Ranked list of M. tuberculosis targets (focused on persistence) for PLOS-NTD

Posted by Dany Shanmugam on 2009-09-05 00:27:19

WARNING: This list was made prior to the version 4 release of TDR Targets (Aug, 2010). Some queries included in this list may not work properly. Most likely reasons for this are changes in parameters, and/or data updates. If you experience any problem, please try re-running each search from the search page. You can also access the previous version of the database at v3.tdrtargets.org

Genomic scale ranking of M. tuberculosis genes emphasizing gene essentiality and expression during persistence. The data for gene attenuation and expression was uploaded into TDRtargets DB along with the original scores provided in the respective publications.


Score for genes in query #10 (Mtb weighted list for persistence expression score as in Murphy-Brown data): 22 to -18 (variable weight values)
Score for genes in query #2 (Hasan 2006 persistence, revised):597 to -2119 (variable weight values)
Score for genes in query #5 (Mtu PDB structures): 20
Score for genes in query #8 (Mtu all proteins): 1
Score for genes in query #9 (Mtb weighted list for gene attenuation score as in Murphy-Brown data): 10 to 0 (variable weight values)

Queries in this set

Click on the links below to browse the contents of each query. You can also use the checkboxes to select queries you would like to import into your history.
Import ranked queries into your history to redo the scoring strategy

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  Uploaded list of targets ranked for persistence (Hasan et. al., 2006) (3915 records). Show parameters.

  Mtu PDB structures (253 records). Show parameters.

  Mtu all proteins (3999 records). Show parameters.

  Uploaded list - Gene attenuation ranking for Mtb genes (Murphy & Brown, 2007) (3998 records). Show parameters.

  Uploaded list - Gene expression in persistence ranking for Mtb genes (Murphy & Brown, 2007) (3998 records). Show parameters.

  Weighted ranking of Mtb targets based on gene essentiality and expression during persistence for PLOS-NTD (3999 records). Show parameters.