 0.0238 | 0.43 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 11 | 0.0497 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0086 | 0.097 | 0.0836 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0497 | 1 | 1 |
Trypanosoma brucei | DNA topoisomerase ii | 0.0311 | 0.5911 | 0.5911 |
Leishmania major | mitogen-activated protein kinase 3, putative,map kinase 3, putative | 0.0497 | 1 | 1 |
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0251 | 0.4603 | 0.4788 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0311 | 0.5911 | 0.5911 |
Echinococcus granulosus | geminin | 0.0165 | 0.2714 | 0.2607 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0298 | 0.5622 | 0.5622 |
Leishmania major | DNA topoisomerase ii | 0.0217 | 0.386 | 0.2152 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0497 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.1134 | 0.1003 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0178 | 0.2992 | 0.3816 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0183 | 0.3097 | 1 |
Echinococcus multilocularis | geminin | 0.0165 | 0.2714 | 0.2607 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0497 | 1 | 1 |
Treponema pallidum | DNA gyrase, subunit A (gyrA) | 0.0354 | 0.6863 | 1 |
Mycobacterium ulcerans | DNA gyrase subunit A | 0.0354 | 0.6863 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.2353 | 0.224 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.0217 | 0.386 | 0.386 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0251 | 0.4603 | 0.6389 |
Mycobacterium tuberculosis | DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0354 | 0.6863 | 1 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0298 | 0.5622 | 0.5622 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0298 | 0.5622 | 0.4404 |
Chlamydia trachomatis | DNA gyrase subunit A | 0.0354 | 0.6863 | 1 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0238 | 0.43 | 0.4216 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0238 | 0.43 | 0.619 |
Plasmodium vivax | DNA gyrase subunit A, putative | 0.0354 | 0.6863 | 1 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0238 | 0.43 | 0.5 |
Trypanosoma brucei | mitogen-activated protein kinase 3, putative | 0.0497 | 1 | 1 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.0217 | 0.386 | 0.386 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.0251 | 0.4603 | 0.1181 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0183 | 0.3097 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.256 | 0.245 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0158 | 0.256 | 0.245 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase subunit A | 0.0354 | 0.6863 | 1 |
Toxoplasma gondii | DNA gyrase/topoisomerase IV, A subunit domain-containing protein | 0.0354 | 0.6863 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0311 | 0.5911 | 0.5911 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0238 | 0.43 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.2316 | 0.2202 |
Loa Loa (eye worm) | CMGC/MAPK/P38 protein kinase | 0.0497 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 14 | 0.0497 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.097 | 0.0836 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.2316 | 0.2202 |
Echinococcus multilocularis | muscleblind protein | 0.0158 | 0.256 | 0.245 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.0238 | 0.43 | 0.3194 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.2714 | 0.6183 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0141 | 0.2176 | 0.2176 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
432 literature references were collected for this gene.