Brugia genome prioritization - druggability inferred by sequence similarity

Posted by Santiago Carmona on 2009-06-21 00:52:26

WARNING: This list was made prior to the version 4 release of TDR Targets (Aug, 2010). Some queries included in this list may not work properly. Most likely reasons for this are changes in parameters, and/or data updates. If you experience any problem, please try re-running each search from the search page. You can also access the previous version of the database at v3.tdrtargets.org

A prioritization session mainly based on phenotypes observed in C. elegans,
absence in human and mouse and druggability (inferred by sequence similarity against known druggable targets,
uploaded list)
Initial Criteria:

Score for genes in query #10 (Sterility in C. elegans): 20
Score for genes in query #11 (3D model available): 2
Score for genes in query #12 (enzyme): 10
Score for genes in query #13 (bibliographic reference): 2
Score for genes in query #2 (in human): -40
Score for genes in query #3 (in mouse): -20
Score for genes in query #4 (in C. elegans): 10
Score for genes in query #5 (any essentiality evidence): 5
Score for genes in query #6 (Embryonic Lethal/Arrest in C. elegans): 30
Score for genes in query #7 (Growth Defect in C. elegans): 20
Score for genes in query #8 (Larval/Adult Lethal/Arrest in C. elegans): 40
Score for genes in query #9 (Morphology Defect in C. elegans): 20
Score for genes in query #19 (druggable genes inferred by sequence simiarity): 30

Queries in this set

Click on the links below to browse the contents of each query. You can also use the checkboxes to select queries you would like to import into your history.
Import ranked queries into your history to redo the scoring strategy

Select: All, None.

  in human (5653 records). Show parameters.

  in mouse (5420 records). Show parameters.

  in C. elegans (7260 records). Show parameters.

  any essentiality evidence (3227 records). Show parameters.

  Embryonic Lethal/Arrest in C. elegans (2284 records). Show parameters.

  Growth Defect in C. elegans (1104 records). Show parameters.

  Larval/Adult Lethal/Arrest in C. elegans (1421 records). Show parameters.

  Morphology Defect in C. elegans (714 records). Show parameters.

  Sterility in C. elegans (1461 records). Show parameters.

  3D model available (7870 records). Show parameters.

  enzyme (637 records). Show parameters.

  bibliographic reference (212 records). Show parameters.

  druggable genes inferred by sequence simiarity (815 records). Show parameters.

  Union of (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 19) (9068 records). Show parameters.