IC50 (functional)
|
> 100 uM
|
PubChem BioAssay. Dose Response Confirmation of SKN-1 Inhibitor hits in a fluorescence ratio assay. (Class of assay: confirmatory)
|
ChEMBL.
|
No reference
|
Inhibition (functional)
|
= -0.23 %
|
ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro
|
ChEMBL.
|
No reference
|
Inhibition (functional)
|
= 0 %
|
GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM.
|
ChEMBL.
|
20485427
|
Inhibition (functional)
|
= 0 %
|
GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM
|
ChEMBL.
|
20485427
|
Inhibition (functional)
|
= 0.43 %
|
ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro
|
ChEMBL.
|
No reference
|
Inhibition (functional)
|
= 1 %
|
GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM
|
ChEMBL.
|
20485427
|
Inhibition (functional)
|
= 2.14 %
|
ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro
|
ChEMBL.
|
No reference
|
Inhibition (functional)
|
= 92 %
|
GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM
|
ChEMBL.
|
20485427
|
Inhibition frequency index (IFI) (functional)
|
= 0
|
Inhibition Frequency Index (IFI)
|
GSK.
|
20485427
|
Percent growth inhibition (functional)
|
= -7 %
|
Percent inhibition of HepG2 growth (at 10 uM)
|
GSK.
|
20485427
|
Percent growth inhibition (functional)
|
= -1 %
|
Percent inhibition of P. falciparum Dd2 growth (at 2 uM)
|
GSK.
|
20485427
|
Percent growth inhibition (functional)
|
= 1 %
|
Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM)
|
GSK.
|
20485427
|
Percent growth inhibition (functional)
|
= 92 %
|
Percent inhibition of P. falciparum 3D7 growth (at 2 uM)
|
GSK.
|
20485427
|
Potency (functional)
|
= 2.5119 um
|
PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory)
|
ChEMBL.
|
No reference
|
Potency (functional)
|
= 3.5481 um
|
PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory)
|
ChEMBL.
|
No reference
|
Potency (functional)
|
= 6.3096 um
|
PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory)
|
ChEMBL.
|
No reference
|
Potency (functional)
|
7.9433 uM
|
PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855]
|
ChEMBL.
|
No reference
|
Potency (functional)
|
= 12.5893 um
|
PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature. (Class of assay: confirmatory)
|
ChEMBL.
|
No reference
|
Potency (functional)
|
13.1154 uM
|
PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]
|
ChEMBL.
|
No reference
|
Potency (functional)
|
= 15.8489 um
|
PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory)
|
ChEMBL.
|
No reference
|
Potency (functional)
|
20.5962 uM
|
PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143]
|
ChEMBL.
|
No reference
|
Potency (functional)
|
20.5962 uM
|
PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125]
|
ChEMBL.
|
No reference
|
Potency (functional)
|
21.3313 uM
|
PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411]
|
ChEMBL.
|
No reference
|
Potency (functional)
|
= 31.6228 um
|
PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature. (Class of assay: confirmatory) [Related pubchem assays: 902 ]
|
ChEMBL.
|
No reference
|
Potency (functional)
|
70.7946 uM
|
PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709]
|
ChEMBL.
|
No reference
|
XC50 (functional)
|
= 6
|
XC50 determination of P. falciparum 3D7 growth
|
GSK.
|
20485427
|
XC50 (functional)
|
= 0.99074 uM
|
GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth.
|
ChEMBL.
|
20485427
|