TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 193.635 | Formula: C5H12ClN5O
H donors: 3 H acceptors: 1 LogP: -0.88 Rotable bonds: 0
Rule of 5 violations (Lipinski): 1
SMILES: NC1=NC(N(C(=N1)N)O)(C)C.Cl
InChi: 1S/C5H11N5O.ClH/c1-5(2)9-3(6)8-4(7)10(5)11;/h11H,1-2H3,(H4,6,7,8,9);1H
InChiKey: XMJVIPYHHQVLOX-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	cellular tumor antigen P53	0.0149	0.0313	0.0307
Brugia malayi	MH2 domain containing protein	0.0026	0.0026	0.0226
Trypanosoma cruzi	DNA polymerase eta, putative	0.003	0.0037	0.3112
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0006	0.1046
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0009	0.0799
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0017	0.0006	0.0053
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0009	0.0799
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0093	0.0813
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0006	0.1046
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0073	0.0637
Trypanosoma brucei	kinesin, putative	0.0019	0.0011	0.0944
Brugia malayi	hypothetical protein	0.0124	0.0254	0.2234
Onchocerca volvulus		0.0149	0.0313	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0009	0.0799
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0006	0.1046
Trypanosoma cruzi	DNA polymerase eta, putative	0.0043	0.0067	0.5644
Onchocerca volvulus		0.0017	0.0006	0.0191
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0019	0.0011	0.0944
Schistosoma mansoni	lamin	0.0056	0.0095	0.0089
Trypanosoma cruzi	cruzipain precursor, putative	0.0066	0.0118	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.0118	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0006	0.1046
Leishmania major	cathepsin L-like protease	0.0017	0.0006	0.0506
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0006	0.1046
Brugia malayi	Papain family cysteine protease containing protein	0.0017	0.0006	0.0053
Schistosoma mansoni	alpha glucosidase	0.0039	0.0057	0.0051
Onchocerca volvulus		0.0046	0.0073	0.2319
Brugia malayi	hypothetical protein	0.0025	0.0024	0.0213
Trypanosoma brucei	calpain-like protein, putative	0.0019	0.0011	0.0944
Trypanosoma cruzi	cysteine peptidase, putative	0.0017	0.0006	0.0506
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.0118	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0009	0.0799
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0009	0.0799
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0039	0.0057	1
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0039	0.0057	0.0502
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0009	0.0799
Leishmania major	cathepsin L-like protease	0.0017	0.0006	0.0506
Trypanosoma cruzi	kinesin, putative	0.0019	0.0011	0.0944
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.0024	0.3557
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0143	0.0297	0.0291
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.003	0.0037	0.6014
Loa Loa (eye worm)	MH2 domain-containing protein	0.0377	0.0841	0.7389
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0177	0.0377	0.331
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0823	0.1874	0.1869
Trichomonas vaginalis	alpha-glucosidase, putative	0.0039	0.0057	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0057	0.4839
Giardia lamblia	DINP protein human, muc B family	0.0019	0.0009	0.5
Echinococcus granulosus	tar DNA binding protein	0.0066	0.012	0.0114
Schistosoma mansoni	calpain C (C02 family)	0.0019	0.0011	0.0005
Echinococcus granulosus	smad	0.0026	0.0026	0.002
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0177	0.0377	0.331
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0019	0.0011	0.0944
Schistosoma mansoni	thyroid hormone receptor	0.0143	0.0297	0.0291
Brugia malayi	TAR-binding protein	0.0066	0.012	0.1057
Onchocerca volvulus		0.0017	0.0006	0.0191
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0019	0.0009	0.0003
Entamoeba histolytica	hypothetical protein	0.0036	0.0051	0.8866
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0069	0.0125	0.0119
Echinococcus multilocularis	musashi	0.0056	0.0095	0.0089
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0006	0.1046
Echinococcus granulosus	intermediate filament protein	0.0056	0.0095	0.0089
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0019	0.0009	0.0003
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.0024	0.2048
Loa Loa (eye worm)	hypothetical protein	0.016	0.0337	0.296
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0069	0.0125	0.0119
Trypanosoma brucei	calpain-like protein, putative	0.0019	0.0011	0.0944
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0066	0.012	0.1057
Brugia malayi	calpain 5	0.0019	0.0011	0.0098
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0006	0.1046
