Plasmodium protease targets

Posted by Stuart Ralph on 2007-08-03 13:27:35

WARNING: This list was made prior to the version 4 release of TDR Targets (Aug, 2010). Some queries included in this list may not work properly. Most likely reasons for this are changes in parameters, and/or data updates. If you experience any problem, please try re-running each search from the search page. You can also access the previous version of the database at

A list of potential Plasmodium protease drug targets.
*NB Relies on the word "protease" or "peptidase" appearing in gene name to identify proteases - maybe also possible with EC numbers?

The weighting is
In Plasmodium, has a name like “peptidase”: 100
In Plasmodium, has a name like “protease”: 100
has literature: 30
has modelled or solved structure: 50
druggability >0.3: 50
no orthologues in mammals: 50
essential in some organism: 30

Queries in this set

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