Posted by Greg Crowther on 2008-07-09 22:02:13
This is an example of incorporating literature rankings of targets into TDRtargets.org. In PLoS Comp Biol 2: e61 (2006), S. Hasan et al. generate 3 ranked lists of M. tuberculosis genes, each based on a separate criterion: metabolic role, whether they are specific to Actinobacteria, and expression during dormancy. My query set includes a list of Hasan's top 400 genes (top ~10%) for each criterion as well as an intersection showing the genes that rank in the top 400 for all 3.
● Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis. (2006). PLoS Comput Biol 2: e61 PubMed, Publisher.