Entamoeba histolytica	hypothetical protein	0.0036	0.0051	0.8866
Entamoeba histolytica	protein kinase, putative	0.0019	0.0011	0.1951
Trichomonas vaginalis	DNA polymerase eta, putative	0.0019	0.0009	0.165
Echinococcus granulosus	mothers against decapentaplegic 5	0.0026	0.0026	0.002
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0019	0.0009	0.165
Echinococcus granulosus	GPCR family 2	0.016	0.0337	0.0331
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0024	0.2048
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0024	1
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0009	0.0799
Schistosoma mansoni	intermediate filament proteins	0.0056	0.0095	0.0089
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0006	0.1046
Trichomonas vaginalis	alpha-glucosidase, putative	0.0039	0.0057	1
Schistosoma mansoni	lamin	0.0056	0.0095	0.0089
Trypanosoma cruzi	kinesin, putative	0.0019	0.0011	0.0944
Trypanosoma brucei	DNA polymerase eta, putative	0.0043	0.0067	0.5644
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.0118	1
Trypanosoma brucei	calpain-like protein, putative	0.0019	0.0011	0.0944
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0019	0.0009	0.0003
Trypanosoma cruzi	major cysteine proteinase, putative	0.0052	0.0086	0.7245
Entamoeba histolytica	cysteine proteinase, putative	0.0017	0.0006	0.1046
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.012	0.0114
Echinococcus granulosus	dna polymerase eta	0.0043	0.0067	0.0061
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0026	0.0026	0.002
Echinococcus multilocularis	calpain A	0.0069	0.0125	0.0119
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0069	0.0125	0.0119
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0019	0.0011	0.0944
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0019	0.0009	0.0799
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.0118	1
Leishmania major	kinesin, putative	0.0019	0.0011	0.0944
Schistosoma mansoni	hypothetical protein	0.0132	0.0273	0.0267
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.012	0.0114
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0095	0.0834
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0132	0.0273	0.0267
Brugia malayi	MH2 domain containing protein	0.0377	0.0841	0.7389
Loa Loa (eye worm)	calpain	0.0019	0.0011	0.0098
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0019	0.0011	0.0944
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0006	0.0053
Loa Loa (eye worm)	calpain 5	0.0019	0.0011	0.0098
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0006	0.1046
Brugia malayi	hypothetical protein	0.0036	0.0051	0.0445
Entamoeba histolytica	hypothetical protein	0.0036	0.0051	0.8866
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0505	0.1138	1
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0118	0.1033
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0024	0.2048
Entamoeba histolytica	cysteine protease, putative	0.0017	0.0006	0.1046
Trypanosoma brucei	glucosidase, putative	0.0039	0.0057	0.4839
Onchocerca volvulus	Cathepsin L homolog	0.0017	0.0006	0.0191
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0017	0.0006	0.1046
Loa Loa (eye worm)	MH2 domain-containing protein	0.0026	0.0026	0.0226
Schistosoma mansoni	hypothetical protein	0.016	0.0337	0.0331
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0009	0.0799
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0017	0.0006	0.0053
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0006	0.1046
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0019	0.0011	0.0944
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0009	0.0799
Leishmania major	cathepsin L-like protease	0.0017	0.0006	0.0506
Echinococcus granulosus	calpain 7 C02 family	0.0019	0.0011	0.0005
Trypanosoma brucei	unspecified product	0.0019	0.0009	0.0799
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0051	0.0045
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0039	0.0057	1
Loa Loa (eye worm)	hypothetical protein	0.0346	0.0767	0.6742
Schistosoma mansoni	calpain-7 (C02 family)	0.0022	0.0018	0.0012
Echinococcus multilocularis	lamin	0.0056	0.0095	0.0089
Onchocerca volvulus		0.0017	0.0006	0.0191
Schistosoma mansoni	DNA polymerase eta	0.0043	0.0067	0.0061
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.016	0.0337	0.0331
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0006	0.0053
Onchocerca volvulus		0.0017	0.0006	0.0191
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0006	0.0053
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.012	0.0114
Loa Loa (eye worm)	hypothetical protein	0.0149	0.0313	0.2747
Brugia malayi	calpain family protein 1	0.0065	0.0118	0.1033
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0019	0.0011	0.0944
