Detailed information for compound 600547

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 913.18 | Formula: C43H53Br2ClN6O4
  • H donors: 2 H acceptors: 2 LogP: 9.25 Rotable bonds: 18
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1ccc(cc1N1CCN(CC1)CCCCCCCN1CCN(CC1)c1cc(ccc1OC)NC(=O)c1cccc(c1)Br)NC(=O)c1cccc(c1)Br.Cl
  • InChi: 1S/C43H52Br2N6O4.ClH/c1-54-40-16-14-36(46-42(52)32-10-8-12-34(44)28-32)30-38(40)50-24-20-48(21-25-50)18-6-4-3-5-7-19-49-22-26-51(27-23-49)39-31-37(15-17-41(39)55-2)47-43(53)33-11-9-13-35(45)29-33;/h8-17,28-31H,3-7,18-27H2,1-2H3,(H,46,52)(H,47,53);1H
  • InChiKey: PRIPEQQQJUCBOD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0048 0.0022 0.0295
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0164 0.0122 0.0762
Trichomonas vaginalis PIKK family atypical protein kinase 0.0077 0.0047 0.0636
Schistosoma mansoni chromobox protein 0.0048 0.0022 0.0022
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0059 0.0793
Brugia malayi glutamate synthase 0.0164 0.0122 0.0797
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0616 0.0515 0.3352
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0027 0.036
Onchocerca volvulus 0.0048 0.0022 0.05
Entamoeba histolytica hypothetical protein 0.0048 0.0022 0.1771
Mycobacterium tuberculosis Probable reductase 0.4056 0.3497 0.8979
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0035 0.0011 0.0072
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0084 0.0053 0.0051
Trichomonas vaginalis set domain proteins, putative 0.0519 0.043 0.5889
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0022 0.0295
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0011 0.0139
Schistosoma mansoni glutamate synthase 0.0164 0.0122 0.0122
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0164 0.0122 0.1663
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0616 0.0515 0.0515
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0164 0.0122 0.0203
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0196 0.015 0.0986
Schistosoma mansoni sulfide quinone reductase 0.0164 0.0122 0.0122
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0164 0.0122 0.0762
Loa Loa (eye worm) hypothetical protein 0.0192 0.0147 0.0965
Echinococcus granulosus chromobox protein 1 0.0296 0.0237 0.0236
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.009 0.0059 0.4769
Brugia malayi Associated with TFs and helicases family protein 0.0048 0.0022 0.0141
Plasmodium falciparum thioredoxin reductase 0.0616 0.0515 0.3333
Trichomonas vaginalis mercuric reductase, putative 0.0616 0.0515 0.7045
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0023 0.0299
Brugia malayi glutathione reductase 0.1778 0.1522 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0027 0.036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0039 0.0518
Mycobacterium tuberculosis Possible penicillin-binding protein 0.047 0.0388 0.0894
Echinococcus multilocularis cysteine protease 0.0035 0.0011 0.0009
Echinococcus multilocularis Chromobox protein 3 0.0048 0.0022 0.0021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0027 0.036
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0043 0.0017 0.0071
Entamoeba histolytica cysteine proteinase, putative 0.0035 0.0011 0.0837
Brugia malayi Valyl-tRNA synthetase 0.0048 0.0022 0.0141
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0048 0.0022 0.0075
Echinococcus multilocularis microtubule associated protein 2 1.1555 1 1
Brugia malayi Heterochromatin protein 1 0.0296 0.0237 0.1553
Trypanosoma cruzi hypothetical protein, conserved 0.0164 0.0122 0.0762
Leishmania major cathepsin L-like protease 0.0035 0.0011 0.0029
Echinococcus multilocularis cathepsin L cysteine protease 0.0035 0.0011 0.0009
Brugia malayi Thioredoxin reductase 0.1778 0.1522 1
Loa Loa (eye worm) hypothetical protein 0.0166 0.0124 0.0817
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0164 0.0122 0.0797
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0616 0.0515 0.3352
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0048 0.0022 0.0295
Loa Loa (eye worm) hypothetical protein 0.0074 0.0044 0.029
Loa Loa (eye worm) hypothetical protein 0.0024 0.0001 0.0006
Loa Loa (eye worm) hypothetical protein 0.0048 0.0022 0.0147
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0011 0.0139
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0039 0.0518
Entamoeba histolytica cysteine protease, putative 0.0035 0.0011 0.0837
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0048 0.0022 0.0075
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0048 0.0022 0.1771
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0164 0.0122 0.0762
Trichomonas vaginalis esterase, putative 0.0074 0.0044 0.0593
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0035 0.0011 0.0072
