Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | lamin | 0.0111 | 0.0142 | 0.0127 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0111 | 0.0142 | 0.0111 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.006 | 0.0049 | 0.0269 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0385 | 0.0638 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0111 | 0.0142 | 0.0111 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0111 | 0.0142 | 0.2222 |
Schistosoma mansoni | lamin | 0.0111 | 0.0142 | 0.0065 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0034 | 0.0032 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0068 | 0.0064 | 0.3944 |
Schistosoma mansoni | tar DNA-binding protein | 0.0385 | 0.0638 | 0.0565 |
Schistosoma mansoni | tar DNA-binding protein | 0.0385 | 0.0638 | 0.0565 |
Schistosoma mansoni | tar DNA-binding protein | 0.0385 | 0.0638 | 0.0565 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0097 | 0.0116 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0034 | 0.0032 |
Schistosoma mansoni | intermediate filament proteins | 0.0111 | 0.0142 | 0.0065 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0141 | 0.0195 | 0.3059 |
Brugia malayi | AMP-binding enzyme family protein | 0.0097 | 0.0116 | 0.181 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0097 | 0.0116 | 1 |
Onchocerca volvulus | 0.0206 | 0.0314 | 1 | |
Echinococcus multilocularis | tumor protein p63 | 0.141 | 0.2493 | 0.247 |
Echinococcus granulosus | tar DNA binding protein | 0.0385 | 0.0638 | 0.0624 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.0116 | 0.1371 |
Brugia malayi | AMP-binding enzyme family protein | 0.0097 | 0.0116 | 0.181 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0111 | 0.0142 | 0.0126 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.0116 | 0.1371 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0068 | 0.0064 | 0.3944 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0351 | 0.0576 | 0.9023 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0097 | 0.0116 | 1 |
Echinococcus multilocularis | lamin | 0.0111 | 0.0142 | 0.0112 |
Loa Loa (eye worm) | hypothetical protein | 0.0206 | 0.0314 | 0.4654 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0111 | 0.0142 | 0.1805 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.024 | 0.0376 | 0.5664 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0111 | 0.0142 | 0.0111 |
Schistosoma mansoni | tar DNA-binding protein | 0.0385 | 0.0638 | 0.0565 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.0078 | 0.1532 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0111 | 0.0142 | 0.0126 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0051 | 0.0032 | 0.2688 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.0116 | 0.1371 |
Schistosoma mansoni | hypothetical protein | 0.0111 | 0.0142 | 0.0064 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0072 | 0.0071 | 0.4786 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0351 | 0.0576 | 0.9023 |
Echinococcus granulosus | peptidase Clp S14 family | 0.005 | 0.0031 | 0.0015 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0051 | 0.0032 | 0.5 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0097 | 0.0116 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0071 | 0.0642 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0076 | 0.0078 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0385 | 0.0638 | 1 |
Brugia malayi | RNA binding protein | 0.0385 | 0.0638 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0385 | 0.0638 | 0.0609 |
Echinococcus granulosus | tumor protein p63 | 0.141 | 0.2493 | 0.2482 |
Mycobacterium ulcerans | hypothetical protein | 0.0097 | 0.0116 | 1 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0076 | 0.0078 | 0.0047 |
Schistosoma mansoni | hypothetical protein | 0.0111 | 0.0142 | 0.0064 |
Loa Loa (eye worm) | TAR-binding protein | 0.0385 | 0.0638 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0097 | 0.0116 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0097 | 0.0116 | 0.181 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0076 | 0.0078 | 0.0063 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0072 | 0.0071 | 0.8917 |
Onchocerca volvulus | 0.0111 | 0.0142 | 0.1348 | |
Schistosoma mansoni | hypothetical protein | 0.024 | 0.0375 | 0.0299 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0054 | 0.0038 | 0.0007 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.0142 | 0.1805 |
Loa Loa (eye worm) | hypothetical protein | 0.0351 | 0.0576 | 0.8971 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0054 | 0.0038 | 0.0022 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.024 | 0.0375 | 0.5875 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0038 | 0.0009 | 0.5 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0206 | 0.0314 | 0.0238 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0097 | 0.0116 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0071 | 0.0642 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0097 | 0.0116 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0071 | 0.0642 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0097 | 0.0116 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.0139 | 0.1752 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.0078 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0051 | 0.0032 | 0.3351 |
Echinococcus granulosus | GPCR family 2 | 0.0111 | 0.0142 | 0.0126 |