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0019	0.0009	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.0118	1
Schistosoma mansoni	microtubule-associated protein tau	0.4326	1	1
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0039	0.0057	1
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0019	0.0011	0.0944
Echinococcus granulosus	Smad4	0.0026	0.0026	0.002
Brugia malayi	RNA binding protein	0.0066	0.012	0.1057
Onchocerca volvulus	Huntingtin homolog	0.0124	0.0254	0.8133
Trypanosoma cruzi	cysteine peptidase, putative	0.0066	0.0118	1
Leishmania major	cathepsin L-like protease	0.0017	0.0006	0.0506
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0177	0.0377	0.0371
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0009	0.0799
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0177	0.0377	0.0371
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0024	0.0213
Onchocerca volvulus		0.0017	0.0006	0.0191
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0039	0.0057	1
Brugia malayi	Latrophilin receptor protein 2	0.016	0.0337	0.296
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0056	0.0095	0.0834
Echinococcus multilocularis	dna polymerase eta	0.0043	0.0067	0.0061
Brugia malayi	hypothetical protein	0.0016	0.0004	0.0032
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0006	0.1046
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0009	0.0799
Echinococcus multilocularis	calpain 7 (C02 family)	0.0019	0.0011	0.0005
Leishmania major	calpain, putative,cysteine peptidase, Clan CA, family C2, putative	0.0019	0.0011	0.0944
Onchocerca volvulus	Cathepsin F homolog	0.0017	0.0006	0.0191
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0039	0.0057	0.0051
Onchocerca volvulus		0.0017	0.0006	0.0191
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0039	0.0057	1
Schistosoma mansoni	smad1 5 8 and	0.0026	0.0026	0.002
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0006	0.1046
Echinococcus granulosus	lamin dm0	0.0056	0.0095	0.0089
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0019	0.0011	0.0944
Loa Loa (eye worm)	cysteine protease	0.0017	0.0006	0.0053
Echinococcus granulosus	lysosomal alpha glucosidase	0.0177	0.0377	0.0371
Loa Loa (eye worm)	calpain family protein 1	0.0046	0.0073	0.0637
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0009	0.0799
Echinococcus multilocularis	microtubule associated protein 2	0.4326	1	1
Plasmodium vivax	calpain, putative	0.0019	0.0011	0.284
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.0009	0.5
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0006	0.0053
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0026	0.0026	0.002
Brugia malayi	calpain 7	0.0019	0.0011	0.0098
Echinococcus multilocularis	GPCR, family 2	0.016	0.0337	0.0331
Loa Loa (eye worm)	Smad1	0.0026	0.0026	0.0226
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.0019	0.0011	0.0944
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0019	0.0011	0.0944
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0006	0.1046
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0026	0.0228
Schistosoma mansoni	hypothetical protein	0.016	0.0337	0.0331
Echinococcus multilocularis	calpain family protein 1, d	0.0046	0.0073	0.0067
Leishmania major	cathepsin L-like protease	0.0017	0.0006	0.0506
Echinococcus multilocularis	Smad4	0.0026	0.0026	0.002
Echinococcus granulosus	dna polymerase kappa	0.0019	0.0009	0.0003
Loa Loa (eye worm)	intermediate filament protein	0.0056	0.0095	0.0834
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.012	0.0114
Brugia malayi	RNA recognition motif domain containing protein	0.0066	0.012	0.1057
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0006	0.1046
Trichomonas vaginalis	alpha-glucosidase, putative	0.0039	0.0057	1
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0019	0.0011	0.0944
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.0118	1
Leishmania major	cysteine peptidase A (CPA)	0.0017	0.0006	0.0506
Echinococcus multilocularis	calpain 5	0.0019	0.0011	0.0005
Brugia malayi	Intermediate filament tail domain containing protein	0.0056	0.0095	0.0834
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0009	0.0799
Loa Loa (eye worm)	latrophilin receptor protein 2	0.016	0.0337	0.296
Leishmania major	DNA polymerase eta, putative	0.0043	0.0067	0.5644
Schistosoma mansoni	alpha-glucosidase	0.0152	0.032	0.0314
Brugia malayi	ImpB/MucB/SamB family protein	0.0043	0.0067	0.0586
Trichomonas vaginalis	alpha-glucosidase, putative	0.0039	0.0057	1
Schistosoma mansoni	hypothetical protein	0.016	0.0337	0.0331
Onchocerca volvulus	Cathepsin L homolog	0.0017	0.0006	0.0191
Loa Loa (eye worm)	TAR-binding protein	0.0066	0.012	0.1057
Trypanosoma cruzi	cysteine peptidase, putative	0.0066	0.0118	1
