Ranked list of L. major targets for PLOS-NTD

Posted by Dany Shanmugam on 2009-09-04 23:51:24

WARNING: This list was made prior to the version 4 release of TDR Targets (Aug, 2010). Some queries included in this list may not work properly. Most likely reasons for this are changes in parameters, and/or data updates. If you experience any problem, please try re-running each search from the search page. You can also access the previous version of the database at v3.tdrtargets.org

Genomic scale ranking of L. major genes demonstrating that combining a wide range of criteria can be quiet useful in target prioritization work. Using this set of queries two different lists were generated - one without including essentiality data and another including essentiality data.


Score for genes in query #100 (Lma modbase): 30
Score for genes in query #101 (Lma not in humans): 25
Score for genes in query #102 (Lma any genetic validation): 50
Score for genes in query #103 (Lma any essentiality evidence): 50
Score for genes in query #104 (Lma dindex >=0.6): 35
Score for genes in query #105 (Lma Compd desirability >0.3): 35
Score for genes in query #106 (Lma assayable): 35
Score for genes in query #107 (Lma all proteins): 1
Score for genes in query #110 (Lma in Tbr and Tcr): 25
Score for genes in query #95 (Lma enz (EC + func. Categ.)): 100
Score for genes in query #96 (Lma Pubmed): 35
Score for genes in query #97 (Lma mwt <100kDa): 20
Score for genes in query #98 (Lma no TM domain): 20
Score for genes in query #99 (Lma PDB): 50

Queries in this set

Click on the links below to browse the contents of each query. You can also use the checkboxes to select queries you would like to import into your history.
Import ranked queries into your history to redo the scoring strategy

Select: All, None.

  Lma enzyme (EC + functional category) (1228 records). Show parameters.

  Lma Pubmed (695 records). Show parameters.

  Lma Molecular weight <100kDa (3942 records). Show parameters.

  Lma no TM domain (3197 records). Show parameters.

  Lma PDB structure (253 records). Show parameters.

  Lma Modbase structure model (2756 records). Show parameters.

  Lma not in humans (3310 records). Show parameters.

  Lma any genetic validation (28 records). Show parameters.

  Lma any essentiality (1054 records). Show parameters.

  Lma Dindex >=0.6 (16 records). Show parameters.

  Lma Compound desirability >0.3 (103 records). Show parameters.

  Lma assayable (254 records). Show parameters.

  Lma all proteins (3999 records). Show parameters.

  Lma in taxon (Tbr & Tcr) (6237 records). Show parameters.

  Weighted ranking of L. major targets for PLOS-NTD (9222 records). Show parameters.

  Weighted ranking (excluding essentiality) of L. major targets for PLOS-NTD (9222 records). Show parameters.