Detailed information for compound 72393

Basic information

Technical information
  • TDR Targets ID: 72393
  • Name: (8R,9S,13S,14S,17S)-2-methoxy-13-methyl-6,7,8 ,9,11,12,14,15,16,17-decahydrocyclopenta[a]ph enanthrene-3,17-diol
  • MW: 302.408 | Formula: C19H26O3
  • H donors: 2 H acceptors: 2 LogP: 3.88 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc2c(cc1O)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C
  • InChi: 1S/C19H26O3/c1-19-8-7-12-13(15(19)5-6-18(19)21)4-3-11-9-16(20)17(22-2)10-14(11)12/h9-10,12-13,15,18,20-21H,3-8H2,1-2H3/t12-,13+,15-,18-,19-/m0/s1
  • InChiKey: CQOQDQWUFQDJMK-SSTWWWIQSA-N  


Substructure search Similarity search

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Synonyms

  • 2-methoxyestradiol
  • Mercaptoethanol
  • 362-07-2
  • Lopac0_000739
  • EU-0100739
  • PulmoLAR
  • 1,3,5(10)-ESTRATRIEN-2,3,17-BETA-TRIOL 2-METHYL ETHER
  • estra-1(10),2,4-triene-3,17-diol, 2-methoxy-, (17beta)-
  • 2-Methoxyestradiol-17beta
  • C05302
  • ESM
  • 2-methoxy-estra-1,3,5(10)-triene-3,17beta-diol
  • LMST02010035
  • 1,3,5(10)-Estratriene-2,3,17-triol 2-methyl ether
  • 2,3,17beta-Trihydroxy-1,3,5(10)-estratriene 2-methyl ether
  • 2-Hydroxyestradiol 2-methyl ether
  • 3,17beta-Dihydroxy-2-methoxy-1,3,5(10)-estratriene
  • M6383_SIGMA
  • (17beta)-2-Methoxyestra-1,3,5(10)-triene-3,17-diol
  • 2-Hydroxyestradol 2-methyl ether
  • 2-Methoxyestra-1,3,5(10)-triene-3,17beta-diol
  • SMP2_000045
  • 2ME2
  • Estra-1,3,5(10)-triene-3,17-diol, 2-methoxy-, (17beta)-
  • Estra-1,3,5(10)-triene-3,17beta-diol, 2-methoxy-
  • Estradiol, 2-methoxy-
  • NSC 659853
  • Panzem
  • 2-MeOE2
  • NSC-659853
  • 2-methoxy-17beta-estradiol
  • CHEBI:28955
  • MLS000028819
  • SMR000058478

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal Starlite/ChEMBL No references
Homo sapiens peripheral myelin protein 22 Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens sex hormone-binding globulin Starlite/ChEMBL References
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Bos taurus Tubulin Starlite/ChEMBL References
Homo sapiens Bloom syndrome, RecQ helicase-like Starlite/ChEMBL No references
Bos taurus Tubulin beta chain Starlite/ChEMBL References
Sus scrofa Tubulin Starlite/ChEMBL References
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens mechanistic target of rapamycin (serine/threonine kinase) Starlite/ChEMBL No references
Bos taurus Tubulin Starlite/ChEMBL References
Trypanosoma brucei gambiense ATP-dependent phosphofructokinase,6-phospho-1-fructokinase No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens regulator of G-protein signaling 4 Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei gambiense beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Schistosoma japonicum ko:K00850 6-phosphofructokinase [EC2.7.1.11], putative Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis expressed protein Get druggable targets OG5_141764 All targets in OG5_141764
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense ATP-dependent phosphofructokinase,6-phospho-1-fructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Cryptosporidium parvum tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin alpha-1C chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Candida albicans frameshifted from upsteam TOR2 CDS (CaP19.9461) Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania donovani Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei phosphatidylinositol 4-kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Candida albicans phosphofructokinase beta-subunit that can functionally substitute for S. cerevisiae PFK2 (YMR205C) Get druggable targets OG5_126758 All targets in OG5_126758
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania mexicana Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin alpha 2 Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Toxoplasma gondii alpha-tubulin I, putative Get druggable targets OG5_126605 All targets in OG5_126605
Brugia malayi phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Brugia malayi tubulin alpha-2 chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis FKBP12 rapamycin complex associated protein Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi Tubulin alpha-2 chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania braziliensis beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit alpha Get druggable targets OG5_126605 All targets in OG5_126605
Candida albicans frameshifted from upstream TOR2 CDS (CaP19.1905) Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania mexicana alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Tubulin alpha-1 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus peroxisome assembly protein 26 Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma mansoni 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase Get druggable targets OG5_126758 All targets in OG5_126758
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Toxoplasma gondii alpha tubulin TUBA1 Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis tubulin alpha 1C chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma congolense alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus tubulin subunit TubB Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania braziliensis alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma cruzi beta tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Babesia bovis tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma congolense ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Neospora caninum hypothetical protein Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis tubulin, beta 4A class IVa Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis tubulin gamma chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) tubulin beta-1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Candida albicans phosphofructokinase beta-subunit that can functionally substitute for S. cerevisiae PFK2 (YMR205C) Get druggable targets OG5_126758 All targets in OG5_126758
Trichomonas vaginalis tubulin alpha chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum ko:K07374 tubulin alpha, putative Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Neospora caninum hypothetical protein Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis tubulin alpha 1C chain Get druggable targets OG5_126605 All targets in OG5_126605
Brugia malayi 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Toxoplasma gondii beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana 6-phospho-1-fructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana phosphatidylinositol 3 kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related Get druggable targets OG5_127212 All targets in OG5_127212
Giardia lamblia Beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Giardia lamblia Beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Babesia bovis tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans phosphofructokinase alpha subunit that can functionally substitute for S. cerevisiae PFK1 (YGR240C) Get druggable targets OG5_126758 All targets in OG5_126758
Brugia malayi beta-tubulin, identical Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus tubulin alpha 3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Giardia lamblia Alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin beta 1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus expressed protein Get druggable targets OG5_141764 All targets in OG5_141764
Loa Loa (eye worm) 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) tubulin alpha 2 Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania donovani ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Tubulin alpha-2/alpha-4 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin beta 4A class IVa Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus granulosus FKBP12 rapamycin complex associated protein Get druggable targets OG5_127212 All targets in OG5_127212
Theileria parva tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit alpha Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium falciparum tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium knowlesi alpha tubulin, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei gambiense beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin beta-7 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin alpha 1C chain Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Loa Loa (eye worm) BEN-1 protein Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Entamoeba histolytica tubulin family protein Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) tubulin alpha 2 Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis tubulin subunit TubB Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum Tubulin beta-1 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Trichomonas vaginalis tubulin alpha-1 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Candida albicans cytoskeletal structural protein Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Entamoeba histolytica tubulin alpha-1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium vivax tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania infantum beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) Get druggable targets OG5_126758 All targets in OG5_126758
Plasmodium berghei alpha tubulin 2 Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum alpha tubulin 1 Get druggable targets OG5_126605 All targets in OG5_126605
Entamoeba histolytica phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Loa Loa (eye worm) tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin alpha 3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Brugia malayi 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Toxoplasma gondii beta-1 tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum ko:K07374 tubulin alpha, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Cryptosporidium hominis alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Entamoeba histolytica phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania braziliensis alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Tubulin beta-1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania infantum beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Giardia lamblia GTOR Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Cryptosporidium parvum alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum Phosphatidylinositol 3-kinase tor2, related Get druggable targets OG5_127212 All targets in OG5_127212
Cryptosporidium hominis beta-catenin-like repeat protein Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania major target of rapamycin (TOR) kinase 1, putative Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Candida albicans similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Candida albicans hypothetical protein Get druggable targets OG5_126758 All targets in OG5_126758
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) phosphatidylinositol 3 Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei gambiense phosphatidylinositol 3-kinase tor, putative Get druggable targets OG5_127212 All targets in OG5_127212
Plasmodium berghei alpha tubulin 1 Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi Tubulin alpha-2 chain Get druggable targets OG5_126605 All targets in OG5_126605
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica tubulin family protein Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium knowlesi alpha-tubulin II, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania donovani Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Theileria parva Tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus tubulin alpha 1C chain Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii beta-tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei gambiense alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum ko:K07375 tubulin beta, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum ATP-dependent phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis tubulin alpha 3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana phosphatidylinositol 3-kinase (tor2)-like protein Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi Tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium vivax tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Entamoeba histolytica phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis 6 phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Trichomonas vaginalis tubulin alpha-1 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126611 All targets in OG5_126611
