Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | Curated by TDR Targets | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | phosphofructokinase | 0.0231 | 1 | 1 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0062 | 0.0039 | 0.0039 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0183 | 0.7147 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0183 | 0.7147 | 1 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0231 | 1 | 1 |
Onchocerca volvulus | 0.013 | 0.402 | 0.5 | |
Echinococcus granulosus | geminin | 0.0186 | 0.7322 | 0.5522 |
Mycobacterium tuberculosis | Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) | 0.0231 | 1 | 1 |
Trypanosoma cruzi | ATP-dependent 6-phosphofructokinase, glycosomal | 0.0231 | 1 | 1 |
Mycobacterium leprae | PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) | 0.0231 | 1 | 1 |
Trichomonas vaginalis | 6-phosphofructokinase, putative | 0.0062 | 0.0039 | 0.0039 |
Schistosoma mansoni | hypothetical protein | 0.0186 | 0.7322 | 0.5522 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0062 | 0.0039 | 0.0039 |
Chlamydia trachomatis | fructose-6-phosphate phosphotransferase | 0.0062 | 0.0039 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0183 | 0.7147 | 1 |
Giardia lamblia | Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit | 0.0062 | 0.0039 | 0.5 |
Mycobacterium ulcerans | 6-phosphofructokinase | 0.0231 | 1 | 1 |
Brugia malayi | 6-phosphofructokinase | 0.0231 | 1 | 1 |
Brugia malayi | 6-phosphofructokinase | 0.0231 | 1 | 1 |
Leishmania major | ATP-dependent phosphofructokinase | 0.0231 | 1 | 1 |
Echinococcus multilocularis | geminin | 0.0186 | 0.7322 | 0.5522 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0231 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0183 | 0.7147 | 0.7147 |
Echinococcus granulosus | 6 phosphofructokinase | 0.0231 | 1 | 1 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0231 | 1 | 1 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0062 | 0.0039 | 0.0039 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0062 | 0.0039 | 0.0039 |
Brugia malayi | thymidylate synthase | 0.013 | 0.402 | 0.402 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.013 | 0.402 | 0.402 |
Trypanosoma brucei | ATP-dependent 6-phosphofructokinase, glycosomal | 0.0231 | 1 | 1 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0231 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0186 | 0.7322 | 0.5522 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0231 | 1 | 1 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0231 | 1 | 1 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0231 | 1 | 1 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0231 | 1 | 1 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0062 | 0.0039 | 0.0039 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0231 | 1 | 1 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0231 | 1 | 1 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0231 | 1 | 1 |
Treponema pallidum | diphosphate--fructose-6-phosphate 1-phosphotransferase | 0.0231 | 1 | 1 |
Echinococcus multilocularis | 6 phosphofructokinase | 0.0231 | 1 | 1 |
Chlamydia trachomatis | fructose-6-phosphate phosphotransferase | 0.0062 | 0.0039 | 0.5 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0062 | 0.0039 | 0.0039 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -9.698 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -9.404 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -8.992 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -7.602 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the P388 Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -7.57 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -7.501 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -7.366 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -7.344 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.125 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.977 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Targets |
---|---|---|---|---|---|---|
catalytic activity (GO:0003824) | decreased (PATO:0000468) | inferred from enzyme inhibition (ECO:0000184) | Trypanosoma cruzi | 35605 | ||
Annotator: | millerja@u.washington.edu | Comment: | References: | 16048931 | ||
growth (GO:0040007) | lethal (sensu genetics) (PATO:0000718) | amastigote (BTO:0000062) | inferred from in vitro culture assay (ECO:0000182) | Trypanosoma cruzi | 35605 | |
Annotator: | millerja@u.washington.edu | Comment: | References: | 16048931 |
2 literature references were collected for this gene.