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.012	0.0114
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0009	0.0799
Schistosoma mansoni	Mername-AA248 (C02 family)	0.0019	0.0011	0.0005
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0039	0.0057	1
Schistosoma mansoni	Smad4	0.0026	0.0026	0.002
Schistosoma mansoni	smad1 5 8 and	0.0026	0.0026	0.002
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0006	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0028	0.0248
Brugia malayi	MH1 domain containing protein	0.0026	0.0026	0.0226
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0039	0.0057	1
Echinococcus multilocularis	smad	0.0026	0.0026	0.002
Echinococcus multilocularis	tumor protein p63	0.1021	0.2334	0.233
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0006	0.1046
Brugia malayi	Smad1	0.0026	0.0026	0.0226
Schistosoma mansoni	smad1 5 8 and	0.0026	0.0026	0.002
Leishmania major	cathepsin L-like protease	0.0066	0.0118	1
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0118	0.1033
Loa Loa (eye worm)	transcription factor SMAD2	0.0377	0.0841	0.7389
Schistosoma mansoni	hypothetical protein	0.016	0.0337	0.0331
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.0118	1
Leishmania major	hypothetical protein, conserved	0.0025	0.0024	0.2048
Brugia malayi	cytoplasmic intermediate filament protein	0.003	0.0035	0.0308
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.003	0.0035	0.0308
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.016	0.0337	0.0331
Echinococcus multilocularis	calpain	0.0019	0.0011	0.0005
Schistosoma mansoni	calpain-7 (C02 family)	0.0022	0.0018	0.0012
Onchocerca volvulus		0.0102	0.0204	0.6511
Echinococcus granulosus	neutral alpha glucosidase AB	0.0039	0.0057	0.0051
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0024	1
Trypanosoma brucei	calpain-like protein, putative	0.0019	0.0011	0.0944
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.0118	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0505	0.1138	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0006	0.1046
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0026	0.0026	0.002
Brugia malayi	latrophilin 2 splice variant baaae	0.0346	0.0767	0.6742
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0006	0.1046
Entamoeba histolytica	cysteine proteinase, putative	0.0017	0.0006	0.1046
Loa Loa (eye worm)	fibroinase	0.0017	0.0006	0.0053
Echinococcus multilocularis	lamin dm0	0.0056	0.0095	0.0089
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0065	0.0118	0.0112
Onchocerca volvulus		0.0056	0.0095	0.3037
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0019	0.0009	0.165
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.0051	0.0045
Leishmania major	DNA polymerase eta, putative	0.003	0.0037	0.3112
Leishmania major	cathepsin L-like protease	0.0066	0.0118	1
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0039	0.0057	0.0502
Loa Loa (eye worm)	MH1 domain-containing protein	0.0026	0.0026	0.0226
Brugia malayi	MH1 domain containing protein	0.0026	0.0026	0.0226
Leishmania major	cathepsin L-like protease	0.0066	0.0118	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0006	0.1046
Echinococcus granulosus	calpain	0.0019	0.0011	0.0005
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0027	0.0028	0.0022
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0006	0.0053
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0019	0.0009	0.0083
Schistosoma mansoni	alpha-glucosidase	0.0152	0.032	0.0314
Onchocerca volvulus		0.0017	0.0006	0.0191
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.006	0.0105	0.8883
Leishmania major	alpha glucosidase II subunit, putative	0.0039	0.0057	0.4839
Schistosoma mansoni	thyroid hormone receptor	0.0143	0.0297	0.0291
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0009	0.0799
Echinococcus granulosus	calpain A	0.0019	0.0011	0.0005
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.0024	1
Brugia malayi	intermediate filament protein	0.0056	0.0095	0.0834
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.0118	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0006	0.1046
Entamoeba histolytica	hypothetical protein	0.0036	0.0051	0.8866
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.0118	1
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0132	0.0273	0.0267
Entamoeba histolytica	calpain large subunit domain III containing protein	0.0019	0.0011	0.1951
Onchocerca volvulus		0.0056	0.0095	0.3037
Trypanosoma cruzi	cysteine peptidase, putative	0.0066	0.0118	1
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0009	0.0083
Brugia malayi	calpain family protein 1	0.0065	0.0118	0.1033
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0006	0.1046
Echinococcus multilocularis	hypothetical protein	0.0019	0.0011	0.0005