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Plasmodium falciparum alpha tubulin 2 Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania infantum target of rapamycin (TOR) kinase 1, putative Get druggable targets OG5_127212 All targets in OG5_127212
Plasmodium berghei tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma congolense Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania braziliensis beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Neospora caninum tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) alpha-tubulin isotype 2 Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Mycobacterium ulcerans 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi tubulin alpha chain - mouse Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Loa Loa (eye worm) alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Echinococcus multilocularis tubulin beta 1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Tubulin beta-1 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Theileria parva tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major ATP-dependent phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) BEN-1 protein Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) tubulin alpha-2 chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus 6 phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Plasmodium vivax tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin alpha-3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium yoelii Tubulin/FtsZ family, putative Get druggable targets OG5_126605 All targets in OG5_126605
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis hypothetical protein Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis peroxisome assembly protein 26 Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Giardia lamblia Alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania donovani alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha 3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei gambiense phosphatidylinositol 3 kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Babesia bovis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Tubulin beta-4 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Trichomonas vaginalis tubulin alpha-1 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Candida albicans similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma congolense Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Giardia lamblia Beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Candida albicans phosphofructokinase alpha subunit that can functionally substitute for S. cerevisiae PFK1 (YGR240C) Get druggable targets OG5_126758 All targets in OG5_126758
Schistosoma japonicum ko:K07203 FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Toxoplasma gondii target of rapamycin (TOR), putative Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) tubulin beta-2A chain Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma mansoni tubulin subunit alpha Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma cruzi alpha tubulin, putative Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania braziliensis ATP-dependent phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Loa Loa (eye worm) tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K07375 tubulin beta, putative Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) tubulin beta-4 chain Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trichomonas vaginalis tubulin gamma chain, putative Tubulin   85 aa 90 aa 28.9 %
Leishmania mexicana beta tubulin Tubulin   85 aa 80 aa 50.0 %
Trichomonas vaginalis tubulin beta chain, putative Tubulin   85 aa 86 aa 74.4 %
Drosophila melanogaster beta-Tubulin at 60D Tubulin   445 aa 435 aa 90.6 %
Leishmania braziliensis epsilon tubulin, putative Tubulin beta chain   445 aa 465 aa 30.1 %
Trypanosoma cruzi tubulin gamma chain Tubulin beta chain   445 aa 436 aa 33.5 %
Onchocerca volvulus Tubulin beta chain   445 aa 427 aa 49.9 %
Neospora caninum hypothetical protein Tubulin   445 aa 430 aa 89.1 %
Echinococcus granulosus Tubulin beta 2C chain Tubulin   445 aa 430 aa 94.4 %
Plasmodium falciparum tubulin epsilon chain, putative Tubulin beta chain   445 aa 461 aa 27.8 %
Babesia bovis tubulin gamma chain Tubulin beta chain   445 aa 441 aa 34.0 %
Echinococcus multilocularis Tubulin alpha 1 chain Tubulin beta chain   445 aa 434 aa 38.9 %
Schistosoma mansoni tubulin subunit beta Tubulin   85 aa 80 aa 50.0 %
Plasmodium vivax tubulin alpha chain, putative Tubulin beta chain   445 aa 434 aa 40.3 %
Leishmania major beta tubulin Tubulin   85 aa 80 aa 50.0 %
Trypanosoma congolense tubulin gamma chain Tubulin beta chain   445 aa 436 aa 33.3 %
Leishmania braziliensis beta-tubulin Tubulin   85 aa 80 aa 50.0 %
Toxoplasma gondii beta tubulin Tubulin   445 aa 430 aa 89.1 %
Onchocerca volvulus Putative methyltransferase KIAA1456 Tubulin beta chain   445 aa 426 aa 49.8 %
Leishmania major beta tubulin Tubulin   85 aa 80 aa 50.0 %
Trypanosoma brucei beta tubulin Tubulin   85 aa 80 aa 52.5 %
Plasmodium knowlesi tubulin gamma chain, putative Tubulin beta chain   445 aa 438 aa 33.3 %
Echinococcus multilocularis tubulin alpha 1C chain Tubulin beta chain   445 aa 434 aa 40.6 %
Echinococcus granulosus tubulin alpha 1C chain Tubulin beta chain   445 aa 434 aa 40.8 %
Echinococcus multilocularis solute carrier family 35 member e1 protein Tubulin   85 aa 75 aa 26.7 %
Giardia lamblia Alpha-tubulin Tubulin beta chain   445 aa 434 aa 40.3 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Cryptosporidium hominis alpha-tubulin Tubulin beta chain   445 aa 438 aa 40.2 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Echinococcus multilocularis prohormone 4 Tubulin   85 aa 76 aa 23.7 %
Leishmania infantum epsilon tubulin, putative Tubulin beta chain   445 aa 475 aa 30.3 %
Onchocerca volvulus Putative cytochrome c-type heme lyase Tubulin beta chain   445 aa 429 aa 87.4 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Echinococcus granulosus prohormone 4 Tubulin   85 aa 76 aa 23.7 %
Toxoplasma gondii alpha tubulin TUBA1 Tubulin beta chain   445 aa 440 aa 40.5 %
Brugia malayi tubulin alpha chain - mouse Tubulin beta chain   445 aa 433 aa 40.0 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Echinococcus granulosus tubulin alpha chain Tubulin beta chain   445 aa 433 aa 33.5 %
Candida albicans gamma tubulin-like protein Tubulin   85 aa 78 aa 32.1 %
Theileria parva tubulin beta chain, putative Tubulin   85 aa 80 aa 52.5 %
Entamoeba histolytica tubulin gamma chain Tubulin beta chain   445 aa 428 aa 33.2 %
Leishmania major beta tubulin Tubulin   85 aa 80 aa 50.0 %
Echinococcus multilocularis tubulin subunit beta Tubulin   85 aa 80 aa 50.0 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Trichomonas vaginalis tubulin epsilon chain, putative Tubulin   445 aa 428 aa 80.8 %
Trypanosoma cruzi epsilon tubulin, putative Tubulin beta chain   445 aa 456 aa 31.4 %
Giardia lamblia Hypothetical protein Tubulin   85 aa 72 aa 27.8 %
Trypanosoma brucei gambiense epsilon tubulin Tubulin beta chain   445 aa 443 aa 29.3 %
Echinococcus multilocularis tubulin delta chain Tubulin beta chain   445 aa 461 aa 25.8 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Brugia malayi Tubulin gamma chain Tubulin beta chain   445 aa 440 aa 31.8 %
Loa Loa (eye worm) BEN-1 protein Tubulin   445 aa 427 aa 57.1 %
Echinococcus granulosus tubulin gamma 1 chain Tubulin beta chain   445 aa 436 aa 34.4 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Leishmania mexicana beta tubulin Tubulin   85 aa 80 aa 50.0 %
Onchocerca volvulus Tubulin beta-1 chain homolog Tubulin   85 aa 79 aa 43.0 %
Brugia malayi alpha-tubulin Tubulin beta chain   445 aa 434 aa 38.7 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Plasmodium falciparum alpha tubulin 1 Tubulin beta chain   445 aa 434 aa 40.8 %
Echinococcus granulosus Tubulin alpha 1 chain Tubulin beta chain   445 aa 434 aa 40.3 %
Trichomonas vaginalis tubulin, putative Tubulin   85 aa 94 aa 30.9 %
Trypanosoma cruzi hypothetical protein Tubulin   85 aa 82 aa 24.4 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Echinococcus multilocularis Tubulin alpha 1 chain Tubulin beta chain   445 aa 434 aa 40.3 %
Babesia bovis tubulin beta chain Tubulin   85 aa 80 aa 51.2 %
Echinococcus multilocularis Tubulin beta 2C chain Tubulin   85 aa 86 aa 50.0 %
Giardia lamblia Alpha-tubulin Tubulin beta chain   445 aa 434 aa 40.3 %
Leishmania major beta tubulin Tubulin   85 aa 80 aa 50.0 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Plasmodium berghei alpha tubulin 1 Tubulin beta chain   445 aa 434 aa 40.3 %
Leishmania braziliensis alpha tubulin Tubulin beta chain   445 aa 434 aa 40.3 %
Trichomonas vaginalis tubulin beta-1 chain, putative Tubulin   85 aa 80 aa 51.2 %
Leishmania infantum beta tubulin Tubulin   85 aa 80 aa 50.0 %
Echinococcus multilocularis tubulin epsilon chain Tubulin   85 aa 100 aa 24.0 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Leishmania donovani epsilon tubulin, putative Tubulin beta chain   445 aa 475 aa 30.3 %
Drosophila melanogaster gamma-Tubulin at 23C Tubulin beta chain   445 aa 439 aa 34.6 %
Echinococcus multilocularis tubulin alpha 3 chain Tubulin beta chain   445 aa 439 aa 40.3 %
Cryptosporidium hominis beta-catenin-like repeat protein Tubulin   85 aa 80 aa 50.0 %
Echinococcus granulosus Tubulin beta 2C chain Tubulin   85 aa 86 aa 50.0 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Schistosoma mansoni tubulin subunit alpha Tubulin   85 aa 86 aa 83.7 %
Onchocerca volvulus Tubulin beta chain   445 aa 433 aa 40.0 %
Brugia malayi tubulin alpha-2 chain Tubulin beta chain   445 aa 440 aa 38.2 %
Trypanosoma brucei gambiense beta tubulin Tubulin   85 aa 80 aa 52.5 %
Schistosoma japonicum Tubulin alpha chain, putative Tubulin beta chain   445 aa 457 aa 36.8 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Echinococcus granulosus tubulin epsilon chain Tubulin   85 aa 100 aa 24.0 %
Leishmania mexicana beta tubulin Tubulin   445 aa 429 aa 85.8 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Loa Loa (eye worm) tubulin alpha-3 chain Tubulin   85 aa 84 aa 84.5 %
Schistosoma japonicum ko:K07375 tubulin beta, putative Tubulin   85 aa 80 aa 50.0 %
Echinococcus multilocularis tubulin alpha chain Tubulin   85 aa 86 aa 58.1 %
Echinococcus multilocularis tubulin beta 1 chain Tubulin   85 aa 80 aa 48.8 %
Leishmania major beta tubulin Tubulin   85 aa 80 aa 50.0 %
Echinococcus multilocularis beta tubulin Tubulin   85 aa 80 aa 50.0 %
Echinococcus multilocularis tubulin alpha chain Tubulin beta chain   445 aa 433 aa 33.5 %
Theileria parva tubulin alpha chain, putative Tubulin beta chain   445 aa 452 aa 36.7 %
Brugia malayi beta-tubulin, identical Tubulin   445 aa 430 aa 90.5 %
Echinococcus granulosus alpha tubulin Tubulin beta chain   445 aa 422 aa 29.9 %
Dictyostelium discoideum hypothetical protein Tubulin beta chain   445 aa 438 aa 38.8 %
Leishmania major beta tubulin Tubulin   85 aa 80 aa 50.0 %
Giardia lamblia Beta tubulin Tubulin   445 aa 428 aa 88.3 %
Echinococcus multilocularis tubulin alpha 3 chain Tubulin beta chain   445 aa 434 aa 40.1 %
Leishmania infantum beta tubulin Tubulin   85 aa 80 aa 50.0 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Entamoeba histolytica tubulin family protein Tubulin   445 aa 429 aa 57.8 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Leishmania major alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Giardia lamblia Epsilon tubulin Tubulin beta chain   445 aa 442 aa 27.6 %
Trichomonas vaginalis tubulin beta chain, putative Tubulin beta chain   445 aa 434 aa 39.6 %
Candida albicans cytoskeletal structural protein Tubulin   85 aa 86 aa 69.8 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Plasmodium berghei alpha tubulin 2 Tubulin beta chain   445 aa 434 aa 41.2 %
Leishmania major alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Trypanosoma brucei alpha tubulin Tubulin beta chain   445 aa 434 aa 40.8 %
Plasmodium vivax tubulin epsilon chain, putative Tubulin beta chain   445 aa 444 aa 28.6 %
Cryptosporidium hominis gamma-tubulin Tubulin beta chain   445 aa 436 aa 37.6 %
Trypanosoma congolense epsilon tubulin Tubulin beta chain   445 aa 464 aa 29.1 %
Leishmania infantum beta tubulin Tubulin   85 aa 80 aa 50.0 %
Leishmania infantum alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Candida albicans gamma tubulin-like protein Tubulin   85 aa 78 aa 32.1 %
Trypanosoma brucei beta tubulin Tubulin   85 aa 80 aa 52.5 %
Neospora caninum hypothetical protein Tubulin   445 aa 430 aa 89.1 %
Entamoeba histolytica tubulin alpha-1 chain Tubulin beta chain   445 aa 439 aa 36.2 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Schistosoma japonicum Tubulin alpha-1 chain, putative Tubulin beta chain   445 aa 439 aa 39.4 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Theileria parva Tubulin alpha chain, putative Tubulin beta chain   445 aa 439 aa 39.6 %