Trichomonas vaginalis chromobox protein, putative 0.0179 0.0135 0.1842
Schistosoma mansoni sulfide quinone reductase 0.0164 0.0122 0.0122
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0164 0.0122 0.0797
Brugia malayi Bromodomain containing protein 0.0042 0.0017 0.0105
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0023 0.0298
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0135 0.0097 0.0598
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0616 0.0515 0.0514
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0007 0.0079
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0164 0.0122 0.0735
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0035 0.0011 0.0139
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0616 0.0515 0.3352
Schistosoma mansoni chromobox protein 0.0296 0.0237 0.0237
Loa Loa (eye worm) RNA binding protein 0.0069 0.004 0.0263
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0011 0.0139
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0039 0.0518
Echinococcus multilocularis cathepsin L cysteine protease 0.0035 0.0011 0.0009
Loa Loa (eye worm) hypothetical protein 0.0074 0.0044 0.029
Trichomonas vaginalis conserved hypothetical protein 0.0166 0.0124 0.1693
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0048 0.0022 0.0295
Brugia malayi RNA recognition motif domain containing protein 0.0069 0.004 0.0258
Onchocerca volvulus 0.0074 0.0044 0.1006
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0616 0.0515 0.3377
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0039 0.0518
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0063 0.0035 0.0034
Schistosoma mansoni cathepsin F (C01 family) 0.0035 0.0011 0.0011
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0616 0.0515 0.1223
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0164 0.0122 0.0762
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0164 0.0122 0.0735
Leishmania major hypothetical protein, conserved 0.0074 0.0044 0.0247
Brugia malayi Papain family cysteine protease containing protein 0.0035 0.0011 0.0067
Onchocerca volvulus 0.0035 0.0011 0.0236
Onchocerca volvulus 0.0114 0.0079 0.1821
Loa Loa (eye worm) hypothetical protein 0.0094 0.0062 0.0409
Echinococcus granulosus cathepsin L cysteine proteinase 0.0035 0.0011 0.001
Plasmodium vivax SET domain protein, putative 0.0065 0.0037 0.0172
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0135 0.0097 0.0598
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0043 0.0573
Brugia malayi beta-lactamase family protein 0.0074 0.0044 0.0284
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0039 0.0518
Loa Loa (eye worm) heterochromatin protein 1 0.0296 0.0237 0.1558
Onchocerca volvulus 0.013 0.0093 0.215
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0048 0.0022 0.0021
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0616 0.0515 0.3352
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0048 0.0022 0.0295
Loa Loa (eye worm) glutathione reductase 0.1778 0.1522 1
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0164 0.0122 0.012
Echinococcus multilocularis musashi 0.0196 0.015 0.0148
Echinococcus granulosus Chromo domain 0.0048 0.0022 0.0021
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0011 0.0139
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0616 0.0515 0.3352
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0164 0.0122 0.0121
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0135 0.0097 0.0598
Trypanosoma cruzi NADH dehydrogenase, putative 0.0164 0.0122 0.0762
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0007 0.0079
Plasmodium falciparum thioredoxin reductase 0.1778 0.1522 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.4056 0.3497 0.8979
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0048 0.0022 0.0022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0039 0.0518
Echinococcus multilocularis glutamate synthase 0.0164 0.0122 0.012
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0022 0.0295
Entamoeba histolytica thioredoxin reductase, putative 0.0164 0.0122 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0043 0.0573
Trichomonas vaginalis PIKK family atypical protein kinase 0.0059 0.0031 0.0416
Onchocerca volvulus 0.0074 0.0044 0.1006
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0048 0.0022 0.1771
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0048 0.0022 0.0022
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0105 0.0071 0.0468
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0011 0.0139
Brugia malayi cytoplasmic intermediate filament protein 0.0105 0.0071 0.0463
Trichomonas vaginalis chromobox protein, putative 0.0296 0.0237 0.324
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0051 0.0024 0.0023
