Detailed information for compound 607169

Basic information

Technical information
  • TDR Targets ID: 607169
  • Name: [1,3]thiazolo[3,2-a]benzimidazol-1-one
  • MW: 190.222 | Formula: C9H6N2OS
  • H donors: 0 H acceptors: 2 LogP: 1.97 Rotable bonds: 0 Rule of 5 violations (Lipinski): 1
  • InChi: 1S/C9H6N2OS/c12-8-5-13-9-10-6-3-1-2-4-7(6)11(8)9/h1-4H,5H2
  • InChiKey: CFXICROPFOOZFI-UHFFFAOYSA-N  

Synonyms

  • thiazolo[3,2-a]benzimidazol-1-one
  • 1-thiazolo[3,2-a]benzimidazolone
  • 3042-01-1
  • MLS000565206
  • CDS1_000940
  • DivK1c_001980
  • SR-01000389083-2
  • ZINC00039272
  • A2163/0090840
  • NSC35794
  • SMR000152365
  • 534242_ALDRICH
  • Benzo[4,5]imidazo[2,1-b]thiazol-3-one
  • Thiazolo[2,3-b]benzimidazole-3(2H)-one
  • Maybridge1_005692

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens hydroxyprostaglandin dehydrogenase 15-(NAD) Starlite/ChEMBL No references

Predicted pathogen targets for this compound

No predicted pathogen genes were found associated with this compound

Activities

Activity type Activity value Assay description Source Reference
CC50 (functional) > 100 uM Huh7 cytotoxicity for Pf inhibitors Novartis-GNF Malaria Box.
EC50 (functional) = 1.063 uM W2 Pf proliferation inhibition Novartis-GNF Malaria Box.
EC50 (functional) = 7.92 uM PF proliferation inhibition 3D7 Novartis-GNF Malaria Box.
IFI promiscuity index = 0 IFI promiscuity index Novartis-GNF Malaria Box.
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL.
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL.
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL.

Phenotypes

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

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TDR Targets Development Release v6, Revision: 1335 (10.Aug.2018)
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