Dictyostelium discoideum alpha tubulin Tubulin beta chain   445 aa 446 aa 41.3 %
Brugia malayi Tubulin alpha-2 chain Tubulin   85 aa 86 aa 82.6 %
Schistosoma japonicum Tubulin beta chain, putative Tubulin   85 aa 80 aa 50.0 %
Trypanosoma cruzi hypothetical protein, conserved Tubulin   85 aa 76 aa 27.6 %
Neospora caninum tubulin alpha chain Tubulin beta chain   445 aa 440 aa 40.5 %
Schistosoma mansoni alpha tubulin Tubulin beta chain   445 aa 434 aa 39.4 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Loa Loa (eye worm) alpha-tubulin Tubulin beta chain   445 aa 440 aa 38.2 %
Leishmania braziliensis beta-tubulin Tubulin   85 aa 80 aa 50.0 %
Leishmania donovani alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Trypanosoma cruzi alpha tubulin, putative Tubulin beta chain   445 aa 434 aa 40.6 %
Neospora caninum tubulin alpha chain, putative Tubulin beta chain   445 aa 433 aa 30.9 %
Plasmodium vivax tubulin alpha chain, putative Tubulin beta chain   445 aa 434 aa 41.2 %
Trypanosoma cruzi beta tubulin, putative Tubulin   85 aa 80 aa 52.5 %
Echinococcus granulosus tubulin alpha chain Tubulin   85 aa 86 aa 58.1 %
Leishmania major alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Schistosoma japonicum Tubulin alpha-1C chain, putative Tubulin beta chain   445 aa 438 aa 38.8 %
Echinococcus multilocularis hypothetical protein Tubulin   85 aa 69 aa 26.1 %
Trypanosoma brucei gambiense alpha tubulin Tubulin beta chain   445 aa 434 aa 40.8 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Leishmania braziliensis alpha tubulin Tubulin beta chain   445 aa 434 aa 40.3 %
Trypanosoma brucei alpha tubulin Tubulin beta chain   445 aa 434 aa 40.8 %
Onchocerca volvulus 60S ribosomal protein L13 homolog Tubulin beta chain   445 aa 430 aa 91.4 %
Leishmania major beta tubulin Tubulin   85 aa 80 aa 50.0 %
Leishmania infantum beta-tubulin Tubulin   85 aa 80 aa 50.0 %
Plasmodium yoelii tubulin beta chain Tubulin beta chain   445 aa 445 aa 29.7 %
Cryptosporidium parvum tubulin beta chain Tubulin   85 aa 80 aa 50.0 %
Echinococcus granulosus Tubulin beta 2C chain Tubulin   445 aa 428 aa 92.3 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Trichomonas vaginalis tubulin beta chain, putative Tubulin beta chain   445 aa 434 aa 39.6 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Plasmodium vivax tubulin gamma chain, putative Tubulin beta chain   445 aa 438 aa 33.3 %
Schistosoma mansoni tubulin subunit gamma Tubulin beta chain   445 aa 436 aa 33.7 %
Leishmania major beta tubulin Tubulin   85 aa 80 aa 50.0 %
Leishmania mexicana epsilon tubulin, putative Tubulin beta chain   445 aa 469 aa 30.9 %
Echinococcus multilocularis tubulin alpha chain Tubulin beta chain   445 aa 438 aa 34.5 %
Echinococcus granulosus tubulin alpha Tubulin beta chain   445 aa 440 aa 30.2 %
Candida albicans C terminus of beta-tubulin Tubulin   85 aa 80 aa 47.5 %
Schistosoma mansoni tubulin subunit beta Tubulin   85 aa 80 aa 50.0 %
Leishmania major alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Plasmodium vivax tubulin beta chain, putative Tubulin   85 aa 80 aa 51.2 %
Onchocerca volvulus Tubulin beta chain   445 aa 433 aa 39.0 %
Trichomonas vaginalis tubulin beta chain, putative Tubulin   445 aa 428 aa 80.6 %
Echinococcus multilocularis tubulin, beta 4A class IVa Tubulin   445 aa 381 aa 71.1 %
Trypanosoma brucei beta tubulin Tubulin   85 aa 80 aa 52.5 %
Echinococcus granulosus tubulin alpha chain Tubulin beta chain   445 aa 434 aa 40.1 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Leishmania braziliensis beta tubulin Tubulin   85 aa 80 aa 50.0 %
Echinococcus granulosus beta tubulin Tubulin   445 aa 427 aa 82.2 %
Echinococcus granulosus tubulin alpha chain Tubulin   85 aa 72 aa 43.1 %
Echinococcus multilocularis tubulin alpha 1C chain Tubulin beta chain   445 aa 434 aa 39.9 %
Onchocerca volvulus Tubulin beta chain   445 aa 435 aa 39.5 %
Loa Loa (eye worm) tubulin alpha-2 chain Tubulin beta chain   445 aa 436 aa 38.5 %
Leishmania major beta tubulin Tubulin   85 aa 80 aa 50.0 %
Loa Loa (eye worm) tubulin alpha chain Tubulin beta chain   445 aa 432 aa 39.8 %
Leishmania major beta tubulin Tubulin   85 aa 80 aa 50.0 %
Leishmania mexicana alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Leishmania major alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Theileria parva tubulin gamma chain, putative Tubulin beta chain   445 aa 420 aa 34.5 %
Leishmania major gamma-tubulin Tubulin beta chain   445 aa 438 aa 34.0 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein Tubulin beta chain   445 aa 433 aa 30.7 %
Trypanosoma brucei epsilon tubulin Tubulin beta chain   445 aa 443 aa 29.3 %
Giardia lamblia Gamma tubulin Tubulin beta chain   445 aa 460 aa 32.4 %
Leishmania major alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Trichomonas vaginalis tubulin gamma chain, putative Tubulin beta chain   445 aa 415 aa 33.3 %
Onchocerca volvulus Regulatory-associated protein of mTOR homolog Tubulin beta chain   445 aa 440 aa 38.4 %
Schistosoma japonicum Tubulin beta chain, putative Tubulin   445 aa 436 aa 96.3 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Trichomonas vaginalis tubulin alpha-1 chain, putative Tubulin beta chain   445 aa 434 aa 39.6 %
Trypanosoma brucei epsilon tubulin Tubulin beta chain   445 aa 443 aa 29.1 %
Leishmania major alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Leishmania donovani tubulin gamma chain Tubulin beta chain   445 aa 438 aa 34.2 %
Loa Loa (eye worm) tubulin beta-2A chain Tubulin   445 aa 430 aa 91.4 %
Onchocerca volvulus Tubulin beta chain   445 aa 427 aa 82.4 %
Loa Loa (eye worm) tubulin beta-1 chain Tubulin   445 aa 432 aa 88.0 %
Plasmodium falciparum tubulin gamma chain Tubulin beta chain   445 aa 438 aa 32.9 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Trypanosoma cruzi epsilon tubulin, putative Tubulin beta chain   445 aa 456 aa 31.4 %
Cryptosporidium parvum gamma tubulin Tubulin beta chain   445 aa 436 aa 37.6 %
Echinococcus multilocularis Tubulin beta 2C chain Tubulin   445 aa 430 aa 93.7 %
Leishmania mexicana alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Babesia bovis tubulin alpha chain Tubulin   85 aa 86 aa 62.8 %
Plasmodium knowlesi tubulin epsilon chain, putative Tubulin beta chain   445 aa 441 aa 29.0 %
Trypanosoma brucei alpha tubulin Tubulin beta chain   445 aa 434 aa 40.8 %
Neospora caninum hypothetical protein Tubulin   445 aa 430 aa 89.8 %
Leishmania mexicana beta tubulin Tubulin   85 aa 80 aa 50.0 %
Echinococcus multilocularis beta tubulin Tubulin   85 aa 80 aa 51.2 %
Trypanosoma brucei epsilon tubulin Tubulin beta chain   445 aa 443 aa 29.3 %
Plasmodium berghei tubulin beta chain, putative Tubulin   85 aa 80 aa 51.2 %
Trichomonas vaginalis tubulin beta chain, putative Tubulin beta chain   445 aa 434 aa 39.6 %
Schistosoma japonicum ko:K07374 tubulin alpha, putative Tubulin beta chain   445 aa 433 aa 40.0 %
Onchocerca volvulus Tubulin beta chain   445 aa 434 aa 39.9 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Onchocerca volvulus Eukaryotic translation initiation factor 2A homolog Tubulin   85 aa 80 aa 51.2 %
Plasmodium berghei tubulin gamma chain, putative Tubulin beta chain   445 aa 438 aa 33.3 %
Leishmania infantum gamma-tubulin Tubulin beta chain   445 aa 438 aa 34.2 %
Leishmania mexicana Tubulin   85 aa 80 aa 50.0 %
Leishmania major epsilon tubulin, putative Tubulin beta chain   445 aa 469 aa 30.9 %
Giardia lamblia Beta tubulin Tubulin   445 aa 428 aa 88.3 %
Echinococcus multilocularis tubulin alpha chain Tubulin beta chain   445 aa 434 aa 40.1 %
Toxoplasma gondii alpha-tubulin I, putative Tubulin beta chain   445 aa 442 aa 39.8 %
Echinococcus granulosus Tubulin alpha 1 chain Tubulin beta chain   445 aa 434 aa 38.9 %
Trichomonas vaginalis tubulin, putative Tubulin   445 aa 428 aa 80.8 %
Echinococcus multilocularis tubulin alpha chain Tubulin   85 aa 72 aa 43.1 %
Leishmania major beta tubulin Tubulin   85 aa 80 aa 50.0 %
Loa Loa (eye worm) alpha-tubulin Tubulin   85 aa 86 aa 80.2 %
Trypanosoma brucei beta tubulin Tubulin   85 aa 80 aa 52.5 %
Entamoeba histolytica tubulin alpha chain, putative Tubulin beta chain   445 aa 439 aa 35.8 %
Trypanosoma congolense beta tubulin Tubulin   85 aa 80 aa 52.5 %
Leishmania major beta tubulin Tubulin   85 aa 80 aa 50.0 %
Schistosoma mansoni tubulin subunit epsilon Tubulin beta chain   445 aa 464 aa 31.7 %
Trichomonas vaginalis tubulin gamma chain, putative Tubulin   85 aa 80 aa 51.2 %
Cryptosporidium parvum alpha tubulin Tubulin beta chain   445 aa 438 aa 40.2 %
Leishmania major beta tubulin Tubulin   85 aa 80 aa 50.0 %
Schistosoma mansoni tubulin subunit alpha Tubulin beta chain   445 aa 434 aa 38.9 %
Toxoplasma gondii beta-1 tubulin, putative Tubulin   445 aa 430 aa 89.1 %
Trypanosoma brucei gambiense beta tubulin Tubulin   85 aa 80 aa 52.5 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Onchocerca volvulus Tyrosine kinase homolog Tubulin beta chain   445 aa 434 aa 38.2 %
Plasmodium berghei tubulin epsilon chain, putative Tubulin beta chain   445 aa 445 aa 29.4 %
Schistosoma mansoni tubulin subunit beta Tubulin   85 aa 80 aa 51.2 %
Trypanosoma brucei beta tubulin Tubulin   85 aa 80 aa 52.5 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Echinococcus multilocularis tubulin alpha Tubulin beta chain   445 aa 443 aa 30.5 %
Echinococcus granulosus tubulin subunit TubB Tubulin beta chain   445 aa 441 aa 30.6 %
Loa Loa (eye worm) BEN-1 protein Tubulin   445 aa 427 aa 82.2 %
Echinococcus multilocularis Tubulin beta 2C chain Tubulin   85 aa 80 aa 50.0 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Loa Loa (eye worm) tubulin beta chain Tubulin   85 aa 80 aa 51.2 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Echinococcus multilocularis peroxisome assembly protein 26 Tubulin beta chain   445 aa 438 aa 29.0 %
Dictyostelium discoideum beta tubulin Tubulin   445 aa 432 aa 75.7 %
Echinococcus granulosus tubulin alpha 3 chain Tubulin beta chain   445 aa 439 aa 40.3 %
Leishmania major beta tubulin Tubulin   85 aa 80 aa 50.0 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Schistosoma mansoni alpha tubulin Tubulin beta chain   445 aa 436 aa 39.9 %
Trichomonas vaginalis tubulin epsilon chain, putative Tubulin   85 aa 80 aa 52.5 %
Leishmania major alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Leishmania major beta tubulin Tubulin   85 aa 80 aa 50.0 %
Leishmania major alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Brugia malayi Tubulin alpha-2 chain Tubulin beta chain   445 aa 435 aa 38.4 %
Schistosoma japonicum ko:K10391 tubulin epsilon, putative Tubulin   85 aa 96 aa 25.0 %
Brugia malayi Tubulin beta-1 chain Tubulin   445 aa 429 aa 87.4 %
Leishmania major beta tubulin Tubulin   85 aa 80 aa 50.0 %
Loa Loa (eye worm) beta-tubulin Tubulin   85 aa 86 aa 38.4 %
Trypanosoma brucei tubulin gamma chain Tubulin beta chain   445 aa 436 aa 33.5 %
Schistosoma japonicum ko:K07374 tubulin alpha, putative Tubulin beta chain   445 aa 433 aa 39.3 %
Trypanosoma congolense alpha tubulin Tubulin beta chain   445 aa 434 aa 40.8 %
Loa Loa (eye worm) tubulin gamma chain Tubulin   85 aa 80 aa 37.5 %
Echinococcus granulosus tubulin subunit beta Tubulin   85 aa 80 aa 50.0 %
Schistosoma japonicum Tubulin alpha-2/alpha-4 chain, putative Tubulin   85 aa 86 aa 82.6 %
Plasmodium yoelii Tubulin/FtsZ family, putative Tubulin   85 aa 86 aa 72.1 %
Plasmodium falciparum alpha tubulin 2 Tubulin beta chain   445 aa 434 aa 41.2 %
Babesia bovis conserved hypothetical protein Tubulin   85 aa 73 aa 27.4 %
Echinococcus multilocularis tubulin gamma 1 chain Tubulin beta chain   445 aa 436 aa 34.4 %
Echinococcus multilocularis Tubulin alpha 1 chain Tubulin beta chain   445 aa 434 aa 40.8 %
Echinococcus multilocularis Tubulin beta 2C chain Tubulin   85 aa 80 aa 50.0 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Echinococcus multilocularis tubulin subunit TubB Tubulin beta chain   445 aa 441 aa 30.6 %
Schistosoma mansoni tubulin subunit beta Tubulin   445 aa 430 aa 92.3 %
Leishmania major alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Plasmodium knowlesi alpha tubulin, putative Tubulin beta chain   445 aa 434 aa 40.3 %
Loa Loa (eye worm) tubulin alpha chain Tubulin   85 aa 86 aa 83.7 %
Echinococcus multilocularis Tubulin beta 2C chain Tubulin   445 aa 428 aa 92.5 %
Giardia lamblia Beta tubulin Tubulin   445 aa 428 aa 88.3 %
Leishmania major beta tubulin Tubulin   85 aa 80 aa 50.0 %
Plasmodium knowlesi alpha-tubulin II, putative Tubulin beta chain   445 aa 434 aa 41.2 %
Neospora caninum Beta-tubulin, related Tubulin beta chain   445 aa 446 aa 35.2 %
