T. brucei targets from HAT survey - Updated July 12th 2007

Posted by Dany Shanmugam on 2007-07-12 22:05:11

WARNING: This list was made prior to the version 4 release of TDR Targets (Aug, 2010). Some queries included in this list may not work properly. Most likely reasons for this are changes in parameters, and/or data updates. If you experience any problem, please try re-running each search from the search page. You can also access the previous version of the database at v3.tdrtargets.org

The aim of the survey is to capture, collate and make publicly available expert knowledge on potential drug targets
against Human African Trypanosomiasis (HAT). This survey is part of the WHO-TDR Drug Targets Networks community-wide
strategy to build a prioritise portfolio of tropical disease drug targets. The idea to survey the scientific community
came from a workshop on Drug Discovery for Trypanosomatid Diseases, held in Dundee in February 2007.

Groups engaged in drug discovery against HAT need to access the best possible drug targets and to contact and
collaborate with experts on that target. This portal is an opportunity to (a) make the community aware of specific
molecular targets and (b) state whether or not you are engaged in, or would be interested in collaborating on, a
drug discovery project related to that target.

This survey on HAT is a pilot scheme. If is considered successful, it may be extended to many other neglected diseases.

List of suggested targets

Currently NO experimental genetic or chemical evidence

Tb927.8.3530 Glycerol-3-phosphate dehydrogenase – NAD-dependent Paul A Michels
Tb927.1.3830 Glucose-6-phosphate isomerase Paul A Michels
Tb927.5.890 Oligosaccharyl transferase (OST) subunit Michael A Ferguson
Tb927.5.900 Oligosaccharyl transferase (OST) subunit Michael A Ferguson
Tb927.5.910 Oligosaccharyl transferase (OST) subunit Michael A Ferguson

Genetic AND chemical evidence

Tb10.389.1360 Glutamate-cysteine ligase Margaret A Phillips
Tb927.6.4410 S-adenosylmethionine decarboxylase Margaret A Phillips
Tb927.6.4460 S-adenosylmethionine decarboxylase Margaret A Phillips
Tb927.1.1240 cytidine triphosphate synthase Gavin A Whitlock
Tb927.1.700 Phosphoglycerate kinase (glycosomal, isoenzyme C) Paul A Michels
Tb11.01.6980 Vps34 (phosphatidylinositol 3-kinase catalytic subunit) Mark Field
Tb927.6.4280 Glyceraldehyde-3-phosphate dehydrogenase (glycosomal) Paul A Michels
Tb927.6.4300 Glyceraldehyde-3-phosphate dehydrogenase (glycosomal) Paul A Michels
Tb10.6k15.3640 Alternative oxidase Christiine E Clayton
Tb927.7.3360 farnesyl pyrophosphate synthase Roberto Docampo
Tb09.160.4300 solanesyl diphosphate synthase Roberto Docampo
Tb10.61.3140 Glycogen Synthase Kinase Frederick S Buckner
Tb11.01.0330 Aurora kinase-1 Larry Ruben
Tb11.01.5300 Ornithine decarboxylase Margaret A Phillips
Tb10.70.6220 Histone deacetylases David Horn
Tb927.2.2190 Histone deacetylases David Horn
Tb10.406.0520 Trypanothione reductase Alan H Fairlamb
Tb09.160.3590 Cyclic nucleotide specific phsphodiesterase Thomas Seebeck
Tb09.160.3630 Cyclic nucleotide specific phsphodiesterase Thomas Seebeck
Tb10.70.5820 Hexokinase 1 James C Morris
Tb10.61.2550 N-myristoyl transferase Andrew L Hopkins
Tb927.7.460 Protein farnesyltransferase beta subunit Wesley C Van Voorhis
Tb927.3.4490 protein farnesyltransferase alpha subunit Wesley C Van Voorhis
Tb11.01.3900 GlcNAc-PI de-N-acetylase Michael A Ferguson

