Posted by Christine Stewart on 2009-03-13 01:16:34

WARNING: This list was made prior to the version 4 release of TDR Targets (Aug, 2010). Some queries included in this list may not work properly. Most likely reasons for this are changes in parameters, and/or data updates. If you experience any problem, please try re-running each search from the search page. You can also access the previous version of the database at

Using the genome comparison software Genlight, two separate in silico workflows were implemented to derive a set of parasite proteins for which gene disruption of the orthologs in both C. elegans and D. melanogaster yielded deleterious phenotypes (e.g., lethal, impairment of motility), i.e., are essential genes/proteins. 71 genes were identified that were expressed in the relevant developmental stages of the parasite infecting humans. Subsequent in depth manual curation of the combined workflow output revealed 57 candidate proteins.
[Smp_122390 ||29042.m003538|notchless-related| could not be found in TDR database and is therefore excluded.]

● A comparative chemogenomics strategy to predict potential drug targets in the metazoan pathogen, Schistosoma mansoni. (2009). PLoS ONE 4: e4413 PubMed, Publisher.

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  Schistosoma_Caffrey_2009 (56 records). Show parameters.