L. major prioritization: a Roos-centric approach

Posted by Greg Crowther on 2008-06-28 04:01:41

Uses the same criteria and weights as David Roos' T. brucei query and applies them to L. major, i.e.,
- enzymes [100]
- MW <100 kDa [20]
- no TM domains [20]
- structure available in PDB [50]
- model available in ModBase [30]
- present in all TriTryps [25]
- NOT in human [25]
- essentiality evidence in some (other) organism(s) [40]
- essential in Leishmania (lethal RNAi or KO phenotype) [50]
- druggability evidence inferred from orthology (>0.6) [35]
- compound desirability inferred from orthology (>0.3) [35]
- publications in PubMed [35]


Queries in this set

Click on the links below to browse the contents of each query or view the parameters used to filter genes. You can also use the checkboxes to select queries you would like to import into your history.

  L. major genes ranked by 13 criteria (9200 records). Show parameters.

  all enzymes (now searched on lma) (730 records). Show parameters.

  with publications (now searched on lma) (458 records). Show parameters.

  with crystal structures (now searched on lma) (49 records). Show parameters.

  with structural models (now searched on lma) (7103 records). Show parameters.

  present in all TriTryps (now searched on lma) (18486 records). Show parameters.

  absent in humans (now searched on lma) (14304 records). Show parameters.

  no transmembrane domains (now searched on lma) (18948 records). Show parameters.

  less than 100 kDa (now searched on lma) (22872 records). Show parameters.

  essential in at least one organism (now searched on lma) (2313 records). Show parameters.

  compound desirability above 0.3 (now searched on lma) (238 records). Show parameters.

  genetic validation in L. major (77 records). Show parameters.

  Assay available (lma) (255 records). Show parameters.

  L. major druggability > 0.6 (230 records). Show parameters.