Trypanosoma brucei alpha tubulin Tubulin beta chain   445 aa 434 aa 40.8 %
Leishmania major beta tubulin Tubulin   85 aa 80 aa 50.0 %
Leishmania mexicana gamma-tubulin Tubulin beta chain   445 aa 438 aa 34.2 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Schistosoma mansoni alpha tubulin Tubulin   85 aa 86 aa 82.6 %
Toxoplasma gondii beta-tubulin, putative Tubulin   445 aa 430 aa 89.8 %
Trichomonas vaginalis tubulin beta chain, putative Tubulin beta chain   445 aa 434 aa 39.6 %
Onchocerca volvulus Tubulin beta chain   445 aa 441 aa 31.7 %
Onchocerca volvulus Tubulin beta chain   445 aa 445 aa 36.2 %
Schistosoma japonicum ko:K10389 tubulin gamma, putative Tubulin beta chain   445 aa 436 aa 34.2 %
Babesia bovis tubulin, putative Tubulin beta chain   445 aa 459 aa 21.1 %
Onchocerca volvulus Tubulin beta-1 chain homolog Tubulin   85 aa 80 aa 51.2 %
Schistosoma mansoni tubulin subunit alpha Tubulin beta chain   445 aa 439 aa 39.4 %
Trypanosoma brucei gambiense gamma tubulin Tubulin beta chain   445 aa 436 aa 33.5 %
Brugia malayi Tubulin alpha chain Tubulin   85 aa 86 aa 83.7 %
Dictyostelium discoideum gamma tubulin Tubulin beta chain   445 aa 429 aa 34.0 %
Leishmania major alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Echinococcus granulosus peroxisome assembly protein 26 Tubulin beta chain   445 aa 438 aa 29.2 %
Leishmania major alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Plasmodium yoelii tubulin beta chain Tubulin   85 aa 80 aa 51.2 %
Leishmania braziliensis gamma-tubulin Tubulin beta chain   445 aa 438 aa 34.2 %
Echinococcus granulosus Tubulin beta 2C chain Tubulin   85 aa 80 aa 50.0 %
Plasmodium falciparum tubulin beta chain Tubulin   85 aa 80 aa 51.2 %
Onchocerca volvulus 1D304 homolog Tubulin beta chain   445 aa 433 aa 40.4 %
Leishmania mexicana Tubulin   85 aa 86 aa 69.8 %
Echinococcus granulosus tubulin beta 4A class IVa Tubulin   445 aa 381 aa 71.1 %
Echinococcus granulosus tubulin alpha chain Tubulin beta chain   445 aa 438 aa 34.7 %
Entamoeba histolytica tubulin family protein Tubulin   445 aa 428 aa 56.3 %
Echinococcus granulosus Tubulin beta 2C chain Tubulin   85 aa 80 aa 50.0 %
Loa Loa (eye worm) tubulin beta-4 chain Tubulin   85 aa 80 aa 51.2 %
Echinococcus multilocularis hypothetical protein Tubulin beta chain   445 aa 422 aa 29.9 %
Plasmodium yoelii tubulin gamma chain Tubulin beta chain   445 aa 438 aa 33.1 %
Echinococcus granulosus Tubulin alpha 1 chain Tubulin beta chain   445 aa 434 aa 40.8 %
Echinococcus granulosus tubulin alpha 3 chain Tubulin beta chain   445 aa 434 aa 40.1 %
Echinococcus granulosus tubulin beta 1 chain Tubulin   85 aa 80 aa 48.8 %
Schistosoma japonicum ko:K07375 tubulin beta, putative Tubulin   85 aa 80 aa 50.0 %
Trichomonas vaginalis tubulin epsilon chain, putative Tubulin beta chain   445 aa 434 aa 39.6 %
Leishmania infantum alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Plasmodium yoelii tubulin alpha chain Tubulin beta chain   445 aa 434 aa 40.3 %
Schistosoma mansoni tubulin subunit beta Tubulin   85 aa 80 aa 50.0 %
Schistosoma mansoni tubulin subunit beta Tubulin   445 aa 430 aa 95.8 %
Trichomonas vaginalis tubulin epsilon chain, putative Tubulin   85 aa 86 aa 74.4 %
Trichomonas vaginalis tubulin beta chain, putative Tubulin beta chain   445 aa 434 aa 39.6 %
Candida albicans C terminus of beta-tubulin Tubulin   85 aa 80 aa 47.5 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Leishmania braziliensis beta-tubulin Tubulin   85 aa 80 aa 50.0 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Babesia bovis tubulin alpha chain, putative Tubulin beta chain   445 aa 433 aa 40.6 %
Trichomonas vaginalis tubulin alpha chain, putative Tubulin   85 aa 86 aa 44.2 %
Trichomonas vaginalis tubulin alpha chain, putative Tubulin   445 aa 428 aa 80.8 %
Echinococcus granulosus tubulin alpha 1C chain Tubulin beta chain   445 aa 434 aa 39.6 %
Echinococcus granulosus beta tubulin Tubulin   85 aa 80 aa 50.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0396016 0.302786 0.363212
Brugia malayi Fibronectin type III domain containing protein 0.00307993 0.00156398 0.0018761
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0116642 0.0723651 0.235046
Trypanosoma cruzi UDP-galactopyranose mutase 0.00874192 0.0482627 0.155031
Echinococcus multilocularis purine nucleoside phosphorylase 0.052797 0.411619 0.490093
Mycobacterium ulcerans monoamine oxidase 0.00874192 0.0482627 0.040321
Brugia malayi Immunoglobulin I-set domain containing protein 0.00307993 0.00156398 0.0018761
Brugia malayi hypothetical protein 0.0296491 0.2207 0.264744
Brugia malayi Fibronectin type III domain containing protein 0.00307993 0.00156398 0.0018761
Trichomonas vaginalis histone deacetylase, putative 0.0237247 0.171837 0.338788
Onchocerca volvulus Putative organic anion transporter 0.0296491 0.2207 0.263362
Echinococcus granulosus lysine specific histone demethylase 1A 0.00874192 0.0482627 0.0558139
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.00882879 0.0489793 0.0569846
Echinococcus granulosus uridine phosphorylase 1 0.0116642 0.0723651 0.0846207
Echinococcus granulosus adenosine kinase 0.00951501 0.054639 0.0634347
Echinococcus granulosus methylthioadenosine phosphorylase 0.0116642 0.0723651 0.0846207
Leishmania major C-8 sterol isomerase-like protein 0.0396016 0.302786 1
Brugia malayi purine nucleoside phosphorylase I, inosine and guanosine-specific family protein 0.052797 0.411619 0.493764
Trypanosoma cruzi adenosine kinase, putative 0.00951501 0.054639 0.176199
Echinococcus granulosus purine nucleoside phosphorylase 0.052797 0.411619 0.490093
Echinococcus granulosus tm gpcr rhodopsin 0.104524 0.838251 1
Brugia malayi celfurPC protein 0.00882879 0.0489793 0.0587538
Loa Loa (eye worm) UNCoordinated family member 0.00307993 0.00156398 0.0018761
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.00398551 0.00903303 0.00892693
Schistosoma mansoni amine oxidase 0.00874192 0.0482627 0.0561235
Brugia malayi hypothetical protein 0.0296491 0.2207 0.264744
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.00882879 0.0489793 0.00197197
Loa Loa (eye worm) hypothetical protein 0.0191544 0.134143 0.160913
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0116642 0.0723651 0.0644877
Echinococcus granulosus histone deacetylase 6 0.00824026 0.0441252 0.0508687
Toxoplasma gondii subtilisin SUB10 0.00882879 0.0489793 0.0274901
Mycobacterium leprae Possible secreted protease 0.00882879 0.0489793 0.00197197
Echinococcus granulosus neuroendocrine convertase 2 0.00882879 0.0489793 0.0566703
Trypanosoma brucei methylthioadenosine phosphorylase, putative 0.0116642 0.0723651 0.235046
Brugia malayi amidase 0.00982424 0.0571894 0.0686025
Echinococcus granulosus fatty acid amide hydrolase 1 0.00982424 0.0571894 0.066483
Brugia malayi Lethal protein 805 0.00307993 0.00156398 0.0018761
Echinococcus granulosus purine nucleoside phosphorylase 0.052797 0.411619 0.490093
Trichomonas vaginalis purine nucleoside phosphorylase I, putative 0.052797 0.411619 1
Schistosoma mansoni adenosine kinase 0.00951501 0.054639 0.0637866
Brugia malayi Immunoglobulin I-set domain containing protein 0.00307993 0.00156398 0.0018761
Trypanosoma cruzi histone deacetylase, putative 0.00824026 0.0441252 0.141295
Plasmodium vivax histone deacetylase 1, putative 0.0237247 0.171837 1
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.00882879 0.0489793 0.000814571
Loa Loa (eye worm) hypothetical protein 0.00860268 0.0471144 0.0565168
Trichomonas vaginalis conserved hypothetical protein 0.0116642 0.0723651 0.0644877
Echinococcus granulosus insulin growth factor 1 receptor beta 0.00398551 0.00903303 0.00892693
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0296491 0.2207 0.261909
Loa Loa (eye worm) endoprotease bli-4 0.00882879 0.0489793 0.0587538
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 30. 0.00307993 0.00156398 0.0018761
Brugia malayi histone deacetylase 1 (HD1) 0.0237247 0.171837 0.20613
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.00882879 0.0489793 0.15741
Brugia malayi Immunoglobulin I-set domain containing protein 0.00307993 0.00156398 0.0018761
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0191544 0.134143 0.160913
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.00882879 0.0489793 0.0569846
Schistosoma mansoni organic anion transporter 0.0296491 0.2207 0.263362
Loa Loa (eye worm) hypothetical protein 0.0191544 0.134143 0.160913
Loa Loa (eye worm) projectin 0.00307993 0.00156398 0.0018761
Schistosoma mansoni histone deacetylase 1 2 3 0.00824026 0.0441252 0.0511509
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.00307993 0.00156398 0.0018761
Loa Loa (eye worm) hypothetical protein 0.00857352 0.0468738 0.0562282
Brugia malayi secreted modular calcium-binding protein 1 0.0191544 0.134143 0.160913
Echinococcus multilocularis purine nucleoside phosphorylase 0.0411328 0.315415 0.375112
Brugia malayi myotactin form A 0.00307993 0.00156398 0.0018761
Schistosoma mansoni ephrin receptor 0.00398551 0.00903303 0.00897645
Plasmodium vivax subtilisin-like protease 1 0.00882879 0.0489793 0.0380079
Trypanosoma brucei C-8 sterol isomerase, putative 0.0396016 0.302786 1
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0116642 0.0723651 0.235046
Echinococcus multilocularis uridine phosphorylase 1 0.0116642 0.0723651 0.0846207
Trypanosoma brucei histone deacetylase, putative 0.00824026 0.0441252 0.141295
Echinococcus multilocularis neuroendocrine convertase 2 0.00882879 0.0489793 0.0566703
Loa Loa (eye worm) hypothetical protein 0.00874192 0.0482627 0.0578943
Trypanosoma cruzi histone deacetylase, putative 0.00824026 0.0441252 0.141295
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.00882879 0.0489793 0.000814571
Brugia malayi Immunoglobulin I-set domain containing protein 0.00307993 0.00156398 0.0018761
Brugia malayi SPRY domain containing protein 0.00307993 0.00156398 0.0018761
Brugia malayi Histone deacetylase family protein 0.00824026 0.0441252 0.0529311
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0116642 0.0723651 0.0644877
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0191544 0.134143 0.509797
Trypanosoma cruzi adenosine kinase, putative 0.00951501 0.054639 0.176199
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0191544 0.134143 0.160913
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.00882879 0.0489793 0.15741
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.00307993 0.00156398 0.0018761
Schistosoma mansoni aryl hydrocarbon receptor 0.0138636 0.090505 0.106891
Onchocerca volvulus 0.0296491 0.2207 0.263362
Echinococcus granulosus Furin 1 0.00882879 0.0489793 0.0566703
Leishmania major histone deacetylase, putative 0.0237247 0.171837 0.565274
Onchocerca volvulus 0.0296491 0.2207 0.263362
Trypanosoma brucei histone deacetylase 4 0.00824026 0.0441252 0.141295
Echinococcus granulosus histone deacetylase 0.00824026 0.0441252 0.0508687
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.00874192 0.0482627 0.0234322
Toxoplasma gondii subtilisin SUB4 0.00882879 0.0489793 0.0274901
Trypanosoma cruzi histone deacetylase 1, putative 0.0237247 0.171837 0.565274
Echinococcus multilocularis transfer RNA-Lys 0.00389365 0.00827537 0.00802139
Echinococcus granulosus histone deacetylase 6 0.00824026 0.0441252 0.0508687
Plasmodium vivax hypothetical protein, conserved 0.00874192 0.0482627 0.0323974
Trichomonas vaginalis histone deacetylase, putative 0.0237247 0.171837 0.338788
Echinococcus granulosus lysine specific histone demethylase 1A 0.00874192 0.0482627 0.0558139
Echinococcus granulosus follistatin 0.0191544 0.134143 0.158457
Mycobacterium leprae Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) 0.052797 0.411619 1
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.00307993 0.00156398 0.0018761
Mycobacterium ulcerans carboxylesterase, LipT 0.01507 0.100456 0.0929494
Leishmania major adenosine kinase, putative 0.00951501 0.054639 0.176199
Echinococcus granulosus purine nucleoside phosphorylase 0.052797 0.411619 0.490093
Trypanosoma cruzi histone deacetylase, putative 0.00824026 0.0441252 0.141295
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0296491 0.2207 0.261909
Echinococcus multilocularis purine nucleoside phosphorylase 0.0411328 0.315415 0.375112
Schistosoma mansoni Lysine-specific histone demethylase 1 0.00874192 0.0482627 0.0561235
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.00874192 0.0482627 0.0561235
Loa Loa (eye worm) hypothetical protein 0.00307993 0.00156398 0.0018761
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.00307993 0.00156398 0.0018761
Trypanosoma brucei histone deacetylase 2 0.00824026 0.0441252 0.141295
Loa Loa (eye worm) lethal protein 805 0.00307993 0.00156398 0.0018761