Genetic OR chemical evidence

Tb927.4.1140 PI4 Kinase III beta Margaret A Phillips
Tb927.7.7420 ATP synthase F1, alpha subunit Achim Schnaufer
Tb927.3.1380 ATP synthase F1, beta subunit Achim Schnaufer
Tb10.70.2210 CRK3:CYC6 Jeremy C Mottram
Tb10.61.3060 GPI:protein transamidase Jeremy C Mottram
Tb927.5.800 TbCK1.2 (Caesin Kinase 1.2) Michael D Urbaniak
Tb927.5.790 TbCK1.2E (Caesin Kinase 1.2) Michael D Urbaniak
Tb10.100.0130 Peroxin 14 (PEX14) Paul A Michels
Tb927.5.1100 Peroxin 5 (PEX5) Paul A Michels
Tb10.61.2680 Pyruvate kinase Paul A Michels
Tb10.6k15.2620 Phosphoglycerate mutase Paul A Michels
Tb927.3.3270 Phosphofructokinase Paul A Michels
Tb10.70.4740 Enolase Paul A Michels
Tb10.70.1370 Fructose-1,6-bisphosphate aldolase Paul A Michels
Tb10.70.5200 Glucose-6-phosphate dehydrogenase Paul A Michels
Tb927.2.3270 Invariant surface glycoprotein Mark Carrington
Tb927.2.3280 Invariant surface glycoprotein Mark Carrington
Tb927.2.3290 Invariant surface glycoprotein Mark Carrington
Tb927.2.3300 Invariant surface glycoprotein Mark Carrington
Tb927.2.3310 Invariant surface glycoprotein Mark Carrington
Tb927.2.3320 Invariant surface glycoprotein Mark Carrington
Tb11.02.3210 Triosephosphate isomerase Paul A Michels
Tb927.7.4900 XRNA Christiine E Clayton
Tb927.1.2600 PUF9 Christiine E Clayton
Tb11.03.0580 UBP1 Christiine E Clayton
Tb11.03.0620 UBP2 Christiine E Clayton
Tb927.3.5280 DRBD1 Christiine E Clayton
Tb927.1.4650 CFB2 Christiine E Clayton
Tb927.6.600 MRNA degradation CAF1 deadenylase Christiine E Clayton
Tb927.7.6310 Polo-like kinase Tansy C Hammarton
Tb09.160.4250 TbCPX (peroxiredoxin) Shane R Wilkinson
Tb09.160.4280 TRYP1 (tryparedoxin peroxidase) Shane R Wilkinson
Tb927.7.1120 TbGPXI-A (non-selenium glutathione peroxidase) Shane R Wilkinson
Tb927.7.1130 TbGPXI-B (non-selenium glutathione peroxidase) Shane R Wilkinson
Tb927.7.1140 TbGPXI-C (non-selenium glutathione peroxidase) Shane R Wilkinson
Tb927.3.3760 TbTPNI (tryparedoxin) Shane R Wilkinson
Tb927.3.3780 TbTPNI (tryparedoxin) Shane R Wilkinson
Tb11.01.7550 TbSODB2 (Superoxide metabolism) Shane R Wilkinson
Tb11.01.6660 TbSODB2 (Superoxide metabolism) Shane R Wilkinson
Tb927.2.4370 Trypanothione synthetase Alan H Fairlamb
Tb11.01.4701 Membrane-bound histidine acid phosphatase Peter Overath
Tb927.6.4220 TbMAPK5 Isabel Roditi
Tb11.01.5220 JBP1 (targetting J biosynthesis Piet Borst
Tb927.6.940 Metacaspases Jeremy C Mottram
Tb11.02.0330 UDP-Glucose 4'-Epimerase (GalE) Michael D Urbaniak
Tb09.160.2970 RNA Editing ligase 1 Kenneth D Stuart
Tb11.02.0120 UDP-GlcNAc diphosphorylase Michael A Ferguson

Queries in this set

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  T. brucei targets from HAT survey - Updated July 12th 2007 (76 records). Show parameters.