Posted by Greg Crowther on 2008-07-10 01:41:55
Based on PLoS ONE 2: e1189, 2007. The authors first narrowed the Brugia genes down to those with essential orthologs in E. coli but lacking close homologs in humans. They then ranked these 589 genes with an algorithm based on data on homology, essentiality, stage-specific expression, druggability, and expressability. My list includes the top 10% of their rankings.
● Mining predicted essential genes of Brugia malayi for nematode drug targets. (2007). PLoS ONE 2: e1189 PubMed, Publisher.