Posted by Christine Stewart on 2009-03-13 01:16:34
Using the genome comparison software Genlight, two separate in silico workflows were implemented to derive a set of parasite proteins for which gene disruption of the orthologs in both C. elegans and D. melanogaster yielded deleterious phenotypes (e.g., lethal, impairment of motility), i.e., are essential genes/proteins. 71 genes were identified that were expressed in the relevant developmental stages of the parasite infecting humans. Subsequent in depth manual curation of the combined workflow output revealed 57 candidate proteins.
[Smp_122390 ||29042.m003538|notchless-related| could not be found in TDR database and is therefore excluded.]
● A comparative chemogenomics strategy to predict potential drug targets in the metazoan pathogen, Schistosoma mansoni. (2009). PLoS ONE 4: e4413 PubMed, Publisher.