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0616 0.0515 0.3333
Trichomonas vaginalis glutathione reductase, putative 0.0616 0.0515 0.7045
Loa Loa (eye worm) MH2 domain-containing protein 0.0251 0.0198 0.1298
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0094 0.0062 0.006
Trichomonas vaginalis chromobox protein, putative 0.0048 0.0022 0.0295
Echinococcus granulosus chromobox protein 2 0.0048 0.0022 0.0021
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0135 0.0097 0.0598
Echinococcus multilocularis chromobox protein 1 0.0296 0.0237 0.0235
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0044 0.0247
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0164 0.0122 0.0203
Loa Loa (eye worm) cysteine protease 0.0035 0.0011 0.0072
Leishmania major hypothetical protein, conserved 0.0164 0.0122 0.0762
Plasmodium vivax heterochromatin protein 1, putative 0.0048 0.0022 0.0075
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0011 0.0139
Brugia malayi MH2 domain containing protein 0.0251 0.0198 0.1293
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0044 0.0593
Trichomonas vaginalis chromobox protein, putative 0.0296 0.0237 0.324
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0164 0.0122 0.1663
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0164 0.0122 0.0762
Onchocerca volvulus 0.0519 0.043 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0023 0.0299
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0007 0.0079
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.009 0.0059 0.0344
Loa Loa (eye worm) fibroinase 0.0035 0.0011 0.0072
Trypanosoma cruzi target of rapamycin kinase 3 0.0072 0.0043 0.0238
Treponema pallidum NADH oxidase 0.0616 0.0515 1
Onchocerca volvulus 0.0035 0.0011 0.0236
Brugia malayi CHD4 protein 0.0051 0.0024 0.0153
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0164 0.0122 0.1138
Loa Loa (eye worm) hypothetical protein 0.0042 0.0017 0.0111
Echinococcus multilocularis lamin 0.0196 0.015 0.0148
Echinococcus granulosus thioredoxin glutathione reductase 0.1789 0.1532 0.1531
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0164 0.0122 0.0203
Entamoeba histolytica hypothetical protein 0.0048 0.0022 0.1771
Schistosoma mansoni chromobox protein 0.0296 0.0237 0.0237
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0048 0.0022 0.0295
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0059 0.0793
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.009 0.0059 0.0057
Schistosoma mansoni chromobox protein 0.0048 0.0022 0.0022
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.4056 0.3497 0.8979
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0164 0.0122 0.0203
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0164 0.0122 0.1663
Loa Loa (eye worm) hypothetical protein 0.0084 0.0053 0.035
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0616 0.0515 0.6859
Mycobacterium ulcerans hypothetical protein 0.0164 0.0122 0.1138
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0069 0.004 0.0263
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0453 0.0373 0.2445
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0164 0.0122 0.0121
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0164 0.0122 0.0203
Loa Loa (eye worm) hypothetical protein 0.0048 0.0022 0.0147
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0011 0.0139
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0616 0.0515 0.3333
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0164 0.0122 0.012
Brugia malayi PHD-finger family protein 0.0027 0.0004 0.0021
Echinococcus multilocularis tar DNA binding protein 0.0069 0.004 0.0038
Plasmodium falciparum glutathione reductase 0.1778 0.1522 1
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0164 0.0122 0.0735
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0164 0.0122 0.0203
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.004 0.0015 0.0013
Schistosoma mansoni cellular tumor antigen P53 0.0105 0.0071 0.0071
Trichomonas vaginalis conserved hypothetical protein 0.0166 0.0124 0.1693
Plasmodium falciparum glutathione reductase 0.0616 0.0515 0.3333
Loa Loa (eye worm) hypothetical protein 0.0196 0.015 0.0986
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0022 0.0295
Mycobacterium ulcerans glutamate synthase subunit beta 0.0164 0.0122 0.1138
Loa Loa (eye worm) hypothetical protein 0.0048 0.0022 0.0147
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0616 0.0515 0.6859
Brugia malayi SET domain containing protein 0.0051 0.0024 0.0155
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0164 0.0122 0.0203
Loa Loa (eye worm) hypothetical protein 0.0091 0.0059 0.0388
Leishmania major cathepsin L-like protease 0.0035 0.0011 0.0029