Schistosoma mansoni purine nucleoside phosphorylase 0.052797 0.411619 0.492812
Toxoplasma gondii subtilisin SUB7 0.00882879 0.0489793 0.0274901
Echinococcus granulosus single minded 2 0.00389365 0.00827537 0.00802139
Loa Loa (eye worm) hypothetical protein 0.00307993 0.00156398 0.0018761
Brugia malayi endoprotease bli-4 precursor 0.00882879 0.0489793 0.0587538
Onchocerca volvulus Histone deacetylase 10 homolog 0.00824026 0.0441252 0.0511509
Brugia malayi Immunoglobulin I-set domain containing protein 0.00307993 0.00156398 0.0018761
Toxoplasma gondii subtilisin SUB6 0.00882879 0.0489793 0.0274901
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0116642 0.0723651 0.0644877
Mycobacterium ulcerans protoporphyrinogen oxidase 0.00874192 0.0482627 0.040321
Brugia malayi aryl hydrocarbon receptor AHR-1 0.00857352 0.0468738 0.0562282
Echinococcus multilocularis 0.00882879 0.0489793 0.0566703
Trypanosoma brucei adenosine kinase, putative 0.00951501 0.054639 0.176199
Schistosoma mansoni methylthioadenosine phosphorylase 0.0116642 0.0723651 0.0850902
Loa Loa (eye worm) hypothetical protein 0.00994075 0.0581505 0.0697553
Onchocerca volvulus 0.0296491 0.2207 0.263362
Loa Loa (eye worm) myotactin form A 0.00307993 0.00156398 0.0018761
Brugia malayi Immunoglobulin I-set domain containing protein 0.00307993 0.00156398 0.0018761
Brugia malayi sodium-independent organic anion transporter family protein 0.0296491 0.2207 0.264744
Brugia malayi Fibronectin type III domain containing protein 0.00307993 0.00156398 0.0018761
Echinococcus granulosus purine nucleoside phosphorylase 0.052797 0.411619 0.490093
Plasmodium vivax subtilisin-like protease 2, putative 0.00882879 0.0489793 0.0380079
Echinococcus granulosus histone deacetylase 3 0.0237247 0.171837 0.203509
Onchocerca volvulus 0.00392282 0.00851594 0.008355
Onchocerca volvulus 0.00863932 0.0474165 0.0551065
Loa Loa (eye worm) hypothetical protein 0.00307993 0.00156398 0.0018761
Brugia malayi Immunoglobulin I-set domain containing protein 0.00307993 0.00156398 0.0018761
Brugia malayi hypothetical protein 0.00307993 0.00156398 0.0018761
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.124135 1 1
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.00882879 0.0489793 0.0410435
Brugia malayi prostaglandin transporter 0.0296491 0.2207 0.264744
Echinococcus multilocularis histone deacetylase 1 0.0237247 0.171837 0.203509
Echinococcus multilocularis adenosine kinase 0.00951501 0.054639 0.0634347
Schistosoma mansoni amine oxidase 0.00874192 0.0482627 0.0561235
Trichomonas vaginalis histone deacetylase, putative 0.0237247 0.171837 0.338788
Loa Loa (eye worm) hypothetical protein 0.0191544 0.134143 0.160913
Mycobacterium tuberculosis Probable bifunctional MTA/SAH nucleosidase Mtn: 5'-methylthioadenosine nucleosidase (methylthioadenosine methylthioribohydrolase 0.0116642 0.0723651 0.0274003
Brugia malayi sodium-independent organic anion transporter family protein 0.0296491 0.2207 0.264744
Toxoplasma gondii transporter, major facilitator family protein 0.0296491 0.2207 1
Loa Loa (eye worm) hypothetical protein 0.00307993 0.00156398 0.0018761
Brugia malayi histone deacetylase 3 (HD3) 0.0237247 0.171837 0.20613
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.00882879 0.0489793 0.0587538
Echinococcus multilocularis follistatin 0.0191544 0.134143 0.158457
Trichomonas vaginalis histone deacetylase, putative 0.0237247 0.171837 0.338788
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.00882879 0.0489793 0.0410435
Loa Loa (eye worm) histone deacetylase 7A 0.00824026 0.0441252 0.0529311
Schistosoma mansoni uridine phosphorylase 0.0116642 0.0723651 0.0850902
Trypanosoma brucei subtilisin peptidase 0.00882879 0.0489793 0.15741
Echinococcus granulosus agrin 0.0191544 0.134143 0.158457
Brugia malayi Fibronectin type III domain containing protein 0.00307993 0.00156398 0.0018761
Echinococcus multilocularis histone deacetylase 3 0.0237247 0.171837 0.203509
Mycobacterium ulcerans dehydrogenase 0.00874192 0.0482627 0.040321
Schistosoma mansoni histone deacetylase hda2 0.00824026 0.0441252 0.0511509
Loa Loa (eye worm) S-methyl-5'-thioadenosine phosphorylase MTAP 0.0116642 0.0723651 0.0868066
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0116642 0.0723651 0.0644877
Brugia malayi PAS domain containing protein 0.00526089 0.019552 0.0234539
Echinococcus granulosus membrane bound transcription factor site 1 0.103964 0.833635 0.994483
Toxoplasma gondii histone deacetylase HDAC2 0.0237247 0.171837 0.723274
Trypanosoma brucei histone deacetylase 3 0.00824026 0.0441252 0.141295
Loa Loa (eye worm) hypothetical protein 0.00951501 0.054639 0.0655431
Loa Loa (eye worm) hypothetical protein 0.00874192 0.0482627 0.0578943
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.00307993 0.00156398 0.0018761
Mycobacterium leprae probable uridine phosphorylase 0.0116642 0.0723651 0.0663325
Leishmania major histone deacetylase, putative 0.00824026 0.0441252 0.141295
Echinococcus multilocularis fatty acid amide hydrolase 1 0.00982424 0.0571894 0.066483
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.00874192 0.0482627 0.0323974
Mycobacterium tuberculosis Hypothetical protein 0.0116642 0.0723651 0.0274003
Brugia malayi Fibronectin type III domain containing protein 0.00307993 0.00156398 0.0018761
Loa Loa (eye worm) hypothetical protein 0.00307993 0.00156398 0.0018761
Echinococcus multilocularis nuclear receptor co repressor related (ncor) 0.0391412 0.298989 0.35548
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.00882879 0.0489793 0.15741
Onchocerca volvulus Putative organic anion transporter 0.0296491 0.2207 0.263362
Trypanosoma brucei histone deacetylase 1 0.0237247 0.171837 0.565274
Loa Loa (eye worm) hypothetical protein 0.0237247 0.171837 0.20613
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.00307993 0.00156398 0.0018761
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.00882879 0.0489793 0.00197197
Plasmodium falciparum subtilisin-like protease 2 0.00882879 0.0489793 0.0380079
Leishmania major UDP-galactopyranose mutase 0.00874192 0.0482627 0.155031
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.00882879 0.0489793 0.0566703
Loa Loa (eye worm) hypothetical protein 0.00307993 0.00156398 0.0018761
Echinococcus granulosus nuclear receptor co repressor related ncor 0.0391412 0.298989 0.35548
Loa Loa (eye worm) hypothetical protein 0.103964 0.833635 1
Echinococcus multilocularis fatty acid amide hydrolase 1 0.00982424 0.0571894 0.066483
Loa Loa (eye worm) hypothetical protein 0.00307993 0.00156398 0.0018761
Leishmania major methylthioadenosine phosphorylase, putative 0.0116642 0.0723651 0.235046
Plasmodium vivax protoporphyrinogen oxidase, putative 0.00874192 0.0482627 0.0323974
Loa Loa (eye worm) uridine phosphorylase 0.0116642 0.0723651 0.0868066
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.0116642 0.0723651 0.235046
Giardia lamblia Histone deacetylase 0.0237247 0.171837 0.293209
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.00307993 0.00156398 0.0018761
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.115393 0.927899 1
Toxoplasma gondii Purine nucleoside phosphorylase 0.0116642 0.0723651 0.159931
Brugia malayi SPARC precursor 0.0191544 0.134143 0.160913
Schistosoma mansoni histone deacetylase 4 5 0.00824026 0.0441252 0.0511509
Plasmodium vivax purine nucleoside phosphorylase, putative 0.0116642 0.0723651 0.221121
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.00307993 0.00156398 0.0018761
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0296491 0.2207 0.261909
Trypanosoma brucei uridine phosphorylase 0.0116642 0.0723651 0.235046
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.00882879 0.0489793 0.000814571
Loa Loa (eye worm) hypothetical protein 0.00307993 0.00156398 0.0018761
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.00882879 0.0489793 0.0410435
Toxoplasma gondii protease inhibitor PI2 0.0191544 0.134143 0.509797
Schistosoma mansoni purine nucleoside phosphorylase 0.052797 0.411619 0.492812
Schistosoma mansoni agrin 0.0191544 0.134143 0.159336
Echinococcus granulosus inosine guanosine and xanthosine phosphorylase 0.0411328 0.315415 0.375112
Schistosoma mansoni single-minded 0.00526089 0.019552 0.0216184
Echinococcus multilocularis lysine specific histone demethylase 1A 0.00874192 0.0482627 0.0558139
Toxoplasma gondii histone deacetylase HDAC3 0.0237247 0.171837 0.723274
Loa Loa (eye worm) histone deacetylase 0.00824026 0.0441252 0.0529311
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0237247 0.171837 0.338788
Onchocerca volvulus 0.0296491 0.2207 0.263362
Echinococcus multilocularis protoporphyrinogen oxidase 0.00874192 0.0482627 0.0558139
Plasmodium falciparum histone deacetylase 1 0.0237247 0.171837 1
Echinococcus multilocularis agrin 0.0191544 0.134143 0.158457
Echinococcus multilocularis 0.00874192 0.0482627 0.0558139
Echinococcus multilocularis expressed protein 0.0191544 0.134143 0.158457
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0191544 0.134143 0.160913
Echinococcus multilocularis purine nucleoside phosphorylase 0.052797 0.411619 0.490093
Loa Loa (eye worm) hypothetical protein 0.00874192 0.0482627 0.0578943
Echinococcus granulosus histone deacetylase 6 0.00824026 0.0441252 0.0508687
Trypanosoma cruzi histone deacetylase, putative 0.00824026 0.0441252 0.141295
Entamoeba histolytica histone deacetylase, putative 0.0237247 0.171837 1
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0191544 0.134143 0.160913
Trichomonas vaginalis histone deacetylase, putative 0.0237247 0.171837 0.338788
Trypanosoma cruzi UDP-galactopyranose mutase 0.00874192 0.0482627 0.155031
Echinococcus granulosus furin 0.00882879 0.0489793 0.0566703
Mycobacterium ulcerans 5'-methylthioadenosine phosphorylase 0.0116642 0.0723651 0.0646245
Treponema pallidum uridine phosphorylase (udp) 0.0116642 0.0723651 0.5
Loa Loa (eye worm) hypothetical protein 0.00307993 0.00156398 0.0018761
Brugia malayi neuroendocrine convertase 1 precursor 0.00882879 0.0489793 0.0587538
Echinococcus granulosus purine nucleoside phosphorylase 0.052797 0.411619 0.490093
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0116642 0.0723651 0.0644877
Onchocerca volvulus 0.103964 0.833635 1
Mycobacterium ulcerans purine nucleoside phosphorylase 0.052797 0.411619 0.406709
Loa Loa (eye worm) hypothetical protein 0.00982424 0.0571894 0.0686025
Loa Loa (eye worm) hypothetical protein 0.0296491 0.2207 0.264744
Treponema pallidum purine nucleoside phosphorylase (deoD) 0.0116642 0.0723651 0.5
Brugia malayi protein unc-22 0.00307993 0.00156398 0.0018761
Brugia malayi histone deacetylase 11 0.00824026 0.0441252 0.0529311
Echinococcus granulosus fatty acid amide hydrolase 1 0.00982424 0.0571894 0.066483
Leishmania major histone deacetylase, putative 0.00824026 0.0441252 0.141295
Giardia lamblia Purine nucleoside phosphorylase lateral transfer candidate 0.052797 0.411619 1
Brugia malayi Adenosine kinase-like 0.00951501 0.054639 0.0655431
Loa Loa (eye worm) hypothetical protein 0.0296491 0.2207 0.264744
Schistosoma mansoni fatty-acid amide hydrolase 0.00982424 0.0571894 0.0668518
Schistosoma mansoni methylthioadenosine phosphorylase 0.0116642 0.0723651 0.0850902
Trypanosoma cruzi subtilisin peptidase 0.00882879 0.0489793 0.15741
Loa Loa (eye worm) hypothetical protein 0.0296491 0.2207 0.264744
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.103964 0.833635 1
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0191544 0.134143 0.160913
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.00874192 0.0482627 0.0323974
Onchocerca volvulus 0.00994075 0.0581505 0.0680068
Trypanosoma cruzi histone deacetylase, putative 0.00824026 0.0441252 0.141295
Loa Loa (eye worm) histone deacetylase 1 0.0237247 0.171837 0.20613
Plasmodium vivax subtilisin-like serine protease, putative 0.00882879 0.0489793 0.0380079
Toxoplasma gondii histone lysine-specific demethylase 0.00874192 0.0482627 0.0234322
Schistosoma mansoni methylthioadenosine phosphorylase 0.0116642 0.0723651 0.0850902
Loa Loa (eye worm) hypothetical protein 0.00307993 0.00156398 0.0018761
Brugia malayi hypothetical protein 0.00307993 0.00156398 0.0018761
Echinococcus multilocularis Furin 1 0.00882879 0.0489793 0.0566703
Loa Loa (eye worm) hypothetical protein 0.0191544 0.134143 0.160913
Trypanosoma brucei adenosine kinase, putative 0.00951501 0.054639 0.176199
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.124135 1 1
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.00882879 0.0489793 0.0569846
Echinococcus multilocularis histone deacetylase 0.00824026 0.0441252 0.0508687
Echinococcus multilocularis histone deacetylase 6 0.00824026 0.0441252 0.0508687
