A Ranked List of T. cruzi Targets

Posted by Fernan Aguero on 2009-03-24 20:01:13

WARNING: This list was made prior to the version 4 release of TDR Targets (Aug, 2010). Some queries included in this list may not work properly. Most likely reasons for this are changes in parameters, and/or data updates. If you experience any problem, please try re-running each search from the search page. You can also access the previous version of the database at v3.tdrtargets.org

I have run a number of queries using different criteria to
retrieve T. cruzi genes.

Each query filters genes based on a single criteria.

These are:
* gene does not have orthologs in human/mouse [50]
* gene has orthologs in T. brucei [40]
* gene has orthologs in Yeast that are essential [50]
* gene has orthologs in Bacteria (E. coli, M. tuberculosis)
that are essential [40]
* gene has 3D Model(s) [30]
* gene has 3D structure(s) [40]
* gene has a druggability index > 0.6 (0-1 scale) [40]

A ranked list of genes was produced by asking for the UNION
of the above queries and assigning a weight (score) to each query
(in square brackets above).

Feel free to use this set, add/remove queries, revise my scoring scheme,
etc. And do share back your revised sets!

Queries in this set

Click on the links below to browse the contents of each query. You can also use the checkboxes to select queries you would like to import into your history.
Import ranked queries into your history to redo the scoring strategy

Select: All, None.

  tcruzi genes with 3D structures (49 records). Show parameters.

  tcruzi genes with 3D models (7103 records). Show parameters.

  tcruzi genes absent in human/mouse (14203 records). Show parameters.

  tcruzi genes with orthologs in T. brucei (12393 records). Show parameters.

  tcruzi genes essential in yeast (1001 records). Show parameters.

  tcruzi genes essential in bacteria (386 records). Show parameters.

  tcruzi genes with moderately good druggability prediction (404 records). Show parameters.

  Union of (2, 3, 4, 5, 6, 7, 8) (18784 records). Show parameters.