Reweightable Leish 12-criteria query and components thereof

Posted by Greg Crowther on 2009-03-26 15:57:12

WARNING: This list was made prior to the version 4 release of TDR Targets (Aug, 2010). Some queries included in this list may not work properly. Most likely reasons for this are changes in parameters, and/or data updates. If you experience any problem, please try re-running each search from the search page. You can also access the previous version of the database at v3.tdrtargets.org

This is an update of a previously published query set, done mostly to take advantage of the reweighting feature option in the new database (version 3). The criteria remain the same as before, i.e., enzymes (100), MW < 100 kDa (20), no TM domains (20), PDB structure (50), Modbase model (30), present in all TriTryps (25), not in humans (25), essential in at least one model organism (40), genetic validation in Leishmania (50), druggability > 0.6 (35), compound desirability > 0.3 (35), and PubMed publications (35).

Queries in this set

Click on the links below to browse the contents of each query. You can also use the checkboxes to select queries you would like to import into your history.
Import ranked queries into your history to redo the scoring strategy

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  Leish enzymes (2100 records). Show parameters.

  Leish < 100 kDa (7732 records). Show parameters.

  Leish no transmembrane domains (7645 records). Show parameters.

  Leish PDB structure (61 records). Show parameters.

  Leish structural model (ModBase) (3973 records). Show parameters.

  Leish present in all TriTryps (6237 records). Show parameters.

  Leish not in humans (2562 records). Show parameters.

  Leish essential (1482 records). Show parameters.

  Leish genetic validation (77 records). Show parameters.

  Leish druggability > 0.6 (230 records). Show parameters.

  Leish compound desirability > 0.3 (182 records). Show parameters.

  Leish PubMed publications (459 records). Show parameters.

  Reweightable Leish rankings (12 criteria) (9184 records). Show parameters.