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.00882879 0.0489793 0.0569846
Onchocerca volvulus Purine nucleoside phosphorylase homolog 0.052797 0.411619 0.492812
Schistosoma mansoni follistatin 0.0191544 0.134143 0.159336
Echinococcus granulosus purine nucleoside phosphorylase 0.052797 0.411619 0.490093
Loa Loa (eye worm) hypothetical protein 0.020335 0.14388 0.172593
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0191544 0.134143 0.509797
Schistosoma mansoni amidase 0.00982424 0.0571894 0.0668518
Echinococcus multilocularis purine nucleoside phosphorylase 0.052797 0.411619 0.490093
Brugia malayi amine oxidase, flavin-containing family protein 0.00874192 0.0482627 0.0578943
Loa Loa (eye worm) hypothetical protein 0.00307993 0.00156398 0.0018761
Brugia malayi myotactin form B 0.00307993 0.00156398 0.0018761
Loa Loa (eye worm) proprotein convertase 2 0.00882879 0.0489793 0.0587538
Plasmodium falciparum subtilisin-like protease 1 0.00882879 0.0489793 0.0380079
Brugia malayi Histone deacetylase family protein 0.00824026 0.0441252 0.0529311
Onchocerca volvulus 0.00874192 0.0482627 0.0561235
Toxoplasma gondii subtilisin SUB5 0.00882879 0.0489793 0.0274901
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0191544 0.134143 0.509797
Plasmodium vivax hypothetical protein, conserved 0.00874192 0.0482627 0.0323974
Plasmodium falciparum purine nucleoside phosphorylase 0.0116642 0.0723651 0.221121
Mycobacterium tuberculosis Carboxylesterase LipT 0.01507 0.100456 0.0593346
Loa Loa (eye worm) hypothetical protein 0.0296491 0.2207 0.264744
Loa Loa (eye worm) hypothetical protein 0.00307993 0.00156398 0.0018761
Trypanosoma cruzi MFS transporter, putative 0.0296491 0.2207 0.72749
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.00307993 0.00156398 0.0018761
Loa Loa (eye worm) hypothetical protein 0.00874192 0.0482627 0.0578943
Toxoplasma gondii subtilisin SUB2 0.00882879 0.0489793 0.0274901
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.00882879 0.0489793 0.15741
Echinococcus multilocularis histone deacetylase 8 0.00824026 0.0441252 0.0508687
Echinococcus granulosus aryl hydrocarbon receptor 0.00996992 0.058391 0.0679191
Mycobacterium tuberculosis Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) 0.052797 0.411619 0.413076
Toxoplasma gondii subtilisin SUB9 0.00882879 0.0489793 0.0274901
Brugia malayi Immunoglobulin I-set domain containing protein 0.00307993 0.00156398 0.0018761
Brugia malayi uridine phosphorylase family protein 0.0116642 0.0723651 0.0868066
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0191544 0.134143 0.509797
Leishmania major nucleoside phosphorylase-like protein 0.0116642 0.0723651 0.235046
Echinococcus multilocularis purine nucleoside phosphorylase 0.052797 0.411619 0.490093
Schistosoma mansoni furin-1 (S08 family) 0.00882879 0.0489793 0.0569846
Schistosoma mansoni histone deacetylase hda2 0.00824026 0.0441252 0.0511509
Trichomonas vaginalis histone deacetylase, putative 0.0237247 0.171837 0.338788
Mycobacterium tuberculosis Conserved hypothetical protein 0.0116642 0.0723651 0.0274003
Brugia malayi Lethal protein 805 0.00307993 0.00156398 0.0018761
Loa Loa (eye worm) hypothetical protein 0.00307993 0.00156398 0.0018761
Brugia malayi proprotein convertase 2 0.00882879 0.0489793 0.0587538
Loa Loa (eye worm) hypothetical protein 0.00307993 0.00156398 0.0018761
Loa Loa (eye worm) hypothetical protein 0.0296491 0.2207 0.264744
Schistosoma mansoni site-1 peptidase (S08 family) 0.103964 0.833635 1
Onchocerca volvulus Putative organic anion transporter 0.0296491 0.2207 0.263362
Echinococcus multilocularis aryl hydrocarbon receptor 0.00996992 0.058391 0.0679191
Brugia malayi MTAP 0.0116642 0.0723651 0.0868066
Echinococcus granulosus histone deacetylase 8 0.00824026 0.0441252 0.0508687
Brugia malayi bHLH-PAS transcription factor 0.00389365 0.00827537 0.00992685
Echinococcus granulosus purine nucleoside phosphorylase 0.052797 0.411619 0.490093
Plasmodium falciparum protoporphyrinogen oxidase 0.00874192 0.0482627 0.0323974
Brugia malayi Protein-tyrosine phosphatase 0.00307993 0.00156398 0.0018761
Loa Loa (eye worm) hypothetical protein 0.00882879 0.0489793 0.0587538
Schistosoma mansoni organic anion transporter 0.0296491 0.2207 0.263362
Brugia malayi Subtilase family protein 0.00882879 0.0489793 0.0587538
Loa Loa (eye worm) hypothetical protein 0.0296491 0.2207 0.264744
Loa Loa (eye worm) agrin synaptic family protein 0.0191544 0.134143 0.160913
Toxoplasma gondii subtilisin SUB8 0.00882879 0.0489793 0.0274901
Echinococcus granulosus histone deacetylase 7 0.00824026 0.0441252 0.0508687
Plasmodium falciparum subtilisin-like protease 3 0.00882879 0.0489793 0.0380079
Loa Loa (eye worm) CAMK protein kinase 0.00307993 0.00156398 0.0018761
Trichomonas vaginalis conserved hypothetical protein 0.0116642 0.0723651 0.0644877
Loa Loa (eye worm) hypothetical protein 0.00307993 0.00156398 0.0018761
Echinococcus multilocularis methylthioadenosine phosphorylase 0.0116642 0.0723651 0.0846207
Loa Loa (eye worm) histone deacetylase 3 0.0237247 0.171837 0.20613
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0116642 0.0723651 0.235046
Echinococcus multilocularis purine nucleoside phosphorylase 0.052797 0.411619 0.490093
Leishmania major subtilisin-like serine peptidase 0.00882879 0.0489793 0.15741
Toxoplasma gondii phosphorylase family protein 0.0116642 0.0723651 0.159931
Brugia malayi Immunoglobulin I-set domain containing protein 0.00307993 0.00156398 0.0018761
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.00874192 0.0482627 0.0323974
Trypanosoma cruzi histone deacetylase 1, putative 0.0237247 0.171837 0.565274
Loa Loa (eye worm) hypothetical protein 0.00307993 0.00156398 0.0018761
Echinococcus granulosus Solute carrier organic anion transporter family 0.0296491 0.2207 0.261909
Brugia malayi SWIRM domain containing protein 0.00874192 0.0482627 0.0578943
Loa Loa (eye worm) hypothetical protein 0.00307993 0.00156398 0.0018761
Echinococcus multilocularis membrane bound transcription factor site 1 0.103964 0.833635 0.994483
Echinococcus multilocularis purine nucleoside phosphorylase 0.052797 0.411619 0.490093
Toxoplasma gondii kinase, pfkB family protein 0.00951501 0.054639 0.059543
Loa Loa (eye worm) hypothetical protein 0.00824026 0.0441252 0.0529311
Loa Loa (eye worm) hypothetical protein 0.00874192 0.0482627 0.0578943
Treponema pallidum pfs protein (pfs) 0.0116642 0.0723651 0.5
Mycobacterium ulcerans bifunctional Mta/Sah nucleosidase Mtn 0.0116642 0.0723651 0.0646245
Brugia malayi sodium-independent organic anion transporter family protein 0.0296491 0.2207 0.264744
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.00307993 0.00156398 0.0018761
Schistosoma mansoni uridine phosphorylase 0.0116642 0.0723651 0.0850902
Loa Loa (eye worm) hypothetical protein 0.0396016 0.302786 0.363212
Schistosoma mansoni site-1 peptidase (S08 family) 0.00882879 0.0489793 0.0569846
Loa Loa (eye worm) hypothetical protein 0.00307993 0.00156398 0.0018761
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.00882879 0.0489793 0.0566703
Loa Loa (eye worm) hypothetical protein 0.0411328 0.315415 0.378361
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0237247 0.171837 0.338788
Brugia malayi hypothetical protein 0.00874192 0.0482627 0.0578943
Schistosoma mansoni histone deacetylase 0.0237247 0.171837 0.204638
Echinococcus granulosus histone deacetylase 1 0.0237247 0.171837 0.203509
Schistosoma mansoni histone deacetylase 4 5 0.00824026 0.0441252 0.0511509
Loa Loa (eye worm) hypothetical protein 0.00307993 0.00156398 0.0018761
Chlamydia trachomatis AMP nucleosidase 0.0116642 0.0723651 1
Toxoplasma gondii subtilisin SUB12 0.00882879 0.0489793 0.0274901
Schistosoma mansoni adenosine kinase 0.00951501 0.054639 0.0637866
Toxoplasma gondii phosphorylase family protein 0.0116642 0.0723651 0.159931
Schistosoma mansoni histone deacetylase 0.0237247 0.171837 0.204638
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 32 0.00307993 0.00156398 0.0018761
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0116642 0.0723651 0.0644877
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.00882879 0.0489793 0.0566703
Mycobacterium ulcerans oxidoreductase 0.00874192 0.0482627 0.040321
Brugia malayi Immunoglobulin I-set domain containing protein 0.00307993 0.00156398 0.0018761
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0116642 0.0723651 0.0644877
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.0116642 0.0723651 0.235046
Loa Loa (eye worm) hypothetical protein 0.0296491 0.2207 0.264744
Echinococcus multilocularis histone deacetylase 6 0.00824026 0.0441252 0.0508687
Echinococcus granulosus purine nucleoside phosphorylase 0.052797 0.411619 0.490093
Onchocerca volvulus 0.0191544 0.134143 0.159336
Loa Loa (eye worm) hypothetical protein 0.00307993 0.00156398 0.0018761
Loa Loa (eye worm) histone deacetylase 11 0.00824026 0.0441252 0.0529311
Brugia malayi Immunoglobulin I-set domain containing protein 0.00307993 0.00156398 0.0018761
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0296491 0.2207 0.264744
Echinococcus multilocularis histone deacetylase 6 0.00824026 0.0441252 0.0508687
Brugia malayi Immunoglobulin I-set domain containing protein 0.00307993 0.00156398 0.0018761
Loa Loa (eye worm) hypothetical protein 0.00874192 0.0482627 0.0578943
Toxoplasma gondii subtilisin SUB1 0.00882879 0.0489793 0.0274901
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0237247 0.171837 0.338788
Toxoplasma gondii subtilisin SUB11 0.00882879 0.0489793 0.0274901
Onchocerca volvulus 0.0296491 0.2207 0.263362
Loa Loa (eye worm) hypothetical protein 0.00307993 0.00156398 0.0018761
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0396016 0.302786 1
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.00882879 0.0489793 0.0566703
Brugia malayi Histone deacetylase 1 0.0237247 0.171837 0.20613
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.00307993 0.00156398 0.0018761
Brugia malayi Fibronectin type III domain containing protein 0.00307993 0.00156398 0.0018761
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.00307993 0.00156398 0.0018761
Echinococcus multilocularis histone deacetylase 7 0.00824026 0.0441252 0.0508687
Leishmania major histone deacetylase, putative 0.0237247 0.171837 0.565274
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.00882879 0.0489793 0.000814571
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.104524 0.838251 1
Loa Loa (eye worm) subtilase 0.00882879 0.0489793 0.0587538

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) In vivo inhibition of neovascularization of solid tumors when administered orally in mice; Active ChEMBL. No reference
Activity (functional) In vivo inhibition of growth of solid tumors when administered orally in mice; Active ChEMBL. No reference
Activity (binding) = 0.79 Inhibition activity of colchicine for tubuline polymerization to that of compound ChEMBL. 9371249
Activity (functional) 0 In vivo inhibition of neovascularization of solid tumors when administered orally in mice; Active ChEMBL. No reference
Activity (functional) 0 In vivo inhibition of growth of solid tumors when administered orally in mice; Active ChEMBL. No reference
Activity (binding) = 0.79 Inhibition activity of colchicine for tubuline polymerization to that of compound ChEMBL. 9371249
Activity (functional) = 0.44 g Antitumor activity against LLC cells inoculated in C57BL/6J mouse assessed as lung weight at 200 mg/kg, ip qd for 12 days ChEMBL. 18052315
Activity (ADMET) = 0 pm/min/mg Specific activity of expressed human recombinant UGT2B7 ChEMBL. 10836148
AUC (ADMET) = 142 nM.hr AUC (0 to infinity) in CD1 mouse at 45 mg/m'2 of body surface, po administered as single dose ChEMBL. 19782564
Binding (binding) = 25 % In vitro displacement of 0.5 nM [3H]-E2 from human Estrogen receptor beta at 10 uM ChEMBL. 12672229
Binding (binding) = 60 % In vitro displacement of 0.5 nM [3H]-E2 from human Estrogen receptor alpha at 10 uM ChEMBL. 12672229
Cmax (ADMET) = 294 nM Cmax in CD1 mouse at 45 mg/m'2 of body surface, po administered as single dose ChEMBL. 19782564
Cp (ADMET) = 5 ng/ml Drug level in Sprague-Dawley rat plasma at 1 mg/kg, iv assessed as 2-methoxyestradiol level after 120 mins ChEMBL. 18052315
Cp (ADMET) = 5 ng/ml Drug level in Sprague-Dawley rat plasma at 1 mg/kg, iv after 120 mins ChEMBL. 18052315
Cp (ADMET) = 5 ng/ml Drug level in Sprague-Dawley rat plasma at 1 mg/kg, iv assessed as 2-methoxyestrone level after 15 mins ChEMBL. 18052315
Cp (ADMET) = 5 ng/ml Drug level in Sprague-Dawley rat plasma at 1 mg/kg, iv assessed as 2-methoxyestrone level after 120 mins ChEMBL. 18052315
Cp (ADMET) = 5 ng/ml Drug level in Sprague-Dawley rat plasma at 1 mg/kg, iv assessed as 2-methoxyestrone level after 60 mins ChEMBL. 18052315
