Posted by Greg Crowther on 2009-06-12 20:06:17
A.G. Tsolaki et al. (PNAS 2004) studied 100 clinical strains of M. tuberculosis and identified over 220 genes that were deleted from at least one strain (supplementary Table 2 of their paper). This list of genes has been added here for possible use in prioritizing TB drug targets. Genes on this list should perhaps be given a negative weight, since the pathogen can survive without them.
● Functional and evolutionary genomics of Mycobacterium tuberculosis: insights from genomic deletions in 100 strains. (2004). Proc Natl Acad Sci U S A 101: 4865-70 PubMed, Publisher.