Onchocerca volvulus 0.0035 0.0011 0.0236
Onchocerca volvulus 0.0105 0.0071 0.1635
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0022 0.0295
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.1778 0.1522 0.3843
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0164 0.0122 0.0121
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0179 0.0135 0.3129
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.003 0.0007 0.0006
Schistosoma mansoni glutaminase 0.0865 0.073 0.073
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0011 0.0139
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0164 0.0122 0.012
Brugia malayi Bromodomain containing protein 0.0083 0.0052 0.0335
Toxoplasma gondii ABC1 family protein 0.0074 0.0044 0.0219
Leishmania major NADH dehydrogenase, putative 0.0164 0.0122 0.0762
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0044 0.0593
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0135 0.0097 0.0598
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0164 0.0122 0.1663
Echinococcus granulosus Chromobox protein 3 0.0048 0.0022 0.0021
Loa Loa (eye worm) hypothetical protein 0.0024 0.0001 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0043 0.0573
Leishmania major cathepsin L-like protease 0.0135 0.0097 0.0598
Schistosoma mansoni microtubule-associated protein tau 1.1555 1 1
Trichomonas vaginalis chromobox protein, putative 0.0179 0.0135 0.1842
Trypanosoma cruzi NADH dehydrogenase, putative 0.0164 0.0122 0.0762
Leishmania major cathepsin L-like protease 0.0135 0.0097 0.0598
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0044 0.0247
Mycobacterium ulcerans glutaminase 0.0865 0.073 1
Schistosoma mansoni hypothetical protein 0.0048 0.0022 0.0022
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0035 0.0011 0.0009
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0166 0.0124 0.2874
Onchocerca volvulus 0.0196 0.015 0.3474
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.0044 0.029
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0135 0.0097 0.0598
Schistosoma mansoni tar DNA-binding protein 0.0069 0.004 0.004
Schistosoma mansoni lamin 0.0196 0.015 0.015
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0048 0.0022 0.0075
Trichomonas vaginalis chromobox protein, putative 0.0048 0.0022 0.0295
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0164 0.0122 0.1138
Onchocerca volvulus Cathepsin L homolog 0.0035 0.0011 0.0236
Plasmodium vivax thioredoxin reductase, putative 0.1778 0.1522 1
Onchocerca volvulus 0.0035 0.0011 0.0236
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0164 0.0122 0.1663
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0048 0.0022 0.0295
Mycobacterium tuberculosis Putative ferredoxin reductase 0.4056 0.3497 0.8979
Trichomonas vaginalis apoptosis inducing factor, putative 0.0164 0.0122 0.1663
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0616 0.0515 0.3352
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0164 0.0122 0.0762
Echinococcus multilocularis thioredoxin glutathione reductase 0.1789 0.1532 0.153
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0616 0.0515 0.3352
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0616 0.0515 0.3352
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.4509 0.389 1
Leishmania major hypothetical protein, conserved 0.0164 0.0122 0.0762
Loa Loa (eye worm) helicase 0.0048 0.0022 0.0147
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0164 0.0122 0.0121
Echinococcus granulosus histone lysine methyltransferase setb 0.0084 0.0053 0.0052
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0011 0.0139
Loa Loa (eye worm) transcription factor SMAD2 0.0251 0.0198 0.1298
Onchocerca volvulus 0.0048 0.0022 0.05
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0043 0.0573
Brugia malayi Cathepsin L-like precursor 0.0035 0.0011 0.0067
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.4509 0.389 1
Entamoeba histolytica disulphide oxidoreductase, putative 0.0164 0.0122 1
Onchocerca volvulus Cathepsin F homolog 0.0035 0.0011 0.0236
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0164 0.0122 0.012
Leishmania major cathepsin L-like protease 0.0035 0.0011 0.0029
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0164 0.0122 0.0203
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0048 0.0022 0.0295
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0002 0.0001
Trypanosoma cruzi trypanothione reductase, putative 0.0616 0.0515 0.3352
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.009 0.0059 0.038
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0456 0.0376 0.2468
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0453 0.0373 0.2445
Trichomonas vaginalis glutamate synthase, putative 0.0164 0.0122 0.1663
Mycobacterium ulcerans ferredoxin reductase 0.0164 0.0122 0.1138
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0164 0.0122 0.1663
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0043 0.0573
Echinococcus granulosus chromobox protein 1 0.0296 0.0237 0.0236
Brugia malayi TAR-binding protein 0.0069 0.004 0.0258
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0007 0.0079
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.4056 0.3497 0.8979
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0044 0.0219
Onchocerca volvulus Cathepsin L homolog 0.0035 0.0011 0.0236
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0011 0.0139
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0164 0.0122 0.0762
Onchocerca volvulus 0.0074 0.0044 0.1006
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0048 0.0022 0.0295
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0164 0.0122 0.1391
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0164 0.0122 0.0735
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0616 0.0515 0.3352
Trichomonas vaginalis PIKK family atypical protein kinase 0.0061 0.0033 0.0439
Brugia malayi intermediate filament protein 0.0196 0.015 0.0981
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0616 0.0515 1
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0164 0.0122 0.0735
Leishmania major cathepsin L-like protease 0.0135 0.0097 0.0598
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.009 0.0059 0.0344
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.009 0.0059 0.0344
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0616 0.0515 0.3352
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0048 0.0022 0.0141
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0011 0.0139
Trypanosoma cruzi cysteine peptidase, putative 0.0035 0.0011 0.0029
Entamoeba histolytica cysteine proteinase, putative 0.0035 0.0011 0.0837
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0616 0.0515 1
Brugia malayi hypothetical protein 0.0048 0.0022 0.0141
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0023 0.0299
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.0044 0.0043
Schistosoma mansoni intermediate filament proteins 0.0196 0.015 0.015
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0164 0.0122 0.012
Loa Loa (eye worm) hypothetical protein 0.013 0.0093 0.0612
Brugia malayi Protein cec-1. 0.0048 0.0022 0.0141
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0065 0.0037 0.0035
Plasmodium falciparum ferrodoxin reductase-like protein 0.0164 0.0122 0.0735
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0164 0.0122 0.0762
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0164 0.0122 0.1663
Brugia malayi Cathepsin L-like precursor 0.0035 0.0011 0.0067
Entamoeba histolytica hypothetical protein 0.0048 0.0022 0.1771
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0135 0.0097 0.0598
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0044 0.0044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0027 0.0354
Schistosoma mansoni cathepsin F (C01 family) 0.0035 0.0011 0.0011
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0164 0.0122 0.0735
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0616 0.0515 0.3352
Schistosoma mansoni lamin 0.0196 0.015 0.015
Leishmania major cysteine peptidase A (CPA) 0.0035 0.0011 0.0029
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0048 0.0022 0.0295
Loa Loa (eye worm) hypothetical protein 0.0074 0.0044 0.029
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.4056 0.3497 0.8979
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0048 0.0022 0.0295
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0164 0.0122 0.1663
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0072 0.0043 0.0238
Brugia malayi Cathepsin L-like precursor 0.0035 0.0011 0.0067
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0616 0.0515 0.3352
Loa Loa (eye worm) hypothetical protein 0.0074 0.0044 0.029
Schistosoma mansoni tar DNA-binding protein 0.0069 0.004 0.004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0023 0.0298
Loa Loa (eye worm) thioredoxin reductase 0.1778 0.1522 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0011 0.0139
Trypanosoma cruzi cysteine peptidase, putative 0.0135 0.0097 0.0598
Trypanosoma cruzi major cysteine proteinase, putative 0.0106 0.0072 0.0433
Loa Loa (eye worm) phosphatidylinositol 3 0.009 0.0059 0.0386
Loa Loa (eye worm) programmed cell death 8 0.0164 0.0122 0.0802
Schistosoma mansoni bromodomain containing protein 0.007 0.0041 0.0041
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0164 0.0122 0.0762
Brugia malayi Pre-SET motif family protein 0.0065 0.0037 0.0238
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0135 0.0097 0.0598