Cp (ADMET) = 5.3 ng/ml Drug level in Sprague-Dawley rat plasma at 1 mg/kg, iv assessed as 2-methoxyestradiol level after 60 mins ChEMBL. 18052315
Cp (ADMET) = 5.4 ng/ml Drug level in Sprague-Dawley rat plasma at 1 mg/kg, iv assessed as 2-methoxyestrone level after 30 mins ChEMBL. 18052315
Cp (ADMET) = 6.3 ng/ml Drug level in Sprague-Dawley rat plasma at 1 mg/kg, iv assessed as 2-methoxyestrone level after 5 mins ChEMBL. 18052315
Cp (ADMET) = 11.3 ng/ml Drug level in Sprague-Dawley rat plasma at 1 mg/kg, iv after 60 mins ChEMBL. 18052315
Cp (ADMET) = 22.3 ng/ml Drug level in Sprague-Dawley rat plasma at 1 mg/kg, iv assessed as 2-methoxyestradiol level after 30 mins ChEMBL. 18052315
Cp (ADMET) = 44.7 ng/ml Drug level in Sprague-Dawley rat plasma at 1 mg/kg, iv after 30 mins ChEMBL. 18052315
Cp (ADMET) = 57.3 ng/ml Drug level in Sprague-Dawley rat plasma at 1 mg/kg, iv assessed as 2-methoxyestradiol level after 15 mins ChEMBL. 18052315
Cp (ADMET) = 153.4 ng/ml Drug level in Sprague-Dawley rat plasma at 1 mg/kg, iv assessed as 2-methoxyestradiol level after 5 mins ChEMBL. 18052315
Cp (ADMET) = 168 ng/ml Drug level in Sprague-Dawley rat plasma at 1 mg/kg, iv after 15 mins ChEMBL. 18052315
Cp (ADMET) = 763.5 ng/ml Drug level in Sprague-Dawley rat plasma at 1 mg/kg, iv after 5 mins ChEMBL. 18052315
GI50 (functional) = 0.08 uM Concentration of the compound required to inhibit the growth of MDA-MB-435 human breast cancer cells by 50% ChEMBL. 16078843
GI50 (functional) = 0.08 uM Cytotoxicity against human MDA-MB-435 cells ChEMBL. 18052315
GI50 (functional) = 0.08 uM Antiproliferative activity against human MDA-MB-435 cells ChEMBL. 18260615
GI50 (functional) = 0.08 uM In vitro cytotoxicity value corresponding to 50% growth inhibition against MDA-MB-435(breast) cell line. ChEMBL. 9240348
GI50 (functional) = 0.08 uM Cytotoxicity against breast MDA-MB-435 cancer cell lines. ChEMBL. 7783135
GI50 (functional) = 0.08 uM Cytotoxicity against the cancer cell lines breast MDA-MB-435 ChEMBL. 12361402
GI50 (functional) = 0.08 uM Growth inhibitory concentration against human breast MDA-MB-435 cancer cell line ChEMBL. 15456256
GI50 (functional) = 0.08 uM Concentration of the compound required to inhibit the growth of MDA-MB-435 human breast cancer cells by 50% ChEMBL. 16078843
GI50 (functional) = 0.08 uM Cytotoxicity against human MDA-MB-435 cells ChEMBL. 18052315
GI50 (functional) = 0.08 uM Antiproliferative activity against human MDA-MB-435 cells ChEMBL. 18260615
GI50 (functional) = 0.21 uM Concentration of the compound required to inhibit the growth of OVCAR-3 human ovarian cancer cells by 50% ChEMBL. 16078843
GI50 (functional) = 0.21 uM Cytotoxicity against human OVCAR3 cells ChEMBL. 18052315
GI50 (functional) = 0.21 uM Antiproliferative activity against human OVCAR3 cells ChEMBL. 18260615
GI50 (functional) = 0.21 uM In vitro cytotoxicity value corresponding to 50% growth inhibition against OVCAR-3(ovarian) cell line. ChEMBL. 9240348
GI50 (functional) = 0.21 uM Cytotoxicity against ovarian OVCAR-3 cancer cell lines. ChEMBL. 7783135
GI50 (functional) = 0.21 uM Cytotoxicity against the cancer cell lines ovarian OVCAR-3 ChEMBL. 12361402
GI50 (functional) = 0.21 uM Growth inhibitory concentration against human ovarian OVCAR-3 cancer cell line ChEMBL. 15456256
GI50 (functional) = 0.21 uM Concentration of the compound required to inhibit the growth of OVCAR-3 human ovarian cancer cells by 50% ChEMBL. 16078843
GI50 (functional) = 0.21 uM Cytotoxicity against human OVCAR3 cells ChEMBL. 18052315
GI50 (functional) = 0.21 uM Antiproliferative activity against human OVCAR3 cells ChEMBL. 18260615
GI50 (functional) = 0.21 uM Antiproliferative activity against human OVCAR-3 cells after 96 hrs by WST-1 assay ChEMBL. 20225862
GI50 (functional) = 0.32 uM Concentration of the compound required to inhibit the growth of SF-539 human CNS cancer cells by 50% ChEMBL. 16078843
GI50 (functional) = 0.32 uM Cytotoxicity against human SF539 cells ChEMBL. 18052315
GI50 (functional) = 0.32 uM Antiproliferative activity against human SF539 cells at ChEMBL. 18260615
GI50 (functional) = 0.32 uM The In vitro cytotoxicity corresponding to 50% growth inhibition against SF-59 (central nervous system) cell line. ChEMBL. 9240348
GI50 (functional) = 0.32 uM Cytotoxicity against CNS SF-539 cancer cell lines. ChEMBL. 7783135
GI50 (functional) = 0.32 uM Cytotoxicity against the cancer cell lines CNS SF-539 ChEMBL. 12361402
GI50 (functional) = 0.32 uM Growth inhibitory concentration against human CNS SF-539 cancer cell line ChEMBL. 15456256
GI50 (functional) = 0.32 uM Concentration of the compound required to inhibit the growth of SF-539 human CNS cancer cells by 50% ChEMBL. 16078843
GI50 (functional) = 0.32 uM Cytotoxicity against human SF539 cells ChEMBL. 18052315
GI50 (functional) = 0.32 uM Antiproliferative activity against human SF539 cells at ChEMBL. 18260615
GI50 (functional) = 0.32 uM Antiproliferative activity against human SF539 cells after 96 hrs by WST-1 assay ChEMBL. 20225862
GI50 (functional) = 0.36 uM Concentration of the compound required to inhibit the growth of UACC-62 human melanoma cells by 50% ChEMBL. 16078843
GI50 (functional) = 0.36 uM Cytotoxicity against human UACC62 cells ChEMBL. 18052315
GI50 (functional) = 0.36 uM Antiproliferative activity against human UACC62 cells ChEMBL. 18260615
GI50 (functional) = 0.36 uM In vitro cytotoxicity value corresponding to 50% growth inhibition against UACC-62(melanoma) cell line. ChEMBL. 9240348
GI50 (functional) = 0.36 uM Cytotoxicity against melanoma UACC-62 cancer cell lines. ChEMBL. 7783135
GI50 (functional) = 0.36 uM Cytotoxicity against the cancer cell lines melanoma UACC-62 ChEMBL. 12361402
GI50 (functional) = 0.36 uM Growth inhibitory concentration against human melanoma UACC-62 cancer cell line ChEMBL. 15456256
GI50 (functional) = 0.36 uM Concentration of the compound required to inhibit the growth of UACC-62 human melanoma cells by 50% ChEMBL. 16078843
GI50 (functional) = 0.36 uM Cytotoxicity against human UACC62 cells ChEMBL. 18052315
GI50 (functional) = 0.36 uM Antiproliferative activity against human UACC62 cells ChEMBL. 18260615
GI50 (functional) = 0.36 uM Antiproliferative activity against human UACC62 cells after 96 hrs by WST-1 assay ChEMBL. 20225862
GI50 (functional) = 0.47 uM Concentration of the compound required to inhibit the growth of HCT-116 human colon cancer cells by 50% ChEMBL. 16078843
GI50 (functional) = 0.47 uM Cytotoxicity against human HCT116 cells ChEMBL. 18052315
GI50 (functional) = 0.47 uM Antiproliferative activity against human HCT116 cells ChEMBL. 18260615
GI50 (functional) = 0.47 uM The In vitro cytotoxicity value is the concentration of the compoundcorresponding to 50% growth inhibition againstHCT-116 (colon) cell line. ChEMBL. 9240348
GI50 (functional) = 0.47 uM Cytotoxicity against colon HCT-116 cancer cell lines. ChEMBL. 7783135
GI50 (functional) = 0.47 uM Cytotoxicity against the cancer cell lines colon HCT-116 ChEMBL. 12361402
GI50 (functional) = 0.47 uM Growth inhibitory concentration against human colon cancer HCT-116 cell line ChEMBL. 15456256
GI50 (functional) = 0.47 uM Concentration of the compound required to inhibit the growth of HCT-116 human colon cancer cells by 50% ChEMBL. 16078843
GI50 (functional) = 0.47 uM Cytotoxicity against human HCT116 cells ChEMBL. 18052315
GI50 (functional) = 0.47 uM Antiproliferative activity against human HCT116 cells ChEMBL. 18260615
GI50 (functional) = 0.47 uM Antiproliferative activity against human HCT116 cells after 96 hrs by WST-1 assay ChEMBL. 20225862
GI50 (functional) = 0.7 uM Concentration of the compound required to inhibit the growth of HOP-6 human lung cancer cells by 50% ChEMBL. 16078843
GI50 (functional) = 0.7 uM Cytotoxicity against human HOP62 cells ChEMBL. 18052315
GI50 (functional) = 0.7 uM Antiproliferative activity against human HOP62 cells ChEMBL. 18260615
GI50 (functional) = 0.7 uM The In vitro cytotoxicity value is the concentration of the compound corresponding to 50% growth inhibition against HOP-62 (non small cell lung) cell line. ChEMBL. 9240348
GI50 (functional) = 0.7 uM Cytotoxicity against lung HOP-62 cancer cell lines. ChEMBL. 7783135
GI50 (functional) = 0.7 uM Cytotoxicity against the cancer cell lines lung HOP-62 ChEMBL. 12361402
GI50 (functional) = 0.7 uM Growth inhibitory concentration against human lung cancer HOP-62 cell line ChEMBL. 15456256
GI50 (functional) = 0.7 uM Cytotoxicity against human HOP62 cells ChEMBL. 18052315
GI50 (functional) = 0.7 uM Antiproliferative activity against human HOP62 cells ChEMBL. 18260615
GI50 (functional) = 0.7 uM Antiproliferative activity against human HOP62 cells after 96 hrs by WST-1 assay ChEMBL. 20225862
GI50 (functional) = 0.94 uM Antiproliferative activity against human MDA-MB-231 cells after 96 hrs by WST1 assay ChEMBL. 17696419
GI50 (functional) = 0.94 uM Antiproliferative activity against estrogen receptor negative human MDA-MB-231 cells ChEMBL. 18260615
GI50 (functional) = 0.94 uM Antiproliferative activity against human MDA-MB-231 cells after 96 hrs by WST1 assay ChEMBL. 17696419
GI50 (functional) = 0.94 uM Antiproliferative activity against estrogen receptor negative human MDA-MB-231 cells ChEMBL. 18260615
GI50 (functional) = 0.94 uM Antiproliferative activity against human MDA-MB-231 cells after 96 hrs by WST-1 assay ChEMBL. 20225862
GI50 (functional) = 0.95 uM Concentration of the compound required to inhibit the growth of SN12C human renal cancer cells by 50% ChEMBL. 16078843
GI50 (functional) = 0.95 uM Cytotoxicity against human SN12C cells ChEMBL. 18052315
GI50 (functional) = 0.95 uM Antiproliferative activity against human SN12-C cells ChEMBL. 18260615
GI50 (functional) = 0.95 uM In vitro cytotoxicity value corresponding to 50% growth inhibition against SN12C (renal) cell line. ChEMBL. 9240348
GI50 (functional) = 0.95 uM Cytotoxicity against renal SN12C cancer cell lines. ChEMBL. 7783135
GI50 (functional) = 0.95 uM Cytotoxicity against the cancer cell lines renal SN12C ChEMBL. 12361402
GI50 (functional) = 0.95 uM Growth inhibitory concentration against human renal SN12C cancer cell line ChEMBL. 15456256
GI50 (functional) = 0.95 uM Concentration of the compound required to inhibit the growth of SN12C human renal cancer cells by 50% ChEMBL. 16078843
GI50 (functional) = 0.95 uM Cytotoxicity against human SN12C cells ChEMBL. 18052315
GI50 (functional) = 0.95 uM Antiproliferative activity against human SN12-C cells ChEMBL. 18260615
GI50 (functional) = 0.95 uM Antiproliferative activity against human SN12C cells after 96 hrs by WST-1 assay ChEMBL. 20225862
GI50 (functional) = 1.2 uM Antiproliferative activity against human DU145 cells at 96 hrs by WST1 assay ChEMBL. 22247790
GI50 (functional) = 1.22 uM Antiproliferative activity against human DU145 cells after 96 hrs by WST1 assay ChEMBL. 17696419
GI50 (functional) = 1.22 uM Antiproliferative activity against human DU145 cells ChEMBL. 18260615
GI50 (functional) = 1.22 uM Antiproliferative activity against human DU145 cells after 96 hrs by WST1 assay ChEMBL. 17696419
GI50 (functional) = 1.22 uM Antiproliferative activity against human DU145 cells ChEMBL. 18260615
GI50 (functional) = 1.22 uM Antiproliferative activity against human DU145 cells after 96 hrs by WST-1 assay ChEMBL. 20225862
GI50 (functional) = 1.3 uM Mean graph midpoint for growth inhibition of all human cancer cell lines ChEMBL. 9240348
GI50 (functional) = 1.3 uM Mean graph midpoint for all human cancer cell line cytotoxicity. ChEMBL. 7783135
GI50 (functional) = 1.8 uM Concentration of the compound required to inhibit the growth of DU-145 human prostate cancer cells by 50% ChEMBL. 16078843
GI50 (functional) = 1.8 uM Cytotoxicity against human DU145 cells ChEMBL. 18052315
GI50 (functional) = 1.8 uM The In vitro cytotoxicity value corresponding to 50% growth inhibition against DU-145(prostate) cell line. ChEMBL. 9240348
GI50 (functional) = 1.8 uM Cytotoxicity against prostate DU-145 cancer cell lines. ChEMBL. 7783135
GI50 (functional) = 1.8 uM Cytotoxicity against the cancer cell lines prostate DU-145 ChEMBL. 12361402
GI50 (functional) = 1.8 uM Growth inhibitory concentration against human prostate DU-145 cancer cell line ChEMBL. 15456256
GI50 (functional) = 1.8 uM Concentration of the compound required to inhibit the growth of DU-145 human prostate cancer cells by 50% ChEMBL. 16078843
GI50 (functional) = 1.8 uM Cytotoxicity against human DU145 cells ChEMBL. 18052315
GI50 (functional) = 2.35 uM Inhibition of the growth of human breast cancer MCF-7 cells done for 2 h at 37 degree C with compound ChEMBL. 16078843
