Hasan TB target prioritization

Posted by Greg Crowther on 2008-07-09 22:02:13

WARNING: This list was made prior to the version 4 release of TDR Targets (Aug, 2010). Some queries included in this list may not work properly. Most likely reasons for this are changes in parameters, and/or data updates. If you experience any problem, please try re-running each search from the search page. You can also access the previous version of the database at v3.tdrtargets.org

This is an example of incorporating literature rankings of targets into TDRtargets.org. In PLoS Comp Biol 2: e61 (2006), S. Hasan et al. generate 3 ranked lists of M. tuberculosis genes, each based on a separate criterion: metabolic role, whether they are specific to Actinobacteria, and expression during dormancy. My query set includes a list of Hasan's top 400 genes (top ~10%) for each criterion as well as an intersection showing the genes that rank in the top 400 for all 3.

● Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis. (2006). PLoS Comput Biol 2: e61 PubMed, Publisher.

Queries in this set

Click on the links below to browse the contents of each query. You can also use the checkboxes to select queries you would like to import into your history.
Import ranked queries into your history to redo the scoring strategy

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  Intersection of (227, 228, 229) (23 records). Show parameters.

  Hasan top 400, metabolism criterion (399 records). Show parameters.

  Hasan top 400, TB-specific criterion (400 records). Show parameters.

  Hasan top 400, persistence criterion (398 records). Show parameters.