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0023 0.0299
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.0044 0.0042
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0164 0.0122 0.0735
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0048 0.0022 0.0022
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0164 0.0122 0.0802
Brugia malayi beta-lactamase family protein 0.0074 0.0044 0.0284
Loa Loa (eye worm) hypothetical protein 0.0078 0.0048 0.0314
Echinococcus multilocularis lamin dm0 0.0196 0.015 0.0148
Trypanosoma cruzi cruzipain precursor, putative 0.0135 0.0097 0.0598
Loa Loa (eye worm) TAR-binding protein 0.0069 0.004 0.0263
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0616 0.0515 0.3352
Toxoplasma gondii selenide, water dikinase 0.0164 0.0122 0.0735
Loa Loa (eye worm) intermediate filament protein 0.0196 0.015 0.0986
Trichomonas vaginalis Heterochromatin protein, putative 0.0048 0.0022 0.0295
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0164 0.0122 0.012
Trypanosoma cruzi cysteine peptidase, putative 0.0135 0.0097 0.0598
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0164 0.0122 0.0121
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0044 0.0247
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0007 0.0079
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.009 0.0059 0.0344
Echinococcus granulosus tar DNA binding protein 0.0069 0.004 0.0039
Loa Loa (eye worm) hypothetical protein 0.0091 0.0059 0.0388
Schistosoma mansoni disulfide oxidoreductase 0.0164 0.0122 0.0122
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0038 0.0013 0.0041
Echinococcus granulosus glutamate synthase 0.0164 0.0122 0.0121
Trypanosoma brucei hypothetical protein, conserved 0.0164 0.0122 0.0762
Trichomonas vaginalis glutaminase, putative 0.0865 0.073 1
Toxoplasma gondii thioredoxin reductase 0.1778 0.1522 1
Onchocerca volvulus 0.0164 0.0122 0.2824
Plasmodium vivax hypothetical protein, conserved 0.0048 0.0022 0.0075
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0066 0.0037 0.0035
Loa Loa (eye worm) hypothetical protein 0.0024 0.0001 0.0006
Echinococcus granulosus lamin dm0 0.0196 0.015 0.0149
Loa Loa (eye worm) hypothetical protein 0.0164 0.0122 0.0802
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0164 0.0122 0.0203
Loa Loa (eye worm) phosphatidylinositol 3 0.003 0.0007 0.0043
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0616 0.0515 0.3333
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0066 0.0037 0.0036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0001 0.0007
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.009 0.0059 0.0058
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.003 0.0007 0.0007
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.009 0.0059 0.0344
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0616 0.0515 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0065 0.0037 0.0037
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0044 0.0044
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0011 0.0139
Mycobacterium tuberculosis Probable oxidoreductase 0.4509 0.389 1
Giardia lamblia NADH oxidase lateral transfer candidate 0.0616 0.0515 1
Trypanosoma cruzi hypothetical protein, conserved 0.0164 0.0122 0.0762
Mycobacterium ulcerans NADH dehydrogenase 0.0164 0.0122 0.1138
Loa Loa (eye worm) hypothetical protein 0.0048 0.0022 0.0147
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0164 0.0122 0.0735
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0044 0.0593
Schistosoma mansoni cathepsin F (C01 family) 0.0024 0.0001 0.0001
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0616 0.0515 0.3352
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0094 0.0062 0.0061
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0164 0.0122 1
Onchocerca volvulus 0.0035 0.0011 0.0236
Brugia malayi M-phase phosphoprotein, mpp8 0.0048 0.0022 0.0141
Brugia malayi glutaminase DH11.1 0.0865 0.073 0.4793
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.004 0.0015 0.0014
Toxoplasma gondii NADPH-glutathione reductase 0.0616 0.0515 0.3333
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0084 0.0053 0.0053
Echinococcus granulosus cathepsin l1 0.0035 0.0011 0.001
Leishmania major cathepsin L-like protease 0.0035 0.0011 0.0029
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0035 0.0011 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0023 0.0298
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.4509 0.389 1
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0051 0.0024 0.0022
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0616 0.0515 0.3333
Trypanosoma cruzi cysteine peptidase, putative 0.0135 0.0097 0.0598
Schistosoma mansoni hypothetical protein 0.0164 0.0122 0.0122
