Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.3798 | 0.4691 | 0.4691 |
Schistosoma mansoni | casein kinase II beta subunit | 0.3798 | 0.4691 | 0.4465 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.3798 | 0.4691 | 0.4691 |
Toxoplasma gondii | CMGC kinase, CK2 family | 0.684 | 1 | 1 |
Onchocerca volvulus | Casein kinase II subunit beta homolog | 0.3798 | 0.4691 | 0.5 |
Echinococcus multilocularis | casein kinase ii subunit beta | 0.3798 | 0.4691 | 0.4465 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.3798 | 0.4691 | 0.4691 |
Loa Loa (eye worm) | TK/FAK protein kinase | 0.1359 | 0.0436 | 0.0436 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.3798 | 0.4691 | 0.4691 |
Schistosoma mansoni | protein kinase | 0.684 | 1 | 1 |
Plasmodium vivax | unspecified product | 0.684 | 1 | 1 |
Entamoeba histolytica | casein kinase II regulatory subunit family protein | 0.3798 | 0.4691 | 0.4691 |
Loa Loa (eye worm) | Csnk2b protein | 0.3798 | 0.4691 | 0.4691 |
Leishmania major | casein kinase II, putative | 0.684 | 1 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.3798 | 0.4691 | 0.4691 |
Brugia malayi | Protein kinase domain containing protein | 0.1359 | 0.0436 | 0.0436 |
Echinococcus multilocularis | casein kinase ii subunit alpha | 0.684 | 1 | 1 |
Plasmodium falciparum | casein kinase 2, alpha subunit | 0.684 | 1 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.3798 | 0.4691 | 0.4691 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.3798 | 0.4691 | 0.4691 |
Giardia lamblia | Casein kinase II beta chain | 0.3798 | 0.4691 | 0.4691 |
Entamoeba histolytica | casein kinase II regulatory subunit family protein | 0.3798 | 0.4691 | 0.4691 |
Trypanosoma brucei | Casein kinase II | 0.684 | 1 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.3798 | 0.4691 | 0.4691 |
Echinococcus granulosus | casein kinase ii subunit alpha | 0.684 | 1 | 1 |
Brugia malayi | Csnk2b protein | 0.3798 | 0.4691 | 0.4691 |
Plasmodium vivax | casein kinase 2, alpha subunit, putative | 0.684 | 1 | 1 |
Echinococcus granulosus | casein kinase ii subunit beta | 0.3798 | 0.4691 | 0.4465 |
Entamoeba histolytica | casein kinase, putative | 0.684 | 1 | 1 |
Giardia lamblia | Kinase, CMGC CK2 | 0.684 | 1 | 1 |
Onchocerca volvulus | Casein kinase II subunit beta homolog | 0.3798 | 0.4691 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.684 | 1 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.3798 | 0.4691 | 0.4691 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.3798 | 0.4691 | 0.4691 |
Entamoeba histolytica | casein kinase II regulatory subunit family protein | 0.3798 | 0.4691 | 0.4691 |
Loa Loa (eye worm) | CMGC/CK2 protein kinase | 0.684 | 1 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.3798 | 0.4691 | 0.4691 |
Trichomonas vaginalis | CMGC family protein kinase | 0.684 | 1 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.3798 | 0.4691 | 0.4691 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.3798 | 0.4691 | 0.4691 |
Trypanosoma cruzi | casein kinase II, putative | 0.684 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.684 | 1 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.3798 | 0.4691 | 0.4691 |
Trichomonas vaginalis | CMGC family protein kinase | 0.684 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.684 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.684 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.684 | 1 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.3798 | 0.4691 | 0.4691 |
Entamoeba histolytica | protein kinase domain containing protein | 0.684 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (functional) | = 5.18 uM | Huh7 cytotoxicity for Pf inhibitors | Novartis-GNF Malaria Box. | No reference |
EC50 (functional) | = 0.0325 uM | PF proliferation inhibition 3D7 | Novartis-GNF Malaria Box. | No reference |
EC50 (functional) | = 0.0517 uM | W2 Pf proliferation inhibition | Novartis-GNF Malaria Box. | No reference |
IFI promiscuity index | = 0.04878 | IFI promiscuity index | Novartis-GNF Malaria Box. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.