Schistosoma mansoni | lamin | 0.0111 | 0.0142 | 0.0065 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.5558 | 1 | 1 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.0078 | 1 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0041 | 0.0016 | 0.5 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0097 | 0.0116 | 1 |
Brugia malayi | MH2 domain containing protein | 0.024 | 0.0376 | 0.5885 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0097 | 0.0116 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0111 | 0.0142 | 0.0127 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0076 | 0.0078 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0111 | 0.0142 | 0.0127 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0076 | 0.0078 | 0.5585 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.024 | 0.0376 | 0.5664 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0038 | 0.0093 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.0078 | 1 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0137 | 0.0188 | 0.0173 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0111 | 0.0142 | 0.223 |
Brugia malayi | intermediate filament protein | 0.0111 | 0.0142 | 0.223 |
Onchocerca volvulus | 0.0111 | 0.0142 | 0.1348 | |
Brugia malayi | hypothetical protein | 0.0051 | 0.0032 | 0.0509 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0097 | 0.0116 | 1 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0041 | 0.0016 | 0.5 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.006 | 0.0049 | 0.0764 |
Schistosoma mansoni | tar DNA-binding protein | 0.0385 | 0.0638 | 0.0565 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0141 | 0.0195 | 0.0118 |
Loa Loa (eye worm) | acetyltransferase | 0.0141 | 0.0195 | 0.2687 |
Schistosoma mansoni | hypothetical protein | 0.0111 | 0.0142 | 0.0064 |
Loa Loa (eye worm) | hypothetical protein | 0.024 | 0.0375 | 0.5654 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0051 | 0.0032 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0111 | 0.0142 | 0.0064 |
Echinococcus multilocularis | musashi | 0.0111 | 0.0142 | 0.0112 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0068 | 0.0064 | 0.3944 |
Brugia malayi | TAR-binding protein | 0.0385 | 0.0638 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0051 | 0.0032 | 0.2688 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0071 | 0.0642 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0097 | 0.0116 | 1 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0141 | 0.0195 | 0.0165 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0071 | 0.0642 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0111 | 0.0142 | 0.2222 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.0142 | 0.1813 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0097 | 0.0116 | 1 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.0078 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0385 | 0.0638 | 1 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0097 | 0.0116 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0351 | 0.0576 | 0.8971 |
Echinococcus multilocularis | lamin dm0 | 0.0111 | 0.0142 | 0.0112 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0111 | 0.0142 | 0.1813 |
Loa Loa (eye worm) | intermediate filament protein | 0.0111 | 0.0142 | 0.1813 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0051 | 0.0032 | 0.5 |
Schistosoma mansoni | microtubule-associated protein tau | 0.5558 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0051 | 0.0032 | 0.3351 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0097 | 0.0116 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0097 | 0.0116 | 1 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0076 | 0.0078 | 1 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0072 | 0.0071 | 0.9015 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.0078 | 0.1532 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0097 | 0.0116 | 1 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.0078 | 0.5 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0068 | 0.0064 | 0.3944 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0078 | 0.0754 |
Brugia malayi | Probable ClpP-like protease | 0.0076 | 0.0078 | 0.1224 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 0 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 0 % | GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 2.11 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 2.88 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 3.51 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 10 % | GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. | ChEMBL. | 20485427 |
Inhibition (functional) | = 97 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition frequency index (IFI) (functional) | = 0.75 | Inhibition Frequency Index (IFI) | GSK. | 20485427 |
Percent growth inhibition (functional) | = -4 % | Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = -1 % | Percent inhibition of P. falciparum Dd2 growth (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 10 % | Percent inhibition of HepG2 growth (at 10 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 97 % | Percent inhibition of P. falciparum 3D7 growth (at 2 uM) | GSK. | 20485427 |
XC50 (functional) | = 6.28 | XC50 determination of P. falciparum 3D7 growth | GSK. | 20485427 |
XC50 (functional) | = 0.52219 uM | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. | ChEMBL. | 20485427 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.