Echinococcus multilocularis tumor protein p63 0.0715 0.06 0.0599
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0072 0.0043 0.0238
Echinococcus granulosus lamin 0.0196 0.015 0.0149
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0011 0.0139
Trichomonas vaginalis hypothetical protein 0.0048 0.0022 0.0295
Onchocerca volvulus 0.0035 0.0011 0.0236
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0048 0.0022 0.0075
Trichomonas vaginalis conserved hypothetical protein 0.0118 0.0082 0.1116
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0164 0.0122 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0011 0.0139
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0164 0.0122 0.1138
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0114 0.0079 0.0079
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0164 0.0122 0.1663
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0011 0.0139
Loa Loa (eye worm) hypothetical protein 0.0048 0.0022 0.0147
Echinococcus multilocularis cysteine protease 0.0035 0.0011 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0022 0.0295
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0164 0.0122 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0135 0.0097 0.0598
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0051 0.0024 0.0024
Giardia lamblia Thioredoxin reductase 0.0164 0.0122 0.1391
Mycobacterium ulcerans dehydrogenase 0.0164 0.0122 0.1138
Loa Loa (eye worm) hypothetical protein 0.0048 0.0022 0.0147
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0164 0.0122 0.1663
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.003 0.0007 0.0005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0011 0.0139
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0616 0.0515 0.6859
Brugia malayi Cathepsin L-like precursor 0.0035 0.0011 0.0067
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0011 0.0139
Echinococcus granulosus cathepsin l cysteine peptidase 0.0035 0.0011 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0022 0.0295
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0011 0.0139
Leishmania major trypanothione reductase 0.1778 0.1522 1
Leishmania major cathepsin L-like protease 0.0035 0.0011 0.0029
Brugia malayi RNA binding protein 0.0069 0.004 0.0258
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0135 0.0097 0.0598
Onchocerca volvulus 0.0035 0.0011 0.0236
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0048 0.0022 0.0021
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0048 0.0022 0.0295
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0616 0.0515 0.3352
Mycobacterium tuberculosis Probable dehydrogenase 0.4056 0.3497 0.8979
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0035 0.0011 0.0072
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0011 0.0139
Schistosoma mansoni glutamate synthase 0.0164 0.0122 0.0122
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.009 0.0059 0.0344
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0039 0.0518
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0065 0.0037 0.0172
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0616 0.0515 0.0513
Schistosoma mansoni tar DNA-binding protein 0.0069 0.004 0.004
Trichomonas vaginalis conserved hypothetical protein 0.0118 0.0082 0.1116
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0022 0.0295
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0011 0.0139
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0164 0.0122 0.0121
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.0044 0.0284
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0022 0.0295
Loa Loa (eye worm) ctsf protein 0.0035 0.0011 0.0072
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0035 0.0011 0.0139
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0044 0.0593
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0616 0.0515 0.3352
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0011 0.0139
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0044 0.0593
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0164 0.0122 0.0762
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0048 0.0022 0.0295
Schistosoma mansoni glutamate synthase 0.0164 0.0122 0.0122
Loa Loa (eye worm) hypothetical protein 0.0045 0.0019 0.0126
Brugia malayi Intermediate filament tail domain containing protein 0.0196 0.015 0.0981
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0048 0.0022 0.0295
Brugia malayi Cathepsin L-like precursor 0.0035 0.0011 0.0067
Loa Loa (eye worm) CHromoDomain protein family member 0.0051 0.0024 0.0159
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0123 0.0087 0.0532
Trypanosoma brucei trypanothione reductase 0.1778 0.1522 1
Trichomonas vaginalis glutamate synthase, putative 0.0164 0.0122 0.1663
