Brugia targets ranked by Kumar et al.
Posted by Greg Crowther on
WARNING: This list was made prior to the version 4 release of TDR
Targets (Aug, 2010). Some queries included in this list may not work properly.
Most likely reasons for this are changes in parameters, and/or data updates. If you
experience any problem, please try re-running each search from the search
page. You can also access the previous version of the database at
Based on PLoS ONE 2: e1189, 2007. The authors first narrowed the Brugia genes down to those with essential orthologs in E. coli but lacking close homologs in humans. They then ranked these 589 genes with an algorithm based on data on homology, essentiality, stage-specific expression, druggability, and expressability. My list includes the top 10% of their rankings.
Mining predicted essential genes of Brugia malayi for nematode drug targets. (2007).
PLoS ONE 2: