Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | lamin | 0.0054 | 0.0187 | 0.014 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0064 | 0.0256 | 0.2009 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0038 | 0.0064 | 0.0017 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0054 | 0.0187 | 0.1465 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.016 | 0.0967 | 0.0924 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0201 | 0.1275 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0064 | 0.0256 | 0.021 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0138 | 0.0803 | 0.6301 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0064 | 0.0256 | 0.021 |
Schistosoma mansoni | hypothetical protein | 0.0138 | 0.0803 | 0.076 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0035 | 0.0047 | 0.5 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0035 | 0.0047 | 0.0368 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0038 | 0.0064 | 0.0017 |
Schistosoma mansoni | alpha-glucosidase | 0.0137 | 0.0802 | 0.0759 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.138 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0064 | 0.0017 |
Echinococcus multilocularis | lamin | 0.0054 | 0.0187 | 0.014 |
Leishmania major | hypothetical protein, conserved | 0.005 | 0.0158 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0054 | 0.0187 | 0.014 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.005 | 0.0158 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.005 | 0.0158 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0054 | 0.0187 | 0.014 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0064 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0201 | 0.1275 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0064 | 0.0256 | 0.2009 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0179 | 0.1407 |
Schistosoma mansoni | hypothetical protein | 0.0064 | 0.0256 | 0.021 |
Schistosoma mansoni | hypothetical protein | 0.0064 | 0.0256 | 0.021 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.0803 | 0.6301 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0035 | 0.0047 | 0.5 |
Echinococcus granulosus | lamin dm0 | 0.0054 | 0.0187 | 0.014 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0158 | 0.1237 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0054 | 0.0187 | 0.1465 |
Echinococcus multilocularis | GPCR, family 2 | 0.0064 | 0.0256 | 0.021 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.005 | 0.0158 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0064 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0137 | 0.0802 | 0.0759 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0035 | 0.0047 | 0.5 |
Brugia malayi | intermediate filament protein | 0.0054 | 0.0187 | 0.1465 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0035 | 0.0047 | 0.5 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0064 | 0.0256 | 0.021 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0064 | 0.0256 | 0.021 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.005 | 0.0158 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0035 | 0.0047 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.005 | 0.0158 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.005 | 0.0158 | 1 |
Schistosoma mansoni | lamin | 0.0054 | 0.0187 | 0.014 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0123 | 0.0698 | 0.5478 |
Echinococcus multilocularis | musashi | 0.0054 | 0.0187 | 0.014 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.016 | 0.0967 | 0.0924 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.005 | 0.0158 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0038 | 0.0064 | 0.0017 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0035 | 0.0047 | 0.0368 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0035 | 0.0047 | 0.5 |
Brugia malayi | hypothetical protein | 0.0033 | 0.0025 | 0.02 |
Schistosoma mansoni | hypothetical protein | 0.0064 | 0.0256 | 0.021 |
Brugia malayi | hypothetical protein | 0.005 | 0.0158 | 0.1237 |
Loa Loa (eye worm) | hypothetical protein | 0.0201 | 0.1275 | 1 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.016 | 0.0967 | 0.0924 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.016 | 0.0967 | 0.7585 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0201 | 0.1275 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.016 | 0.0967 | 0.7585 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0187 | 0.1465 |
Onchocerca volvulus | 0.0092 | 0.0468 | 1 | |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0035 | 0.0047 | 0.5 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0064 | 0.0256 | 0.2009 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0256 | 0.2009 |
Brugia malayi | hypothetical protein | 0.0038 | 0.0064 | 0.0502 |
Loa Loa (eye worm) | intermediate filament protein | 0.0054 | 0.0187 | 0.1465 |
Echinococcus granulosus | GPCR family 2 | 0.0064 | 0.0256 | 0.021 |
Schistosoma mansoni | lamin | 0.0054 | 0.0187 | 0.014 |
Schistosoma mansoni | intermediate filament proteins | 0.0054 | 0.0187 | 0.014 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0035 | 0.0047 | 0.5 |
Schistosoma mansoni | microtubule-associated protein tau | 0.138 | 1 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0035 | 0.0047 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0064 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0123 | 0.0698 | 0.5478 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0064 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0064 | 0.0256 | 0.021 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0123 | 0.0698 | 0.5478 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 0 % | GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. | ChEMBL. | 20485427 |
Inhibition (functional) | = 1.61 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 2 % | GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 2.16 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 3.72 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 8 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 92 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition frequency index (IFI) (functional) | = 0.75 | Inhibition Frequency Index (IFI) | GSK. | 20485427 |
Percent growth inhibition (functional) | = -2 % | Percent inhibition of HepG2 growth (at 10 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 2 % | Percent inhibition of P. falciparum Dd2 growth (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 8 % | Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 92 % | Percent inhibition of P. falciparum 3D7 growth (at 2 uM) | GSK. | 20485427 |
XC50 (functional) | = 5.97 | XC50 determination of P. falciparum 3D7 growth | GSK. | 20485427 |
XC50 (functional) | = 1.07633 uM | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. | ChEMBL. | 20485427 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.