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.003 0.0007 0.0038
Brugia malayi Cathepsin L-like precursor 0.0035 0.0011 0.0067
Leishmania major hypothetical protein, conserved 0.0164 0.0122 0.0762
Plasmodium vivax glutathione reductase, putative 0.1778 0.1522 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0011 0.0139
Echinococcus multilocularis chromobox protein 2 0.0048 0.0022 0.0021
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0048 0.0022 0.1771
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0048 0.0022 0.0075
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0164 0.0122 0.0735
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.009 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0074 0.0044 0.029
Onchocerca volvulus 0.0196 0.015 0.3474
Echinococcus multilocularis chromobox protein 1 0.0296 0.0237 0.0235
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0084 0.0053 0.0053
Plasmodium vivax hypothetical protein, conserved 0.0048 0.0022 0.0075
Trichomonas vaginalis chromobox protein, putative 0.0048 0.0022 0.0295
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0164 0.0122 0.1138
Loa Loa (eye worm) hypothetical protein 0.0105 0.0071 0.0467
Echinococcus multilocularis Chromo domain 0.0048 0.0022 0.0021
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0164 0.0122 0.0203
Plasmodium falciparum heterochromatin protein 1 0.0048 0.0022 0.0075
Trypanosoma cruzi trypanothione reductase, putative 0.1778 0.1522 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0164 0.0122 0.0797
Brugia malayi beta-lactamase 0.0074 0.0044 0.0284
Loa Loa (eye worm) hypothetical protein 0.0048 0.0022 0.0147
Loa Loa (eye worm) beta-lactamase 0.0074 0.0044 0.029
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0164 0.0122 0.0762
Plasmodium vivax ferrodoxin reductase, putative 0.0164 0.0122 0.0735
Giardia lamblia Glutamate synthase 0.0164 0.0122 0.1391
Trypanosoma brucei NADH dehydrogenase 0.0164 0.0122 0.0762
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0164 0.0122 0.1138
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0164 0.0122 1
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0022 0.0295
Loa Loa (eye worm) hypothetical protein 0.0047 0.0021 0.0138
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0164 0.0122 1
Mycobacterium ulcerans monoxygenase 0.0164 0.0122 0.1138
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0616 0.0515 0.3333
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0027 0.0354
Echinococcus granulosus intermediate filament protein 0.0196 0.015 0.0149
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0135 0.0097 0.0598
Echinococcus granulosus tumor protein p63 0.0715 0.06 0.0599
Loa Loa (eye worm) glutaminase 2 0.0865 0.073 0.4796
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0164 0.0122 0.1138
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.009 0.0059 0.4769
Toxoplasma gondii target of rapamycin (TOR), putative 0.0067 0.0039 0.0183
Brugia malayi Pre-SET motif family protein 0.0456 0.0376 0.2463
Schistosoma mansoni tar DNA-binding protein 0.0069 0.004 0.004
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0059 0.0793
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0164 0.0122 0.1138
Brugia malayi chromobox protein homolog 3 0.0166 0.0124 0.0811
Schistosoma mansoni tar DNA-binding protein 0.0069 0.004 0.004
Loa Loa (eye worm) glutaminase 0.0865 0.073 0.4796
Loa Loa (eye worm) hypothetical protein 0.0074 0.0044 0.029

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 0 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 0.78 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 2.27 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 3.47 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 93 % GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 97 % GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. ChEMBL. 20485427
Inhibition (functional) = 99 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition frequency index (IFI) (functional) = 5.97 Inhibition Frequency Index (IFI) GSK. 20485427
Percent growth inhibition (functional) = 0 % Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 93 % Percent inhibition of P. falciparum Dd2 growth (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 97 % Percent inhibition of HepG2 growth (at 10 uM) GSK. 20485427
Percent growth inhibition (functional) = 99 % Percent inhibition of P. falciparum 3D7 growth (at 2 uM) GSK. 20485427
XC50 (functional) = 6.74 XC50 determination of P. falciparum 3D7 growth GSK. 20485427
XC50 (functional) = 0.18356 uM GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. ChEMBL. 20485427

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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