GI50 (functional) = 2.35 uM Antiproliferative activity against estrogen receptor positive human MCF7 cells ChEMBL. 18260615
GI50 (functional) = 2.35 uM Inhibition of the growth of human breast cancer MCF-7 cells done for 2 h at 37 degree C with compound ChEMBL. 16078843
GI50 (functional) = 2.35 uM Antiproliferative activity against estrogen receptor positive human MCF7 cells ChEMBL. 18260615
GI50 (functional) = 2.35 uM Growth inhibition of human MCF7 cells ChEMBL. 25992880
IC50 (functional) = -4.9 Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay ChEMBL. 19734910
IC50 (binding) = 14.2 mM Inhibition of tubulin polymerization ChEMBL. 9371249
IC50 (binding) = 14.2 mM Inhibition of tubulin polymerization ChEMBL. 9371249
IC50 (functional) = 523 nM Antiangiogenic activity against HUVEC cells assessed as inhibition of proliferation ChEMBL. 18260615
IC50 (functional) = 523 nM Antiangiogenic activity against HUVEC cells assessed as inhibition of proliferation ChEMBL. 18260615
IC50 (functional) = 586 nM Antiproliferative activity against human HeLa cells expressing tubulin 3beta by sulforhodamine B assay ChEMBL. 20973488
IC50 (functional) = 608 nM Antiproliferative activity against human HeLa cells by sulforhodamine B assay ChEMBL. 20973488
IC50 (functional) = 867 nM Antiproliferative activity against human SKOV3 cells by sulforhodamine B assay ChEMBL. 20973488
IC50 (functional) = 2268 nM Antiproliferative activity against human SKOV3 cells expressing MDR1-6/6 by sulforhodamine B assay ChEMBL. 20973488
IC50 (functional) = 0.25 uM Inhibition of estrogen receptor negative MDA-MB 231 breast cancer cell proliferation at 1 uM ChEMBL. 9357519
IC50 (functional) = 0.5 uM Antiproliferative activity against human LNCaP cell line ChEMBL. 16650989
IC50 (functional) = 0.68 uM Antiangiogenic activity against HUVEC assessed as growth inhibition after 48 hrs by WST1 assay ChEMBL. 19782564
IC50 (functional) = 0.68 uM Antiangiogenic activity in HUVEC assessed as inhibition of cell proliferation ChEMBL. 19782568
IC50 (functional) = 0.79 uM Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by WST1 assay ChEMBL. 19782564
IC50 (functional) = 0.79 uM Antiproliferative activity against human MDA-MB-231 cells ChEMBL. 19782568
IC50 (functional) = 0.8 uM Anticancer activity against human K562 cells assessed as cell growth inhibition after 5 days by MTT assay ChEMBL. 25108078
IC50 (ADMET) = 0.84 uM Antiproliferative activity against human HUVECs after 48 hrs ChEMBL. 17910916
IC50 (functional) = 0.84 uM Growth inhibitory concentration against MDA-MB-231 cancer cell line ChEMBL. 15456256
IC50 (ADMET) = 0.84 uM Antiproliferative activity against human HUVECs after 48 hrs ChEMBL. 17910916
IC50 (functional) = 0.84 uM Antiangiogenic activity against HUVECs by Brdu incorporation assay ChEMBL. 19762246
IC50 (functional) = 0.842 uM Antiproliferative activity against human MCF7 cells after 72 hrs by crystal violet biomass reduction assay ChEMBL. 20334421
IC50 (functional) = 0.9 uM Cytotoxicity against vincristine-resistant human HL60 cells after 72 hrs MTS assay ChEMBL. 20411988
IC50 (functional) = 1 uM Antiproliferative activity against human MDA-MB-231 cells after 48 hrs ChEMBL. 17910916
IC50 (functional) = 1 uM Growth inhibitory concentration against HUVEC cancer cell line ChEMBL. 15456256
IC50 (functional) = 1 uM Antiproliferative activity against human MDA-MB-231 cells after 48 hrs ChEMBL. 17910916
IC50 (functional) = 1 uM Antiproliferative activity against human MDA-MB-435 cells by Brdu incorporation assay ChEMBL. 19762246
IC50 (functional) = 1.4 uM Inhibition of polymerization of purified bovine tubulin ChEMBL. 10882369
IC50 (binding) = 2.2 uM Inhibition of porcine brain tubulin polymerization after 60 mins ChEMBL. 25108078
IC50 (functional) = 2.39 uM Anti-proliferative activity of the compound against MCF-7 human breast cancer cells was determined by using MCF-7 plate assay ChEMBL. 15149660
IC50 (functional) = 2.65 uM Antiproliferative activity against human PC3 cells by Brdu incorporation assay ChEMBL. 19762246
IC50 (binding) = 2.9 uM In vitro inhibition of tubulin polymerization. ChEMBL. 7783135
IC50 (functional) = 2.91 uM Antiproliferative activity against human U937 cells by sulforhodamine B assay ChEMBL. 20334421
IC50 (functional) = 3.1 uM Evaluated for inhibition of tubulin polymerization. ChEMBL. 9240348
IC50 (functional) = 3.4 uM Cytotoxicity against human HL60 cells after 72 hrs MTS assay ChEMBL. 20411988
IC50 (binding) = 4.7 uM Inhibition of tubulin polymerization measured at 12 uM tubulin concentration. ChEMBL. 12361402
IC50 (functional) = 5 uM Inhibition of estrogen receptor negative MDA-MB 231 breast cancer cell proliferation at 10 uM ChEMBL. 9357519
IC50 (functional) = 5.3 uM Inhibitory concentration against bovine brain tubulin polymerization ChEMBL. 15456256
IC50 (functional) = 12 uM Inhibition of tubulin polymerization using isolated calf brain at 26 degrees C ChEMBL. 9357519
IC50 (functional) = 60 uM Inhibition of tubulin polymerization using isolated calf brain ChEMBL. 9357519
Inhibition (binding) = 4.4 % Inhibition of recombinant human CYP1B1 expressed in bacterial microsomes co-expressing P450 reductase at 3 uM using 7-ethyl-O-resorufin as substrate after 45 mins in presence of NADPH by fluorescence assay relative to control LITERATURE. 27687674
Inhibition (binding) = 19 % Evaluated for % inhibition of colchicine binding to tubulin. ChEMBL. 9240348
Inhibition (binding) = 19 % Compound was evaluated for inhibition of colchicine binding to tubulin in experiment I. ChEMBL. 10882369
Inhibition (functional) = 25 % In vitro inhibition of primary human umbilial vein endothelial cell (HUVEC) proliferation at 3 uM ChEMBL. 12672229
Inhibition (binding) = 38 % Percentage inhibition of colchicine binding to tubulin. ChEMBL. 7783135
Inhibition (functional) = 44 % Inhibition of colchicine binding to tubulin ChEMBL. 9357519
Inhibition (binding) = 60 % Compound was evaluated for inhibition of colchicine binding to tubulin in experiment II. ChEMBL. 10882369
Inhibition (functional) = 60 % In vitro inhibition of primary human umbilial vein endothelial cell (HUVEC) proliferation at 1 uM ChEMBL. 12672229
Inhibition (binding) = 74.3 % Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells at 100 uM by confocal microscopy ChEMBL. 18788725
Inhibition (functional) = 100 % In vitro inhibition of primary human umbilial vein endothelial cell (HUVEC) proliferation in presence of bFGF ChEMBL. 12672229
Inhibition (functional) = 100 % In vitro inhibition of primary human umbilial vein endothelial cell (HUVEC) proliferation at 0.01 uM ChEMBL. 12672229
Inhibition (functional) = 100 % IIn vitro inhibition of primary human umbilial vein endothelial cell (HUVEC) proliferation at 0.1 uM ChEMBL. 12672229
Kd (binding) = 9.08 Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulin ChEMBL. 18330978
MGM (functional) = 1.3 uM Mean graph midpoint (MGM) of the compound against a panel of human tumor cell lines ChEMBL. 16078843
MGM (functional) = 1.3 uM Tested for cytotoxicities and mean graph midpoint (MGM) for growth inhibition of all 55 human cell lines ChEMBL. 10882369
pKd (binding) = 9.08 Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulin ChEMBL. 18330978
Potency (functional) = 0.0071 um PUBCHEM_BIOASSAY: qHTS Validation Assay for Inhibitors of Bloom's syndrome helicase (BLM). (Class of assay: confirmatory) [Related pubchem assays: 593 (Fluorescein region spectral profiling screen), 594 (Rhodamine region spectral profiling screen)] ChEMBL. No reference
Potency (functional) = 0.0071 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bloom's syndrome helicase (BLM). (Class of assay: confirmatory) [Related pubchem assays: 593 (Fluorescein region spectral profiling screen), 2386 (Probe Development Summary for Inhibitors of Bloom's syndrome helicase (BLM)), 594 (Rhodamine region spectral profiling screen), 2364 (qHTS Validation Assay for Inhibitors of Bloom's syndrome helicase (BLM))] ChEMBL. No reference
Potency (functional) 0.2119 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference
Potency (functional) 0.7519 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 0.8913 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 1.4125 uM PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 2.5119 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 2.5119 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.5929 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 2.6855 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Human Peripheral Myelin Protein 22 (PMP22) Expression/Activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: Validation screen for small molecules that induce DNA re-replication in MCF 10A normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.2643 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.1095 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors: Validation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493163, AID504444, AID504648] ChEMBL. No reference
Potency (functional) 4.6109 uM PUBCHEM_BIOASSAY: Validation screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463097, AID463113, AID493165, AID493166, AID504806, AID504809] ChEMBL. No reference
Potency (functional) 4.7611 uM PUBCHEM_BIOASSAY: Retest of LOPAC molecules that induce DNA re-replication in MCF 10A normal breast cells. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463097, AID463113, AID493165, AID504364, AID504806, AID504809] ChEMBL. No reference
Potency (functional) = 5.2119 um PUBCHEM_BIOASSAY: Cytometry Cell-Based qHTS for Inhibitors of the mTORC1 Signaling Pathway in MEF cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.7252 uM PUBCHEM_BIOASSAY: Retest of LOPAC molecules that induce DNA re-replication in SW480 adenocarcinoma cells. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463097, AID463113, AID493166, AID504364, AID504806, AID504809] ChEMBL. No reference
Potency (functional) 7.5686 uM PUBCHEM_BIOASSAY: qHTS Validation Assay to Find Inhibitors of T. brucei phosphofructokinase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488768, AID492961] ChEMBL. No reference
Potency (functional) 7.9433 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 9.2 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 9.2 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: Validation of Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.5774 uM PUBCHEM_BIOASSAY: Validation screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493125, AID504467] ChEMBL. No reference
Potency (functional) 11.5774 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (binding) = 14.1254 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of ATXN expression: Validation of Cytotoxic Assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588378, AID588380] ChEMBL. No reference
Potency (functional) = 20.5962 um PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.5068 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: Counterscreen for APE1 Inhibitors: qHTS Validation Assay for Inhibitors of Endonuclease IV. (Class of assay: confirmatory) [Related pubchem assays: 1705, 1707 ] ChEMBL. No reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Validation Assay for Inhibitors for MPP8 Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Validation Assay for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
RBA (binding) = 0.0225 Relative binding affinity (RBA) for estrogen receptor at 25 degree C ChEMBL. 7783135
RBA (binding) = 0.245 Relative binding affinity (RBA) for estrogen receptor at 0C ChEMBL. 7783135
RBA (binding) = 0.245 Relative binding affinity for estrogen receptor using a tritiumlabeled estrogen as the tracer and immature rat uterine cytosol ChEMBL. 9240348
Stability (ADMET) > 65 % Metabolic stability in human Hepatocyte assessed as compound remaining at 1 umol/L after 2 hrs by RP-HPLC analysis ChEMBL. 22305612
Stability (ADMET) = 85 % Metabolic stability at human liver cytosol assessed as sulfotransferase-mediated sulfonylation after 60 min ChEMBL. 17910916
Stabilty (ADMET) = 9.4 % Metabolic stability at human liver microsome assessed as UDPGT-mediated glucuronidation after 60 min ChEMBL. 17910916
Stabilty (ADMET) = 85 % Metabolic stability at human liver cytosol assessed as sulfotransferase-mediated sulfonylation after 60 min ChEMBL. 17910916
T1/2 (ADMET) = 0.3 hr Half life in CD1 mouse at 45 mg/m'2 of body surface, po administered as single dose ChEMBL. 19782564

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23 19734910
Homo sapiens ChEMBL23 15149660

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

11 literature references were collected for this gene.

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