Brugia genome prioritization - druggability inferred by sequence similarity
Posted by Santiago Carmona on
2009-06-21 00:52:26
WARNING: This list was made prior to the version 4 release of TDR
Targets (Aug, 2010). Some queries included in this list may not work properly.
Most likely reasons for this are changes in parameters, and/or data updates. If you
experience any problem, please try re-running each search from the search
page. You can also access the previous version of the database at
v3.tdrtargets.org
A prioritization session mainly based on phenotypes observed in C. elegans,
absence in human and mouse and druggability (inferred by sequence similarity against known druggable targets,
uploaded list)
Initial Criteria:
Score for genes in query #10 (Sterility in C. elegans): 20
Score for genes in query #11 (3D model available): 2
Score for genes in query #12 (enzyme): 10
Score for genes in query #13 (bibliographic reference): 2
Score for genes in query #2 (in human): -40
Score for genes in query #3 (in mouse): -20
Score for genes in query #4 (in C. elegans): 10
Score for genes in query #5 (any essentiality evidence): 5
Score for genes in query #6 (Embryonic Lethal/Arrest in C. elegans): 30
Score for genes in query #7 (Growth Defect in C. elegans): 20
Score for genes in query #8 (Larval/Adult Lethal/Arrest in C. elegans): 40
Score for genes in query #9 (Morphology Defect in C. elegans): 20
Score for genes in query #19 (druggable genes inferred by sequence simiarity): 30