Echinococcus granulosus	tumor protein p63	0.1021	0.2334	0.233
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0019	0.0011	0.0944
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0254	0.2234
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0006	0.1046
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0006	0.0053
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.016	0.0337	0.0331
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0067	0.0586
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0006	0.1046
Echinococcus granulosus	calpain 5	0.0019	0.0011	0.0005
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0009	0.0799
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.016	0.0337	0.296
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0026	0.0026	0.002
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0019	0.0009	0.5
Onchocerca volvulus	Huntingtin homolog	0.0124	0.0254	0.8133
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0073	0.0637
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0019	0.0009	0.0003
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0019	0.0011	0.0944
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0069	0.0125	0.0119
Schistosoma mansoni	hypothetical protein	0.0036	0.0051	0.0045
Echinococcus multilocularis	dna polymerase kappa	0.0019	0.0009	0.0003
Loa Loa (eye worm)	ctsf protein	0.0017	0.0006	0.0053
Loa Loa (eye worm)	RNA binding protein	0.0066	0.012	0.1057
Loa Loa (eye worm)	hypothetical protein	0.0505	0.1138	1
Echinococcus multilocularis	tar DNA binding protein	0.0066	0.012	0.0114
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0026	0.0228
Leishmania major	DNA polymerase kappa, putative	0.0019	0.0009	0.0799
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.0118	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0505	0.1138	1
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.016	0.0337	0.0331
Echinococcus granulosus	calpain A	0.0069	0.0125	0.0119
Trypanosoma brucei	antigen, putative	0.0019	0.0011	0.0944
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0006	0.1046
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0027	0.0028	0.0022
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.0051	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0254	0.2234
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0009	0.0799
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0017	0.0006	0.1046
Trichomonas vaginalis	alpha-glucosidase, putative	0.0039	0.0057	1
Schistosoma mansoni	hypothetical protein	0.0346	0.0767	0.0762
Schistosoma mansoni	smad	0.0026	0.0026	0.002
Echinococcus granulosus	lamin	0.0056	0.0095	0.0089
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.0009	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0057	0.4839
Schistosoma mansoni	calpain (C02 family)	0.0019	0.0011	0.0005
Loa Loa (eye worm)	calpain family protein 1	0.0065	0.0118	0.1033
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0019	0.0011	0.0944
Brugia malayi	MH2 domain containing protein	0.0026	0.0026	0.0226

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (functional)	= -0.13 %	ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro	ChEMBL.	No reference
Inhibition (functional)	= 0 %	GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM	ChEMBL.	20485427
Inhibition (functional)	= 0.94 %	ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro	ChEMBL.	No reference
Inhibition (functional)	= 1 %	GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM	ChEMBL.	20485427
Inhibition (functional)	= 1.38 %	ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro	ChEMBL.	No reference
Inhibition (functional)	= 7 %	GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM.	ChEMBL.	20485427
Inhibition (functional)	= 93 %	GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM	ChEMBL.	20485427
Inhibition frequency index (IFI) (functional)	= 0	Inhibition Frequency Index (IFI)	GSK.	20485427
Percent growth inhibition (functional)	= -5 %	Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM)	GSK.	20485427
Percent growth inhibition (functional)	= 1 %	Percent inhibition of P. falciparum Dd2 growth (at 2 uM)	GSK.	20485427
Percent growth inhibition (functional)	= 7 %	Percent inhibition of HepG2 growth (at 10 uM)	GSK.	20485427
Percent growth inhibition (functional)	= 93 %	Percent inhibition of P. falciparum 3D7 growth (at 2 uM)	GSK.	20485427
XC50 (functional)	= 6.72	XC50 determination of P. falciparum 3D7 growth	GSK.	20485427
XC50 (functional)	= 0.19248 uM	GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth.	ChEMBL.	20485427

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL549179
Search by GSK

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 601554